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Microelectrode Technologies for Deep Brain Stimulation

  • Martin Han
  • Douglas B. McCreery
Chapter
Part of the Biological and Medical Physics, Biomedical Engineering book series (BIOMEDICAL)

Abstract

This chapter discusses stimulation and recording microelectrodes used in deep brain stimulation (DBS). DBS has become an established treatment for movement disorders and a promising treatment for a number of other neurological conditions. However, there is need for improved implantable devices, better tailored to specific neurological disorders and the corresponding targets in the brain. The development of miniaturized devices would permit effective treatment with minimal side effects and would facilitate research on the pathophysiology of diseases treatable by DBS. We will discuss some of the challenges in the implementation of microelectrode systems for successful clinical translation.

Keywords

Deep Brain Stimulation Essential Tremor Electrode Site Microelectrode Array Recording Microelectrode 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

The authors thank the technical and animal care staffs at HMRI, and Stuart Cogan at EIC Laboratories for his help with the EIROF process. Funding for the development of the silicon microelectrode array at HMRI was provided in parts by NIH contract NO1-DC-4-0005 and grant R01NS054121.

References

  1. 1.
    Abosch A, Hutchison WD, Saint-Cyr JA et al. (2002) Movement-related neurons of the subthalamic nucleus in patients with Parkinson disease. J Neurosurg 97(5): 1167–72Google Scholar
  2. 2.
    Adams C, Mathieson K, Gunning D et al. (2005) Development of flexible arrays for in vivo neuronal recording and stimulation. Nucl Instrum Methods Phys Res Sect A-Accel Spectrom Dect Assoc Equip 546(1–2): 154–159Google Scholar
  3. 3.
    Afsharpour S (1985) Topographical projections of the cerebral cortex to the subthalamic nucleus. J Comp Neurol 236(1): 14–28Google Scholar
  4. 4.
    Anderson T, Hu B, Pittman Q et al. (2004) Mechanisms of deep brain stimulation: an intracellular study in rat thalamus. J Physiol 559(Pt 1): 301–13Google Scholar
  5. 5.
    Anderson WS, Lenz FA (2006) Surgery insight: deep brain stimulation for movement disorders. Nat Clin Pract Neurol 2(6): 310–320Google Scholar
  6. 6.
    Ashkan K, Wallace B, Bell BA et al. (2004) Deep brain stimulation of the subthalamic nucleus in Parkinson’s disease 1993–2003: where are we 10 years on? Br J Neurosurg 18(1): 19–34Google Scholar
  7. 7.
    Beckstead RM (1983) A reciprocal axonal connection between the subthalamic nucleus and the neostriatum in the cat. Brain Res 275(1): 137–42Google Scholar
  8. 8.
    Beebe X, Rose TL (1988) Charge injection limits of activated iridium oxide electrodes with 0.2 ms pulses in bicarbonate buffered saline. IEEE Trans Biomed Eng 35(6): 494–495Google Scholar
  9. 9.
    Benabid AL (2003) Deep brain stimulation for Parkinson’s disease. Curr Opin Neurobiol 13(6): 696–706Google Scholar
  10. 10.
    Benabid AL, Koudsie A, Benazzouz A et al. (2002) Imaging of subthalamic nucleus and ventralis intermedius of the thalamus. Mov Disord 17(Suppl 3): S123–9.Google Scholar
  11. 11.
    Benazzouz A, Breit S, Koudsie A et al. (2002) Intraoperative microrecordings of the subthalamic nucleus in Parkinson’s disease. Mov Disord 17: S145–S149Google Scholar
  12. 12.
    Biran R, Martin DC, Tresco PA (2005) Neuronal cell loss accompanies the brain tissue response to chronically implanted silicon microelectrode arrays. Exp Neurol 195(1): 115–126Google Scholar
  13. 13.
    Biran R, Noble MD, Tresco PA (1999) Characterization of cortical astrocytes on materials of differing surface chemistry. J Biomed Mater Res 46(2): 150–9Google Scholar
  14. 14.
    Birdno MJ, Cooper SE, Rezai AR et al. (2007) Pulse-to-pulse changes in the frequency of deep brain stimulation affect tremor and modeled neuronal activity. J Neurophysiol 98(3): 1675–84Google Scholar
  15. 15.
    Birdno MJ, Grill WM (2008) Mechanisms of deep brain stimulation in movement disorders as revealed by changes in stimulus frequency. Neurotherapeutics 5(1): 14–25Google Scholar
  16. 16.
