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References
Aalto-Setala, K., & Vuorio, E. (1997). Gene Therapy of single-gene disorders: preface to the special section. Ann Med, 29, 549–551.
Allen, T. M., Newman, M. S., Woodle, M. C., Mayhew, E., & Uster, P. S. (1995). Pharmacokinetics and anti-tumor activity of vincristine encapsulated in sterically stabilized liposomes. Int J Cancer, 62(2), 199–204.
Arnheiter, H., & Haller, O. (1988). Antiviral sTATe against influenza virus neutralized by microinjection of antibodies to interferon-induced Mx proteins. Embo J, 7(5), 1315–1320.
Asin-Cayuela, J., Manas, A. R., James, A. M., Smith, R. A., & Murphy, M. P. (2004). Fine-tuning the hydrophobicity of a mitochondria-targeted antioxidant. FEBS Lett, 571(1–3), 9–16.
Asokan, A., & Cho, M. J. (2002). Exploitation of intracellular pH gradients in the cellular delivery of macromolecules. J Pharm Sci, 91(4), 903–913.
Asokan, A., & Cho, M. J. (2003). Cytosolic delivery of macromolecules. II. Mechanistic studies with pH-sensitive morpholine lipids. Biochim Biophys Acta, 1611(1–2), 151–160.
Bae, Y., Nishiyama, N., Fukushima, S., Koyama, H., Yasuhiro, M., & Kataoka, K. (2005). Preparation and biological characterization of polymeric micelle drug carriers with intracellular pH-triggered drug release property: tumor permeability, controlled subcellular drug distribution, and enhanced in vivo antitumor efficacy. Bioconjug Chem, 16(1), 122–130.
Bathori, G., Cervenak, L., & Karadi, I. (2004). Caveolae – an alternative endocytotic pathway for targeted drug delivery. Crit Rev Ther Drug Carrier Syst, 21(2), 67–95.
Becker, M. L., Bailey, L. O., & Wooley, K. L. (2004). Peptide-derivatized shell-cross-linked nanoparticles. 2. Biocompatibility evaluation. Bioconjug Chem, 15(4), 710–717.
Becker, M. L., Remsen, E. E., Pan, D., & Wooley, K. L. (2004). Peptide-derivatized shell-cross-linked nanoparticles. 1. Synthesis and characterization. Bioconjug Chem, 15(4), 699–709.
Belchetz, P. E., Crawley, J. C., Braidman, I. P., & Gregoriadis, G. (1977). Treatment of Gaucher's disease with liposome-entrapped glucocerebroside: beta-glucosidase. Lancet, 2(8029), 116–117.
Boddapati, S. V., Tongcharoensirikul, P., Hanson, R. N., D'Souza, G. G., Torchilin, V. P., & Weissig, V. (2005). Mitochondriotropic liposomes. J Liposome Res, 15(1–2), 49–58.
Boomer, J. A., & Thompson, D. H. (1999). Synthesis of acid-labile diplasmenyl lipids for drug and gene delivery applications. Chem Phys Lipids, 99(2), 145–153.
Boussif, O., Lezoualc'h, F., Zanta, M. A., Mergny, M. D., Scherman, D., Demeneix, B., et al. (1995). A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine. Proc Natl Acad Sci USA, 92(16), 7297–7301.
Brady, R. O., Pentchev, P. G., Gal, A. E., Hibbert, S. R., & Dekaban, A. S. (1974). Replacement therapy for inherited enzyme deficiency. Use of purified glucocerebrosidase in Gaucher's disease. N Engl J Med, 291(19), 989–993.
Brady, R. O., Tallman, J. F., Johnson, W. G., Gal, A. E., Leahy, W. R., Quirk, J. M., et al. (1973). Replacement therapy for inherited enzyme deficiency. Use of purified ceramidetrihexosidase in Fabry's disease. N Engl J Med, 289(1), 9–14.
Branden, L. J., Mohamed, A. J., & Smith, C. I. (1999). A peptide nucleic acid-nuclear localization signal fusion that mediates nuclear transport of DNA. Nat Biotechnol, 17(8), 784–787.
Burns, R. J., & Murphy, M. P. (1997). Labeling of mitochondrial proteins in living cells by the thiol probe thiobutyltriphenylphosphonium bromide. Arch Biochem Biophys, 339, 33–39.
Burns, R. J., Smith, R. A. J., & Murphy, M. P. (1995). Synthesis and characterization of thiobutyltriphenylphosphonium bromide, a novel thiol reagent targeted to the mitochondrial matrix. Arch Biochem Biophys, 322, 60–68.
Chakrabarti, R., Wylie, D. E., & Schuster, S. M. (1989). Transfer of monoclonal antibodies into mammalian cells by electroporation. J Biol Chem, 264(26), 15494–15500.
Chen, G., & Hoffman, A. S. (1995). Graft copolymers that exhibit temperature-induced phase transitions over a wide range of pH. Nature, 373(6509), 49–52.
Chen, L. B., Summerhayes, I. C., Johnson, L. V., Walsh, M. L., Bernal, S. D., & Lampidis, T. J. (1982a). Probing mitochondria in living cells with rhodamine 123. Cold Spring Harb Symp Quant Biol, 46 Pt 1, 141–155.
Chen, L. B., Summerhayes, I. C., Johnson, L. V., Walsh, M. L., Bernal, S. D., & Lampidis, T. J. (1982b). Probing mitochondria in living cells with rhodamine 123. Cold Spring Harb Symp Quant Biol, 46, 141–155.
Colley, C. M., & Ryman, B. E. (1976). The use of a liposomally entrapped enzyme in the treatment of an artificial storage condition. Biochim Biophys Acta, 451(2), 417–425.
Costantini, P., Jacotot, E., Decaudin, D., & Kroemer, G. (2000). Mitochondrion as a novel target of anticancer chemotherapy. J Natl Cancer Inst, 92(13), 1042–1053.
