Respiratory Failure

  • Gerard J. Criner


Define respiratory failure. Classify respiratory failure into hypoxemic or hypercapnic subtypes. Recognize the signs and symptoms of respiratory failure. Define the alveolar gas equation and apply it to evaluate respiratory failure. Recognize the changes in blood gases that accompany respiratory failure. Know the major treatment strategies for respiratory failure.


Respiratory Failure Respiratory Muscle Hypoxic Pulmonary Vasoconstriction Flail Chest Intrapulmonary Shunt 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. 1.
    Decramer M, Roussos C. Treatment of respiratory failure: introduction. Eur Respir J Suppl. 2003;47:1s-2s.PubMedGoogle Scholar
  2. 2.
    Roussos C. Respiratory muscle fatigue and ventilatory failure. Chest. 1990;97:89S-96S.PubMedGoogle Scholar
  3. 3.
    Roussos C. The failing ventilatory pump. Lung. 1982;160:59-84.PubMedCrossRefGoogle Scholar
  4. 4.
    Roussos C, Koutsoukou A. Respiratory failure. Eur Respir J Suppl. 2003;47:3s-14s.PubMedCrossRefGoogle Scholar
  5. 5.
    Roussos C, Macklem PT. The respiratory muscles. N Engl J Med. 1982;307:786-797.PubMedCrossRefGoogle Scholar
  6. 6.
    Roussos C, Zakynthinos S. Fatigue of the respiratory muscles. Intensive Care Med. 1996;22:134-155.PubMedCrossRefGoogle Scholar
  7. 7.
    Vassilakopoulos T, Zakynthinos S, Roussos C. Respiratory muscles and ventilatory failure. Monaldi Arch Chest Dis. 1996;51:489-498.PubMedGoogle Scholar
  8. 8.
    Fleury B, Murciano D, Talamo C, Aubier M, Pariente R, Milic-Emili J. Work of breathing in patients with chronic obstructive pulmonary disease in acute respiratory failure. Am Rev Respir Dis. 1985;131:822-827.PubMedGoogle Scholar
  9. 9.
    Kennedy JD, Martin AJ. Chronic respiratory failure and neuromuscular disease. Pediatr Clin North Am. 2009;56:261-273, xii.Google Scholar
  10. 10.
    Murciano D, Aubier M, Bussi S, Derenne JP, Pariente R, Milic-Emili J. Comparison of esophageal, tracheal, and mouth occlusion pressure in patients with chronic obstructive pulmonary disease during acute respiratory failure. Am Rev Respir Dis. 1982;126:837-841.PubMedGoogle Scholar
  11. 11.
    Murciano D, Boczkowski J, Lecocguic Y, Emili JM, Pariente R, Aubier M. Tracheal occlusion pressure: a simple index to monitor respiratory muscle fatigue during acute respiratory failure in patients with chronic obstructive pulmonary disease. Ann Intern Med. 1988;108:800-805.PubMedGoogle Scholar
  12. 12.
    Murciano D, Aubier M, Derenne JP. Assessment of respiratory control in hypercapnic patients (author’s transl). Bull Eur Physiopathol Respir. 1979;15(Suppl):233-243.PubMedGoogle Scholar
  13. 13.
    Milic-Emili J, Aubier M. Some recent advances in the study of the control of breathing in patients with chronic obstructive lung disease. Anesth Analg. 1980;59:865-873.PubMedCrossRefGoogle Scholar
  14. 14.
    Mentzelopoulos SD, Roussos C, Zakynthinos SG. Static pressure volume curves and body posture in acute respiratory failure. Intensive Care Med. 2005;31:1683-1692.PubMedCrossRefGoogle Scholar
  15. 15.
    Roussos C, Aubier M. Neural drive and electromechanical alterations in the fatiguing diaphragm. Ciba Found Symp. 1981;82: 213-233.PubMedGoogle Scholar
  16. 16.
