Homeostatic synaptic plasticity mechanisms provide a means for neurons and circuitsto maintain stable function in the face of perturbations such as developmental or activitydependent changes in synapse number or strength. These forms of plasticity use negative feedback signaling to adjust synaptic properties to keep activity close to some internal set point value. Recent work suggests that there are likely multiple forms of synaptic homeostasis, mediated by distinct signaling pathways and with distinct expression mechanisms. Both excitatory and inhibitory synapses are subject to homeostatic regulation, and the form of plasticity present at a particular synapse likely depends on its function within a neuronal circuit.


Pyramidal Neuron AMPA Receptor Synaptic Strength Excitatory Synapse Inhibitory Synapse 
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© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Gina Turrigiano
    • 1
  1. 1.Department of Biology and Center for Behavioral GenomicsBrandeis UniversityWalthamUSA

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