    Blanche TJ, Spacek MA, Hetke JF et al. (2005) Polytrodes: High-density silicon electrode arrays for large-scale multiunit recording. J Neurophysiol 93(5): 2987–3000Google Scholar
  17. 17.
    Breit S, Schulz JB, Benabid AL (2004) Deep brain stimulation. Cell and Tissue Res 318(1): 275–288Google Scholar
  18. 18.
    Burmeister JJ, Pomerleau F, Palmer M et al. (2002) Improved ceramic-based multisite microelectrode for rapid measurements of L-glutamate in the CNS. J Neurosci Methods 119(2): 163–171Google Scholar
  19. 19.
    Butson CR, Maks CB, McIntyre CC (2006) Sources and effects of electrode impedance during deep brain stimulation. Clin Neurophysiol 117(2): 447–454Google Scholar
  20. 20.
    Chen SY, Lee CC, Lin SH et al. (2006) Microelectrode recording can be a good adjunct in magnetic resonance image-directed subthalamic nucleus deep brain stimulation for parkinsonism. Surg Neurol 65(3): 253–261MathSciNetGoogle Scholar
  21. 21.
    Chen YY, Kuo TS, Jaw FS (2004) A laser micromachined probe for recording multiple field potentials in the thalamus. J Neurosci Methods 139(1): 99–109Google Scholar
  22. 22.
    Cheung KC (2007) Implantable microscale neural interfaces. Biomed. Microdevices 9(6): 923–938Google Scholar
  23. 23.
    Cheung KC, Djupsund K, Dan Y et al. (2003) Implantable Multichannel Electrode Array Based on SOI Technology. J Microelectromech Syst 12(2): 179–184Google Scholar
  24. 24.
    Chou KL, Hurtig HI, Jaggi JL et al. (2005) Bilateral subthalamic nucleus deep brain stimulation in a patient with cervical dystonia and essential tremor. Mov Disord 20(3): 377–380Google Scholar
  25. 25.
    Cintas P, Simonetta-Moreau M, Ory F et al. (2003) Deep brain stimulation for Parkinson’s disease: Correlation between Intraoperative subthalamic nucleus neurophysiology and most effective contacts. Stereotact Funct Neurosurg 80(1–4): 108–113Google Scholar
  26. 26.
    Cogan SF, Guzelian AA, Agnew WF et al. (2004) Over-pulsing degrades activated iridium oxide films used for intracortical neural stimulation. J Neurosci Methods 137(2): 141–150Google Scholar
  27. 27.
    Cogan SF, Plante TD, Ehrlich J (2004) Sputtered iridium oxide films (SIROFs) for low-impedance neural stimulation and recording electrodes. Pro. 26th Ann Int Conf of the IEEE EMBS (San Francisco, CA)Google Scholar
  28. 28.
    Cogan SF, Troyk PR, Ehrlich J et al. (2005) In vitro comparison of the charge-injection limits of activated iridium oxide (AIROF) and platinum-iridium microelectrodes. IEEE Trans Biomed Eng 52(9): 1612–4.Google Scholar
  29. 29.
    Cui X, Wiler J, Dzaman M et al. (2003) In vivo studies of polypyrrole/peptide coated neural probes. Biomaterials 24: 777–787Google Scholar
  30. 30.
    Cyberkinetics Neurotechnology Systems Inc. (2008). http://www.cyberkineticsinc.com. Accessed 4 October 2008
  31. 31.
    Edell DJ, Toi VV, McNeil VM et al. (1992) Factors Influencing the Biocompatibility of Insertable Silicon Microshafts in Cerebral-Cortex. IEEE Trans Biomed Eng 39(6): 635–643Google Scholar
  32. 32.
    Ekstrom AD, Kahana MJ, Caplan JB et al. (2003) Cellular networks underlying human spatial navigation. Nature 425(6954): 184–187Google Scholar
  33. 33.
    Ensell G, Banks DJ, Ewins DJ et al. (1996) Silicon-Based Microelectrodes for Neurophysiology Fabrication Using a Gold Metallization/Nitride Passivation System. J Microelectromech Syst 5(2): 117–121Google Scholar
  34. 34.
    Ensell G, Banks DJ, Richards PR et al. (2000) Silicon-based microelectrodes for neurophysiology, micromachined from silicon-on-insulator wafers. Med Biol Eng Comput 38(2): 175–179Google Scholar
  35. 35.
