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Acid-Sensing Ion Channels (ASICs) and pH in Synapse Physiology

  • Chapter
Structural And Functional Organization Of The Synapse

Abstract

Although brain pH is tightly controlled, it can be more dynamic than commonly appreciated. Physiological fluctuations in extracellular pH provide ample opportunity for protons to influence synaptic signaling. A number of synaptic proteins are modified by extracellular pH. Of these, the acid sensing ion channels (ASICs) are gated by extracellular protons and thus they may be particularly well suited to respond to synaptic pH. Here we review extracellular pH changes that accompany neural activity, the synaptic localization of ASICs, and their known effects on synapse function. Results from manipulating ASICs in mice suggest important roles for synaptic ASICs in behavior and neurological disease.

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Authors and Affiliations

  1. Department of Psychiatry Neuroscience Program and Department of Veterans Affairs Medical Center, Iowa City, IA, USA

    John A. Wemmie

  2. Department of Internal Medicine and Howard Hughes Medical Institute, Iowa City, IA 52242, USA

    Xiang-ming Zha

  3. Departments of Internal Medicine and Molecular Physiology and Howard Hughes Medical Institute, Iowa City, IA 52242, USA

    Michael J. Welsh

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  1. John A. Wemmie
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  2. Xiang-ming Zha
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  3. Michael J. Welsh
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Editors and Affiliations

  1. Department of Pharmacology 2-512 BSB, University of Iowa, Iowa City, IA 52242

    Johannes W. Hell

  2. Department of Neurobiology, Duke University Medical Center, Box 3209, Durham, NC 27710

    Michael D. Ehlers

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Wemmie, J.A., Zha, Xm., Welsh, M.J. (2008). Acid-Sensing Ion Channels (ASICs) and pH in Synapse Physiology. In: Hell, J.W., Ehlers, M.D. (eds) Structural And Functional Organization Of The Synapse. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-77232-5_22

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