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Involvement of Plasmalogens in Neurological Disorders

Neural membranes are complex, well-organized, and highly specialized structures involved in receiving, processing, transporting, and transmitting information, not only from the plasma membrane to the nucleus, but also from one cell to another through chemical mediators generated during the catabolism of various glycerophospholipids (Guan et al., 1999; Farooqui and Horrocks, 2007). Neural membranes are highly interactive and dynamic. These properties facilitate optimal interactions of lipid mediators with transmembrane proteins, receptors, and ion channels and maintain normal brain function and adaptive responses (Farooqui et al., 1995; Farooqui and Horrocks, 2004). Although very little is known about the regulation of lipid dynamics in neural membranes, this process has been reported to link with the biosynthesis, metabolism, and transport of individual molecular species of glycerophospholipid (Farooqui and Horrocks, 2007). The catabolism of neural membrane glycerophospholipids, including plasmalogens, involves phospholipases, whose activities are modulated by receptors and ion channels. Plasmalogens provide neural membranes with suitable stability, fluidity, and permeability. They serve as storage depot and precursors for eicosanoids, docosanoids, and platelet activating factor.

In neural membranes, the maintenance of lipid asymmetry requires up to 20– 26% consumption of ATP (Purdon et al., 2002; Purdon and Rapoport, 2007). This high rate of ATP consumption includes 1.4% of net brain ATP consumption for de novo synthesis of ether lipids, 5% for recycling of fatty acids within glycerophospholipid, 7.7% for maintaining membrane asymmetries of charged aminophospholipids, and about 12% for maintaining the phosphorylation state and de novo synthesis of inositol containing phospholipids involving phosphatidylinositol signaling (Purdon and Rapoport, 2007). Much of the remaining ATP maintains the distribution and transport of ions and activities of membrane-bound enzymes and ion channels. The high rate of ATP consumption is consistent with the role of glycerophospholipids in neural cell signaling, apoptosis, and membrane-associated processes such as membrane fusion, anchoring, and recycling (Purdon and Rapoport, 2007). At present, no information is available on ATP consumption during traffick- ing and sorting of various glycerophospholipids in neurons, astrocytes, oligodendrocytes, and microglial glial cells. The situation on ATP consumption during glycerophospholipid trafficking and sorting becomes more complex at the subcellular level (endoplasmic reticulum, Golgi apparatus, nucleus, etc.) of various cell types of neural cells in normal brain and brains from patients with neural trauma and neurodegenerative diseases.

Keywords

Fetal Alcohol Syndrome Ether Lipid Fatty Aldehyde Zellweger Syndrome Peroxisomal Disorder 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Bams-Mengerink A. M., Majoie C. B., Duran M., Wanders R. J., Van Hove J., Scheurer C. D., Barth P. G., and Poll-The B. T. (2006). MRI of the brain and cervical spinal cord in rhizomelic chondrodysplasia punctata. Neurology 66:798–803.PubMedGoogle Scholar
  2. Berry K. A. Z. and Murphy R. C. (2005). Free radical oxidation of plasmalogen glycerophosphocholine containing esterified docosahexaenoic acid: Structure determination by mass spectrometry. Antioxidants and Redox Signaling 7:157–169.Google Scholar
  3. Bichenkov E. and Ellingson J. S. (1999). Temporal and quantitative expression of the myelin-associated lipids, ethanolamine plasmalogen, galactocerebroside, and sulfatide, in the differentiating CG-4 glial cell line. Neurochem. Res. 24:1549–1556.PubMedGoogle Scholar