    Finelli DA, Rezai AR, Ruggieri PM et al. (2002) MR imaging-related heating of deep brain stimulation electrodes: In vitro study. Am J Neuroradiol 23(10): 1795–1802Google Scholar
  36. 36.
    Fofonoff TA, Martel SM, Hatsopoulos NG et al. (2004) Microelectrode array fabrication by electrical discharge machining and chemical etching. IEEE Trans Biomed Eng 51(6): 890–895Google Scholar
  37. 37.
    Garcia L, D’Alessandro G, Bioulac B et al. (2005) High-frequency stimulation in Parkinson’s disease: more or less? Trends Neurosci 28(4): 209–216Google Scholar
  38. 38.
    Garonzik IM, Hua SE, Ohara S et al. (2002) Intraoperative microelectrode and semi-microelectrode recording during the physiological localization of the thalamic nucleus ventral intermediate. Mov Disord 17: S135–S144Google Scholar
  39. 39.
    George MS, Nahas Z, Borckardt JJ et al. (2007) Brain stimulation for the treatment of psychiatric disorders. Curr Opin Psychiatry 20(3): 250–4Google Scholar
  40. 40.
    Ghika J, Villemure JG, Fankhauser H et al. (1998) Efficiency and safety of bilateral contemporaneous pallidal stimulation (deep brain stimulation) in levodopa-responsive patients with Parkinson’s disease with severe motor fluctuations: a 2-year follow-up review. J Neurosurg 89(5): 713–718Google Scholar
  41. 41.
    Giacobbe P, Kennedy SH (2006) Deep brain stimulation for treatment-resistant depression: a psychiatric perspective. Curr Psychiatry Rep 8(6): 437–44Google Scholar
  42. 42.
    Gilletti A, Muthuswamy J (2006) Brain micromotion around implants in the rodent somatosensory cortex. J Neural Eng 3: 189–195Google Scholar
  43. 43.
    Godinho F, Thobois S, Magnin M et al. (2006) Subthalamic nucleus stimulation in Parkinson’s disease : anatomical and electrophysiological localization of active contacts. J Neurol 253(10): 1347–55Google Scholar
  44. 44.
    Guridi J, Rodriguez-Oroz MC, Lozano AM et al. (2000) Targeting the basal ganglia for deep brain stimulation in Parkinson’s disease. Neurology 55(12): S21–S28Google Scholar
  45. 45.
    Haber SN, Lynd-Balta E, Mitchell SJ (1993) The organization of the descending ventral pallidal projections in the monkey. J Comp Neurol 329(1): 111–28Google Scholar
  46. 46.
    Halgren E, Babb TL, Crandall PH (1978) Activity of Human Hippocampal Formation and Amygdala Neurons During Memory Testing. Electroencephalogr Clin Neurophysiol 45(5): 585–601Google Scholar
  47. 47.
    Hamani C, Saint-Cyr JA, Fraser J et al. (2004) The subthalamic nucleus in the context of movement disorders. Brain 127(Pt 1): 4–20Google Scholar
  48. 48.
    Hamel W, Fietzek U, Morsnowski A et al. (2003) Subthalamic nucleus stimulation in Parkinson’s disease: correlation of active electrode contacts with intraoperative microrecordings. Stereotact Funct Neurosurg 80(1–4): 37–42.Google Scholar
  49. 49.
    Hamel W, Herzog J, Kopper F et al. (2007) Deep brain stimulation in the subthalamic area is more effective than nucleus ventralis intermedius stimulation for bilateral intention tremor. Acta Neurochirurgica 149(8): 749–758Google Scholar
  50. 50.
    Han M, Bullara LA, McCreery DB (2007) Development of a Robust Chronic Neural Probe. Proc Biomed Eng Soc Ann Fall Meeting, Los Angeles, CA. Program No. P2.146Google Scholar
  51. 51.
    Han M, McCreery DB (2008) A New Chronic Neural Probe with Electroplated Iridium Oxide Electrodes. Proc Ann Int Conf of the IEEE Eng Med Biol Soc, Vancouver, Canada. 4220–4221Google Scholar
  52. 52.
    Hardesty DE, Sackeim HA (2007) Deep brain stimulation in movement and psychiatric disorders. Biol Psychiatry 61(7): 831–5Google Scholar
  53. 53.
    Herzog J, Fietzek U, Hamel W et al. (2004) Most effective stimulation site in subthalamic deep brain stimulation for Parkinson’s disease. Mov Disord 19(9): 1050–4Google Scholar
  54. 54.
