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Acute Lung Injury (ALI) and Acute Respiratory Distress Syndrome (ARDS)

  • Rita Pechulis
  • Aditi G. Satti
  • Ping Wang
  • Qin Xue-Bing
  • Gerard J. Criner
Chapter

Abstarct

Define acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). Recognize the signs and symptoms of ALI/ARDS. Recognize the inflammatory mechanisms involved in ALI/ARDS. Recognize the changes in respiratory mechanics that accompany ALI/ARDS. Know the major treatment strategies for ALI/ARDS.

Keywords

Mechanical Ventilation Acute Lung Injury Acute Respiratory Distress Syndrome Pulmonary Capillary Wedge Pressure Alveolar Epithelial Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Laennec RTH. A treatise on the diseases of the chest: in which they are described according to their anatomical characters, and their diagnosis established on a new principle by means of acoustic instruments. Translated by Forbes. Birmingham, AL: Classics of Medicine Library; 1979.Google Scholar
  2. 2.
    Ashbaugh DG, Bigelow DB, Petty TL, Levine BE. Acute respiratory distress in adults. Lancet. 1967;2:319-323.PubMedCrossRefGoogle Scholar
  3. 3.
    Petty TL, Ashbaugh DG. The adult respiratory distress syndrome: clinical features, factors influencing prognosis and principles of management. Chest. 1971;60:233-239.PubMedCrossRefGoogle Scholar
  4. 4.
    Murray JF, Matthay MA, Luce JM, Flick MR. An expanded definition of the adult respiratory distress syndrome. Am Rev Respir Dis. 1988;138:720-723.PubMedGoogle Scholar
  5. 5.
    Bernard GR, Artigas A, Brigham KL, et al. The American-European Consensus Conference on ARDS. Definitions, mechanisms, relevant outcomes, and clinical trial coordination. Am J Respir Crit Care Med. 1994;149(3 Pt 1):818-824.PubMedGoogle Scholar
  6. 6.
    Rubenfeld GD, Caldwell E, Peabody E, et al. Incidence and outcomes of acute lung injury. N Engl J Med. 2005;353(16): 1685-1693.PubMedCrossRefGoogle Scholar
  7. 7.
    Goss CH, Brower RG, Hudson LD, Rubenfeld GD. Incidence of acute lung injury in the United States. Crit Care Med. 2003;31(6): 1607-1611.PubMedCrossRefGoogle Scholar
  8. 8.
    Hudson LD, Steinberg KP. Epidemiology of acute lung injury and ARDS. Chest. 1999;116(1 Suppl):74S-82S.PubMedGoogle Scholar
  9. 9.
    Gong MN, Wei Z, Xu LL, Miller DP, Thompson BT, Christiani DC. Polymorphism in the surfactant protein-B gene, gender, and the risk of direct pulmonary injury and ARDS. Chest. 2004;125(1):203-211.PubMedCrossRefGoogle Scholar
  10. 10.
    Marshall RP, Webb S, Bellingan GJ, et al. Angiotensin converting enzyme insertion/deletion polymorphism is associated with susceptibility and outcome in acute respiratory distress syndrome. Am J Respir Crit Care Med. 2002;166:646-650.PubMedCrossRefGoogle Scholar
  11. 11.
    Stapleton RD, Wang BM, Hudson LD, Rubenfeld GD, Caldwell ES, Steinberg KP. Causes and timing of death in patients with ARDS. Chest. 2005;128(2):525-532.PubMedCrossRefGoogle Scholar
  12. 12.
    Davidson TA, Rubenfeld GD, Caldwell ES, Hudson LD, Steinberg KP. The effect of acute respiratory distress syndrome on long-term survival. Am J Respir Crit Care Med. 1999;160(6): 1838-1842.PubMedGoogle Scholar
  13. 13.
    Doyle RL, Szaflarski N, Modin GW, Wiener-Kronish JP, Matthay MA. Identification of patients with acute lung injury. Predictors of mortality. Am J Respir Crit Care Med. 1995;152(6):1818-1824.PubMedGoogle Scholar
  14. 14.
    Monchi M, Bellenfant F, Cariou A, et al. Early predictive factors of survival in the acute respiratory distress syndrome. A multivariate analysis. Am J Respir Crit Care Med. 1998;158(4):1076-1081.PubMedGoogle Scholar
  15. 15.
    Ware LB, Matthay MA. Alveolar fluid clearance is impaired in the majority of patients with acute lung injury and the acute respiratory distress syndrome. Am J Respir Crit Care Med. 2001; 163(6):1376-1383.PubMedGoogle Scholar
  16. 16.
    Montgomery AB, Stager MA, Carrico CJ, Hudson LD. Causes of mortality in patients with the adult respiratory distress syndrome. Am Rev Respir Dis. 1985;132(3):485-489.PubMedGoogle Scholar
  17. 17.
    Nuckton TJ, Alonso JA, Kallet RH, et al. Pulmonary dead-space fraction as a risk factor for death in the acute respiratory distress syndrome. N Engl J Med. 2002;346(17):1281-1286.PubMedCrossRefGoogle Scholar
  18. 18.