Costin, G. E., Trif, M., Nichita, N., Dwek, R. A., & Petrescu, S. M. (2002). pH-sensitive liposomes are efficient carriers for endoplasmic reticulum-targeted drugs in mouse melanoma cells. Biochem Biophys Res Commun, 293(3), 918–923.
Coulter, C. V., Smith, R. A. J., & Murphy, M. P. (2001). Synthesis, characterization, and biological properties of a fullerene triphenylphosphonium salt. Fullerene Science and Technology, 9, 339–350.
Csermely, P., Schnaider, T., & Szanto, I. (1995). Signaling and transport through the nuclear membrane. Biochim Biophys Acta, 1241, 425–452.
D'Souza, G. G., Rammohan, R., Cheng, S. M., Torchilin, V. P., & Weissig, V. (2003). DQAsome-mediated delivery of plasmid DNA toward mitochondria in living cells. J Control Release, 92(1–2), 189–197.
Das, P. K., Murray, G. J., Zirzow, G. C., Brady, R. O., & Barranger, J. A. (1985). Lectin-specific targeting of beta-glucocerebrosidase to different liver cells via glycosylated liposomes. Biochem Med, 33(1), 124–131.
Daugelavicius, R., Cvirkaite, V., Gaidelyte, A., Bakiene, E., Gabrenaite-Verkhovskaya, R., & Bamford, D. H. (2005). Penetration of enveloped double-stranded RNA bacteriophages phi13 and phi6 into Pseudomonas syringae cells. J Virol, 79(8), 5017–5026.
de la Fuente, J. M., & Berry, C. C. (2005). Tat peptide as an efficient molecule to translocate gold nanoparticles into the cell nucleus. Bioconjug Chem, 16(5), 1176–1180.
Del Gaizo, V., MacKenzie, J. A., & Payne, R. M. (2003). Targeting proteins to mitochondria using TAT. Mol Genet Metab, 80(1–2), 170–180.
Derossi, D., Calvet, S., Trembleau, A., Brunissen, A., Chassaing, G., & Prochiantz, A. (1996). Cell internalization of the third helix of the Antennapedia homeodomain is receptor-independent. J Biol Chem, 271(30), 18188–18193.
Derossi, D., Joliot, A. H., Chassaing, G., & Prochiantz, A. (1994). The third helix of the Antennapedia homeodomain translocates through biological membranes. J Biol Chem, 269(14), 10444–10450.
Desnick, R. J., Thorpe, S. R., & Fiddler, M. B. (1976). Toward enzyme therapy for lysosomal storage diseases. Physiol Rev, 56(1), 57–99.
Dodd, C. H., Hsu, H. C., Chu, W. J., Yang, P., Zhang, H. G., Mountz, J. D., Jr., et al. (2001). Normal T-cell response and in vivo magnetic resonance imaging of T cells loaded with HIV transactivator-peptide-derived superparamagnetic nanoparticles. J Immunol Methods, 256(1–2), 89–105.
Egleton, R. D., & Davis, T. P. (1997). Bioavailability and transport of peptides and peptide drugs into the brain. Peptides, 18(9), 1431–1439.
Elliott, G., & O'Hare, P. (1997). Intercellular trafficking and protein delivery by a herpesvirus structural protein. Cell, 88(2), 223–233.
Elmquist, A., Lindgren, M., Bartfai, T., & Langel, U. (2001). VE-cadherin-derived cell-penetrating peptide, pVEC, with carrier functions. Exp Cell Res, 269(2), 237–244.
Elouahabi, A., & Ruysschaert, J. M. (2005). Formation and intracellular trafficking of lipoplexes and polyplexes. Mol Therv, 11(3), 336–347.
Espinola, L. G., Wider, E. A., Stella, A. M., & Batlle, A. M. D. C. (1983). Enzyme replacement therapy in porphyrias—II: Entrapment of δ-aminolaevulinate dehydratase in liposomes. Int J Biochem, 15(3), 439–445.
Farhood, H., Serbina, N., & Huang, L. (1995). The role of dioleoyl phosphatidylethanolamine in cationic liposome mediated gene transfer. Biochim Biophys Acta, 1235(2), 289–295.
Fawell, S., Seery, J., Daikh, Y., Moore, C., Chen, L. L., Pepinsky, B., et al. (1994). TAT-mediated delivery of heterologous proteins into cells. Proc Natl Acad Sci USA, 91(2), 664–668.
Felgner, J. H., Kumar, R., Sridhar, C. N., Wheeler, C. J., Tsai, Y. J., Border, R., et al. (1994). Enhanced gene delivery and mechanism studies with a novel series of cationic lipid formulations. J Biol Chem, 269(4), 2550–2561.
Felgner, P. L., Gadek, T. R., Holm, M., Roman, R., Chan, H. W., Wenz, M., et al. (1987). Lipofection: a highly efficient, lipid-mediated DNA-transfection procedure. Proc Natl Acad Sci USA, 84(21), 7413–7417.
Ferrari, A., Pellegrini, V., Arcangeli, C., Fittipaldi, A., Giacca, M., & Beltram, F. (2003). Caveolae-mediated internalization of extracellular HIV-1 tat fusion proteins visualized in real time. Mol Ther, 8(2), 284–294.
Filion, M. C., & Phillips, N. C. (1997). Toxicity and immunomodulatory activity of liposomal vectors formulated with cationic lipids toward immune effector cells. Biochim Biophys Acta, 1329(2), 345–356.
Fittipaldi, A., Ferrari, A., Zoppe, M., Arcangeli, C., Pellegrini, V., Beltram, F., et al. (2003). Cell membrane lipid rafts mediate caveolar endocytosis of HIV-1 Tat fusion proteins. J Biol Chem, 278(36), 34141–34149.
Fonseca, M. J., Jagtenberg, J. C., Haisma, H. J., & Storm, G. (2003). Liposome-mediated targeting of enzymes to cancer cells for site-specific activation of prodrugs: comparison with the corresponding antibody-enzyme conjugate. Pharm Res, 20(3), 423–428.