    Hochberg LR, Serruya MD, Friehs GM et al. (2006) Neuronal ensemble control of prosthetic devices by a human with tetraplegia. Nature 442(7099): 164–171Google Scholar
  55. 55.
    Holtzheimer PE, 3rd, Nemeroff CB (2006) Emerging treatments for depression. Expert Opin Pharmacother 7(17): 2323–39Google Scholar
  56. 56.
    Howland RH (2008) Neurosurgical approaches to therapeutic brain stimulation for treatment-resistant depression. J Psychosoc Nurs Ment Health Serv 46(4): 15–9Google Scholar
  57. 57.
    Hutchison WD, Allan RJ, Opitz H et al. (1998) Neurophysiological identification of the subthalamic nucleus in surgery for Parkinson’s disease. Annals of Neurology 44(4): 622–628Google Scholar
  58. 58.
    Ishijima B, Hori T, Yoshimasu N et al. (1975) Neuronal Activities in Human Epileptic Foci and Surrounding Areas. Electroencephalogr Clin Neurophysiol 39(6): 643–650Google Scholar
  59. 59.
    Johansen-Berg H, Gutman DA, Behrens TE et al. (2008) Anatomical connectivity of the subgenual cingulate region targeted with deep brain stimulation for treatment-resistant depression. Cereb Cortex 18(6): 1374–83Google Scholar
  60. 60.
    Kennedy SH, Giacobbe P (2007) Treatment resistant depression – advances in somatic therapies. Ann Clin Psychiatry 19(4): 279–87Google Scholar
  61. 61.
    Kern DS, Kumar R (2007) Deep brain stimulation. Neurologist 13(5): 237–252Google Scholar
  62. 62.
    Kewley DT, Hills MD, Borkholder DA et al. (1997) Plasma-etched neural probes. Sens Actuator A-Phys 58(1): 27–35Google Scholar
  63. 63.
    Kindlundh M, Norlin P, Hofmann UG (2004) A neural probe process enabling variable electrode configurations. Sens Actuator B-Chem 102(1): 51–58Google Scholar
  64. 64.
    Kipke DR, Vetter RJ, Williams JC et al. (2003) Silicon-substrate intracortical microelectrode arrays for long-term recording of neuronal spike activity in cerebral cortex. IEEE Trans Neural Syst Rehabil Eng 11(2): 151–155Google Scholar
  65. 65.
    Kisban S, Herwik S, Seidl K et al. (2007) Microprobe Array with Low Impedance Electrodes and Highly Flexible Polyimide Cables for Acute Neural Recording. 29th Ann Int Conf IEEE EMBS, Lyon, France.Google Scholar
  66. 66.
    Kovacs GT, Storment CW, Halks-Miller M et al. (1994) Silicon-substrate microelectrode arrays for parallel recording of neural activity in peripheral and cranial nerves. IEEE Trans Biomed Eng 41(6): 567–77Google Scholar
  67. 67.
    Krack P, Batir A, Van Blercom N et al. (2003) Five-year follow-up of bilateral stimulation of the subthalamic nucleus in advanced Parkinson’s disease. New England Journal of Medicine 349(20): 1925–1934Google Scholar
  68. 68.
    Krauss JK, Yianni J, Loher TJ et al. (2004) Deep brain stimulation for dystonia. J Clin Neurophysiol 21(1): 18–30Google Scholar
  69. 69.
    Kringelbach ML, Jenkinson N, Owen SLF et al. (2007) Translational principles of deep brain stimulation. Nat Rev Neurosci 8(8): 623–635Google Scholar
  70. 70.
    Kuncel AM, Cooper SE, Wolgamuth BR et al. (2007) Amplitude- and frequency-dependent changes in neuronal regularity parallel changes in tremor With thalamic deep brain stimulation. IEEE Trans Neural Syst Rehabil Eng 15(2): 190–7Google Scholar
  71. 71.
    Kuncel AM, Grill WM (2004) Selection of stimulus parameters for deep brain stimulation. Clin Neurophysiol 115(11): 2431–41Google Scholar
  72. 72.
    Larson PS (2008) Deep brain stimulation for psychiatric disorders. Neurotherapeutics 5(1): 50–8Google Scholar
  73. 73.
    Lee KK, He JP, Singh A et al. (2004) Polyimide-based intracortical neural implant with improved structural stiffness. J Micromech Microeng 14(1): 32–37Google Scholar
  74. 74.
    Lenz FA, Dostrovsky JO, Tasker RR et al. (1988) Single-unit analysis of the human ventral thalamic nuclear group – somatosensory responses. J Neurophysiol 59(2): 299–316Google Scholar
  75. 75.
