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Hypergeometric Testing Used for Gene Set Enrichment Analysis

  • S. Falcon
  • R. Gentleman
Part of the Use R! book series (USE R)

Abstract

After the set of interesting genes has been determined, say those that are differentially expressed, a next step in the analysis is to attempt to find functional relationships among those genes that might help better elucidate the underlying biology. These methods typically rely on existing or predefined sets of genes. In this chapter we show how to carry out Hypergeometric tests to identify potentially interesting gene sets.

Keywords

Acute Lymphoblastic Leukemia Chromosome Band Interesting Gene Hypergeometric Test Conditional Test 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  1. 1.Scientific Software EngineerSeattleUSA
  2. 2.Division of Public Health Sciences, Program in Computational BiologyFred Hutchinson Cancer Research CenterSeattleUSA

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