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Nanotechnology for Intracellular Delivery and Targeting

  • Vladimir P. Torchilin
Part of the Biotechnology: Pharmaceutical Aspects book series (PHARMASP, volume X)

Intracellular Drug Delivery and Pharmaceutical Nanocarriers

Intracellular transport of biologically active molecules with therapeutic properties is one of the key problems in drug delivery in general. Many pharmaceutical agents need to be delivered intracellularly to exert their therapeutic action inside cytoplasm or onto the nucleus or other individual organelles, such as lysosomes, mitochondria, or endoplasmic reticulum. Among such agents we can find preparations for gene and antisense therapy, which have to reach cell nuclei; pro-apoptotic drugs, which target mitochondria; lysosomal enzymes, which have to reach lysosomal compartment; and some others (see Figure 11.1). Namely intracellular drug delivery can overcome certain important limitations for drug action, such as multidrug resistance in cancer chemotherapy. However, the very nature of cell membranes prevents proteins, peptides, and nanoparticulate drug carriers from entering cells unless there is an active transport...

Keywords

Polymeric Micelle Cationic Lipid Intracellular Delivery Endosomal Membrane Endosomal Escape 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© American Association of Pharmaceutical Scientists 2009

Authors and Affiliations

  • Vladimir P. Torchilin
    • 1
  1. 1.Department of Pharmaceutical Sciences and Center for Pharmaceutical Biotechnology and NanomedicineNortheastern UniversityBostonUSA

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