Ca2+ Signaling in Dendritic Spines

  • Bernardo L. Sabatini
  • Karel Svoboda


Dendritic spines are neuronal microcompartments that are diffusionally isolated from their parent dendrites and neighboring spines. Optical studies of spine Ca2+ dynamics have revealed the Ca2+ sources and Ca2+ clearance mechanisms under a variety of experimental conditions and in diverse experimental systems. Here we review our understanding of Ca2+ signaling in spines, point out gaps in our knowledge, and discuss the limits of the existing experimental techniques.


NMDA Receptor Pyramidal Neuron Dendritic Spine Cerebellar Purkinje Cell Dorsal Cochlear Nucleus 
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© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Bernardo L. Sabatini
    • 1
  • Karel Svoboda
    • 2
  1. 1.Department of NeurobiologyHarvard Medical SchoolBostonUSA
  2. 2.Janelia Farm Research CampusHHMIAshburnUSA

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