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References

  1. Adam G and Matus A. Role of actin in the organisation of brain postsynaptic densities. Brain Res Mol Brain Res 43: 246–250, 1996.

    PubMed  CAS  Google Scholar 

  2. Ahmed R, Zha XM, Green SH, and Dailey ME. Synaptic activity and F-actin coordinately regulate CaMKIIalpha localization to dendritic postsynaptic sites in developing hippocampal slices. Mol Cell Neurosci 31: 37–51, 2006.

    PubMed  CAS  Google Scholar 

  3. Allison DW, Chervin AS, Gelfand VI, and Craig AM. Postsynaptic scaffolds of excitatory and inhibitory synapses in hippocampal neurons: maintenance of core components independent of actin filaments and microtubules. J Neurosci 20: 4545–4554, 2000.

    PubMed  CAS  Google Scholar 

  4. Allison DW, Gelfand VI, Spector I, and Craig AM. Role of actin in anchoring postsynaptic receptors in cultured hippocampal neurons: differential attachment of NMDA versus AMPA receptors. J Neurosci 18: 2423–2436, 1998.

    PubMed  CAS  Google Scholar 

  5. Ango F, Prezeau L, Muller T, Tu JC, Xiao B, Worley PF, Pin JP, Bockaert J, and Fagni L. Agonist-independent activation of metabotropic glutamate receptors by the intracellular protein Homer. Nature 411: 962–965, 2001.

    PubMed  CAS  Google Scholar 

  6. Apperson ML, Moon I-S, and Kennedy MB. Characterization of densin-180, a new brain-specific synaptic protein of the O-sialoglycoprotein family. J Neurosci 16: 6839– 6852, 1996.

    PubMed  CAS  Google Scholar 

  7. Bagal AA, Kao JP, Tang CM, and Thompson SM. Long-term potentiation of exogenous glutamate responses at single dendritic spines. Proc Natl Acad Sci USA 102: 14434– 14439, 2005.

    PubMed  CAS  Google Scholar 

  8. Baron MK, Boeckers TM, Vaida B, Faham S, Gingery M, Sawaya MR, Salyer D, Gundelfinger ED, and Bowie JU. An architectural framework that may lie at the core of the postsynaptic density. Science 311: 531–535, 2006.

    PubMed  CAS  Google Scholar 

  9. Barry MF and Ziff EB. Receptor trafficking and the plasticity of excitatory synapses. Curr Opin Neurobiol 12: 279–286, 2002.

    PubMed  CAS  Google Scholar 

  10. Baude A, Nusser Z, Roberts JD, Mulvihill E, McIlhinney RA, and Somogyi P. The metabotropic glutamate receptor (mGluR1 alpha) is concentrated at perisynaptic membrane of neuronal subpopulations as detected by immunogold reaction. Neuron 11: 771– 787, 1993.

    PubMed  CAS  Google Scholar 

  11. Bayer KU, De Koninck P, Leonard AS, Hell JW, and Schulman H. Interaction with the NMDA receptor locks CaMKII in an active conformation. Nature 411: 801–805, 2001.

    PubMed  CAS  Google Scholar 

  12. Beique JC, Lin DT, Kang MG, Aizawa H, Takamiya K, and Huganir RL. Synapsespecific regulation of AMPA receptor function by PSD-95. Proc Natl Acad Sci US 103: 19535–19540, 2006.

    CAS  Google Scholar 

  13. Beneken J, Tu JC, Xiao B, Nuriya M, Yuan JP, Worley PF, and Leahy DJ. Structure of the Homer EVH1 domain-peptide complex reveals a new twist in polyproline recognition. Neuron 26: 143–154, 2000.

    PubMed  CAS  Google Scholar 

  14. Bennett MK, Erondu NE, and Kennedy MB. Purification and characterization of a calmodulin-dependent protein kinase that is highly concentrated in brain. J Biol Chem 258: 12735–12744, 1983.

    PubMed  CAS  Google Scholar 

  15. Bennett MK and Kennedy MB. Deduced primary structure of the β subunit of brain type II Ca2+/calmodulin-dependent protein kinase determined by molecular cloning. Proc Natl Acad Sci USA 84: 1794–1798, 1987.