    Aubier M, Farkas G, De Troyer A, Mozes R, Roussos C. Detection of diaphragmatic fatigue in man by phrenic stimulation. J Appl Physiol. 1981;50:538-544.PubMedGoogle Scholar
  17. 17.
    Cohen CA, Zagelbaum G, Gross D, Roussos C, Macklem PT. Clinical manifestations of inspiratory muscle fatigue. Am J Med. 1982;73:308-316.PubMedCrossRefGoogle Scholar
  18. 18.
    Aubier M, Murciano D, Lecocguic Y, et al. Effect of hypophosphatemia on diaphragmatic contractility in patients with acute respiratory failure. N Engl J Med. 1985;313:420-424.PubMedCrossRefGoogle Scholar
  19. 19.
    Aubier M, Lecocguic Y, Murciano D, Pariente R. Function of the respiratory muscles in acute cardiac decompensation. Schweiz Med Wochenschr. 1985;115:190-193.PubMedGoogle Scholar
  20. 20.
    Aubier M, Trippenbach T, Roussos C. Respiratory muscle fatigue during cardiogenic shock. J Appl Physiol. 1981;51:499-508.PubMedGoogle Scholar
  21. 21.
    Aubier M, De Troyer A, Sampson M, Macklem PT, Roussos C. Aminophylline improves diaphragmatic contractility. N Engl J Med. 1981;305:249-252.PubMedCrossRefGoogle Scholar
  22. 22.
    Aubier M. Pharmacotherapy of respiratory muscles. Clin Chest Med. 1988;9:311-324.PubMedGoogle Scholar
  23. 23.
    Aubier M, Murciano D, Viires N, et al. Effects of digoxin on diaphragmatic strength generation in patients with chronic obstructive pulmonary disease during acute respiratory failure. Am Rev Respir Dis. 1987;135:544-548.PubMedGoogle Scholar
  24. 24.
    Aubier M, Murciano D, Menu Y, Boczkowski J, Mal H, Pariente R. Dopamine effects on diaphragmatic strength during acute respiratory failure in chronic obstructive pulmonary disease. Ann Intern Med. 1989;110:17-23.PubMedGoogle Scholar
  25. 25.
    Vires N, Aubier M, Murciano D, Fleury B, Talamo C, Pariente R. Effects of aminophylline on diaphragmatic fatigue during acute respiratory failure. Am Rev Respir Dis. 1984;129:396-402.PubMedGoogle Scholar
  26. 26.
    Aubier M. Pharmacological treatment of respiratory insufficiency. Recenti Prog Med. 1990;81:193-199.PubMedGoogle Scholar
  27. 27.
    Dantsker MD, David R. Pulmonary gas exchange. In: Bone R, ed. Pulmonary and Critical Care Medicine. St. Louis: Mosby; 1997.Google Scholar
  28. 28.
    Murray JF. The Normal Lung. Philadelphia: Saunders; 1976:224.Google Scholar

Additional Reading

  1. Roussos C. Ventilatory failure and respiratory muscles. In: Roussos C, Macklem PT, eds. The Thorax. New York: Marcel Dekker; 1985:884-888.Google Scholar
  2. Roussos C, Koutsoukou A. Respiratory failure. Eur Respir J. 2003;22(suppl 47):3S-14S.CrossRefGoogle Scholar
  3. Grippi M. Acute respiratory failure: introduction. In: Fishman AP, ed. Pulmonary Disease and Disorders. 4th ed. New York: McGraw-Hill; 2008:2185-2188.Google Scholar
  4. DeTroyer A, Estenne M. The respiratory system in neuromuscular disorders. In: Roussos C, ed. Thorax. 2nd ed. New York: Marcel Dekker; 1995 (part C):2177-2212.Google Scholar
  5. Calverley P, Gorini M. Chronic respiratory failure. In: Ambrosino N, Goldstein R, eds. Ventilatory Support for Chronic Respiratory Failure. New York, NY: Informa Healthcare; 2008.Google Scholar

Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Gerard J. Criner
    • 1
  1. 1.Pulmonary and Critical Care Medicine and Temple Lung CenterTemple University School of MedicinePhiladelphiaUSA

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