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Antiparasitic Chemotherapy:

Tinkering with the Purine Salvage Pathway

  • Chapter
Drug Targets in Kinetoplastid Parasites

Part of the book series: Advances In Experimental Medicine And Biology ((AEMB,volume 625))

Abstract

Distinguishable differences between infecting organisms and their respective hosts with respect to metabolism and macromolecular structure provide scopes for detailed characterization of target proteins and/or macromolecules as the focus for the devel opment of selective inhibitors. In order to develop a rational approach to antiparasitic chemo therapy, finding differences in the biochemical pathways of the parasite with respect to the host it infects is therefore of primary importance. Like most parasitic protozoan, the genus Leishmania is an obligate auxotroph of purines and hence for requirement of purine bases depends on its own purine salvage pathways.

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Author information

Authors and Affiliations

  1. Emeritus Scientist, CSIR (Govt. of India), Indian Institute of Chemical Biology, 4, Raja S.C.Mullick Road, Jadavpur, Kolkata 700032, India

    Alok Kumar Datta

  2. Division of Infectious Diseases, Indian Institute of Chemical Biology Jadavpur, Kolkata, India

    Rupak Datta & Banibrata Sen

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  1. Alok Kumar Datta
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  2. Rupak Datta
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  3. Banibrata Sen
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Editors and Affiliations

  1. Molecular Parasitology Laboratory, Indian Institute of Chemical Biology, Kolkata, India

    Hemanta K. Majumder

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Datta, A.K., Datta, R., Sen, B. (2008). Antiparasitic Chemotherapy:. In: Majumder, H.K. (eds) Drug Targets in Kinetoplastid Parasites. Advances In Experimental Medicine And Biology, vol 625. Springer, New York, NY. https://doi.org/10.1007/978-0-387-77570-8_10

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