Skip to main content
SpringerLink
Log in

Radiation Therapy for Adrenocortical Carcinoma

  • Chapter
  • First Online:
Adrenocortical Carcinoma

Abstract

Radiotherapy has been historically considered ineffective in the management of ACC, despite the fact that the modality provides good palliation in unresectable tumors. Further, new research has shown that radiotherapy may also be effective in an adjuvant setting, though it remains underutilized in this regard.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Percarpio B, Knowlton AH (1976) Radiation therapy of adrenal cortical carcinoma. Acta Radiol Ther Phys Biol 15:288–292

    CAS  PubMed  Google Scholar 

  2. Bradley III EL (1975) Primary and adjunctive therapy in carcinoma of the adrenal cortex. Surg Gynecol Obstet 141:507–511

    Google Scholar 

  3. Cohn K et al (1986) Adrenocortical carcinoma. Surgery 100:1170–1177

    CAS  PubMed  Google Scholar 

  4. Didolkar MS et al (1981) Natural history of adrenal cortical carcinoma: a clinicopathologic study of 42 patients. Cancer 47:2153–2161

    Article  CAS  PubMed  Google Scholar 

  5. King DR, Lack EE (1979) Adrenal cortical carcinoma: a clinical and pathologic study of 49 cases. Cancer 44:239–244

    Article  CAS  PubMed  Google Scholar 

  6. Magee BJ et al (1987) Adrenal cortical carcinoma: survival after radiotherapy. Clin Radiol 38:587–588

    Article  CAS  PubMed  Google Scholar 

  7. Markoe AM et al (1991) Radiation therapy for adjunctive treatment of adrenal cortical carcinoma. Am J Clin Oncol 14:170–174

    Article  CAS  PubMed  Google Scholar 

  8. Nader S et al (1983) Adrenal cortical carcinoma: a study of 77 cases. Cancer 52:707–711

    Article  CAS  PubMed  Google Scholar 

  9. Vassilopoulou-Sellin R et al (1993) Impact of adjuvant mitotane on the clinical course of patients with adrenocortical cancer. Cancer 71:3119–3123

    Article  CAS  PubMed  Google Scholar 

  10. Polat B et al (2009) Radiotherapy in adrenocortical carcinoma. Cancer 115:2816–2823

    Article  PubMed  Google Scholar 

  11. Kebebew E et al (2006) Extent of disease at presentation and outcome for adrenocortical caricnoma: have we made progress? World J Surg 30:872–878

    Article  PubMed  Google Scholar 

  12. Macfarlane DA (1958) Cancer of the adrenal cortex: the natural hisotry, prognosis, and treatment in a study of 55 cases. Ann R Coll Surg Engl 23:155–186

    CAS  PubMed  Google Scholar 

  13. Sullivan M et al (1978) Adrenal cortical carcinoma. J Urol 120:660–665

    CAS  PubMed  Google Scholar 

  14. DeLellis RA et al (eds) (2004) Pathology and genetics of tumours of endocrine organs. International Agency for Research on Cancer, Lyon

    Google Scholar 

  15. Icard P et al (2001) Adrenocortical carcinomas: surgical trends and results of a 253-patient series from the French Association of Endocrine Surgeons Study Group. World J Surg 25:891–897

    Article  CAS  PubMed  Google Scholar 

  16. Fassnacht M et al (2009) Limited prognostic value of the 2004 International union against cancer staging classification for adrenocortical carcinoma: proposal for a revised TNM classification. Cancer 115:243–250

    Article  PubMed  Google Scholar 

  17. Abiven G et al (2006) Clinical and biological features in the prognosis of adrenocortical cancer: poor outcome of cortisol-secreting tumors in a series of 202 consecutive patients. J Clin Endocrinol Metab 91:2650–2655

    Article  CAS  PubMed  Google Scholar 

  18. Bellantone Rl et al (1997) Role of reoperation in recurrence of adrenal cortical carcinoma: results from 188 cases collected in the Italian National Registry for Adrenal Cortical Carcinoma. Surgery 122:1212–1218

