Early Cooling in Cardiac Arrest: What is the Evidence?

  • L. Hammer
  • C. Adrie
  • J. -F. Timsit
Conference paper


Cardiac arrest is a major cause of unexpected death in developed countries, with survival rates ranging from less than 5% to 35% [1, 2]. In patients who are initially resuscitated, anoxic neurological injury is an important cause of morbidity and mortality [3]. For successful resuscitation, rapid return to spontaneous circulation is mandatory, but overcoming post-resuscitation tissue injury is necessary as well [4, 5]. Various treatment strategies have been used to attenuate ischemic-related pathophysiological damage and behavioral deficits. Prolonged therapeutic hypothermia is the only post-resuscitation therapy clinically demonstrated to improve the outcome of cardiac arrest survivors [6, 7, 8, 9]. Therapeutic hypothermia is recommended by the International Liaison Committee on Resuscitation (ILCOR) [8].


Cardiac Arrest Therapeutic Hypothermia Mild Hypothermia Spontaneous Circulation Cold Fluid 
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Copyright information

© Springer Science + Business Media Inc. 2008

Authors and Affiliations

  • L. Hammer
    • 1
  • C. Adrie
    • 2
  • J. -F. Timsit
    • 1
  1. 1.Department of Intensive CareGrenoble University HospitalGrenobleFrance
  2. 2.Department of Intensive CareDelafontaine HospitalSaint DenisFrance

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