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Perioperative Cardioprotection

  • H. -J. Priebe
Conference paper

Abstract

The perioperative period induces large, unpredictable and unphysiological changes in sympathetic tone, cardiovascular performance, coagulation and inflammatory response (to name just a few). These changes induce, in turn, unpredictable alterations in coronary plaque morphology, function, and progression. Simultaneous perioperative alterations in homeostasis and coronary plaque characteristics may trigger a mismatch of myocardial oxygen supply and demand by numerous mechanisms. If not alleviated in time, this will ultimately result in myocardial infarction, irrespective of its etiology (morphological, hemodynamic, inflammatory, or coagulation-induced). Thus, not surprisingly, in patients with coronary artery disease, the incidence of perioperative cardiac morbidity and mortality remains high and is associated with adverse outcome [1]. Consequently, the quest for perioperative cardioprotective strategies continues.

Keywords

Stable Coronary Artery Disease Noncardiac Surgery Optimal Medical Therapy Percutaneous Coronary Intervention Group Major Vascular Surgery 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science + Business Media Inc. 2008

Authors and Affiliations

  • H. -J. Priebe
    • 1
  1. 1.Department of AnesthesiologyUniversity Hospital Hugstetter Str.FreiburgGermany

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