Frankel, A. D., & Pabo, C. O. (1988). Cellular uptake of the tat protein from human immunodeficiency virus. Cell, 55(6), 1189–1193.
Futaki, S., Suzuki, T., Ohashi, W., Yagami, T., Tanaka, S., Ueda, K., et al. (2001). Arginine-rich peptides. An abundant source of membrane-permeable peptides having potential as carriers for intracellular protein delivery. J Biol Chem, 276(8), 5836–5840.
Gaspar, M. M., Perez-Soler, R., & Cruz, M. E. (1996). Biological characterization of L-asparaginase liposomal formulations. Cancer Chemother Pharmacol, 38(4), 373–377.
Geisert, E. E., Jr., Del Mar, N. A., Owens, J. L., & Holmberg, E. G. (1995). Transfecting neurons and glia in the rat using pH-sensitive immunoliposomes. Neurosci Lettv, 184(1), 40–43.
Grabowsky, G. A., & Desnick, R. J. (1981). Enzyme replacement in genetic diseases. In J. S. Holcenberg & J. Roberts (Eds.), Enzymes as drugs (pp. 167). New York: Wiley.
Green, M., & Loewenstein, P. M. (1988). Autonomous functional domains of chemically synthesized human immunodeficiency virus tat trans-activator protein. Cell, 55(6), 1179–1188.
Gregoriadis, G. (1978). Liposomes in the therapy of lysosomal storage diseases. Nature, 275(5682), 695–696.
Gregoriadis, G., & Dean, M. F. (1979). Enzyme therapy in genetic diseases. Nature, 278(5705), 603–604.
Gregoriadis, G., Putman, D., Louis, L., & Neerunjun, D. (1974). Comparative effect and fate of non-entrapped and liposome-entrapped neuraminidase injected into rats. Biochem J, 140(2), 323–330.
Gregoriadis, G., & Ryman, B. E. (1972). Lysosomal localization of -fructofuranosidase-containing liposomes injected into rats. Biochem J, 129(1), 123–133.
Guo, X., & Szoka, F. C., Jr. (2001). Steric stabilization of fusogenic liposomes by a low-pH sensitive PEG-diortho ester-lipid conjugate. Bioconjugate Chem, 12(2), 291–300.
Gupta, B., Levchenko, T. S., & Torchilin, V. P. (2005). Intracellular delivery of large molecules and small particles by cell-penetrating proteins and peptides. Adv Drug Deliv Rev 57(4), 637–651.
Hafez, I. M., Maurer, N., & Cullis, P. R. (2001). On the mechanism whereby cationic lipids promote intracellular delivery of polynucleic acids. Gene Ther, 8(15), 1188–1196.
Harding, A. E. (1991). Neurological disease and mitochondrial genes. Trends Neurosci, 14(4), 132–138.
Heeremans, J. L., Prevost, R., Bekkers, M. E., Los, P., Emeis, J. J., Kluft, C., et al. (1995). Thrombolytic treatment with tissue-type plasminogen activator (t-PA) containing liposomes in rabbits: a comparison with free t-PA. Thromb Haemost, 73(3), 488–494.
Helms, J. B., & Zurzolo, C. (2004). Lipids as targeting signals: lipid rafts and intracellular trafficking. Traffic, 5(4), 247–254.
Hirota, Y., Masuyama, N., Kuronita, T., Fujita, H., Himeno, M., & Tanaka, Y. (2004). Analysis of post-lysosomal compartments. Biochem Biophys Res Commun, 314(2), 306–312.
Hoekstra, D., de Boer, T., Klappe, K., & Wilschut, J. (1984). Fluorescence method for measuring the kinetics of fusion between biological membranes. Biochemistry, 23(24), 5675–5681.
Hoekstra, D., & Klappe, K. (1986). Use of a fluorescence assay to monitor the kinetics of fusion between erythrocyte ghosts, as induced by Sendai virus. Biosci Rep, 6(11), 953–960.
Holt, I. J., Harding, A. E., & Morgan-Hughes, J. A. (1988). Deletions of muscle mitochondrial DNA in patients with mitochondrial myopathies. Nature, 331(6158), 717–719.
Horobin, R. W. (2002). Xanthenes. In R. W. Horobin, Kiernan, J.A. (Ed.), Conn's Biological Stains, 10th Edition (pp. 237). Oxford, UK: BIOS Scientific Publishers.
Horobin, R. W., & Kiernan, J.A. (eds). (2002). Conn's Biological Stains (10th ed.). Oxford, UK: BIOS Scientific Publishers.
Huth, U., Wieschollek, A., Garini, Y., Schubert, R., & Peschka-Suss, R. (2004). Fourier transformed spectral bio-imaging for studying the intracellular fate of liposomes. Cytometry A, 57(1), 10–21.
Inoue, M., Yoshida, H., & Akisaka, T. (1999). Visualization of acidic compartments in cultured osteoclasts by use of an acidotrophic amine as a marker for low pH. Cell Tissue Res, 298(3), 527–537.
James, A. M., Blaikie, F. H., Smith, R. A., Lightowlers, R. N., Smith, P. M., & Murphy, M. P. (2003). Specific targeting of a DNA-alkylating reagent to mitochondria. Synthesis and characterization of [4-((11aS)-7-methoxy-1,2,3,11a-tetrahydro-5H-pyrrolo[2,1-c][1,4]benzodiaze pin-5-on-8-oxy)butyl]-triphenylphosphonium iodide. Eur J Biochem, 270(13), 2827–2836.
Jeang, K. T., Xiao, H., & Rich, E. A. (1999). Multifaceted activities of the HIV-1 transactivator of transcription, Tat. J Biol Chem, 274(41), 28837–28840.
Jeong, J. H., Kim, S. W., & Park, T. G. (2003). Novel intracellular delivery system of antisense oligonucleotide by self-assembled hybrid micelles composed of DNA/PEG conjugate and cationic fusogenic peptide. Bioconjug Chem, 14(2), 473–479.
