Abstract
Interactions between anthocyanin pigments and other flavonoids or other phytochemicals accumulating within a plant contribute significantly to the ability of natural plant extracts (ingested as food or pharmaceutical product) to protect human health or mitigate disease damage. Interactions are the rule, rather than the exception, for biologically-active plant-derived components. Given the complex, multi-faceted roles interacting phytochemicals play in the human body, the use of plant cell culture production and research models can contribute novel insights as to competing mechanisms of action, bioavailability, and distribution in situ.
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References
Allred, C.D., Ju, Y.H., Allred, K.E., Change, J. and Helferich, W.G. (2001) Dietary genistin stimulates growth of estrogen-dependent breast cancer tumors similar to that observed with genistein. Carcinogenesis 22, 1667–1673
Allred, C.D., Allred, K.E., Ju, Y.H., Virant, S.M. and Helferich, W.G. (2004) Dietary genistein results in larger MNU-induced, estrogen-dependent mammary tumors following ovarioectomy of Sprague-Dawley rats. Carcinogenesis 25, 211–218.
Aparico-Fernandez, X., Yousef, G., Loarca-Pina, G., de Mejia, E. and Lila, M. (2005) Characterization of polyphenolics in the seed coat of black Jamapa bean (Phaseolus vulgaris. L.). J. Ag. Food Chem. 53, 4615–4622.
Aparico-Fernandez, X., Garcia-Gasca, X., Yousef, G., Lila, M., de Mejia, E. and Loarca-Pina, G. (2006) Chemopreventive activity of polyphenolics from black Jamapa bean (Phaseolus vulgaris L.) on HeLa and HaCaT cells. J. Ag. Food Chem. 54, 2118–2122.
Aviram, M., Dornfeld, L., Rosenblat, M., Volkova, N., Kaplan, M., Coleman, R., Hayek, T., Presser, D. and Fuhrman, B. (2000) Pomegranate juice consumption reduces oxidative stress, atherogenic modifications to LDL, and platelet aggregation: studies in humans and in atherosclerotic apolipoprotein E-deficient mice. Am. J. Clin. Nutr. 71, 1062–1076.
Aviram, M., Dornfeld, L., Kaplan, M., Coleman, R., Gaitini, D., Nitecki, S., Hofman, A., Rosenblat, M., Volkova, N., Presser, D., Attias, J., Hayek, T. and Fuhrman B. (2002) Pomegranate juice flavonoids inhibit low-density lipoprotein oxidation and cardiovascular diseases: Studies in atherosclerotic mice and in humans. Drugs Exp. Clin. Res. 28, 40–62.
Boileau, T.W., Liao, Z., Kim, S., Lemeshow, S., Erdman, J.W. Jr., Clinton, D.K. (2003) Prostate carcinogenesis in N-methyl-N-nitrosourea (NMU)-testosterone-treated rats fed tomato powder, lycopene, or energy-restricted diets. J. Nat. Cancer Inst. 95, 1578–1586.
Brinker, A., Ma, J., Lipsky, P.E. and Raskin, I. (2007) Medicinal chemistry and pharmacology of genusTripterygium (Celastraceae). Phytochemistry (In Press).
Campbell, J., King, J., Harmston, M., Lila, M.A. and Erdman, J.W. Jr. (2006a) Synergistic effects of flavonoids on cell proliferation in Hepa-1c1c7 and LNCap cancer cell lines. J. Food Sci. 71, S358-S363.
Campbell, J., Lila, M.A., Nakamura, M. and Erdman, J. Jr. (2006b). Serum testosterone reduction following short-term phytofluene, lycopene, or tomato powder consumption in F344 rats. J. Nutr. 136, 2813–2819.
Canen-Adams, K., Lindshield, B., Wang, S., Jeffery, E., Clinton, S.K. and Erdman, J.W. Jr. (2007) Combinations of tomato and broccoli enhance antitumor activity in Dunning R3327-H prostate adenocarcinomas. Cancer Res. 67, 836–843.
Chan, M., Mattiacci, J., Hwang, H., Shah, A. and Fong, D. (2000) Synergy between ethanol and grape polyphenols, quercetin, and resveratrol, in the inhibition of the inducible nitric oxide synthase pathway. Biochem. Pharmacol. 60, 1539–1548.
