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TP53 Molecular Genetics

  • Gerard P. Zambetti
  • Raul C. Ribeiro
Chapter

Abstract

The TP53 tumor suppressor normally functions as a transcription factor within a stress response signaling pathway to activate genes that block cell proliferation, repair DNA, inhibit angiogenesis, and induce apoptotic cell death. Collectively, TP53 limits the growth and survival of abnormal cells. It is therefore not surprising that TP53 is the most frequently mutated gene detected in human cancer. Pediatric adrenocortical tumors (ACC) are rare, usually aggressive malignancies that are often associated with inherited or de novo mutations in the TP53 tumor suppressor gene. Recent molecular and biochemical analyses of childhood ACC have revealed new insight into TP53 genotype–phenotype relationships and the factors that cooperate with the loss of TP53 functions to promote tumorigenesis. This chapter will review the TP53 signaling pathway and its clinical implications to pediatric and adult ACC and cancer in general.

Keywords

TP53 Mutation Adrenocortical Carcinoma Germline TP53 Mutation TP53 Function TP53 Tumor Suppressor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  1. 1.Department of BiochemistrySt. Jude Children’s Research HospitalMemphisUSA
  2. 2.Department of OncologySt. Jude Children’s Research HospitalMemphisUSA

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