Johnson, W. G., Desnick, R. J., Long, D. M., Sharp, H. L., Krivit, W., Brady, B., et al. (1973). Intravenous injection of purified hexosaminidase A into a patient with Tay-Sachs disease. Birth Defects Orig Artic Ser, 9(2), 120–124.
Joliot, A., Pernelle, C., Deagostini-Bazin, H., & Prochiantz, A. (1991). Antennapedia homeobox peptide regulates neural morphogenesis. Proc Natl Acad Sci U S A, 88(5), 1864–1868.
Josephson, L., Tung, C. H., Moore, A., & Weissleder, R. (1999). High-efficiency intracellular magnetic labeling with novel superparamagnetic-Tat peptide conjugates. Bioconjug Chem, 10(2), 186–191.
Kamata, H., Yagisawa, H., Takahashi, S., & Hirata, H. (1994). Amphiphilic peptides enhance the efficiency of liposome-mediated DNA transfection. Nucleic Acids Res, 22(3), 536–537.
Kaufman, C. L., Williams, M., Ryle, L. M., Smith, T. L., Tanner, M., & Ho, C. (2003). Superparamagnetic iron oxide particles transactivator protein-fluorescein isothiocyanate particle labeling for in vivo magnetic resonance imaging detection of cell migration: uptake and durability. Transplantation, 76(7), 1043–1046.
Kelso, G. F., Porteous, C. M., Coulter, C. V., Hughes, G., Porteous, W. K., Ledgerwood, E. C., et al. (2001). Selective targeting of a redox-active ubiquinone to mitochondria within cells: antioxidant and antiapoptotic properties. J Biol Chem, 276(7), 4588–4596.
Kelso, G. F., Porteous, C. M., Hughes, G., Ledgerwood, E. C., Gane, A. M., Smith, R. A., et al. (2002). Prevention of mitochondrial oxidative damage using targeted antioxidants. Ann NY Acad Sci, 959, 263–274.
Khaw, B. A., daSilva, J., Vural, I., Narula, J., & Torchilin, V. P. (2001). Intracytoplasmic gene delivery for in vitro transfection with cytoskeleton-specific immunoliposomes. J Control Release, 75(1–2), 199–210.
Khaw, B. A., Fallon, J. T., Beller, G. A., & Haber, E. (1979). Specificity of localization of myosin-specific antibody fragments in experimental myocardial infarction. Histologic, histochemical, autoradiographic and scintigraphic studies. Circulation, 60(7), 1527–1531.
Khaw, B. A., Scott, J., Fallon, J. T., Cahill, S. L., Haber, E., & Homcy, C. (1982). Myocardial injury: quantitation by cell sorting initiated with antimyosin fluorescent spheres. Science, 217(4564), 1050–1053.
Khaw, B. A., Torchilin, V. P., Vural, I., & Narula, J. (1995). Plug and seal: prevention of hypoxic cardiocyte death by sealing membrane lesions with antimyosin-liposomes. Nat Med, 1(11), 1195–1198.
Khaw, B. A., Vural, I., DaSilva, J., & Torchilin, V. P. (2000). Use of cytoskeleton-specific immunoliposomes for preservation of cell viability and gene delivery. S.T.P, Pharma Sci, 10, 279–283.
Kisel, M. A., Kulik, L. N., Tsybovsky, I. S., Vlasov, A. P., Vorob'yov, M. S., Kholodova, E. A., et al. (2001). Liposomes with phosphatidylethanol as a carrier for oral delivery of insulin: studies in the rat. Int J Pharm, 216(1–2), 105–114.
Koch, A. M., Reynolds, F., Merkle, H. P., Weissleder, R., & Josephson, L. (2005). Transport of surface-modified nanoparticles through cell monolayers. Chembiochem, 6(2), 337–345.
Koltover, I., Salditt, T., Radler, J. O., & Safinya, C. R. (1998). An inverted hexagonal phase of cationic liposome-DNA complexes related to DNA release and delivery. Science, 281(5373), 78–81.
Kratz, F., Beyer, U., & Schutte, M. T. (1999). Drug-polymer conjugates containing acid-cleavable bonds. Crit Rev Ther Drug Carrier Syst, 16(3), 245–288.
Kunath, K., von Harpe, A., Fischer, D., Petersen, H., Bickel, U., Voigt, K., et al. (2003). Low-molecular-weight polyethylenimine as a non-viral vector for DNA delivery: comparison of physicochemical properties, transfection efficiency and in vivo distribution with high-molecular-weight polyethylenimine. J Control Release, 89(1), 113–125.
Kuwana, T., Mullock, B. M., & Luzio, J. P. (1995). Identification of a lysosomal protein causing lipid transfer, using a fluorescence assay designed to monitor membrane fusion between rat liver endosomes and lysosomes. Biochem J, 308 (Pt 3), 937–946.
Kwon, G. S., & Kataoka, K. (1995). Block copolymer micelles as long-circulating drug vehicles. Adv Drug Deliv Rev, 16, 295–309.
Labat-Moleur, F., Steffan, A. M., Brisson, C., Perron, H., Feugeas, O., Furstenberger, P., et al. (1996). An electron microscopy study into the mechanism of gene transfer with lipopolyamines. Gene Ther, 3(11), 1010–1017.
Lackey, C. A., Press, O. W., Hoffman, A. S., & Stayton, P. S. (2002). A biomimetic pH-responsive polymer directs endosomal release and intracellular delivery of an endocytosed antibody complex. Bioconjug Chem, 13(5), 996–1001.
Larsson, L., Clapp, W. L., 3rd, Park, C. H., Cannon, J. K., & Tisher, C. C. (1987). Ultrastructural localization of acidic compartments in cells of isolated rabbit PCT. Am J Physiol, 253(1 Pt 2), F95–F103.
