Differential Expression

  • W. HuberEmail author
  • D. Scholtens
  • F. Hahne
  • A. von Heydebreck
Part of the Use R! book series (USE R)


In this chapter we will cover some of the basic principles of finding differentially expressed genes. We cover nonspecific filtering, multiple testing, the moderated test statistics provided by the limma package, and gene selection by ROC curves.


Acute Lymphoblastic Leukemia Receiver Operator Characteristic Curve Limma Package Volcano Plot Multiple Testing Adjustment 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • W. Huber
    • 1
    Email author
  • D. Scholtens
    • 2
  • F. Hahne
    • 3
  • A. von Heydebreck
    • 4
  1. 1.Wellcome Trust Genome CampusEuropean Bioinformatics Institute, EMBL Outstation HinxtonCambridgeUK
  2. 2.Department of Preventive MedicineNorthwestern UniversityChicagoUSA
  3. 3.Division of Public Health Sciences, Program in Computational BiologyFred Hutchinson Cancer Research CenterSeattleUSA
  4. 4.Global TechnologiesMerck KGaA, Darmstadt, FRGSeattleUSA

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