  4. Brosche T., Platt D., and Knopf B. (2002). Decreased concentrations of serum phospholipid plasmalogens indicate oxidative burden of uraemic patients undergoing haemodialysis. Nephron 90:58–63.PubMedGoogle Scholar
  5. Brosche T., Brueckmann M., Haase K. K., Sieber C., and Bertsch T. (2007). Decreased plasmalogen concentration as a surrogate marker of oxidative stress in patients presenting with acute coronary syndromes or supraventricular tachycardias. Clin. Chem. Lab. Med. 45:689–691.PubMedGoogle Scholar
  6. Burdge G. C. (1998). The role of docosahexaenoic acid in brain development and fetal alcohol syndrome. Biochem. Soc. Trans. 26:246–252.PubMedGoogle Scholar
  7. Caldwell R. A. and Baumgarten C. M. (1998). Plasmalogen-derived lysolipid induces a depolarizing cation current in rabbit ventricular myocytes. Circ. Res. 83:533–540.PubMedGoogle Scholar
  8. Clarren S. K. and Smith D. W. (1978). The fetal alcohol syndrome. N. Engl. J. Med. 298:1063–1067.PubMedGoogle Scholar
  9. Cummings B. S., McHowat J., and Schnellmann R. G. (2000). Phospholipase A2s in cell injury and death. J. Pharmacol. Exp. Ther. 294:793–799.PubMedGoogle Scholar
  10. Daniel L. W., Sciorra V. A., and Ghosh S. (1999). Phospholipase D, tumor promoters, proliferation and prostaglandins. Biochim. Biophys. Acta Mol. Cell Biol. Lipids 1439:265–276.Google Scholar
  11. Das A. K., Holmes R. D., Wilson G. N., and Hajra A. K. (1992). Dietary ether lipid incorporation into tissue plasmalogens of humans and rodents. Lipids 27:401–405.PubMedGoogle Scholar
  12. Datta N. S., Wilson G. N., and Hajra A. K. (1984). Deficiency of enzymes catalyzing the biosynthesis of glycerol-ether lipids in Zellweger syndrome. A new category of metabolic disease involving the absence of peroxisomes. N. Engl. J. Med. 311:1080–1083.PubMedGoogle Scholar
  13. Dawson R. M. and Clarke N. (1971). Cerebral phospholipids in ‘quaking’ mice. J. Neurochem. 18:1313–1316.PubMedGoogle Scholar
  14. Demediuk P., Saunders R. D., Anderson D. K., Means E. D., and Horrocks L. A. (1985). Membrane lipid changes in laminectomized and traumatized cat spinal cord. Proc. Natl. Acad. Sci. USA 82:7071–7075.PubMedGoogle Scholar
  15. de Vet E. C. and van den Bosch H. (2000). Alkyl-dihydroxyacetonephosphate synthase. Cell Biochem. Biophys. 32:117–121.PubMedGoogle Scholar
  16. Edger A. D., Strosznajder J., Horrocks L. A. (1982). Activation of ethanolamine phospholipase A2 in Brain during ischemia. J. Neurochem. 39:1111–1116.Google Scholar
  17. Engelmann B., Streich S., Schönthier U. M., Richter W. O., and Duhm J. (1992). Changes of membrane phospholipid composition of human erythrocytes in hyperlipidemias. I. Increased phosphatidylcholine and reduced sphingomyelin in patients with elevated levels of triacylglycerol-rich lipoproteins. Biochim. Biophys. Acta Lipids Lipid Metab. 1165:32–37.Google Scholar
  18. Engelmann B., Bräutigam C., and Thiery J. (1994). Plasmalogen phospholipids as potential protectors against lipid peroxidation of low density lipoproteins. Biochem. Biophys. Res. Commun. 204:1235–1242.PubMedGoogle Scholar
  19. Farooqui A. A. and Horrocks L. A. (1991). Excitatory amino acid receptors, neural membrane phospholipid metabolism and neurological disorders. Brain Res. Rev. 16:171–191.PubMedGoogle Scholar
  20. Farooqui A. A. and Horrocks L. A. (2001). Plasmalogens: Workhorse lipids of membranes in normal and injured neurons and glia. Neuroscientist 7:232–245.PubMedGoogle Scholar
  21. Farooqui A. A. and Horrocks L. A. (2004). Plasmalogens, platelet-activating factor, and other ether lipids. In: Nicolaou A. and Kokotos G. (Eds.), Bioactive Lipids. Oily, Bridgwater, England, pp. 107–134.Google Scholar