    Liu X, McCreery DB, Carter RR et al. (1999) Stability of the interface between neural tissue and chronically implanted intracortical microelectrodes. IEEE Trans Neural Syst Rehabil Eng 7: 315–326Google Scholar
  76. 76.
    Lyons KE, Pahwa R (2004) Deep brain stimulation and essential tremor. J Clin Neurophysiol 21(1): 2–5Google Scholar
  77. 77.
    Lyons KE, Pahwa R (2004) Deep brain stimulation in Parkinson’s disease. Curr Neurol Neurosci Rep 4(4): 290–5Google Scholar
  78. 78.
    Lyons KE, Pahwa R (2008) Deep brain stimulation and tremor. Neurotherapeutics 5(2): 331–8Google Scholar
  79. 79.
    Mallet L, Schupbach M, N’Diaye K et al. (2007) Stimulation of subterritories of the subthalamic nucleus reveals its role in the integration of the emotional and motor aspects of behavior. Proc Natl Acad Sci USA 104(25): 10661–6Google Scholar
  80. 80.
    Maynard EM, Fernandez E, Normann RA (2000) A technique to prevent dural adhesions to chronically implanted microelectrode arrays. J Neurosci Methods 97(2): 93–101Google Scholar
  81. 81.
    Mazzone P, Lozano A, Stanzione P et al. (2005) Implantation of human pedunculopontine nucleus: a safe and clinically relevant target in Parkinson’s disease. Neuroreport 16(17): 1877–1881Google Scholar
  82. 82.
    McCreery D, Lossinsky A, Pikov V (2007) Performance of multisite silicon microprobes implanted chronically in the ventral cochlear nucleus of the cat. IEEE Trans Biomed Eng 54(6): 1042–1052Google Scholar
  83. 83.
    McCreery D, Lossinsky A, Pikov V et al. (2006) Microelectrode array for chronic deep-brain microstimulation and recording. IEEE Trans Biomed Eng 53(4): 726–37Google Scholar
  84. 84.
    McCreery D, Pikov V, Lossinsky A et al. (2004) Arrays for chronic functional micro stimulation of the lumbosacral spinal cord. IEEE Trans Neural Syst Rehabil Eng 12(2): 195–207Google Scholar
  85. 85.
    McCreery DB, Agnew WF, Yuen TG et al. (1990) Charge density and charge per phase as cofactors in neural injury induced by electrical stimulation. IEEE Trans Biomed Eng 37(10): 996–1001Google Scholar
  86. 86.
    McIntyre CC, Grill WM, Sherman DL et al. (2004) Cellular effects of deep brain stimulation: model-based analysis of activation and inhibition. J Neurophysiol 91(4): 1457–69.Epub 2003 Dec 10.Google Scholar
  87. 87.
    McIntyre CC, Mori S, Sherman DL et al. (2004) Electric field and stimulating influence generated by deep brain stimulation of the subthalamic nucleus. Clin Neurophysiol 115(3): 589–95.Google Scholar
  88. 88.
    McIntyre CC, Savasta M, Kerkerian-Le Goff L et al. (2004) Uncovering the mechanism(s) of action of deep brain stimulation: activation, inhibition, or both. Clin Neurophysiol 115(6): 1239–1248Google Scholar
  89. 89.
    McIntyre CC, Savasta M, Walter BL et al. (2004) How does deep brain stimulation work? Present understanding and future questions. J Clin Neurophysiol 21(1): 40–50Google Scholar
  90. 90.
    Medtronic Neuromodulation (2003) Stimulation of the Anterior Nucleus of the Thalamus for Epilepsy. ClinicalTrials.gov. Identifier: NCT00101933. http://www.clinicaltrials.gov. Accessed 4 October 2008
  91. 91.
    Meissner W, Leblois A, Hansel D et al. (2005) Subthalamic high frequency stimulation resets subthalamic firing and reduces abnormal oscillations. Brain 128(10): 2372–82Google Scholar
  92. 92.
    Mettler FA, Stern GM (1962) Somatotopic localization in rhesus subthalamic nucleus. Arch Neurol 7: 328–9Google Scholar
  93. 93.
    Meyer RD, Cogan SF, Nguyen TH et al. (2001) Electrodeposited iridium oxide for neural stimulation and recording electrodes. IEEE Trans Neural Syst Rehabil Eng 9(1): 2–11Google Scholar
  94. 94.
