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Are Pharmacogenetics and Pharmacogenomics Important for Critically III Patients?

  • C. Kirwan
  • I. MacPhee
  • B. Philips
Conference paper

Abstract

Drugs are administered to patients using dosing regimens established from animal data, clinical trials, and population studies. However, there may be enormous variation in dose requirement, efficacy, and adverse effects between individuals within a given population. Although this may partly be attributed to factors such as age, concomitant drug interactions, co-morbidities, and the underlying disease itself, genetic factors are estimated to account for 15–30% of between individual differences and for some drugs the impact of genetics may be much higher [1, 2]. Genetic variation may influence all aspects of pharmacokinetics and pharmacodynamics and although the clinical relevance of pharmacogenetics remains uncertain, the idea is developing that some drug therapies may be individualized in the future.

Keywords

Warfarin Maintenance Dose Poor Metabolizer Phenotype Sodium Lithium Countertransport Midazolam Clearance TPMT Gene 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science + Business Media Inc. 2008

Authors and Affiliations

  • C. Kirwan
    • 1
  • I. MacPhee
    • 1
  • B. Philips
    • 1
  1. 1.Department of Intensive CareSt George’s University of LondonLondonUK

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