Chen, L., Yang, X., Jiao, H. and Zhao, B. (2002) Tea catechins protect against lead-induce cytotoxicity, lipid peroxidation, and membrane fluidity in HepG2 cells. Toxicol. Sci. 69, 149–156.
Eder, M. and Mehnert, W. (1998) Bedeutung planzlicher begleitstoffe in extrackten. Pharmazie 53, 285–293.
Elattar, T. and Virji, A. (1999) The effect of red wine and its components on growth and proliferation of human oral squamous carcinoma cells. Anticancer Res. 19, 5407–5414.
Fang, Y., Smith, M.A., Rogers, R. and Pépin, M.-F. (1999) The effects of exogenous methyl jasmonate in elicited anthocyanin-producing cell cultures of ohelo (Vaccinium pahalae). In Vitro Cell. Devel. Biol. Plant 35, 106–113.
Franke, A., Cooney R., Custer L., Mordan, L. and Tanaka, Y. (1998) Inhibition of neoplastic transformation and bioavailability of dietary flavonoid agents Adv. Exp. Med. Biol. 439, 237–248.
Gartner, C., Stahl W. and Sies, H. (1997) Lycopene is more bioavailable from tomato paste than from fresh tomatoes. Am J. Clin. Nutri. 66, 116–122.
Gould, K. (2004) Nature’s Swiss army knife. The diverse protective roles of anthocyanins in leaves. J. Biomed. Biotech. 5, 314–320.
Grusak, M., Rogers, R., Yousef, G., Erdman, J. Jr. and Lila, M. (2004) An enclosed-chamber labeling system for the safe14C-enrichment of phytochemicals in plant cell suspension cultures. In Vitro Cell. Devel. Biol. – Plant 40, 80–85.
Honda, K. (1990) Identification of host-plant chemicals stimulating oviposition by swallowtail butterfly,Papilio protenor. J. Chem. Ecol. 16, 325–337.
Honda, K., Nishii, W. and Hayashi, N. (1997) Oviposition stimulants for sulfur butterfly,Colias erate poliographys: cyanoglucosides as synergists involved in host preference. J. Chem. Ecol. 23, 323–331.
Hora, J., Maydew, E., Lansky, E. and Dwivedi C. (2003) Chemopreventive effects of pomegranate seed oil on skin tumor development in CD1 mice. J Med Food 6, 157–161.
Janle, E., Lila, M., Wood, L., Higgins, A., Yousef, G, Rogers, R., Kim, H., Jackson, G. and Weaver, C. (2007) Kinetics and tissue distribution of14C labeled grape polyphenol fractions. FASEB J. 21, A1070-a-.
Jo, J.Y. (2005) Characterization, interaction, and chemoprevention of potent constituents from grape cell culture. PhD thesis dissertation, University of Illinois.
Jo, J.Y., de Mejia, E. and Lila, M.A. (2005) Effects of grape cell culture extracts on human topoisomerase II catalytic activity and characterization of active fractions. J. Agric. Food Chem. 53, 2489–2498.
Jo, J.Y., de Mejia, E. and Lila, M. (2006a). Catalytic inhibition of human DNA topoisomerase II by interactions of grape cell culture polyphenols. J. Agric. Food Chem. 54, 2083–2087.
Jo, J.Y., de Mejia, E. and Lila, M. (2006b) Cytotoxicity of bioactive polymeric fractions from grape cell culture on human hepatocellular carcinoma, murine leukemia, and non-cancerous PK15 kidney cells. Food Chem. Toxicol. 44, 1758–1767.
Joseph, J., Shukitt-Hale, B., Denisova, N., Bielinski, D., Martin, A., McEwen, J. and Bickford, P. (1999) Reversals of age-related declines in neuronal signal transduction, cognitive, and motor behavioral deficits with blueberry, spinach, or strawberry dietary supplementation. J. Neurosci. 19, 8114–8121.
Kraft, T.F.B., Schmidt, B., Knight, C., Cuendet, M., Kang, Y-H., Pezzuto, J., Seigler, D. and Lila, M. (2005) Chemopreventive potential of wild blueberry fruits in multiple stages of carcinogenesis. J. Food Sci. 70, S159–S166.
