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PAMAM Dendrimers as Nanoscale Oral Drug Delivery Systems

  • Kelly M. Kitchens
  • Hamidreza Ghandehari
Part of the Biotechnology: Pharmaceutical Aspects book series (PHARMASP, volume X)

Introduction

The application of nanotechnology to the diagnosis and treatment of diseases has coined the term nanomedicine. Nanometer-scale biomaterials have their role in nanomedicine since their nanoscopic size allows interaction with cellular membranes, subcellular organelles, passage through the microvasculature, and may reduce immunogenicity by avoiding reticuloendothelial uptake. Such features are desirable for nanomaterials to enhance the residence of poorly bioavailable drugs in the systemic circulation. Nanomaterials used as drug delivery systems, also termed nanocarriers, should be freely permeable to tumor vasculature since the endothelial pores range from 100 to 1000 nm (Hobbs et al., 1998). On the other hand, several moieties can be incorporated in these nanocarriers to enhance the delivery of bioactive and diagnostic agents. These include imaging agents for detection of the nanocarriers in the body, targeting ligands to direct the carrier to the site of action, enhanced...

Keywords

Surface Group PAMAM Dendrimers Carbosilane Dendrimers Extravasation Time Cationic Dendrimers 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations

Abbreviations:

Full name:

1B4M

p-Isothiocyanatobenzyl)-6-methyl-diethylenetriamine pentaacetic acid

AB

Apical-to-basolateral

BA

Basolateral-to-apical

BRI

Biomolecular Research Institute

CAT

Chloramphenicol acetyl-transferase

CT

Computed topography

Da

Daltons

DAB

Diaminobutane

DMPC

1,2-Dimyristoyl-sn-glycero-3-phosphocholine

DNA

Deoxyribonucleic acid

DTPA

Diethylenetriaminepentaacetic acid

EEA-1

Early endosomal antigen 1

FITC

Fluorescein isothiocyanate

G

Generation

Gd

Gadolinium

GI

Gastrointestinal

HSV-2

Herpes simplex virus type 2

ID/g

Injected dose per gram

IR

Infra-red

LAMP-1

Lysosome-associated membrane protein 1

LDH

Lactate dehydrogenase

MALDI-TOF

Matrix-assisted laser desorption ionization time of flight

MDCK

Madin–Darby canine kidney

MRI

Magnetic resonance imaging

MTT

3-(4,5-Dimethylthiazole-2-yl)-2,5-diphenyltetrazolium bromide

NMR

Nuclear magnetic resonance

Papp

Apparent permeability

PAGE

Polyacrylamide gel electrophoresis

PAMAM

Poly(amidoamine)

PEG

Poly(ethylene glycol)

PEI

Poly(ethyleneimine)

PEO

Poly(ethylene oxide)

P-gp

P-glycoprotein

PPI

Poly(propyleneimine)

PVA

Poly(vinyl alcohol)

SANS

Small-angle neutron scattering

SAXS

Small-angle X-ray scattering

SDS

Sodium dodecyl sulfate

TEER

Transepithelial electrical resistance

TEM

Transmission electron microscopy

TNF-α

Tumor necrosis factor

Notes

Acknowledgments

Financial support was in part provided by the National Institute of General Medical Sciences National Research Service Award predoctoral fellowship to Kelly Kitchens (F31-GM67278) and a grant from the National Institutes of Health (RO1EB007470).

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Copyright information

© American Association of Pharmaceutical Scientists 2009

Authors and Affiliations

  • Kelly M. Kitchens
    • 1
  • Hamidreza Ghandehari
    • 2
  1. 1.Alba Therapeutics CorporationDiscovery and Preclinical DevelopmentBaltimoreUSA
  2. 2.Department of Pharmaceutics and Pharmaceutical Chemistry and BioengineeringUniversity of UtahSalt Lake CityUSA

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