Lasch, J., Meye, A., Taubert, H., Koelsch, R., Mansa-ard, J., & Weissig, V. (1999). Dequalinium vesicles form stable complexes with plasmid DNA which are protected from DNase attack. Biol Chem, 380(6), 647–652.
Lasic, D. D. (1993). Liposomes : from physics to applications. Amsterdam ; New York: Elsevier.
Lasic, D. D., & Martin, F. J. (1995). Stealth liposomes. Boca Raton: CRC Press.
Lee, E. S., Na, K., & Bae, Y. H. (2003). Polymeric micelle for tumor pH and folate-mediated targeting. J Control Release, 91(1–2), 103–113.
Lee, E. S., Shin, H. J., Na, K., & Bae, Y. H. (2003). Poly(L-histidine)-PEG block copolymer micelles and pH-induced destabilization. J Control Release, 90(3), 363–374.
Leroux, J., Roux, E., Le Garrec, D., Hong, K., & Drummond, D. C. (2001). N-isopropylacrylamide copolymers for the preparation of pH-sensitive liposomes and polymeric micelles. J Control Release, 72(1–3), 71–84.
Lewin, M., Carlesso, N., Tung, C. H., Tang, X. W., Cory, D., Scadden, D. T., et al. (2000). TAT peptide-derivatized magnetic nanoparticles allow in vivo tracking and recovery of progenitor cells. Nat Biotechnol, 18(4), 410–414.
Lin, T. K., Hughes, G., Muratovska, A., Blaikie, F. H., Brookes, P. S., Darley-Usmar, V., et al. (2002). Specific modification of mitochondrial protein thiols in response to oxidative stress: a proteomics approach. J Biol Chem, 277(19), 17048–17056.
Lindgren, M., Hallbrink, M., Prochiantz, A., & Langel, U. (2000). Cell-penetrating peptides. Trends Pharmacol Sci, 21(3), 99–103.
Lisziewicz, J., Sun, D., Lisziewicz, A., & Gallo, R. C. (1995). Antitat gene therapy: a candidate for late-stage AIDS patients. Gene Ther, 2(3), 218–222.
Liu, J., Zhang, Q., Remsen, E. E., & Wooley, K. L. (2001). Nanostructured materials designed for cell binding and transduction. Biomacromolecules, 2(2), 362–368.
Lloyd, J. B. (2000). Lysosome membrane permeability: implications for drug delivery. Adv Drug Deliv Rev, 41(2), 189–200.
Lo, Y. L., Tsai, J. C., & Kuo, J. H. (2004). Liposomes and disaccharides as carriers in spray-dried powder formulations of superoxide dismutase. J Control Release, 94(2–3), 259–272.
Lukyanov, A. N., Hartner, W. C., & Torchilin, V. P. (2004). Increased accumulation of PEG-PE micelles in the area of experimental myocardial infarction in rabbits. J Control Release, 94(1), 187–193.
Maeda, H., Wu, J., Sawa, T., Matsumura, Y., & Hori, K. (2000). Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review. J Control Releasev, 65(1–2), 271–284.
Marty, C., Meylan, C., Schott, H., Ballmer-Hofer, K., & Schwendener, R. A. (2004). Enhanced heparan sulfate proteoglycan-mediated uptake of cell-penetrating peptide-modified liposomes. Cell Mol Life Sci, 61(14), 1785–1794.
Mastrobattista, E., Koning, G. A., van Bloois, L., Filipe, A. C., Jiskoot, W., & Storm, G. (2002). Functional characterization of an endosome-disruptive peptide and its application in cytosolic delivery of immunoliposome-entrapped proteins. J Biol Chem, 277(30), 27135–27143.
Midoux, P., Kichler, A., Boutin, V., Maurizot, J. C., & Monsigny, M. (1998). Membrane permeabilization and efficient gene transfer by a peptide containing several histidines. Bioconjug Chem, 9(2), 260–267.
Minier, C., & Moore, M. N. (1996). Rhodamine B accumulation and MXR protein expression in mussel blood cells: effects of exposure to vincristine. Marine Ecology – Progress Series, 142, 165–173.
Morris, M. C., Vidal, P., Chaloin, L., Heitz, F., & Divita, G. (1997). A new peptide vector for efficient delivery of oligonucleotides into mammalian cells. Nucleic Acids Res, 25(14), 2730–2736.
Moyer, B. D., & Balch, W. E. (2001). A new frontier in pharmacology: the endoplasmic reticulum as a regulated export pathway in health and disease. Expert Opin Ther Targets, 5(2), 165–176.
Murphy, M. P. (1989). Slip and leak in mitochondrial oxidative phosphorylation. Biochim Biophys Acta, 977(2), 123–141.
Oehlke, J., Scheller, A., Wiesner, B., Krause, E., Beyermann, M., Klauschenz, E., et al. (1998). Cellular uptake of an alpha-helical amphipathic model peptide with the potential to deliver polar compounds into the cell interior non-endocytically. Biochim Biophys Acta, 1414(1–2), 127–139.
Ogris, M., Steinlein, P., Carotta, S., Brunner, S., & Wagner, E. (2001). DNA/polyethylenimine transfection particles: influence of ligands, polymer size, and PEGylation on internalization and gene expression. AAPS PharmSci, 3(3), E21.
Ohashi, M., Miwako, I., Nakamura, K., Yamamoto, A., Murata, M., Ohnishi, S., et al. (1999). An arrested late endosome-lysosome intermediate aggregate observed in a Chinese hamster ovary cell mutant isolated by novel three-step screening. J Cell Sci, 112(Pt 8), 1125–1138.
Ohashi, M., Murata, M., & Ohnishi, S. (1992). A novel fluorescence method to monitor the lysosomal disintegration of low density lipoprotein. Eur J Cell Biol, 59(1), 116–126.
Park, J. W., Kirpotin, D. B., Hong, K., Shalaby, R., Shao, Y., Nielsen, U. B., et al. (2001). Tumor targeting using anti-her2 immunoliposomes. J Control Release, 74(1–3), 95–113.
