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Antiparasitic Chemotherapy:

Tinkering with the Purine Salvage Pathway
  • Alok Kumar Datta
  • Rupak Datta
  • Banibrata Sen
Part of the Advances In Experimental Medicine And Biology book series (AEMB, volume 625)

Abstract

Distinguishable differences between infecting organisms and their respective hosts with respect to metabolism and macromolecular structure provide scopes for detailed characterization of target proteins and/or macromolecules as the focus for the devel opment of selective inhibitors. In order to develop a rational approach to antiparasitic chemo therapy, finding differences in the biochemical pathways of the parasite with respect to the host it infects is therefore of primary importance. Like most parasitic protozoan, the genus Leishmania is an obligate auxotroph of purines and hence for requirement of purine bases depends on its own purine salvage pathways.

Keywords

Visceral Leishmaniasis Toxoplasma Gondii Purine Base Leishmania Species Adenosine Kinase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Landes Bioscience and Springer Science+Business Media 2008

Authors and Affiliations

  • Alok Kumar Datta
    • 1
  • Rupak Datta
    • 2
  • Banibrata Sen
    • 2
  1. 1.Emeritus Scientist, CSIR (Govt. of India)Indian Institute of Chemical BiologyKolkata 700032India
  2. 2.Division of Infectious DiseasesIndian Institute of Chemical Biology JadavpurKolkataIndia

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