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Mouse Models of Adrenal Tumorigenesis

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Adrenocortical Carcinoma

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Abstract

Over the past decade, a number of high-throughput techniques have emerged as powerful tools for molecular and functional characterization of cancer cells. These techniques allow for genetic or epigenetic analysis of DNA, determination of RNA expression pattern, proteomic profiling, or characterization of posttranslational modification. Despite these technical advances that aid thorough molecular characterization of surgical tumor material, most of the functional properties of biological molecules are still unpredictable from pure expression and sequence analysis. For functional studies of gene products, mouse models continue to be intensively utilized as an experimental system due to the similarity to humans with respect to genome organization, development, and physiology.

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Authors and Affiliations

  1. Department of Medicine, Endocrine Research, University Hospital Innenstadt, Ziemssenstr. 1, 80336, Munich, Germany

    Felix Beuschlein

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  1. Felix Beuschlein
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Correspondence to Felix Beuschlein .

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Editors and Affiliations

  1. Zina Pitcher Place 109, Ann Arbor, 48109-2200, Michigan, USA

    Gary D. Hammer

  2. Dept. Internal Medicine, Div. Pulmonary & Critical Care Medicine, University of Michigan Health System, Zina Pitcher Place 109, Ann Arbor, 48109-2200, Michigan, USA

    Tobias Else

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Beuschlein, F. (2009). Mouse Models of Adrenal Tumorigenesis. In: Hammer, G., Else, T. (eds) Adrenocortical Carcinoma. Springer, New York, NY. https://doi.org/10.1007/978-0-387-77236-3_19

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