Patel, H. M., & Ryman, B. E. (1974). α-Mannosidase in zinc-deficient rats. Possibility of liposomal therapy in mannosidosis. Biochem Soc Transv, 2, 1014–1017.
Pollard, H., Remy, J. S., Loussouarn, G., Demolombe, S., Behr, J. P., & Escande, D. (1998). Polyethylenimine but not cationic lipids promotes transgene delivery to the nucleus in mammalian cells. J Biol Chem, 273(13), 7507–7511.
Pollard, H., Toumaniantz, G., Amos, J. L., Avet-Loiseau, H., Guihard, G., Behr, J. P., et al. (2001). Ca2+-sensitive cytosolic nucleases prevent efficient delivery to the nucleus of injected plasmids. J Gene Med, 3(2), 153–164.
Pooga, M., Hallbrink, M., Zorko, M., & Langel, U. (1998). Cell penetration by transportan. Faseb J, 12(1), 67–77.
Pozzi, D., Lisi, A., De Ros, I., Ferroni, L., Giuliani, A., Ravagnan, G., et al. (1993). Use of octadecylrhodamine fluorescence dequenching to study vesicular stomatitis virus fusion with human aged red blood cells. Photochem Photobiol, 57(3), 426–430.
Preston, T. J., Abadi, A., Wilson, L., & Singh, G. (2001). Mitochondrial contributions to cancer cell physiology: potential for drug development. Adv Drug Deliv Rev, 49(1–2), 45–61.
Ragin, A. D., Morgan, R.A., & Chmielewski, J. (2002). Cellular import mediated by nuclear localization signal Peptide sequences. Chem Biol, 9(8), 943–948.
Reynolds, G. C., Baker, H. J., & Reynolds, R. H. (1978). Enzyme replacement using liposome carriers in feline Gm1 gangliosidosis fibroblasts. Nature, 275(5682), 754–755.
Rideout, D., Bustamante, A., & Patel, J. (1994). Mechanism of inhibition of FaDu hypopharyngeal carcinoma cell growth by tetraphenylphosphonium chloride. Int J Cancer, 57(2), 247–253.
Rojas, M., Donahue, J. P., Tan, Z., & Lin, Y. Z. (1998). Genetic engineering of proteins with cell membrane permeability. Nat Biotechnol, 16(4), 370–375.
Ross, M. F., Filipovska, A., Smith, R. A., Gait, M. J., & Murphy, M. P. (2004). Cell-penetrating peptides do not cross mitochondrial membranes even when conjugated to a lipophilic cation: evidence against direct passage through phospholipid bilayers. Biochem J, 383(pt 3), 457–458.
Roth, J. A., Swisher, S. G., Merritt, J. A., Lawrence, D. D., Kemp, B. L., Carrasco, C. H., et al. (1998). Gene therapy for non-small cell lung cancer: a preliminary report of a phase I trial of adenoviral p53 gene replacement. Semin Oncol, 25(3 Suppl 8), 33–37.
Rothbard, J. B., Jessop, T. C., Lewis, R. S., Murray, B. A., & Wender, P. A. (2004). Role of membrane potential and hydrogen bonding in the mechanism of translocation of guanidinium-rich peptides into cells. J Am Chem Soc, 126(31), 9506–9507.
Rothbard, J. B., Jessop, T. C., & Wender, P. A. (2005). Adaptive translocation: the role of hydrogen bonding and membrane potential in the uptake of guanidinium-rich transporters into cells. Adv Drug Deliv Rev, 57(4), 495–504.
Roux, E., Francis, M., Winnik, F. M., & Leroux, J. C. (2002). Polymer based pH-sensitive carriers as a means to improve the cytoplasmic delivery of drugs. Int J Pharm, 242(1–2), 25–36.
Roux, E., Passirani, C., Scheffold, S., Benoit, J. P., & Leroux, J. C. (2004). Serum-stable and long-circulating, PEGylated, pH-sensitive liposomes. J Control Release, 94(2–3), 447–451.
Roux, E., Stomp, R., Giasson, S., Pezolet, M., Moreau, P., & Leroux, J. C. (2002). Steric stabilization of liposomes by pH-responsive N-isopropylacrylamide copolymer. J Pharm Sci, 91(8), 1795–1802.
Rubas, W., Supersaxo, A., Weder, H. G., Hartmann, H. R., Hengartner, H., Schott, H., et al. (1986). Treatment of murine L1210 lymphoid leukemia and melanoma B16 with lipophilic cytosine arabinoside prodrugs incorporated into unilamellar liposomes. Int J Cancer, 37(1), 149–154.
Rudolph, C., Schillinger, U., Ortiz, A., Tabatt, K., Plank, C., Muller, R. H., et al. (2004). Application of novel solid lipid nanoparticle (SLN)-gene vector formulations based on a dimeric HIV-1 TAT-peptide in vitro and in vivo. Pharm Res, 21(9), 1662–1669.
Sakurai, F., Inoue, R., Nishino, Y., Okuda, A., Matsumoto, O., Taga, T., et al. (2000). Effect of DNA/liposome mixing ratio on the physicochemical characteristics, cellular uptake and intracellular trafficking of plasmid DNA/cationic liposome complexes and subsequent gene expression. J Control Release, 66(2–3), 255–269.
Salem, A. K., Searson, P. C., & Leong, K. W. (2003). Multifunctional nanorods for gene delivery. Nat Mater, 2(10), 668–671.
Sawant, R. M., Hurley, J. P., Salmaso, S., Kale, A., Tolcheva, E., Levchenko, T. S., et al. (2006). “SMART” drug delivery systems: double-targeted pH-responsive pharmaceutical nanocarriers. Bioconjug Chem, 17(4), 943–949.
Scheule, R. K., St George, J. A., Bagley, R. G., Marshall, J., Kaplan, J. M., Akita, G. Y., et al. (1997). Basis of pulmonary toxicity associated with cationic lipid-mediated gene transfer to the mammalian lung. Hum Gene Ther, 8(6), 689–707.