    Miyata M (1986) Interconnections between the subthalamic nucleus and the cerebral cortex of the cat. Neurosci Res 4(1): 1–11.Google Scholar
  95. 95.
    Montgomery EB, Jr. (2004) Deep brain stimulation for hyperkinetic disorders. Neurosurg Focus 17(1): E1Google Scholar
  96. 96.
    Moss J, Ryder T, Aziz TZ et al. (2004) Electron microscopy of tissue adherent to explanted electrodes in dystonia and Parkinson’s disease. Brain 127: 2755–2763Google Scholar
  97. 97.
    Motta PS, Judy JW (2005) Multielectrode microprobes for deep-brain stimulation fabricated with a customizable 3-D electroplating process. IEEE Trans Biomed Eng 52(5): 923–933Google Scholar
  98. 98.
    Moxon KA, Leiser SC, Gerhardt GA et al. (2004) Ceramic-based multisite electrode arrays for chronic single-neuron recording. IEEE Trans Biomed Eng 51(4): 647–656Google Scholar
  99. 99.
    Mueller J, Skogseid IM, Benecke R et al. (2008) Pallidal deep brain stimulation improves quality of life in segmental and generalized dystonia: results from a prospective, randomized sham-controlled trial. Mov Disord 23(1): 131–4Google Scholar
  100. 100.
    Muthuswamy J, Okandan M, Jackson N (2005) Single neuronal recordings using surface micromachined polysilicon microelectrodes. J Neurosci Methods 142(1): 45–54Google Scholar
  101. 101.
    NeuroNexus Technologies (2008). http://www.neuronexustech.com. Accessed 4 October 2008
  102. 102.
    NeuroPace (2004) Study of a Responsive Neurostimulator System to Treat Epilepsy. ClinicalTrials.gov Identifier: NCT00079781. http://www.clinicaltrials.gov. Accessed 4 October 2008
  103. 103.
    Norlin P, Kindlundh M, Mouroux A et al. (2002) A 32-site neural recording probe fabricated by DRIE of SOI substrates. J Micromech Microeng 12(4): 414–419Google Scholar
  104. 104.
    Normann RA (2007) Technology Insight: future neuroprosthetic therapies for disorders of the nervous system. Nat Clin Pract Neurol 3(8): 444–452Google Scholar
  105. 105.
    Normann RA, Campbell PK, Jones KE (1993) Three-dimensional electrode device. The United States of America, The University of Utah, Salt Lake City, UT, 45–81Google Scholar
  106. 106.
    Normann RA, Maynard EM, Rousche PJ et al. (1999) A neural interface for a cortical vision prosthesis. Vision Res 39(15): 2577–2587Google Scholar
  107. 107.
    Oh SJ, Song JK, Kim JW et al. (2006) A high-yield fabrication process for silicon neural probes. IEEE Trans Biomed Eng 53(2): 351–354Google Scholar
  108. 108.
    Paik SJ, Park Y, Cho DI (2003) Roughened polysilicon for low impedance microelectrodes in neural probes. J Micromech Microeng 13(3): 373–379Google Scholar
  109. 109.
    Peck ME (2007) Deep-Brain Stimulators for Parkinson’s Disease Increase Impulsive Decision Making. IEEE Spectrum Online. http://www.spectrum.ieee.org/oct07/5669. Accessed 4 October 2008
  110. 110.
    Perale G, Giordano C, Daniele F et al. (2008) A novel process for the manufacture of ceramic microelectrodes for biomedical applications. Int J Appl Ceram Technol 5(1): 37–43Google Scholar
  111. 111.
    Pereira EA, Green AL, Nandi D et al. (2007) Deep brain stimulation: indications and evidence. Expert Rev Med Devices 4(5): 591–603Google Scholar
  112. 112.
    Perlmutter JS, Mink JW (2006) Deep brain stimulation. Annu Rev Neurosci 29: 229–257Google Scholar
  113. 113.
    Petersen KE (1982) Silicon as a Mechanical Material. Proc IEEE 70(5): 420–457Google Scholar
  114. 114.
    Plaha P, Ben-Shlomo Y, Patel NK et al. (2006) Stimulation of the caudal zona incerta is superior to stimulation of the subthalamic nucleus in improving contralateral parkinsonism. Brain 129(Pt 7): 1732–47Google Scholar
  115. 115.
    Plaha P, Gill SS (2005) Bilateral deep brain stimulation of the pedunculopontine nucleus for Parkinson’s disease. Neuroreport 16(17): 1883–1887Google Scholar
  116. 116.
