Advertisement

Laser and Radiofrequency Ablation Procedures

  • Roberto Valcavi
  • Angelo Bertani
  • Marialaura Pesenti
  • Laura Raifa Al Jandali Rifa'Y
  • Andrea Frasoldati
  • Debora Formisano
  • Claudio M. Pacella

Several ultrasound-guided interventional procedures have been proposed to treat benign thyroid nodules without open surgery. The basic principle is to destroy thyroid nodular tissue by physical means. Percutaneous ethanol injection (PEI) was introduced in 1990 and it has since proven to be very helpful in cystic benign thyroid nodules, whereas it is poorly effective in solid lesions and is discussed in Chapter 11. HIFU (High Intensity Focused Ultrasound) is a promising new interventional US-guided technique for solid nodules, illustrated in Chapter 13.

Keywords

Thyroid Nodule Percutaneous Ethanol Injection Nodular Goiter Nodule Volume Benign Thyroid Nodule 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Livraghi T, Paracchi A, Ferrari C, Bergonzi M, Garavaglia G, Raineri P, Vettori C (1990) Treatment of autonomous thyroid nodules with percutaneous ethanol injection: preliminary results.Work in progress. Radiology 175:827–9PubMedGoogle Scholar
  2. 2.
    Valcavi R, Frasoldati A (2004) Ultrasound-guided percutaneous ethanol injection therapy in thyroid cystic nodules. Endocr Pract 10:269–75PubMedGoogle Scholar
  3. 3.
    American Association of Clinical Endocrinoligists and Associazione Medici Endocrinologi (2006) Medical guidelines for clinical practice for the diagnosis and management of thyroid nodules. Endocr Pract 12:63–102Google Scholar
  4. 4.
    Esnault O, Franc B, Monteil JP, Chapelon JY (2004) High-intensity focused ultrasound for localized thyroid-tissue ablation: preliminary experimental animal study. Thyroid 14:1072–6PubMedCrossRefGoogle Scholar
  5. 5.
    Gazelle GS, Goldberg SN, Solbiati L, Livraghi T (2000) Tumor ablation with radio-frequency energy. Radiology 217:633–46PubMedGoogle Scholar
  6. 6.
    Kim YS, Rhim H, Tae K, Park DW, Kim ST (2006) Radiofrequency ablation of benign cold thyroid nodules: initial clinical experience. Thyroid 16:361–7PubMedCrossRefGoogle Scholar
  7. 7.
    Roh JL (2006) Intrathyroid hemorrhage and acute upper airway obstruction after fine needle aspiration of the thyroid gland. Laryngoscope 116:154–6PubMedCrossRefGoogle Scholar
  8. 8.
    Jacques SL (1992) Laser-tissue interactions: photochemical, photothermal, and photomechanical. Surg Clin North Am 72:531–558PubMedGoogle Scholar
  9. 9.
    Thomsen S (1991) Pathologic analysis of photothermal and photomechanical effects of laser-tissue interactions. Photochem Photobiol 53:825–835PubMedGoogle Scholar
  10. 10.
    Pacella CM, Bizzarri G, Guglielmi R, Anelli V, Bianchini A, Crescenzi A, Pacella S, Papini E (2000) Thyroid tissue: US-guided percutaneous interstitial laser ablation—a feasibility study. Radiology 217:673–7PubMedGoogle Scholar
  11. 11.
    Dossing H, Bennedbaek FN, Karstrup S, Hegedus L (2002) Benign solitary solid cold thyroid nodules: US-guided interstitial laser photocoagulation-initial experience. Radiology 225:53–7PubMedCrossRefGoogle Scholar
  12. 12.
    Pacella CM, Bizzarri G, Spiezia S, Bianchini A, Guglielmi R, Crescenzi A, Pacella S, Toscano V, Papini E (2004) Thyroid tissue: US-guided percutaneous laser thermal ablation. Radiology 232:272–80PubMedCrossRefGoogle Scholar
  13. 13.
    Papini E, Guglielmi R, Bizzarri G, Pacella CM (2004) Ultrasound-guided laser thermal ablation for treatment of benign thyroid nodules. Endocr Pract 10:276–83PubMedGoogle Scholar
  14. 14.
    Dossing H, Bennedbaek FN, Hegedus L (2005) Effect of ultrasound-guided interstitial laser photocoagulation on benign solitary solid cold thyroid nodules— a randomised study. Eur J Endocrinol 152:341–5PubMedCrossRefGoogle Scholar
  15. 15.