  22. Farooqui A. A. and Horrocks L. A. (2005). Signaling and interplay mediated by phospholipases A2, C, and D in LA-N-1 cell nuclei. Reprod. Nutr. Dev. 45:613–631.PubMedGoogle Scholar
  23. Farooqui A. A. and Horrocks L. A. (2006). Phospholipase A2-generated lipid mediators in the brain: The good, the bad, and the ugly. Neuroscientist 12:245–260.PubMedGoogle Scholar
  24. Farooqui A. A. and Horrocks L. A. (2008). Glycerophospholipids in the Brain: Phospholipases A 2 in Neurological Disorders. Springer, New York, pp. 1–290.Google Scholar
  25. Farooqui A. A., Hirashima Y., and Horrocks L. A. (1992). Brain phospholipases and their role in signal transduction. Adv. Exp. Med. Biol. 318:11–25.PubMedGoogle Scholar
  26. Farooqui A. A., Yang H. C., and Horrocks L. A. (1995). Plasmalogens, phospholipases A2, and signal transduction. Brain Res. Rev. 21:152–161.PubMedGoogle Scholar
  27. Farooqui A. A., Rapoport S. I., and Horrocks L. A. (1997a). Membrane phospholipid alterations in Alzheimer disease: Deficiency of ethanolamine plasmalogens. Neurochem. Res. 22:523–527.PubMedGoogle Scholar
  28. Farooqui A. A., Yang H. C., Rosenberger T. A., and Horrocks L. A. (1997b). Phospholipase A2 and its role in brain tissue. J. Neurochem. 69:889–901.PubMedGoogle Scholar
  29. Farooqui A. A., Yang H. C., and Horrocks L. A. (1997c). Involvement of phospholipase A2 in neurodegeneration. Neurochem. Int. 30:517–522.PubMedGoogle Scholar
  30. Farooqui A. A., Horrocks L. A., and Farooqui T. (2000). Glycerophospholipids in brain: Their metabolism, incorporation into membranes, functions, and involvement in neurological disorders. Chem. Phys. Lipids 106:1–29.PubMedGoogle Scholar
  31. Farooqui A. A., Ong W. Y., and Horrocks L. A. (2003a). Plasmalogens, docosahexaenoic acid, and neurological disorders. In: Roels F., Baes M., and de Bies S. (Eds.), Peroxisomal Disorders and Regulation of Genes. Kluwer Academic/Plenum, London, pp. 335–354.Google Scholar
  32. Farooqui A. A., Ong W. Y., and Horrocks L. A. (2003b). Stimulation of lipases and phospholipases in Alzheimer disease. In: Szuhaj B. and van Nieuwenhuyzen W. (Eds.), Nutrition and Biochemistry of Phospholipids. AOCS, Champaign, IL, pp. 14–29.Google Scholar
  33. Farooqui A. A., Ong W. Y., and Horrocks L. A. (2006). Inhibitors of brain phospholipase A2 activity: Their neuropharmacological effects and therapeutic importance for the treatment of neurologic disorders. Pharmacol. Rev. 58:591–620.PubMedGoogle Scholar
  34. Farooqui A. A., Ong W. Y., and Horrocks L. A. (2008). Neurochemical Aspects of Excitotoxicity. Springer, New York, pp. 1–290.Google Scholar
  35. Forrester J. S., Milne S. B., Ivanova P. T., and Brown H. A. (2004). Computational lipidomics: A multiplexed analysis of dynamic changes in membrane lipid composition during signal transduction. Mol. Pharmacol. 65:813–821.PubMedGoogle Scholar
  36. Gaposchkin D. P. and Zoeller R. A. (1999). Plasmalogen status influences docosahexaenoic acid levels in a macrophage cell line: Insights using ether lipid-deficient variants. J. Lipid Res. 40:495–503.PubMedGoogle Scholar
  37. Ginsberg L., Rafique S., Xuereb J. H., Rapoport S. I., and Gershfeld N. L. (1995). Disease and anatomic specificity of ethanolamine plasmalogen deficiency in Alzheimer’s disease brain. Brain Res. 698:223–226.PubMedGoogle Scholar
  38. Ginsberg L., Xuereb J. H., and Gershfeld N. L. (1998). Membrane instability, plasmalogen content, and Alzheimer’s disease. J. Neurochem. 70:2533–2538.PubMedGoogle Scholar
  39. Gorgas K., Teigler A., Komljenovic D., and Just W. W. (2006). The ether lipid-deficient mouse: Tracking down plasmalogen functions. Biochim. Biophys. Acta Mol. Cell Res. 1763:1511–1526.Google Scholar
  40. Gross R. W. (1985). Identification of plasmalogen as the major phospholipid constituent of cardiac sarcoplasmic reticulum. Biochemistry 24:1662–1668.PubMedGoogle Scholar
