B-Type Natriuretic Peptide: An Emerging Biomarker in Pediatric Critical Care

  • P. E. Oishi
  • J. -H. Hsu
  • J. R. Fineman
Conference paper


In 1988, Sudoh and colleagues described a novel natriuretic peptide in porcine brain [1]. Subsequent studies found that brain natriuretic peptide was most abundant in the heart, and thus it was termed B-type natriuretic peptide (BNP). The release of BNP is triggered in large part by myocyte stretch and BNP levels are easily quantified by several commercially available assays. Thus, over the past decade numerous investigators sought to determine the clinical utility of BNP and together have now firmly established a role for BNP as a biomarker for diagnosis, prognostication, and management of adults with cardiac disease [2]. Unfortunately, far fewer data are available on the role of BNP in the management of critically ill neonates, infants, and children. Potential uses for BNP in pediatric critical care are outlined in Table 1. This chapter will provide a brief review of these data with the goal of helping clinicians make use of BNP in the care of these patients.


Natriuretic Peptide Kawasaki Disease Brain Natriuretic Peptide Patent Ductus Arteriosus Plasma Brain Natriuretic Peptide 


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Copyright information

© Springer Science + Business Media Inc. 2008

Authors and Affiliations

  • P. E. Oishi
    • 1
  • J. -H. Hsu
    • 2
  • J. R. Fineman
    • 1
  1. 1.Pediatric Critical CareUniversity of CaliforniaSan FranciscoUSA
  2. 2.Department of Pediatrics Kaohsiung MedicalUniversity HospitalKaohsiungTaiwan

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