    Amabile G, Rotondi M, Chiara GD, Silvestri A, Filippo BD, Bellastella A, Chiovato L (2006) Low-energy interstitial laser photocoagulation for treatment of nonfunctioning thyroid nodules: therapeutic outcome in relation to pretreatment and treatment parameters. Thyroid 16:749–55PubMedCrossRefGoogle Scholar
  16. 16.
    Dossing H, Bennedbaek FN, Hegedus L (2006) Effect of ultrasound-gGuided iInterstitial laser photocoagulation on benign solitary solid cold thyroid nodules: one versus three treatments. Thyroid 16:763–768PubMedCrossRefGoogle Scholar
  17. 17.
    Gambelunghe G, Fatone C, Ranchelli A, Fanelli C, Lucidi P, Cavaliere A, Avenia N, d’Ajello M, Santeusanio F, De Feo P (2006) A randomized controlled trial to evaluate the efficacy of ultrasound-guided laser photocoagulation for treatment of benign thyroid nodules. J Endocrinol Invest 29:RC23–6PubMedGoogle Scholar
  18. 18.
    Cakir B, Topaloglu O, Gul K, Agac T, Aydin C, Dirikoc A, Gumus M, Yazicioglu K, Ersoy RU, Ugras S (2006) Effects of percutaneous laser ablation treatment in benign solitary thyroid nodules on nodule volume, thyroglobulin and anti-thyroglobulin levels, and cytopathology of nodule in 1 yr follow-up. J Endocrinol Invest 29:876–84PubMedGoogle Scholar
  19. 19.
    Papini E, Guglielmi R, Bizzarri G, Graziano F, Bianchini A, Brufani C, Pacella S, Valle D, Pacella CM (2007) Treatment of benign cold thyroid nodules: a randomized clinical trial of percutaneous laser ablation versus levothyroxine therapy or follow-up. Thyroid 17:229–35PubMedCrossRefGoogle Scholar
  20. 20.
    Pacella CM, Bizzarri G, Francica G, Bianchini A, De Nuntis S, Pacella S, Crescenzi A, Taccogna S, Forlini G, Rossi Z, Osborn J, Stasi R (2005) Percutaneous laser ablation in the treatment of hepatocellular carcinoma with small tumors: analysis of factors affecting the achievement of tumor necrosis. J Vasc Interv Radiol 16:1447–1457PubMedGoogle Scholar
  21. 21.
    Valcavi R, Pesenti M, Bertani A, Frasoldati A, Formisano D (2006) Percutaneous laser ablation (PLA) in 119 benign thyroid nodules. RSNA Annual Meeting SSC 15–04Google Scholar
  22. 22.
    Barbaro D, Orsini P, Lapi P, Pasquini C, Tuco A, Righini A, Lemmi P (2007) Percutaneous laser ablation in the treatment of toxic and pretoxic nodular goiter. Endocr Pract 13:30–6PubMedGoogle Scholar
  23. 23.
    Dossing H, Bennedbaek FN, Hegedus L (2006) Beneficial effect of combined aspiration and interstitial laser therapy in patients with benign cystic thyroid nodules: a pilot study. Br J Radiol 79:943–7PubMedCrossRefGoogle Scholar
  24. 24.
    Dossing H, Bennedbaek FN, Hegedus L (2003) Ultrasound-guided interstitial laser photocoagulation of an autonomous thyroid nodule: the introduction of a novel alternative. Thyroid 13:885–8PubMedCrossRefGoogle Scholar
  25. 25.
    Spiezia S, Vitale G, Di Somma C, Pio Assanti A, Ciccarelli A, Lombardi G, Colao A (2003) Ultrasound-guided laser thermal ablation in the treatment of autonomous hyperfunctioning thyroid nodules and compressive nontoxic nodular goiter. Thyroid 13:941–7PubMedCrossRefGoogle Scholar
  26. 26.
    Dossing H, Bennedbaek FN, Bonnema SJ, Grupe P, Hegedus L (2007) Randomized prospective study comparing a single radioiodine dose and a single laser therapy session in autonomously functioning thyroid nodules. Eur J Endocrinol 157:95–100PubMedCrossRefGoogle Scholar
  27. 27.
    Guglielmi R, Papini E, Pacella CM, Todino V, Bizzarri G (2006) Combined treatment of large toxic nodular goiter by percutaneous laser ablation and radioiodine 131I: a pilot study. American Association of Clinical Endocrinologists 15th Annual Meeting & Clinical Congress Abstract Book: 72Google Scholar

Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Roberto Valcavi
    • 1
  • Angelo Bertani
    • 1
  • Marialaura Pesenti
    • 1
  • Laura Raifa Al Jandali Rifa'Y
    • 1
  • Andrea Frasoldati
    • 1
  • Debora Formisano
    • 1
  • Claudio M. Pacella
    • 2
  1. 1.Endocrinology UnitArcispedale Santa Maria NuovaItaly
  2. 2.Department of Radiology and Diagnostics ImagingOspedale Regina ApostolorumItaly

Personalised recommendations