Glutathione in Sepsis and Multiple Organ Failure

  • U. Fläring
  • J. Wernerman
Conference paper


Glutathione, a tripeptide (L-γ-glutamyl-L-cysteinyl-glycine) with antioxidant properties, is present at high concentrations (mmol) in most tissues in man. Its major functions are to scavenge toxic reactive oxidant species (ROS), to detoxify exogenous toxic compounds, including drugs, and to regulate protein metabolism. The ubiquitous cytoprotective effects of glutathione are well established [1]. In skeletal muscle from intensive care unit (ICU) patients, low glutathione concentrations are seen, which correlates with glutamine depletion [2] and with mortality [3]. The consequences of glutathione deplertion are not fully understood. In this chapter, new insights into the glutathione status of ICU patients are presented including the temporal pattern [4, 5], the effect of exogenous glutamine supplementation [6], and the relation between glutathione status in different tissues [7].


Intensive Care Unit Patient Reactive Oxidant Species Glutathione Depletion Glutathione Concentration Glutamine Supplementation 
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Copyright information

© Springer Science + Business Media Inc. 2008

Authors and Affiliations

  • U. Fläring
    • 1
  • J. Wernerman
    • 2
  1. 1.Department of Anesthesia and Intensive CareAstrid Lindgren’s Children Hospital Karolinska University HospitalHuddingeSweden
  2. 2.Department of Anesthesia and Intensive CareKarolinska University HospitalHuddingeSweden

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