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p53 Protein and Pathogenesis of Melanoma and Nonmelanoma Skin Cancer

  • Chapter
Sunlight, Vitamin D and Skin Cancer

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 624))

Abstract

The p53 tumor suppressor gene and gene product are among the most diverse and complex molecules involved in cellular functions. Genetic alterations within the p53 gene have been shown to have a direct correlation with cancer development and have been shown to occur in nearly 50% of all cancers. p53 mutations are particularly common in skin cancers and UV irradiation has been shown to be a primary cause of specific’ signature’ mutations that can result in oncogenic transformatiorn. There are certain ‘hot-spots’ in the p53 gene where mutations are commonly found that result in a mutated dipyrimidine site. This review discusses the role of p53 from normal function and its dysfunction in precancerous lesions, nonmelanoma and melanoma skin cancers. Additionally, molecules that associate with p53 and alter its function to produce neoplastic conditions are also explored in this chapter.

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Authors and Affiliations

  1. Department of Immunology, The University of Texas M.D. Anderson Cancer Center, P.O. Box 301402, Unit #902, Houston, TX, 77030-1903, USA

    Cara L. Benjamin & Honnavara N. Ananthaswamy

  2. Department of Cancer Biology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA

    Vladislava O. Melnikova

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  1. Cara L. Benjamin
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  2. Vladislava O. Melnikova
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  3. Honnavara N. Ananthaswamy
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  1. Clinic for Dermatology, Venerology and Allergology, The Saarland University Hospital, Homburg/Saar, Germany

    Jörg Reichrath

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Benjamin, C.L., Melnikova, V.O., Ananthaswamy, H.N. (2008). p53 Protein and Pathogenesis of Melanoma and Nonmelanoma Skin Cancer. In: Reichrath, J. (eds) Sunlight, Vitamin D and Skin Cancer. Advances in Experimental Medicine and Biology, vol 624. Springer, New York, NY. https://doi.org/10.1007/978-0-387-77574-6_21

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