Schwarze, S. R., & Dowdy, S. F. (2000). In vivo protein transduction: intracellular delivery of biologically active proteins, compounds and DNA. Trends Pharmacol Sci, 21(2), 45–48.
Schwarze, S. R., Hruska, K. A., & Dowdy, S. F. (2000). Protein transduction: unrestricted delivery into all cells? Trends Cell Biol, 10(7), 290–295.
Senior, J. H. (1987). Fate and behavior of liposomes in vivo: a review of controlling factors. Crit Rev Ther Drug Carrier Syst, 3(2), 123–193.
Shalaev, E. Y., & Steponkus, P. L. (1999). Phase diagram of 1,2-dioleoylphosphatidylethanolamine (DOPE):water system at subzero temperatures and at low water contents. Biochim Biophys Acta, 1419(2), 229–247.
Sheff, D. (2004). Endosomes as a route for drug delivery in the real world. Adv Drug Deliv Rev, 56(7), 927–930.
Simoes, S., Moreira, J. N., Fonseca, C., Duzgunes, N., & de Lima, M. C. (2004). On the formulation of pH-sensitive liposomes with long circulation times. Adv Drug Deliv Rev, 56(7), 947–965.
Smith, R. A., Porteous, C. M., Coulter, C. V., & Murphy, M. P. (1999). Selective targeting of an antioxidant to mitochondria. Eur J Biochem, 263(3), 709–716.
Smith, R. A., Porteous, C. M., Gane, A. M., & Murphy, M. P. (2003). Delivery of bioactive molecules to mitochondria in vivo. Proc Natl Acad Sci USA, 100(9), 5407–5412.
Sperl, W. (1997). [Diagnosis and therapy of mitochondriopathies]. Wien Klin Wochenschr, 109(3), 93–99.
Stanimirovic, D. B., Markovic, M., Micic, D. V., Spatz, M., & Mrsulja, B. B. (1994). Liposome-entrapped superoxide dismutase reduces ischemia/reperfusion ‘oxidative stress’ in gerbil brain. Neurochem Res, 19(12), 1473–1478.
Steger, L. D., & Desnick, R. J. (1977). Enzyme therapy. VI: Comparative in vivo fates and effects on lysosomal integrity of enzyme entrapped in negatively and positively charged liposomes. Biochim Biophys Acta, 464(3), 530–546.
Stroh, M., Zimmer, J. P., Duda, D. G., Levchenko, T. S., Cohen, K. S., Brown, E. B., et al. (2005). Quantum dots spectrally distinguish multiple species within the tumor milieu in vivo. Nat Med, 11(6), 678–682.
Sudimack, J. J., Guo, W., Tjarks, W., & Lee, R. J. (2002). A novel pH-sensitive liposome formulation containing oleyl alcohol. Biochim Biophys Acta, 1564(1), 31–37.
Tager, J. M., Daems, W. T., & Hooghwinkel, G. J. M. (1974). Enzyme therapy in lysosomal storage diseases. Proceedings of the Workshop on Cell Biological and Enzymological Aspects of the Therapy of Lysosomal Storage Diseases, Leiden, The Netherlands, April 2–3, 1974 and Papers presented at a Boerhaave Advanced Course on Lysosomal Enzymopathies, Leiden, The Netherlands, April 4–5, 1974. Amsterdam: North-Holland Pub. Co., New York American Elsevier Pub. CO.
Tang, F., & Hughes, J. A. (1999). Use of dithiodiglycolic acid as a tether for cationic lipids decreases the cytotoxicity and increases transgene expression of plasmid DNA in vitro. Bioconjug Chem, 10(5), 791–796.
Tkachenko, A. G., Xie, H., Liu, Y., Coleman, D., Ryan, J., Glomm, W. R., et al. (2004). Cellular trajectories of peptide-modified gold particle complexes: comparison of nuclear localization signals and peptide transduction domains. Bioconjug Chem, 15(3), 482–490.
Torchilin, V. P. (1985). Liposomes as targetable drug carriers. Crit Rev Ther Drug Carrier Syst, 2(1), 65–115.
Torchilin, V. P. (2005). Recent advances with liposomes as pharmaceutical carriers. Nat Rev Drug Discov, 4(2), 145–160.
Torchilin, V. P. (Ed.). (1991). Immobilized enzymes in medicine. Berlin, New York: Springer-Verlag.
Torchilin, V. P., Khaw, B. A., & Weissig, V. (2002). Intracellular targets for DNA delivery: nuclei and mitochondria. Somat Cell Mol Genet, 27(1–6), 49–64.
Torchilin, V. P., Levchenko, T. S., Lukyanov, A. N., Khaw, B. A., Klibanov, A. L., Rammohan, R., et al. (2001). p-Nitrophenylcarbonyl-PEG-PE-liposomes: fast and simple attachment of specific ligands, including monoclonal antibodies, to distal ends of PEG chains via p-nitrophenylcarbonyl groups. Biochim Biophys Acta, 1511(2), 397–411.
Torchilin, V. P., Levchenko, T. S., Rammohan, R., Volodina, N., Papahadjopoulos-Sternberg, B., & D'Souza, G. G. (2003). Cell transfection in vitro and in vivo with nontoxic TAT peptide-liposome-DNA complexes. Proc Natl Acad Sci U S A, 100(4), 1972–1977.
Torchilin, V. P., Narula, J., Halpern, E., & Khaw, B. A. (1996). Poly(ethylene glycol)-coated anti-cardiac myosin immunoliposomes: factors influencing targeted accumulation in the infarcted myocardium. Biochim Biophys Acta, 1279(1), 75–83.
Torchilin, V. P., Rammohan, R., Weissig, V., & Levchenko, T. S. (2001). TAT peptide on the surface of liposomes affords their efficient intracellular delivery even at low temperature and in the presence of metabolic inhibitors. Proc Natl Acad Sci USA, 98(15), 8786–8791.
