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Acute Liver Failure

  • Chan Y. Chung
  • Wissam Chatila
Chapter

Abstract

After studying this chapter, you should be able to: Recognize patients presenting with acute liver failure (ALF). Identify different etiologies of ALF. Understand the pathophysiology of underlying various organ and system dysfunctions in ALF. Monitor and manage patients with ALF.

Keywords

International Normalize Ratio Hepatic Encephalopathy Cerebral Edema Orthotopic Liver Transplantation Cerebral Perfusion Pressure 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Additional Reading

  1. Lee WM, Squires RH, Nyberg SL, et al. Acute liver failure: summary of a workshop. Hepatology. 2008;47:1401-1415.PubMedCrossRefGoogle Scholar
  2. Bernal Q, Auzinger G, Sizer E, et al. Intensive care management of acute liver failure. Semin Liver Dis. 2008;28:188-200.PubMedCrossRefGoogle Scholar
  3. Stravitz RT, Kramer AH, Davern T, et al. Intensive care of patients with acute liver failure: recommendations of the U.S. acute liver failure study group. Crit Care Med. 2007;35:2498-2508.PubMedCrossRefGoogle Scholar
  4. Blei AT. Brain edema in acute liver failure. Crit Care Clin. 2008;24:99-114.PubMedCrossRefGoogle Scholar
  5. O’Grady J. Modern management of acute liver failure. Clin Liver Dis. 2007;11:291-303.PubMedCrossRefGoogle Scholar
  6. Larson AM. Acetaminophen hepatotoxicity. Clin Liver Dis. 2007;11:525-548.PubMedCrossRefGoogle Scholar
  7. Khan SA, Shah N, Williams R, et al. Acute liver failure: a review. Clin Liver Dis. 2006;10:239-258.PubMedCrossRefGoogle Scholar
  8. Larson AM, Polson J, Fontana RJ, et al. Acetaminophen-induced acute liver failure: results of a United States multicenter, prospective study. Hepatology. 2005;42(6):1364-1372.PubMedCrossRefGoogle Scholar
  9. Vaquero J, Fontana RJ, Larson AM, et al. Complications and use of intracranial pressure monitoring in patients with acute liver failure and severe encephalopathy. Liver Transpl. 2005;11(12):1581-1589.PubMedCrossRefGoogle Scholar
  10. Polson J, Lee WM. AASLD position paper: the management of acute liver failure. Hepatology. 2005;41(5):1179-1197.PubMedCrossRefGoogle Scholar
  11. Davern TJ, James LP, Hinson JA, et al. Measurement of serum acetaminophen-protein adducts in patients with acute liver failure. Gastroenterology. 2006;130:687-694.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Chan Y. Chung
    • 1
  • Wissam Chatila
    • 2
  1. 1.Department of GastroenterologyTemple University School of MedicinePhiladelphiaUSA
  2. 2.Division of Pulmonary and Critical Care MedicineTemple University School of MedicinePhiladelphiaUSA

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