Extracorporeal Life-Support for Acute Drug-induced Cardiac Toxicity
Cardiovascular toxicity is a potential complication following accidental or intentional overdose with various classes of drugs. The term ‘cardio-toxic drug’ is not limited to cardiovascular drugs but also includes various other toxicants, such as antidepressants, meprobamate, H1-antihistaminic agents, nivaquine, cocaine, organophosphates, cyanide, and plants (Table 1). Despite improvement in critical care, drug-induced cardiovascular failure still remains a leading cause of death. The mortality rate remains high in poisonings with compounds that include membrane stabilizing agents in addition to their main pharmacological activity . Of 847,483 exposures in adults reported to the American Association of Poison Control Centers in 2005, cardiovascular drugs were involved in 5.8% of cases; however, they accounted for approximately 19% of the total 1,261 poisoning fatalities, representing the fifth toxicant category responsible for death, following analgesics, sedative drugs, antidepressants, and stimulants . In this register, calcium channel blockers and beta-blockers accounted for 40% of cardiovascular drug exposures, while calcium channel blockers represented the first cause of cardiovascular agent-related death.
KeywordsPoison Control Center Extracorporeal Life Support Toxicol Clin Toxicol Cardiotoxic Drug Chloroquine Poisoning
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