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Role of Poly(ADP-Ribose) Polymerase in Acute Kidney Injury

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Intensive Care Medicine

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Abstract

Acute renal failure or acute kidney injury (AKI) is common in critically ill patients and carries significant morbidity and mortality. AKI has been used to describe the fullblown clinical picture of, predominantly, acute tubular necrosis following ischemic or nephrotoxic injury. Once risk factors for impending renal failure have been recognized, current clinical management is hardly able to beneficially affect the natural course, so that renal replacement therapy has to be instituted when hyperkalemia, overhydration, or other detrimental sequelae of AKI occur [1–3]. A better understanding of early mechanisms could help to design trials in the future to attenuate the development of AKI in high-risk patients. These mechanisms are, however, still poorly understood.

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Author information

Authors and Affiliations

  1. Faculty of Medicine, University of Eastern Piedmont, Novara, Italy

    R. Vaschetto

  2. Department of Pediatric Intensive Care, Vrije Universiteit Medical Centre, De Boelelaan 1117, 1081 HV, Amsterdam, Netherlands

    F. B. Plötz

  3. Department of Intensive Care, Vrije Universiteit Medical Centre, De Boelelaan 1117, 1081 HV, Amsterdam, Netherlands

    A. B. J. Groeneveld

Authors
  1. R. Vaschetto
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  2. F. B. Plötz
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  3. A. B. J. Groeneveld
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Editor information

Editors and Affiliations

  1. Department of Intensive Care Erasme Hospital, Université libre de Bruxelles, Route de Lennik 808, 1070, Brussels, Belgium

    Jean-Louis Vincent MD, PhD, FCCM, FCCP (Head) (Head)

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Vaschetto, R., Plötz, F.B., Groeneveld, A.B.J. (2008). Role of Poly(ADP-Ribose) Polymerase in Acute Kidney Injury. In: Vincent, JL. (eds) Intensive Care Medicine. Springer, New York, NY. https://doi.org/10.1007/978-0-387-77383-4_52

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  • DOI: https://doi.org/10.1007/978-0-387-77383-4_52

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-0-387-77382-7

  • Online ISBN: 978-0-387-77383-4

  • eBook Packages: MedicineMedicine (R0)

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