Strict Glycemic Control: Not If and When, but Who and How?

  • M. J. de Graaff
  • P. E. Spronk
  • M. J. Schultz
Conference paper


Nurse-driven strict glycemic control aimed at normoglycemia (i.e., blood glucose concentrations between 80–110 mg/dl) decreases mortality and morbidity of intensive care unit (ICU) patients [1, 2]. Of note, with more successful strict glycemic control (i.e., blood glucose concentrations closer to 80 mg/dl) more benefit is achieved [3, 4]. Indeed, the lowered blood glucose concentration rather than the insulin dose is related to reduced mortality, critical illness polyneuropathy, bacteremia, and inflammation [3].


Intensive Care Unit Patient Blood Glucose Concentration Severe Hypoglycemia Intensive Insulin Therapy Tight Glycemic Control 
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Copyright information

© Springer Science + Business Media Inc. 2008

Authors and Affiliations

  • M. J. de Graaff
    • 1
  • P. E. Spronk
    • 1
  • M. J. Schultz
    • 1
  1. 1.Department of Intensive CareAcademic Medical CenterAmsterdamNetherlands

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