    Article  CAS  PubMed  Google Scholar 

  19. Gonzalez RJ et al (2007) Response to mitotane predicts outcome in patients with recurrent adrenal cortical carcinoma. Surgery 142:869–875

    Article  Google Scholar 

  20. Paton BL et al (2006) Outcomes of adrenal cortical carcinoma in the United States. Surgery 140:914–920

    Article  PubMed  Google Scholar 

  21. Schulick RD, Brennan MF (1999) Long-term survival after complete resection and repeat resection in patients with adrenocortical carcinoma. Ann Surg Oncol 6:719–726

    Article  CAS  PubMed  Google Scholar 

  22. Billimoria KY et al (2008) Adrenocortical carcinoma in the United States: treatment utilization and prognostic factors. Cancer 113:3130–3136

    Article  Google Scholar 

  23. Soreide JA et al (1992) Adrenal cortical carcinoma in Norway, 1970–1984. World J Surg 16:663–668

    Article  CAS  PubMed  Google Scholar 

  24. Bodie B et al (1989) The Cleveland clinic experience with adrenal cortical carcinoma. J Urol 141:257–260

    CAS  PubMed  Google Scholar 

  25. Henley DJ et al (1983) Adrenal cortical carcinoma: a continuing challenge. Surgery 94:926–931

    CAS  PubMed  Google Scholar 

  26. Pommier RF, Brennan MF (1992) An eleven-year experience with adrenocortical carcinoma. Surgery 112:963–971

    CAS  PubMed  Google Scholar 

  27. Zografos GC et al (1994) Adrenal adenocarcinoma: a review of 53 cases. J Surg Oncol 55:160–164

    Article  CAS  PubMed  Google Scholar 

  28. Luton JP et al (1990) Clinical features of adrenocortical carcinoma, prognostic factors, and the effect of mitotane therapy. N Engl J Med 322:1195–1201

    Article  CAS  PubMed  Google Scholar 

  29. Fassnacht M et al (2006) Efficacy of adjuvant radiotherapy of the tumor bed on local recurrence of adrenocortical carcinoma. J Clin Endocrinol Metab 91:4501–4504

    Article  CAS  PubMed  Google Scholar 

  30. Kirschner LS (2006) Editorial: paradigms for adrenal cancer: think globally, act locally. J Clin Endocrinol Metab 91:4250–4252

    Article  CAS  PubMed  Google Scholar 

  31. Haak HR et al (1994) Optimal treatment of adrenocortical carcinoma with mitotane: results in a consecutive series of 96 patients. Br J Cancer 69:947–951

    CAS  PubMed  Google Scholar 

  32. Icard P et al (1992) Adrenocortical carcinoma in surgically treated patients: a retrospective study on 156 cases by the French Association of Endocrine Surgery. Surgery 112:972–980

    CAS  PubMed  Google Scholar 

  33. Kendrick ML et al (2001) Adrenocortical carcinoma: surgical progress or status quo? Arch Surg 136:543–549

    Article  CAS  PubMed  Google Scholar 

  34. Venkatesh S et al (1989) Adrenal cortical carcinoma. Cancer 64:765–769

    Article  CAS  PubMed  Google Scholar 

  35. Terzolo M et al (2007) Adjuvant mitotane treatment for adrenocortical carcinoma. N Engl J Med 356:2372–2380

    Article  CAS  PubMed  Google Scholar 

  36. Hutter Jr AM, Kayhoe DE (1966) Adrenal cortical carcinoma: clinical features of 138 patients. Am J Med 41:572–580

    Article  PubMed  Google Scholar 

  37. Hogan TF et al (1980) A clinical and pathological study of adrenocortical carcinoma. Cancer 45:2880–2883

    Article  CAS  PubMed  Google Scholar 

  38. Volante M et al (2008) Pathological and molecular features of adrenocortical carcinoma: an update. J Clin Pathol 61:787–793

    Article  CAS  PubMed  Google Scholar 

  39. Berruti A et al (2008) Emerging drugs for adrenocortical carcinoma. Expert Opin Emerg Drugs 13:497–509

    Article  CAS  PubMed  Google Scholar 

  40. Harrison LE et al (1999) Pathologic features of prognostic significance for adrenocortical carcinoma after curative resection. Arch Surg 134:181–185