    Chesnutt AN, Matthay MA, Tibayan FA, Clark JG. Early detection of type III procollagen peptide in acute lung injury. Pathogenetic and prognostic significance. Am J Respir Crit Care Med. 1997;156(3 Pt 1):840-845.PubMedGoogle Scholar
  19. 19.
    Karmpaliotis D, Kirtane AJ, Ruisi CP, et al. Diagnostic and prognostic utility of brain natriuretic peptide in subjects admitted to the ICU with hypoxic respiratory failure due to noncardiogenic and cardiogenic pulmonary edema. Chest. 2007;131:964.PubMedCrossRefGoogle Scholar
  20. 20.
    Amato MBP, Barbas CSV, Medeiros DM, et al. Effect of a protective – ventilation strategy on mortality in the acute respiratory distress syndrome. N Eng J Med. 1998;338:347-354.CrossRefGoogle Scholar
  21. 21.
    The Acute Respiratory Distress Syndrome Network. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. N Engl J Med. 2000;342:1301-1308.CrossRefGoogle Scholar
  22. 22.
    Brower RG, Lanken PN, MacIntyre N, et al. Higher versus lower positive end-expiratory pressures in patients with the acute respiratory distress syndrome. N Engl J Med. 2004;351:327-336.PubMedCrossRefGoogle Scholar
  23. 23.
    The Acute Respiratory Distress Syndrome Network. Effects of recruitment maneuvers in patients with acute lung injury and acute respiratory distress syndrome ventilated with high positive end-expiratory pressure. Crit Care Med. 2003;31:2592-2597.CrossRefGoogle Scholar
  24. 24.
    Lamm WJE, Graham MM, Albert RK. Mechanism by which the prone position improves oxygenation in acute lung injury. Am J Respir Crit Care Med. 1994;150:184-193.PubMedGoogle Scholar
  25. 25.
    Albert and Humayer. The prone position eliminates compression of the lungs by the heart. Am J Respir Crit Care Med. 2000;161: 1660-1665.Google Scholar
  26. 26.
    Gattinoni L et al. Effect of prone positioning on the survival of patients with acute respiratory failure. N Engl J Med. 2001;345: 568-573.PubMedCrossRefGoogle Scholar
  27. 27.
    Meduri U et al. Effect of prolonged methylprednisolone therapy in unresolving acute respiratory distress syndrome. N Engl J Med. 1998;280:159-165.Google Scholar
  28. 28.
    The National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome (ARDS) Clinical Trials Network. Efficacy and safety of corticosteroids for persistent acute respiratory distress syndrome. N Engl J Med. 2006;354:1671-1684.CrossRefGoogle Scholar
  29. 29.
    Rossaint R, Falke KJ, Lopez F, Slama K, Pison U, Zapol WM. Inhaled nitric oxide for the adult respiratory distress syndrome. N Engl J Med. 1993;328:399-405.PubMedCrossRefGoogle Scholar
  30. 30.
    Inhaled Nitric Oxide in ARDS Study Group; Dellinger RP, Zimmerman JL, Taylor RW, et al. Effects of inhaled nitric oxide in patients with acute respiratory distress syndrome: results of a randomized phase II trial. Crit Care Med. 1998;26:15-23.Google Scholar
  31. 31.
    Mira JP, Monchi M, Brunet F, Fierobe L, Dhainaut JF, Dinh-Xuan AT. Lack of efficacy of inhaled nitric oxide in ARDS. Intensive Care Med. 1994;20(7):532.PubMedCrossRefGoogle Scholar
  32. 32.
    The National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome (ARDS) Clinical Trials Network. Comparison of two fluid management strategies in acute lung injury. N Engl J Med. 2006;354:2564-2575.CrossRefGoogle Scholar
  33. 33.
    The National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome (ARDS) Clinical Trials Network. Pulmonary-artery versus central venous catheter to guide treatment of acute lung injury. N Engl J Med. 2006;354:2213-2224.CrossRefGoogle Scholar
  34. 34.
    Neff TA, Stocker R, Frey HR, Stein S, Russi EW. Long-term assessment of lung function in survivors of severe ARDS. Chest. 2003;123(3):845-853.PubMedCrossRefGoogle Scholar
  35. 35.
    Hopkins RO, Weaver LK, Collingridge D, Parkinson RB, Chan KJ, Orme JF Jr. Two-year cognitive, emotional, and quality of life outcomes in acute respiratory distress syndrome. Am J Respir Crit Care Med. 2005;171(4):340-347. Epub 2004 Nov 12.Google Scholar
  36. 36.
    Hopkins RO, Weaver LK, Pope D, Orme JF, Bigler ED, Larson-LOHR V. Neuropsychological sequelae and impaired health status in survivors of severe acute respiratory distress syndrome. Am J Respir Crit Care Med. 1999;160(1):50-56.PubMedGoogle Scholar
  37. 37.
    Malhotra A. Low-tidal-volume ventilation in the acute respiratory distress syndrome. N Engl J Med. 2007;357(11):1113-1120.PubMedCrossRefGoogle Scholar