  41. Gross R. W., Jenkins C. M., Yang J. Y., Mancuso D. J., and Han X. L. (2005). Functional lipidomics: The roles of specialized lipids and lipid–protein interactions in modulating neuronal function. Prostaglandins Other Lipid Mediat. 77:52–64.PubMedGoogle Scholar
  42. Guan Z. Z., Wang Y. A., Cairns N. J., Lantos P. L., Dallner G., and Sindelar P. J. (1999). Decrease and structural modifications of phosphatidylethanolamine plasmalogen in the brain with Alzheimer disease. J. Neuropathol. Exp. Neurol. 58:740–747.PubMedGoogle Scholar
  43. Hack M. H. and Helmy F. M. (1978). The diminution of the myelin ethanolamine plasmalogen in brain of the jimpy mouse and brain and spinal cord of the quaking mouse as visualized by thin-layer chromatography. J. Chromatogr. 145:307.PubMedGoogle Scholar
  44. Halliwell B. (1994). Free radicals and antioxidants: A personal view [Review]. Nutr. Rev. 52:253–265.PubMedGoogle Scholar
  45. Hamazaki T., Sawazaki S., Itomura M., Asaoka E., Nagao Y., Nishimura N., Yazawa K., Kuwamori T., and Kobayashi M. (1996). The effect of docosahexaenoic acid on aggression in young adults – A placebo-controlled double-blind study. J. Clin. Invest. 97:1129–1133.PubMedGoogle Scholar
  46. Han X. and Gross R. W. (1991). Alterations in membrane dynamics elicited by amphiphilic compounds are augmented in plasmenylcholine bilayers. Biochim. Biophys. Acta Biomembr. 1069:37–45.Google Scholar
  47. Han X. L., Holtzman D. M., and McKeel D. W., Jr. (2001). Plasmalogen deficiency in early Alzheimer’s disease subjects and in animal models: Molecular characterization using electrospray ionization mass spectrometry. J. Neurochem. 77:1168–1180.PubMedGoogle Scholar
  48. Hara H., Wakisaka T., and Aoyama Y. (2003). Lymphatic absorption of plasmalogen in rats. Br. J. Nutr. 90:29–32.PubMedGoogle Scholar
  49. Hashimoto M., Hossain S., Shimada T., Sugioka K., Yamasaki H., Fujii Y., Ishibashi Y., Oka J. I., and Shido O. (2002). Docosahexaenoic acid provides protection from impairment of learning ability in Alzheimer’s disease model rats. J. Neurochem. 81:1084–1091.PubMedGoogle Scholar
  50. Hazen S. L., Ford D. A., and Gross R. W. (1991). Activation of a membrane-associated phospholipase A2 during rabbit myocardial ischemia which is highly selective for plasmalogen substrate. J. Biol. Chem. 266:5629–5633.PubMedGoogle Scholar
  51. Heikoop J. C., van Roermund C. W., Just W. W., Ofman R., Schutgens R. B., Heymans H. S., Wanders R. J., and Tager J. M. (1990). Rhizomelic chondrodysplasia punctata. Deficiency of 3-oxoacyl-coenzyme A thiolase in peroxisomes and impaired processing of the enzyme. J. Clin. Invest. 86:126–130.PubMedGoogle Scholar
  52. Heymans H. S. A., Schutgens R. B. H., Tan R., van den Bosch H., and Borst P. (1983). Severe plasmalogen deficiency in tissues of infants without peroxisomes (Zellweger syndrome). Nature 306:69–70.PubMedGoogle Scholar
  53. Heymans H. S. A., Oorthuys J. W. E., Nelck G., Wanders R. J. A., Dingemans K. P., and Schutgens R. B. H. (1985). Peroxisomal abnormalities in rhizomelic chondrodysplasia punctata. J. Inherit. Metab. Dis. 9:329–331.Google Scholar
  54. Hofteig J. H., Noronha A. B., Druse M. J., and Keresztes-Nagy C. (1985). Synaptic membrane phospholipids: Effects of maternal ethanol consumption. Exp. Neurol. 87:165–171.PubMedGoogle Scholar
  55. Horrocks L. A. and Sharma M. (1982). Plasmalogens and O-alkyl glycerophospholipids. In: Hawthorne J. N. and Ansell G. B. (Eds.), Phospholipids, New Comprehensive Biochemistry, Vol. 4. Elsevier Biomedical, Amsterdam, pp. 51–93.Google Scholar
  56. Horrocks L. A. and Yeo Y. K. (1999). Health benefits of docosahexaenoic acid (DHA). Pharmacol. Res. 40:211–225.PubMedGoogle Scholar