    Article  CAS  PubMed  Google Scholar 

  41. Weis LM (1984) Comparitive histologic study of 43 metastasizing and nonmetastasizing adrenocortical tumors. Am J Surg Pathol 8:163–169

    Article  Google Scholar 

  42. Weiss LM et al (1989) Pathologic features of prognostic significance in adrenocortical carcinoma. Am J Surg Pathol 13:202–206

    Article  CAS  PubMed  Google Scholar 

  43. Barzon L et al (1999) Is there a role for low doses of mitotane (o,p’-DDD) as adjuvant therapy in adrenocortical carcinoma? J Clin Endocrinol Metab 84:1488–1489

    Article  CAS  PubMed  Google Scholar 

  44. Skogseid B et al (2008) First International Randomized trial in locally advanced and Metastatic Adrenocortical Carcinoma Treatment. http://www.firm-act.org/. Accessed 11 Dec 2008

  45. Hajjar RA et al (1975) Adrenal cortical carcinoma: a study of 32 patients. Cancer 35:549–554

    Article  CAS  PubMed  Google Scholar 

  46. Huvos AG et al (1970) Adrenal cortical carcinoma: clinicopathologic study of 34 cases. Cancer 25:354–361

    Article  CAS  PubMed  Google Scholar 

  47. Murphy WT (1967) Radiation therapy. WB Saunders, Philadelphia, PA

    Google Scholar 

  48. Kasperlik-Zaluska AA et al (1995) Adrenocortical carcinoma: a clinical study and treatment results of 52 patients. Cancer 75:2587–2591

    Article  CAS  PubMed  Google Scholar 

  49. Sathya J et al (2005) Randomized trial comparing iridium implant plus external-beam radiation therapy with external-beam radiation therapy alone in node-negative locally advanced cancer of the prostate. J Clin Oncol 23:1192–1199

    Article  PubMed  Google Scholar 

  50. Zietman A et al (2005) Comparison of Conventional-Dose vs High-Dose conformal radiation therapy in clinically localized adenocarcinoma of the prostate a randomized controlled trial. JAMA 294:1233–1239

    Article  CAS  PubMed  Google Scholar 

  51. Kuban D et al (2008) Long-term results of the MD Anderson randomized dose-escalation trial for prostate cancer. Int J Radiat Oncol Biol Phys 70:67–74

    Article  PubMed  Google Scholar 

  52. Viani G et al (2009) Higher-than-conventional radiation doses in localized prostate cancer treatment: a meta-analysis of randomized, controlled trials. Int J Radiat Oncol Biol Phys 74:1405–1418

    Article  PubMed  Google Scholar 

  53. Overgaard M et al (1999) Postoperative radiotherapy in high-risk postmenopausal breast-cancer patients given adjuvant tamoxifen: Danish Breast Cancer Cooperative Group DBCG 82c randomised trial. Lancet 353:1641–1648

    Article  CAS  PubMed  Google Scholar 

  54. Ragaz J et al (1997) Adjuvant radiotherapy and chemotherapy in node-positive premenopausal women with breast cancer. N Engl J Med 337:956–962

    Article  CAS  PubMed  Google Scholar 

  55. Commission on Cancer (2008) The American College of Surgeons Commission on cancer: national cancer data base. http://www.facs.org/cancer/ncdb/index.html. Accessed 9 Dec 2008

  56. Surveillance Research Program of the National Cancer Institute (2008) Surveillance, epidemiology, and end results web site. http://seer.cancer.gov/. Accessed 9 Dec 2008

  57. Schteingart DE et al (2005) Management of patients with adrenal cancer: recommendations of an international consensus conference. Endocr Relat Cancer 12:667–680

    Article  CAS  PubMed  Google Scholar 

  58. Stewart DR et al (1974) Carcinoma of the adrenal gland in children. J Pediatr Surg 9:59–67

    Article  CAS  PubMed  Google Scholar 

  59. Cerquetti L et al (2008) Mitotane increases the radiotherapy inhibitory effect and induces G2-arrest in combined treatment on both H295r and SW13 adrenocortical cell lines. Endocr Relat Cancer 15:623–634

