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The Effects of Activated Protein C on the Septic Endothelium

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Intensive Care Medicine

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Abstract

Sepsis is a serious disorder with high morbidity and mortality worldwide and an increasing incidence [1]. Sepsis is the result of an overwhelming and maladaptive response of the host organism to the invasion of pathogenic microorganisms, which generates an uncontrolled and auto-destructive inflammatory process [2]. The septic syndrome carries various degrees of severity, and critically ill patients often develop sepsis-induced acute organ dysfunction (i.e., severe sepsis) and fluid-refractory hypotension (i.e., septic shock). Extensive research performed during the past two decades has greatly improved our understanding of the mechanisms underlying sepsis pathophysiology: Widespread devastating inflammation and microvascular coagulation are common denominators in severe sepsis, while endothelial cell dysfunction appears to be a key determinant in the development of the syndrome [3, 4].

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Author information

Authors and Affiliations

  1. 2nd Department of Critical Care Medicine, Attikon Hospital, 1, Rimini St., 12462, Haidari, Greece

    S. E. Orfanos

  2. M. Simou Laboratory, University of Athens Medical School Evangelismos General Hospital, 3 Ploutarchou St, 10675, Athens, Greece

    N. A. Maniatis

  3. 1st Department of Critical Care, University of Athens Medical School Evangelismos General Hospital, 45-47 Ipsilandou St, 10675, Athens, Greece

    A. Kotanidou

Authors
  1. S. E. Orfanos
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  2. N. A. Maniatis
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  3. A. Kotanidou
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Editor information

Editors and Affiliations

  1. Department of Intensive Care Erasme Hospital, Université libre de Bruxelles, Route de Lennik 808, 1070, Brussels, Belgium

    Jean-Louis Vincent MD, PhD, FCCM, FCCP (Head) (Head)

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© 2008 Springer Science + Business Media Inc.

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Orfanos, S.E., Maniatis, N.A., Kotanidou, A. (2008). The Effects of Activated Protein C on the Septic Endothelium. In: Vincent, JL. (eds) Intensive Care Medicine. Springer, New York, NY. https://doi.org/10.1007/978-0-387-77383-4_67

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  • DOI: https://doi.org/10.1007/978-0-387-77383-4_67

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-0-387-77382-7

  • Online ISBN: 978-0-387-77383-4

  • eBook Packages: MedicineMedicine (R0)

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