  57. Huterer S. J., Tourtellotte W. W., and Wherrett J. R. (1995). Alterations in the activity of phospholipases A2 in post-mortem white matter from patients with multiple sclerosis. Neurochem. Res. 20:1335–1343.PubMedGoogle Scholar
  58. Infante J. P. and Huszagh V. A. (2001). Zellweger syndrome knockout mouse models challenge putative peroxisomal beta-oxidation involvement in docosahexaenoic acid (22: 6n–3) biosynthesis. Mol. Genet. Metab. 72:1–7.PubMedGoogle Scholar
  59. Jagannatha H. M. and Sastry P. S. (1981). Ethanolamine plasmalogen and cholesterol ester metabolism in experimental allergic encephalomyelitis. Indian J. Biochem. Biophys. 18:411–416.PubMedGoogle Scholar
  60. Janssen A., Baes M., Gressens P., Mannaerts G. P., Declercq P., and Van Veldhoven P. P. (2000). Docosahexaenoic acid deficit is not a major pathogenic factor in peroxisome-deficient mice. Lab. Invest. 80:31–35.PubMedGoogle Scholar
  61. Jones C. R., Arai T., and Rapoport S. I. (1997). Evidence for the involvement of docosahexaenoic acid in cholinergic stimulated signal transduction at the synapse. Neurochem. Res. 22:663–670.PubMedGoogle Scholar
  62. Kubota M., Nakane M., Nakagomi T., Tamura A., Hisaki H., Shimasaki H., and Ueta N. (2001). Regional distribution of ethanolamine plasmalogen in the hippocampal CA1 and CA3 regions and cerebral cortex of the gerbil. Neurosci. Lett. 301:175–178.PubMedGoogle Scholar
  63. Lee S. H., Williams M. V., and Blair I. A. (2005). Targeted chiral lipidomics analysis. Prostaglandins Other Lipid Mediat. 77:141–157.PubMedGoogle Scholar
  64. Lee T. C. (1998). Biosynthesis and possible biological functions of plasmalogens. Biochim. Biophys. Acta Lipids Lipid Metab. 1394:129–145.Google Scholar
  65. Liu S. J., McHowat J., and Creer M. H. (1999). Effects of lysoplasmenylcholine on membrane currents in rabbit ventricular myocytes. J. Mol. Cell Cardiol. 31, 27 (abstract)Google Scholar
  66. Lukácová N., Halát G., Chavko M., and Maršala J. (1996). Ischemia-reperfusion injury in the spinal cord of rabbits strongly enhances lipid peroxidation and modifies phospholipid profiles. Neurochem. Res. 21:869–873.PubMedGoogle Scholar
  67. Maeba R. and Ueta N. (2004). A novel antioxidant action of ethanolamine plasmalogens in lowering the oxidizability of membranes. Biochem. Soc. Trans. 32:141–143.PubMedGoogle Scholar
  68. Mandel H., Sharf R., Berant M., Wanders R. J. A., Vreken P., and Aviram M. (1998). Plasmalogen phospholipids are involved in HDL-mediated cholesterol efflux: Insights from investigations with plasmalogen-deficient cells. Biochem. Biophys. Res. Commun. 250:369–373.PubMedGoogle Scholar
  69. Martínez M. (1990). Severe deficiency of docosahexaenoic acid in peroxisomal disorders: A defect of delta 4 desaturation? Neurology 40:1292–1298.PubMedGoogle Scholar
  70. Martínez M. (1992). Abnormal profiles of polyunsaturated fatty acids in the brain, liver, kidney and retina of patients with peroxisomal disorders. Brain Res. 583:171–182.PubMedGoogle Scholar
  71. Martínez M., Vázquez E., García-Silva M. T., Manzanares J., Bertran J. M., Castelló F., and Mougan I. (2000). Therapeutic effects of docosahexaenoic acid ethyl ester in patients with generalized peroxisomal disorders. Am. J. Clin. Nutr. 71:376S–385S.PubMedGoogle Scholar
  72. McHowat J., Creer M. H., Hicks K. K., Jones J. H., McCrory R., and Kennedy R. H. (2000). Induction of Ca-independent PLA2 and conservation of plasmalogen polyunsaturated fatty acids in diabetic heart. Am. J. Physiol. Endocrinol. Metab. 279:E25–E32.PubMedGoogle Scholar
  73. Mochel F., Grebille A. G., Benachi A., Martinovic J., Razavi F., Rabier D., Simon I., Boddaert N., Brunelle F., and Sonigo P. (2006). Contribution of fetal MR imaging in the prenatal diagnosis of Zellweger syndrome. AJNR Am. J. Neuroradiol. 27:333–336.PubMedGoogle Scholar
