Early Optimization of Oxygen Delivery in High-risk Surgical Patients

  • S. M. Lobo
  • E. Rezende
  • F. Suparregui Dias
Conference paper


Total tissue perfusion relies on adequate arterial oxygen saturation, cardiac output, and hemoglobin concentration, and global perfusion is usually assessed by calculation of the oxygen delivery index (DO2I) [1]. More than 20 years ago Shoemaker et al. reported that perioperative alterations in DO2 were closely correlated to the development of multiple organ failure (MOF) and death [2]. Since then goal-directed therapy, defined as the use of the cardiac output or a surrogate to guide intravenous fluid and inotropic therapy, has been used in an attempt to improve outcome in surgical patients [1].


Oxygen Delivery Anaerobic Threshold Fluid Challenge Pulmonary Artery Occlusion Pressure Cardiopulmonary Exercise Testing 
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Copyright information

© Springer Science + Business Media Inc. 2008

Authors and Affiliations

  • S. M. Lobo
    • 1
  • E. Rezende
    • 2
  • F. Suparregui Dias
    • 3
  1. 1.Division of Critical Care Medicine Department of Internal MedicineMedical School-FUNFARME and Hospital de BaseBrazil
  2. 2.Intensive Care DepartmentHospital do Servidor Publico EstadualSao PauloBrazil
  3. 3.Intensive Care UnitHospital Sao Lucas da PUCRSPorto AlegreBrazil

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