Block Copolymer Synthesis for Nanoscale Drug and Gene Delivery

  • Motoi Oishi
  • Yukio Nagasaki
Part of the Biotechnology: Pharmaceutical Aspects book series (PHARMASP, volume X)


One of the fascinating subjects in areas such as materials science, nanochemistry, and biomimetic chemistry is concerned with the creation of supramolecular architectures with well-defined shapes and functions. Self-assembly of block polymers through non-covalent forces including hydrophobic and hydrophilic effects, electrostatic interactions, hydrogen bonding, and metal complication has great potential for creating such supramolecular structures. In particular, polymeric micelles formed in aqueous media through the self-assembly of block copolymers containing poly(ethylene glycol) (PEG) as the corona-forming segment have attracted considerable attention in the field of drug and gene delivery systems due to their excellent biocompatibility, long blood circulation time, and nontoxicity (Otsuka, Nagasaki & Kataoka, 2003). As can be seen in Figure 2.1, the number of publications on drug and gene delivery systems using block copolymer and PEG-based block copolymer is...


Block Copolymer Triblock Copolymer Polymeric Micelle Ethyl Methacrylate RNAi Activity 
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Copyright information

© American Association of Pharmaceutical Scientists 2009

Authors and Affiliations

  • Motoi Oishi
    • 1
  • Yukio Nagasaki
    • 1
  1. 1.Tsukuba Research Center for Interdisciplinary Materials Science (TIMS) and Graduate School of Pure and Applied SciencesUniversity of TsukubaTsukubaJapan

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