  74. Motley A. M., Hettema E. H., Hogenhout E. M., Brites P., ten Asbroek A. L., Wijburg F. A., Baas F., Heijmans H. S., Tabak H. F., Wanders R. J., and Distel B. (1997). Rhizomelic chondrodysplasia punctata is a peroxisomal protein targeting disease caused by a non-functional PTS2 receptor. Nat. Genet. 15:377–380.PubMedGoogle Scholar
  75. Munn N. J., Arnio E., Liu D., Zoeller R. A., and Liscum L. (2003). Deficiency in ethanolamine plasmalogen leads to altered cholesterol transport. J. Lipid Res. 44:182–192.PubMedGoogle Scholar
  76. Murphy E. J., Schapiro M. B., Rapoport S. I., and Shetty H. U. (2000). Phospholipid composition and levels are altered in Down syndrome brain. Brain Res. 867:9–18.PubMedGoogle Scholar
  77. Murphy R. C. (2001). Free-radical-induced oxidation of arachidonoyl plasmalogen phospholipids: Antioxidant mechanism and precursor pathway for bioactive eicosanoids. Chem. Res. Toxicol. 14:463–472.PubMedGoogle Scholar
  78. Nishimukai M., Wakisaka T., and Hara H. (2003). Ingestion of plasmalogen markedly increased plasmalogen levels of blood plasma in rats. Lipids 38:1227–1235.PubMedGoogle Scholar
  79. Nussbaum J. L., Neskovic N., and Mandel P. (1969). A study of lipid components in brain of the ‘Jimpy’ mouse, a mutant with myelin deficiency. J. Neurochem. 16:927–934.PubMedGoogle Scholar
  80. Ong W. Y., Ling S. F., Yeo J. F., Chiueh C. C., and Farooqui A. A. (2005). Injury and recovery of pyramidal neurons in the rat hippocampus after a single episode of oxidative stress induced by intracerebroventricular injection of ferrous ammonium citrate. Reprod. Nutr. Dev. 45:647–662.PubMedGoogle Scholar
  81. Owada Y., Tominaga T., Yoshimoto T., and Kondo H. (1994). Molecular cloning of rat cDNA for cytosolic phospholipase A2 and the increased gene expression in the dentate gyrus following transient forebrain ischemia. Brain Res Mol Brain Res. 25:364–368.PubMedGoogle Scholar
  82. Périchon R., Moser A. B., Wallace W. C., Cunningham S. C., Roth G. S., and Moser H. W. (1998). Peroxisomal disease cell lines with cellular plasmalogen deficiency have impaired muscarinic cholinergic signal transduction activity and amyloid precursor protein secretion. Biochem. Biophys. Res. Commun. 248:57–61.PubMedGoogle Scholar
  83. Pettegrew J. W., Panchalingam K., Hamilton R. L., and McClure R. J. (2001). Brain membrane phospholipid alterations in Alzheimer’s disease. Neurochem. Res. 26:771–782.PubMedGoogle Scholar
  84. Piomelli D. (2005). The challenge of brain lipidomics. Prostaglandins Other Lipid Mediat. 77:23–34.PubMedGoogle Scholar
  85. Porcellati G. (1983). Phospholipid metabolism in neural membranes. In: Sun G. Y., Bazan N., Wu J. Y., Porcellati G., and Sun A. Y. (Eds.), Neural Membranes. Humana, New York, pp. 3–35.Google Scholar
  86. Portilla D., Shah S. V., Lehman P. A., and Creer M. H. (1994). Role of cytosolic calcium-independent plasmalogen-selective phospholipase A2 in hypoxic injury to rabbit proximal tubules. J. Clin. Invest. 93:1609–1615.PubMedGoogle Scholar
  87. Poulos A., Bankier A., Beckman K., Johnson D., Robertson E. F., Sharp P., Sheffield L., Singh H., Usher S., and Wise G. (1991). Glyceryl ethers in peroxisomal disease. Clin Genet. 39:13–25.PubMedGoogle Scholar
  88. Purdon A. D. and Rapoport S. I. (2007). Energy consumption by phospholipid metabolism in mammalian brain. In: Gibson G. and Dienel G. (Eds.), Brain Energetics. Integration of Molecular and Cellular Processes, in Handbook of Neurochemistry and Molecular Neurobiology (Lajtha, A., Ed.). Springer, New York. (In press).Google Scholar
