Easy Differential Expression
In this short exercise, we explore the most basic approach to the selection of differentially expressed genes between two classes: first, a nonspecific filtering step to remove probes for genes that appear to be always unexpressed or at least not differentially expressed. Second, a probe-by-probe statistical test, and third, multiple testing correction to get an attenuated test statistic through the false discovery rate (FDR). There are many variations and improvements to the procedure shown here, and you can learn more about these in Chapter 7.
KeywordsFalse Discovery Rate Cytogenetic Abnormality Multiple Testing Correction True Probability Implicit Testing
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