Krisa, S., Waffo Téguo, P., Decendit, A., Deffleux, G., Vercauteren, J. and Mérillon, J. (1999) Production of13C-labeled anthocyanins byVitis viniferacell suspension cultures. Phytochemistry 51, 651–656.
Kroon, P., Clifford, M., Crozier, A., Day, A., Donovan, J., Manach, C. and Williamson, G. (2004) How should we assess the effects of exposure to dietary polyphenols in vitro? Am. J. Clin. Nutr. 80, 15–21.
Lansky E., Jiang, W., Mo, H., Bravo, L., Froom, P., Yu, W., Harris, N., Neeman, I. and Campbell, M. (2005) Possible synergistic prostate cancer suppression by anatomically discrete pomegranate fractions. Investigational New Drugs 23, 11–20.
Lila, M.A. (2004) Anthocyanins and human health: anin vitro investigative approach. J. Biomed. Biotech. 5, 306–313.
Lila, M., Yousef, G., Jiang, Y. and Weaver, C. (2005) Sorting out bioactivity in flavonoid mixtures. J. Nutr. 135, 1231–1235.
Lila, M.A. and Raskin, I. (2005) Health-related interactions of phytochemicals. J. Food Sci. 7, R20–R27.
Liu, R. (2003) Health benefits of fruit and vegetables are from additive and synergistic combinations of phytochemicals. Am. J. Clin. Nutr. 78, 517S–520S.
Matito, C., Mastorakou, F., Centelles, J., Torres, J. and Cascante, M. (2003) Antiproliferative effect of antioxidant polyphenols from grape in murine Hepa-1c1c7. Eur. J. Nutr. 42, 43–49.
Mertens-Talcott S., Bomser, J., Romero, C., Talcott, S. and Percival S. (2005) Ellagic acid potentiates the effect of quercetin on p21waf1 / cip1 , p53, and MAP-kinanses without affecting intracellular generation of reactive oxygen species in vitro. J Nutr. 135, 609–614.
Mertens-Talcott S., Talcott, S. and Percival S. (2003) Low concentrations of quercetin and ellagic acid synergistically influence proliferation, cytotoxicity and apoptosis in MOLT-4 human leukemia cells. J. Nutr. 133, 2669–2674.
Meyer, J., Pépin, M.-F. and Smith, M. (2002) Anthocyanin production fromVaccinium pahalae: limitations of the physical microenvironment. J. Biotech. 93, 45–57.
Miller, E., Biovannucci, E., Erdman Jr., J., Bahnson, R., Schwartz, S. and Clinton, S. (2002) Tomato products, lycopene, and prostate cancer risk. Urol. Clin. North Am. 29, 83–93.
Mouria, M., Gukovskaya, A., Jung. Y., Buechler, P., Hines, O., Reber, H. and Pandol, S. (2002) Food-derived polyphenols inhibit pancreatic cancer growth through mitochondrial cytochrome C release and apoptosis. Int. J. Cancer 98, 761–769.
Mullen, W., Graf, B., Caldwell, S., Hartley, R., Duthie, G., Edwards, C., Lean, M. and Crozier, A. (2002) Determination of flavonol metabolites in plasma and tissue of rats by HPLC radiocounting and tandem mass spectroscopy following oral ingestion of [2-14C] quercetin-4’-glucoside. J. Ag Food Chem. 50, 6902–6909.
Nishida, R., Ohsugi, T. and Fukami, H. (1990) Oviposition stimulant activity of tryptamine analogs on a Rutaceae-feeding swallowtail butterfly,Papilio xuthus. Agric. Biol. Chem. 54, 1853–1855.
Nishida, S. and Satoh, H. (2004) Comparative vasodilating actions amoung terpenoids and flavonoids contained inGinkgo biloba. Clinica Chimica Acta 339, 129–133.
Pignatelli, P., Pulcinelli, F., Celestini, A., Lenti, L., Ghiselli, A., Gazzaniga, P. and Viola, F. (2000) The flavonoids quercetin and catechin synergistically inhibit platelet function by antagonizing the intracellular production of hydrogen peroxide. Am J. Clin. Nutr. 72, 1150–1155.
