Cortisol Metabolism in Inflammation and Sepsis

  • B. Venkatesh
  • J. Cohen
Conference paper


Steroid therapy has not been consistently shown to provide benefit in severe sepsis and may even be associated with adverse effects. The driver for steroid therapy is based on the controversial and unproven premise that there is relative adrenal insufficiency (based on a blunted cortisol response to corticotropin) in septic shock [1].


Septic Shock Chronic Fatigue Syndrome Glycyrrhetinic Acid Relative Adrenal Insufficiency Total Cortisol 


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Copyright information

© Springer Science + Business Media Inc. 2008

Authors and Affiliations

  • B. Venkatesh
    • 1
  • J. Cohen
    • 2
  1. 1.Department of Intensive Care Princess Alexandra & Wesley HospitalsUniversity of QueenslandQueenslandAustralia
  2. 2.Department of Intensive Care Royal Brisbane & Ipswich HospitalsUniversity of QueenslandQueenslandAustralia

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