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Dendritic Organelles for Postsynaptic Trafficking

  • Cyril Hanus
  • Michael D. Ehlers

Abstract

The development, maintenance, and plasticity of synapses require the trafficking of molecular components to postsynaptic specializations distributed across elaborate dendritic arbors. The large size and geometric complexity of dendrites necessitate specialized mechanisms that can both deliver postsynaptic cargo over extended distances and regulate dendritic composition on a submicron scale. Despite the fundamental importance of membrane trafficking in neuronal development and synaptic plasticity, the cellular rules governing postsynaptic trafficking are only now emerging. We review here current knowledge on the organization of dendritic organelles, and describe cell biological mechanisms that allow long-range transport of postsynaptic components that are then locally processed at individual synapses.

Keywords

NMDA Receptor Hippocampal Neuron AMPA Receptor Dendritic Spine Membrane Trafficking 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Cyril Hanus
    • 1
  • Michael D. Ehlers
    • 1
  1. 1.Howard Hughes Medical Institute Department of Neurobiology Duke University Medical CenterDurhamNC 27710

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