Adrenocortical Cell Lines



Initially, primary cultures of adrenocortical cells have traditionally been utilized to study the mechanisms controlling adrenocortical steroidogenesis. However, the eventual onset of senescence in culture creates a recurring need for the costly and difficult isolation of fresh cultures, and subsequently increases the risk of contamination. For these reasons, the use of primary cultures has been increasingly replaced by immortalized cell lines. This chapter describes the major adrenocortical cell lines that are available for the study of physiologic and pathologic adrenocortical functions.


Adrenal Tumor Adrenal Cell Adrenocortical Cell Zona Fasciculata RL251 Cell 
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© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  1. 1.Department of PhysiologyMedical College of GeorgiaAugustaUSA
  2. 2.Department of Pediatrics, Pathology and CytogeneticsMedical College of GeorgiaAugustaUSA

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