    Article  CAS  PubMed  Google Scholar 

  60. Li F et al (1988) A cancer family syndrome in twenty-four kindreds. Cancer Res 48:5358–5362

    CAS  PubMed  Google Scholar 

  61. Henry I et al (1989) Molecular definition of the 11p15. 5 region involved in Beckwith-Wiedemann syndrome and probably in predisposition to adrenocortical carcinoma. Hum Genet 81:273–277

    Article  CAS  PubMed  Google Scholar 

  62. Skogseid B et al (1992) Clinical and genetic features of adrenocortical lesions in multiple endocrine neoplasia type 1. J Clin Endocrinol Metab 75:76–81

    Article  CAS  PubMed  Google Scholar 

  63. Painter T, Jagelman D (1985) Adrenal adenomas and adrenal carcinomas in association with hereditary adenomatosis of the colon and rectum. Cancer 55:2001–2004

    Article  CAS  PubMed  Google Scholar 

  64. Li F, Fraumeni J (1969) Soft-tissue sarcomas, breast cancer, and other neoplasms: a familial syndrome? Ann Intern Med 71:747–752

    CAS  PubMed  Google Scholar 

  65. Li F, Fraumeni J (1982) Prospective study of a family cancer syndrome. JAMA 247:2692–2694

    Article  CAS  PubMed  Google Scholar 

  66. Hartley A et al (1989) Are germ cell tumors part of the Li-Fraumeni cancer family syndrome? Cancer Genet Cytogenet 42:221–226

    Article  CAS  PubMed  Google Scholar 

  67. Malkin D et al (1990) Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms. Science 250:1233–1238

    Article  CAS  PubMed  Google Scholar 

  68. Hisada M et al (1998) Multiple primary cancers in families with Li-Fraumeni syndrome. J Nat Cancer Inst 90:606–611

    Article  CAS  PubMed  Google Scholar 

  69. Varley J et al (1999) Are there low-penetrance TP53 alleles? evidence from childhood adrenocortical tumors. Am J Hum Genet 65:995–1006

    Article  CAS  PubMed  Google Scholar 

  70. Limacher J et al (2001) Two metachronous tumors in the radiotherapy fields of a patient with Li-Fraumeni syndrome. Int J Cancer 96:238–242

    Article  CAS  PubMed  Google Scholar 

  71. Birch J et al (2001) Relative frequency and morphology of cancers in carriers of germline TP 53 mutations. Oncogene 20:4621–4628

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgment

Grateful acknowledgement is made to Karen Vineberg and Steven Kronenberg for their exceptional assistance with all figures.

Author information

Authors and Affiliations

  1. Radiation Oncology, University of Michigan Medical School, 1500 East Medical Center Drive, Ann Arbor, MI, 48109, USA

    Aaron Sabolch

  2. Department of Radiation Oncology, University of Michigan Health System, University of Michigan, 1500 East Medical Center Drive, Room UHB2C490, Ann Arbor, MI, 48109-0010, USA

    Edgar Ben-Josef

Authors
  1. Aaron Sabolch
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Edgar Ben-Josef
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Edgar Ben-Josef .

Editor information

Editors and Affiliations

  1. Zina Pitcher Place 109, Ann Arbor, 48109-2200, Michigan, USA

    Gary D. Hammer

  2. Dept. Internal Medicine, Div. Pulmonary & Critical Care Medicine, University of Michigan Health System, Zina Pitcher Place 109, Ann Arbor, 48109-2200, Michigan, USA

    Tobias Else

Rights and permissions

Reprints and permissions

Copyright information

© 2009 Springer Science+Business Media, LLC

About this chapter

Cite this chapter

Sabolch, A., Ben-Josef, E. (2009). Radiation Therapy for Adrenocortical Carcinoma. In: Hammer, G., Else, T. (eds) Adrenocortical Carcinoma. Springer, New York, NY. https://doi.org/10.1007/978-0-387-77236-3_25

Download citation

Publish with us

Policies and ethics

Search

Navigation