Selenocompounds and Selenium: A Biochemical Approach to Sepsis

  • X. Forceville
  • P. Van Antwerpen
Conference paper


Septic shock, an uncontrolled systemic host response to invasive infection leading to multiple organ failure (MOF), is a major public health issue due to its frequency, associated cost, and a 45% mortality rate despite all the improvements made in intensive care over the past 20 years. However, the pathophysiology of sepsis is now better understood, with increasing data supporting the key role of oxidant free radicals, especially in endothelial damage [1, 2, 3, 4].


Septic Shock Sodium Selenite Selenium Deficiency Selenium Compound Keshan Disease 
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Copyright information

© Springer Science + Business Media Inc. 2008

Authors and Affiliations

  • X. Forceville
    • 1
  • P. Van Antwerpen
    • 2
  1. 1.Department of Intensive CareCentre Hospitalier de Meaux Hôpital Saint FaronMeauxFrance
  2. 2.Pharmacy InstituteService de Chimie Pharmaceutique OrganiqueBrusselsBelgium

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