    Pollak P, Krack P, Fraix V et al. (2002) Intraoperative micro- and macrostimulation of the subthalamic nucleus in Parkinson’s disease. Mov Disord 17(Suppl 3): S155–61.Google Scholar
  117. 117.
    Rau A, Grossheinrich N, Palm U et al. (2007) Transcranial and deep brain stimulation approaches as treatment for depression. Clin EEG Neurosci 38(2): 105–15Google Scholar
  118. 118.
    Robblee LS, Lefko JL, Brummer SB (1983) Activated Ir: An Electrode Suitable for Reversible Charge Injection in Saline Solution. J Electrochem Soc 130(3): 731–733Google Scholar
  119. 119.
    Rodriguez MC, Guridi OJ, Alvarez L et al. (1998) The subthalamic nucleus and tremor in Parkinson’s disease. Mov Disord 13(Suppl 3): 111–8.Google Scholar
  120. 120.
    Rodriguez-Oroz MC, Rodriguez M, Guridi J et al. (2001) The subthalamic nucleus in Parkinson’s disease: somatotopic organization and physiological characteristics. Brain 124(Pt 9): 1777–90Google Scholar
  121. 121.
    Romanelli P, Heit G, Hill BC et al. (2004) Microelectrode recording revealing a somatotopic body map in the subthalamic nucleus in humans with Parkinson disease. J Neurosurg 100(4): 611–8Google Scholar
  122. 122.
    Rose TL, Robblee LS (1990) Electrical stimulation with Pt electrodes. VIII. Electrochemically safe charge injection limits with 0.2 ms pulses. IEEE Trans Biomed Eng 37(11): 1118–20.Google Scholar
  123. 123.
    Rousche PJ, Pellinen DS, Pivin DP et al. (2001) Flexible polyimide-based intracortical electrode arrays with bioactive capability. IEEE Trans Biomed Eng 48(3): 361–371Google Scholar
  124. 124.
    Rutten WLC, Vanwier HJ, Put JHM (1991) Sensitivity and selectivity of intraneural stimulation using a silicon electrode array. IEEE Trans Biomed Eng 38(2): 192–198Google Scholar
  125. 125.
    Schmidt EM (1980) Single neuron recording from motor cortex as a possible source of signals for control of external devices. Ann Biomed Eng 8(4–6): 339–349Google Scholar
  126. 126.
    Schuettler M, Praetorius M, Kammer S et al. (2002) Recording of Auditory Evoked Potentials in Rat Using a 60 Channel Polyimide Electrode Array: Preliminary Results. Proc. 2nd Joint EMBS/BMES Conf., Houston, TX, USA.Google Scholar
  127. 127.
    Schwartz AB (2004) Cortical neural prosthetics. Annu Rev Neurosci 27: 487–507Google Scholar
  128. 128.
    Seymour JP, Kipke DR (2007) Neural probe design for reduced tissue encapsulation in CNS. Biomaterials 28(25): 3594–3607Google Scholar
  129. 129.
    Shain W, Spataro L, Dilgen J et al. (2003) Controlling cellular reactive responses around neural prosthetic devices using peripheral and local intervention strategies. IEEE Trans Neural Syst Rehabil Eng 11(2): 186–188Google Scholar
  130. 130.
    Simon SL, Douglas P, Baltuch GH et al. (2005) Error analysis of MRI and Leksell stereotactic frame target localization in deep brain stimulation surgery. Stereotact Funct Neurosurg 83(1): 1–5Google Scholar
  131. 131.
    Slavcheva E, Vitushinsky R, Mokwa W et al. (2004) Sputtered iridium oxide films as charge injection material for functional electrostimulation. J Electrochem Soc 151(7): E226–E237Google Scholar
  132. 132.
    Sreenivas G, Ang SS, Fritsch I et al. (1996) Fabrication and characterization of sputtered-carbon microelectrode arrays. Anal Chem 68(11): 1858–1864Google Scholar
  133. 133.
    Starr PA (2002) Placement of deep brain stimulators into the subthalamic nucleus or globus pallidus internus: Technical approach. Stereotact Funct Neurosurg 79(3–4): 118–145Google Scholar
  134. 134.
    Stathis P, Panourias IG, Themistocleous MS et al. (2007) Connections of the basal ganglia with the limbic system: implications for neuromodulation therapies of anxiety and affective disorders. Acta Neurochir Suppl 97(Pt 2): 575–86Google Scholar
  135. 135.