Torchilin, V. P., Trubetskoy, V. S., Milshteyn, A. M., Canillo, J., Wolf, G. L., Papisov, M. I., et al. (1994). Targeted delivery of diagnostic agents by surface-modified liposomes. J. Controlled Release, 28, 45–58.
Torchilin, V. P., & Weissig, V. (2000). Polymeric micelles for delivery of poorly soluble drugs. In K. Park & R. J. Mrsny (Eds.), Controlled drug delivery : designing technologies for the future (pp. 297–313). Washington, D.C: American Chemical Society.
Torchilin, V. P., Zhou, F., & Huang, L. (1993). pH-Sensitive liposomes. J Liposome Res, 3, 201–255.
Tseng, Y. L., Liu, J. J., & Hong, R. L. (2002). Translocation of liposomes into cancer cells by cell-penetrating peptides penetratin and tat: a kinetic and efficacy study. Mol Pharmacol, 62(4), 864–872.
Umezawa, F., Eto, Y., Tokoro, T., Ito, F., & Maekawa, K. (1985). Enzyme replacement with liposomes containing beta-galactosidase from Charonia lumpas in murine globoid cell leukodystrophy (twitcher). Biochem Biophys Res Commun, 127(2), 663–667.
Verlander, J. W., Madsen, K. M., Larsson, L., Cannon, J. K., & Tisher, C. C. (1989). Immunocytochemical localization of intracellular acidic compartments: rat proximal nephron. Am J Physiol, 257(3 Pt 2), F454–F462.
Vives, E., Brodin, P., & Lebleu, B. (1997). A truncated HIV-1 Tat protein basic domain rapidly translocates through the plasma membrane and accumulates in the cell nucleus. J Biol Chem, 272(25), 16010–16017.
Wadia, J. S., Stan, R. V., & Dowdy, S. F. (2004). Transducible TAT-HA fusogenic peptide enhances escape of TAT-fusion proteins after lipid raft macropinocytosis. Nat Med, 10(3), 310–315.
Wallace, D. C. (1999). Mitochondrial diseases in man and mouse. Science, 283(5407), 1482–1488.
Wang, J., Mongayt, D., & Torchilin, V. P. (2005). Polymeric micelles for delivery of poorly soluble drugs: preparation and anticancer activity in vitro of paclitaxel incorporated into mixed micelles based on poly(ethylene glycol)-lipid conjugate and positively charged lipids. J Drug Target, 13(1), 73–80.
Weissig, V., Lasch, J., Erdos, G., Meyer, H. W., Rowe, T. C., & Hughes, J. (1998). DQAsomes: a novel potential drug and gene delivery system made from Dequalinium. Pharm Res, 15(2), 334–337.
Weissig, V., & Torchilin, V. P. (2000). Mitochondriotropic cationic vesicles: a strategy towards mitochondrial gene therapy. Curr Pharm Biotechnol, 1(4), 325–346.
Weissig, V., & Torchilin, V. P. (2001). Cationic bolasomes with delocalized charge centers as mitochondria-specific DNA delivery systems. Adv Drug Deliv Rev, 49(1–2), 127–149.
Wu, G. Y., & Wu, C. H. (1987). Receptor-mediated in vitro gene transformation by a soluble DNA carrier system. J Biol Chem, 262(10), 4429–4432.
Wunderbaldinger, P., Josephson, L., & Weissleder, R. (2002). Tat peptide directs enhanced clearance and hepatic permeability of magnetic nanoparticles. Bioconjug Chem, 13(2), 264–268.
Xu, Y., & Szoka, F. C., Jr. (1996). Mechanism of DNA release from cationic liposome/DNA complexes used in cell transfection. Biochemistry, 35(18), 5616–5623.
Yessine, M. A., & Leroux, J. C. (2004). Membrane-destabilizing polyanions: interaction with lipid bilayers and endosomal escape of biomacromolecules. Adv Drug Deliv Rev, 56(7), 999–1021.
Yuan, F., Dellian, M., Fukumura, D., Leunig, M., Berk, D. A., Torchilin, V. P., et al. (1995). Vascular permeability in a human tumor xenograft: molecular size dependence and cutoff size. Cancer Res, 55(17), 3752–3756.
Zalipsky, S., Qazen, M., Walker, J. A., 2nd, Mullah, N., Quinn, Y. P., & Huang, S. K. (1999). New detachable poly(ethylene glycol) conjugates: cysteine-cleavable lipopolymers regenerating natural phospholipid, diacyl phosphatidylethanolamine. Bioconjug Chem, 10(5), 703–707.
Zhang, J. X., Zalipsky, S., Mullah, N., Pechar, M., & Allen, T. M. (2004). Pharmaco attributes of dioleoylphosphatidylethanolamine/cholesterylhemisuccinate liposomes containing different types of cleavable lipopolymers. Pharmacol Res, 49(2), 185–198.
Zhao, M., Kircher, M. F., Josephson, L., & Weissleder, R. (2002). Differential conjugation of tat peptide to superparamagnetic nanoparticles and its effect on cellular uptake. Bioconjug Chem, 13(4), 840–844.
Zorko, M., & Langel, U. (2005). Cell-penetrating peptides: mechanism and kinetics of cargo delivery. Adv Drug Deliv Rev, 57(4), 529–545.
Zuhorn, I. S., & Hoekstra, D. (2002). On the mechanism of cationic amphiphile-mediated transfection. To fuse or not to fuse: is that the question? J Membr Biol, 189(3), 167–179.
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Torchilin, V.P. (2009). Nanotechnology for Intracellular Delivery and Targeting. In: de Villiers, M.M., Aramwit, P., Kwon, G.S. (eds) Nanotechnology in Drug Delivery. Biotechnology: Pharmaceutical Aspects, vol X. Springer, New York, NY. https://doi.org/10.1007/978-0-387-77668-2_11
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