Protein C and Antithrombin Levels in Surgical and Septic Patients
Activation of blood coagulation is a common observation in patients with sepsis. The clinical manifestations of an activated coagulation system depend on the degree of pro-coagulant conditions and may lead to overt disseminated intravascular coagulation (DIC), consumption coagulopathy, defibrination syndrome, and purpura fulminans. The protein C anticoagulant pathway regulates thrombin formation, prevents microvascular thrombosis, and has anti-inflammatory and profibrinolytic properties. Decreased plasma levels of antithrombin and protein C can occur in a variety of clinical conditions associated with DIC, such as sepsis, trauma, and after surgical interventions. Recent data suggest that in surgical patients admitted to the intensive care unit (ICU), antithrombin and protein C levels are low, and it has been suggested that antithrombin and protein C levels may have a potential role as predictors of outcome in critically ill patients.
KeywordsSevere Sepsis Disseminate Intravascular Coag Sequential Organ Failure Assessment Score Intensive Care Unit Mortality Drotrecogin Alfa
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