    Stieglitz T (2001) Flexible biomedical microdevices with double-sided electrode arrangements for neural applications. Sens Actuator A-Phys 90(3): 203–211Google Scholar
  136. 136.
    Stieglitz T, Gross M (2002) Flexible BIOMEMS with electrode arrangements on front and back side as key component in neural prostheses and biohybrid systems. Sens Actuator B-Chem 83(1–3): 8–14Google Scholar
  137. 137.
    Stover NP, Okun MS, Evatt ML et al. (2005) Stimulation of the subthalamic nucleus in a patient with Parkinson disease and essential tremor. Arch of Neurology 62(1): 141–143Google Scholar
  138. 138.
    Suner S, Fellows MR, Vargas-Irwin C et al. (2005) Reliability of signals from a chronically implanted, silicon-based electrode array in non-human primate primary motor cortex. IEEE Trans Neural Syst Rehabil Eng 13(4): 524–541Google Scholar
  139. 139.
    Szarowski DH, Andersen MD, Retterer S et al. (2003) Brain responses to micro-machined silicon devices. Brain Res 983: 23–35Google Scholar
  140. 140.
    Tass PA (2003) A model of desynchronizing deep brain stimulation with a demand-controlled coordinated reset of neural subpopulations. Biol Cybern 89(2): 81–88MATHGoogle Scholar
  141. 141.
    Tehovnik EJ (1996) Electrical stimulation of neural tissue to evoke behavioral responses. J Neurosci Methods 65(1): 1–17.Google Scholar
  142. 142.
    The Cleveland Clinic (2008) Deep Brain Stimulation. http://my.clevelandclinic.org/services/deep_brain_stimulation/ns_overview.aspx. Accessed 4 October 2008
  143. 143.
    Theodore WH, Fisher R (2007) Brain stimulation for epilepsy. Acta Neurochir Suppl 97(Pt 2): 261–72Google Scholar
  144. 144.
    Theodosopoulos PV, Marks WJ, Jr., Christine C et al. (2003) Locations of movement-related cells in the human subthalamic nucleus in Parkinson’s disease. Mov Disord 18(7): 791–8Google Scholar
  145. 145.
    Truccolo W, Friehs GM, Donoghue JP et al. (2008) Primary motor cortex tuning to intended movement kinematics in humans with tetraplegia. J Neurosci Methods 28: 1163–1178Google Scholar
  146. 146.
    Ulbert I, Halgren E, Heit G et al. (2001) Multiple microelectrode-recording system for human intracortical applications. J Neurosci Methods 106(1): 69–79Google Scholar
  147. 147.
    Vetter RJ, Williams JC, Hetke JF et al. (2004) Chronic neural recording using silicon-substrate microelectrode arrays implanted in cerebral cortex. IEEE Trans Biomed Eng 51(6): 896–904Google Scholar
  148. 148.
    Vitek JL, Bakay RAE, Hashimoto T et al. (1998) Microelectrode-guided pallidotomy: technical approach and its application in medically intractable Parkinson’s disease. J Neurosurg 88(6): 1027–1043Google Scholar
  149. 149.
    Wessling B, Mokwa W, Schnakenberg U (2006) RF-sputtering of iridium oxide to be used as stimulation material in functional medical implants. J Micromech Microeng 16(6): S142–S148Google Scholar
  150. 150.
    Wise KD, Anderson DJ, Hetke JF et al. (2004) Wireless implantable microsystems: High-density electronic interfaces to the nervous system. Proc IEEE 92(1): 76–97Google Scholar
  151. 151.
    Wise KD, Angell JB, Starr A (1970) An integrated-circuit approach to extracellular microelectrodes. IEEE Trans Biomed Eng 17(3): 238–47Google Scholar
  152. 152.
    Yokoyama T, Ando N, Sugiyama K et al. (2006) Relationship of stimulation site location within the subthalamic nucleus region to clinical effects on parkinsonian symptoms. Stereotact Funct Neurosurg 84(4): 170–5Google Scholar
  153. 153.
    Yokoyama T, Sugiyama K, Nishizawa S et al. (2001) The optimal stimulation site for chronic stimulation of the subthalamic nucleus in Parkinson’s disease. Stereotact Funct Neurosurg 77(1–4): 61–7Google Scholar
  154. 154.
    Yoon TH, Hwang EJ, Shin DY et al. (2000) A micromachined silicon depth probe for multichannel neural recording. IEEE Trans Biomed Eng 47(8): 1082–1087Google Scholar

Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  1. 1.Neural Engineering ProgramHuntington Medical Research InstitutesPasadenaUSA

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