  89. Purdon A. D., Rosenberger T. A., Shetty H. U., and Rapoport S. I. (2002). Energy consumption by phospholipid metabolism in mammalian brain. Neurochem. Res. 27:1641–1647.PubMedGoogle Scholar
  90. Rapoport S. I. (1999). In vivo fatty acid incorporation into brain phospholipids in relation to signal transduction and membrane remodeling. Neurochem. Res. 24:1403–1415.PubMedGoogle Scholar
  91. Ray P., Ray R., Broomfield C. A., and Berman J. D. (1994). Inhibition of bioenergetics alters intracellular calcium, membrane composition, and fluidity in a neuronal cell line. Neurochem. Res. 19:57–63.PubMedGoogle Scholar
  92. Reddy T. S. and Horrocks L. A. (1982). Effects of neonatal undernutrition on the lipid composition of gray matter and white matter in rat brain. J. Neurochem. 38:601–605.PubMedGoogle Scholar
  93. Reddy T. S., Rajalakshmi R., and Ramakrishnan C. V. (1982). Effects of nutritional rehabilitation on the content and lipid composition of brain gray and white matter of neonatally undernourished rats. J. Neurochem. 39:1297–1301.PubMedGoogle Scholar
  94. Rizzo W. B. and Craft D. A. (1991). Sjögren-Larsson syndrome. Deficient activity of the fatty aldehyde dehydrogenase component of fatty alcohol:NAD+ oxidoreductase in cultured fibroblasts. J. Clin. Invest. 88:1643–1648.PubMedGoogle Scholar
  95. Rizzo W. B., Heinz E., Simon M., and Craft D. A. (2000). Microsomal fatty aldehyde dehydrogenase catalyzes the oxidation of aliphatic aldehyde derived from ether glycerolipid catabolism: Implications for Sjögren-Larsson syndrome. Biochim. Biophys. Acta Mol. Basis Dis. 1535:1–9.Google Scholar
  96. Rodemer C., Thai T. P., Brugger B., Kaercher T., Werner H., Nave K. A., Wieland F., Gorgas K., and Just W. W. (2003). Inactivation of ether lipid biosynthesis causes male infertility, defects in eye development and optic nerve hypoplasia in mice. Hum. Mol. Genet. 12:1881–1895.PubMedGoogle Scholar
  97. Roels F., Fischer S., and Kissling W. (1993). Polyunsaturated fatty acids in peroxisomal disorders: A hypothesis and a proposal for treatment. J. Neurol. Neurosurg. Psychiatry 56:937.PubMedGoogle Scholar
  98. Rosenberger T. A., Oki J., Purdon A. D., Rapoport S. I., and Murphy E. J. (2002). Rapid synthesis and turnover of brain microsomal ether phospholipids in the adult rat. J. Lipid Res. 43:59–68.PubMedGoogle Scholar
  99. Roth G. S., Joseph J. A., and Mason R. P. (1995). Membrane alterations as causes of impaired signal transduction in Alzheimer’s disease and aging. Trends Neurosci. 18:203–206.PubMedGoogle Scholar
  100. Rüdiger M., von Baehr A., Haupt R., Wauer R. R., and Rüstow B. (2000). Preterm infants with high polyunsaturated fatty acid and plasmalogen content in tracheal aspirates develop bronchopulmonary dysplasia less often. Crit. Care Med. 28:1572–1577.PubMedGoogle Scholar
  101. Sapirstein A. and Bonventre J. V. (2000). Phospholipases A2 in ischemic and toxic brain injury. Neurochem. Res. 25:745–753.PubMedGoogle Scholar
  102. Schedin S., Sindelar P. J., Pentchev P., Brunk U., and Dallner G. (1997). Peroxisomal impairment in Niemann-Pick type C disease. J. Biol. Chem. 272:6245–6251.PubMedGoogle Scholar
  103. Shoemaker W. J. and Bloom F. E. (1977). Effect of undernutrition on brain morphology. In: Wurtman R. J. and Wurtman J. J. (Eds.), Nutrition and the Brain. Raven, New York, pp. 147–192.Google Scholar
  104. Sindelar P. J., Guan Z. Z., Dallner G., and Ernster L. (1999). The protective role of plasmalogens in iron-induced lipid peroxidation. Free Radic. Biol. Med. 26:318–324.PubMedGoogle Scholar
  105. Singh I., Paintlia A. S., Khan M., Stanislaus R., Paintlia M. K., Haq E., Singh A. K., and Contreras M. A. (2004). Impaired peroxisomal function in the central nervous system with inflammatory disease of experimental autoimmune encephalomyelitis animals and protection by lovastatin treatment. Brain Res. 1022:1–11.PubMedGoogle Scholar