Additional Reading

  1. Bernard GR, Artigas A, Brigham KL, et al. The American-European Consensus Conference on ARDS. Definitions, mechanisms, relevant outcomes, and clinical trial coordination. Am J Respir Crit Care Med. 1994;149(3 Pt 1):818-824.PubMedGoogle Scholar
  2. Artigas A, Bernard GR, Carlet J, et al. The American-European Consensus Conference on ARDS, part 2: Ventilatory, pharmacologic, supportive therapy, study design strategies, and issues related to recovery and remodeling. Acute respiratory distress syndrome. Am J Respir Crit Care Med. 1998;157(4 Pt 1):1332-1347.PubMedGoogle Scholar
  3. Matthay MA, Zimmerman GA, Esmon C, et al. Future research directions in acute lung injury: summary of a National Heart, Lung, and Blood Institute working group. Am J Respir Crit Care Med. 2003;167(7):1027-1035.PubMedCrossRefGoogle Scholar
  4. Ashbaugh DG, Bigelow DB, Petty TL, Levine BE. Acute respiratory distress in adults. Lancet. 1967;2:319-323.PubMedCrossRefGoogle Scholar
  5. Bernard GR. Acute respiratory distress syndrome: a historical perspective. Am J Respir Crit Care Med. 2005;172(7):798-806.PubMedCrossRefGoogle Scholar
  6. The Acute Respiratory Distress Syndrome Network. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. N Engl J Med. 2000;342:1301-1308.CrossRefGoogle Scholar
  7. The National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome (ARDS) Clinical Trials Network. Comparison of two fluid management strategies in acute lung injury. N Engl J Med. 2006;354:2564-2575.CrossRefGoogle Scholar
  8. The National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome (ARDS) Clinical Trials Network. Pulmonary-artery versus central venous catheter to guide treatment of acute lung injury. N Engl J Med. 2006;354:2213-2224.CrossRefGoogle Scholar
  9. Suratt BT, Parsons PE. Mechanisms of acute lung injury/acute respiratory distress syndrome. Clin Chest Med. 2006;27(4):581-589.CrossRefGoogle Scholar
  10. Peñuelas O, Arambur JA, Frutos-Vivar F, Esteban A. Pathology of acute lung injury and acute respiratory distress syndrome: a clinical–pathological correlation. Clin Chest Med. 2006;27(4):571-578.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Rita Pechulis
    • 1
  • Aditi G. Satti
    • 2
  • Ping Wang
    • 3
  • Qin Xue-Bing
    • 4
  • Gerard J. Criner
    • 5
  1. 1.Department of Medicine, Division of Pulmonary and Critical CareTemple University HospitalPhiladelphiaUSA
  2. 2.Department of Pulmonary and Critical CareTemple University School of MedicinePhiladelphiaUSA
  3. 3.Pulmonary Department306th HospitalBeijingChina
  4. 4.Respiratory DepartmentGeneral Hospital of PLA.BeijingChina
  5. 5.Pulmonary and Critical Care Medicine and Temple Lung CenterTemple University School of MedicinePhiladelphiaUSA

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