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PAMAM Dendrimers as Nanoscale Oral Drug Delivery Systems

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Book cover Nanotechnology in Drug Delivery

Part of the book series: Biotechnology: Pharmaceutical Aspects ((PHARMASP,volume X))

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Abbreviations

Abbreviations::

Full name:

1B4M:

p-Isothiocyanatobenzyl)-6-methyl-diethylenetriamine pentaacetic acid

AB:

Apical-to-basolateral

BA:

Basolateral-to-apical

BRI:

Biomolecular Research Institute

CAT:

Chloramphenicol acetyl-transferase

CT:

Computed topography

Da:

Daltons

DAB:

Diaminobutane

DMPC:

1,2-Dimyristoyl-sn-glycero-3-phosphocholine

DNA:

Deoxyribonucleic acid

DTPA:

Diethylenetriaminepentaacetic acid

EEA-1:

Early endosomal antigen 1

FITC:

Fluorescein isothiocyanate

G:

Generation

Gd:

Gadolinium

GI:

Gastrointestinal

HSV-2:

Herpes simplex virus type 2

ID/g:

Injected dose per gram

IR:

Infra-red

LAMP-1:

Lysosome-associated membrane protein 1

LDH:

Lactate dehydrogenase

MALDI-TOF:

Matrix-assisted laser desorption ionization time of flight

MDCK:

Madin–Darby canine kidney

MRI:

Magnetic resonance imaging

MTT:

3-(4,5-Dimethylthiazole-2-yl)-2,5-diphenyltetrazolium bromide

NMR:

Nuclear magnetic resonance

P app :

Apparent permeability

PAGE:

Polyacrylamide gel electrophoresis

PAMAM:

Poly(amidoamine)

PEG:

Poly(ethylene glycol)

PEI:

Poly(ethyleneimine)

PEO:

Poly(ethylene oxide)

P-gp:

P-glycoprotein

PPI:

Poly(propyleneimine)

PVA:

Poly(vinyl alcohol)

SANS:

Small-angle neutron scattering

SAXS:

Small-angle X-ray scattering

SDS:

Sodium dodecyl sulfate

TEER:

Transepithelial electrical resistance

TEM:

Transmission electron microscopy

TNF-α:

Tumor necrosis factor

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Acknowledgments

Financial support was in part provided by the National Institute of General Medical Sciences National Research Service Award predoctoral fellowship to Kelly Kitchens (F31-GM67278) and a grant from the National Institutes of Health (RO1EB007470).

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Authors and Affiliations

  1. Alba Therapeutics Corporation, Discovery and Preclinical Development, Baltimore, MD 21201, USA

    Kelly M. Kitchens

  2. Department of Pharmaceutics and Pharmaceutical Chemistry and Bioengineering, University of Utah, Salt Lake City, Utah, 84108, USA

    Hamidreza Ghandehari

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  1. Kelly M. Kitchens
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  1. University of Wisconsin, Madison, WI, USA

    Melgardt M. de Villiers  & Glen S. Kwon  & 

  2. Chulalongkorn University, Bangkok, Thailand

    Pornanong Aramwit

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Kitchens, K.M., Ghandehari, H. (2009). PAMAM Dendrimers as Nanoscale Oral Drug Delivery Systems. In: de Villiers, M.M., Aramwit, P., Kwon, G.S. (eds) Nanotechnology in Drug Delivery. Biotechnology: Pharmaceutical Aspects, vol X. Springer, New York, NY. https://doi.org/10.1007/978-0-387-77668-2_14

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