  106. Stadelmann-Ingrand S., Pontcharraud R., and Fauconneau B. (2004). Evidence for the reactivity of fatty aldehydes released from oxidized plasmalogens with phosphatidylethanolamine to form Schiff base adducts in rat brain homogenates. Chem. Phys. Lipids 131:93–105.PubMedGoogle Scholar
  107. van den Bosch H., Schrakamp G., Hardeman D., Zomer A. W. M., Wanders R. J. A., and Schutgens R. B. H. (1993). Ether lipid synthesis and its deficiency in peroxisomal disorders. Biochimie 75:183–189.PubMedGoogle Scholar
  108. Viani P., Zini I., Cervato G., Biagini G., Agnati L. F., and Cestaro B. (1995). Effect of endothelin-1 induced ischemia on peroxidative damage and membrane properties in rat striatum synaptosomes. Neurochem. Res. 20:689–695.PubMedGoogle Scholar
  109. Voelker D. R. (2003). New perspectives on the regulation of intermembrane glycerophospholipid traffic. J. Lipid Res. 44:441–449.PubMedGoogle Scholar
  110. Vreken P., Valianpour F., Overmars H., Barth P. G., Selhorst J. J. M., Van Gennip A. H., and Wanders R. J. A. (2000). Analysis of plasmenylethanolamines using electrospray tandem mass spectrometry and its application in screening for peroxisomal disorders. J. Inherit. Metab. Dis. 23:429–433.PubMedGoogle Scholar
  111. Wanders R. J. A., Purvis Y. R., Heymans H. S. A., Bakkeren J. A. J. M., Parmentier G. G., van Eldere J., Eyssen H., van den Bosch H., Tager J. M., and Schutgens R. B. H. (1986). Age-related differences in plasmalogen content of erythrocytes from patients with the cerebro-hepato-renal (Zellweger) syndrome: Implications for postnatal detection of the disease. J. Inherit. Metab. Dis. 9:335–342.PubMedGoogle Scholar
  112. Wells K., Farooqui A. A., Liss L., and Horrocks L. A. (1995). Neural membrane phospholipids in Alzheimer disease. Neurochem. Res. 20:1329–1333.PubMedGoogle Scholar
  113. Wing D. R., Harvey D. J., Hughes J., Dunbar P. G., McPherson K. A., and Paton W. D. (1982). Effects of chronic ethanol administration on the composition of membrane lipids in the mouse. Biochem. Pharmacol. 31:3431–3439.PubMedGoogle Scholar
  114. Wissing D., Mouritzen H., Egeblad M., Poirier G. G., and Jäättelä M. (1997). Involvement of caspase-dependent activation of cytosolic phospholipase A2 in tumor necrosis factor-induced apoptosis. Proc. Natl. Acad. Sci. USA 94:5073–5077.PubMedGoogle Scholar
  115. Yanagihara T. and Cumings J. N. (1969). Alterations of phospholipids, particularly plasmalogens, in the demyelination of multiple sclerosis as compared with that of cerebral oedema. Brain 92:59–70.PubMedGoogle Scholar
  116. Yehuda S., Rabinovitz S., and Mostofsky D. I. (1999). Essential fatty acids are mediators of brain biochemistry and cognitive functions. J. Neurosci. Res. 56:565–570.PubMedGoogle Scholar
  117. Yehuda S., Rabinovitz S., Carasso R. L., and Mostofsky D. I. (2002). The role of polyunsaturated fatty acids in restoring the aging neuronal membrane. Neurobiol. Aging 23:843–853.PubMedGoogle Scholar
  118. Zhang J. P. and Sun G. Y. (1995). Free fatty acids, neutral glycerides, and phosphoglycerides in transient focal cerebral ischemia. J. Neurochem. 64:1688–1695.PubMedGoogle Scholar
  119. Zoeller R. A., Lake A. C., Nagan N., Gaposchkin D. P., Legner M. A., and Lieberthal W. (1999). Plasmalogens as endogenous antioxidants: Somatic cell mutants reveal the importance of the vinyl ether. Biochem. J. 338:769–776.PubMedGoogle Scholar
  120. Zoeller R. A., Grazia T. J., LaCamera P., Park J., Gaposchkin D. P., and Farber H. W. (2002). Increasing plasmalogen levels protects human endothelial cells during hypoxia. Am. J. Physiol. Heart Circ. Physiol. 283:H671–H679.PubMedGoogle Scholar

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