Reyes-Carmona, J., Yousef, G., Martínez-Peniche, R. and Lila, M. (2005) Antioxidant capacity of fruit extracts of blackberry (Rubus sp.) produced in different climatic regions. J. Food Sci. 70, S497-S503.
Schmidt, B., Howell, A., McEniry, B., Knight, C., Seigler, D., Erdman Jr., J. and Lila, M. (2004) Effective isolation of potent antiproliferation and antiadhesion components from wild blueberry (Vaccinium angustifolium Ait.) fruits. J. Ag. Food Chem. 52, 6433–6442.
Schmidt, B., Erdman Jr., J. and Lila, M.A. (2005) Effects of food processing on blueberry antiproliferative and antioxidant activity. J. Food Sci. 70, S389–S394.
Schmidt, B.M, Erdman Jr., J. and Lila, M. (2006) Differential effects of blueberry proanthocyanidins on androgen sensitive and insensitive human prostate cancer cell lines. Cancer Lett. 231, 240–246.
Seeram, N.P., Adams, L.S., Hardy, M.I. and Heber, D. (2004) Total cranberry extract versus its phytochemical constituents: antiproliferative and synergistic effects against human tumor cell lines. J. Agric. Food Chem. 52, 2512–2517.
Shanmuganayagam, D., Beahm, M., Osman, H., Krueger, C., Reed, J. and Folts, J. (2002) Grape seed and grape skin extracts elicit a greater antiplatelet effect when used in combination than when used individually in dogs and humans. J. Nutr. 132, 3592–3598.
Sueiro, L, Yousef, G., Seigler, D., de Mejia, E., Grace, M. and Lila, M.A. (2006) Chemopreventive potential of flavonoid extracts from plantation-bred and wildAronia melanocarpa (Black chokeberry) fruits. J. Food Sci. 71, C480-C488.
Thole, J., Kraft, T., Sueiro, L., Kang, Y.-H., Gills, J., Cuendet, M., Pezzuto, J., Seigler, D. and Lila, M.A. (2006) A comparative evaluation of the anticancer properties of European and American elderberry fruits. J. Med. Food 9, 498–504.
Vitrac, X.; Desmouliere, A.; Brouillaud, B.; Krisa, S.; Deffieux, G.; Barthe, N.; Rosenbaum, J.; Mérillon, J. M. (2003) Distribution of [C-14] - trans-resveratrol, a cancer chemopreventive polyphenol, in mouse tissues after oral administration. Life Sci. 72, 2219–2233.
Vitrac, X., Krisa, S., Decendit, A., Vercauteren, J., Nührich, A., Monti, J.-P., Deffieux, G. and Mérillon, J.-M. (2002) Carbon-14 biolabelling of wine polyphenols inVitis vinifera cell suspension cultures. J. Biotech. 95, 49–56.
Ye, X., Krohn, R., Liu, W., Joshi, S., Kuszynski, C., McGinn, T., Bagchi, M., Preuss, H., Stohs, S. and Bagchi, D. (1999) The cytotoxic effects of a novel IH636 grape seed proanthocyanidin extract on cultured human cancer cells. Mol. Cell. Biochem. 196, 99–108.
Yousef, G., Seigler, D., Grusak, M., Rogers, R., Knight, C., Kraft, T., Erdman Jr., J.and Lila, M. (2004) Biosynthesis and characterization of14C-enriched flavonoid fractions from plant cell suspension cultures. J. Agric. Food Chem. 52, 1138–1145.
Acknowledgements
This work was supported by the National Center for Complementary and Alternative Medicine-sponsored Purdue-UAB Botanicals Center for Dietary Supplement Research (P50 AT-00477) and the USDA/IFAFS grant #00-52101-9695.
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Lila, M.A. (2008). Interactions Between Flavonoids that Benefit Human Health. In: Winefield, C., Davies, K., Gould, K. (eds) Anthocyanins. Springer, New York, NY. https://doi.org/10.1007/978-0-387-77335-3_10
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DOI: https://doi.org/10.1007/978-0-387-77335-3_10
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