    PubMed  CAS  Google Scholar 

  16. Bliss TVP and Collingridge GL. A synaptic model of memory: long-term potentiation in the hippocampus. Nature 361: 31–39, 1993.

    PubMed  CAS  Google Scholar 

  17. Bloch RJ. Actin at receptor-rich domains of isolated acetylcholine receptor clusters. J Cell Biol 102: 1447–1458, 1986.

    PubMed  CAS  Google Scholar 

  18. Bockers TM, Mameza MG, Kreutz MR, Bockmann J, Weise C, Buck F, Richter D, Gundelfinger ED, and Kreienkamp HJ. Synaptic scaffolding proteins in rat brain. Ankyrin repeats of the multidomain Shank protein family interact with the cytoskeletal protein alpha-fodrin. J Biol Chem 276: 40104–40112, 2001.

    PubMed  CAS  Google Scholar 

  19. Boeckers TM, Bockmann J, Kreutz MR, and Gundelfinger ED. ProSAP/Shank proteins – a family of higher order organizing molecules of the postsynaptic density with an emerging role in human neurological disease. J Neurochem 81: 903–910, 2002.

    PubMed  CAS  Google Scholar 

  20. Boeckers TM, Kreutz MR, Winter C, Zuschratter W, Smalla KH, Sanmarti-Vila L, Wex H, Langnaese K, Bockmann J, Garner CC, and Gundelfinger ED. Proline-rich synapseassociated protein-1/cortactin binding protein 1 (ProSAP1/CortBP1) is a PDZ-domain protein highly enriched in the postsynaptic density. J Neurosci 19: 6506–6518, 1999.

    PubMed  CAS  Google Scholar 

  21. Boeckers TM, Winter C, Smalla KH, Kreutz MR, Bockmann J, Seidenbecher C, Garner CC, and Gundelfinger ED. Proline-rich synapse-associated proteins ProSAP1 and ProSAP2 interact with synaptic proteins of the SAPAP/GKAP family. Biochem Biophys Res Commun 264: 247–252, 1999.

    PubMed  CAS  Google Scholar 

  22. Bortolotto ZA, Fitzjohn SM, and Collingridge GL. Roles of metabotropic glutamate receptors in LTP and LTD in the hippocampus. Curr Opin Neurobiol 9: 299–304, 1999.

    PubMed  CAS  Google Scholar 

  23. Braithwaite SP, Xia H, and Malenka RC. Differential roles for NSF and GRIP/ABP in AMPA receptor cycling. Proc Natl Acad Sci USA 99: 7096–7101, 2002.

    PubMed  CAS  Google Scholar 

  24. Brakeman PR, Lanahan AA, O’Brien R, Roche K, Barnes CA, Huganir RL, and Worley PF. Homer: a protein that selectively binds metabotropic glutamate receptors. Nature 386: 284–288, 1997.

    PubMed  CAS  Google Scholar 

  25. Brambilla R, Gnesutta N, Minichiello L, White G, Roylance AJ, Herron CE, Ramsey M, Wolfer DP, Cestari V, Rossi -A, C., Grant SGN, Chapman PF, Lipp H-P, Sturani E, and Klein R. A role for the Ras signalling pathway in synaptic transmission and long-term memory. Nature 390: 281–286, 1997.

    PubMed  CAS  Google Scholar 

  26. Bredt DS and Nicoll RA. AMPA receptor trafficking at excitatory synapses. Neuron 40: 361–379, 2003.

    PubMed  CAS  Google Scholar 

  27. Brenman JE, Chao DS, Gee SH, McGee AW, Craven SE, Santillano DR, Wu Z, Huang F, Xia H, Peters MF, Froehner SC, and Bredt DS. Interaction of nitric-oxide synthase with the postsynaptic density protein PSD-95 and a-1-syntrophin mediated by PDZ domains. Cell 84: 757–767, 1996.

    PubMed  CAS  Google Scholar 

  28. Brenman JE, Christopherson KS, Craven SE, McGee AW, and Bredt DS. Cloning and characterization of postsynaptic density-93, a nitric oxide synthase interacting protein. J Neurosci 16: 7407–7415, 1996.

    PubMed  CAS  Google Scholar 

  29. Bulleit RF, Bennett MK, Molloy SS, Hurley JB, and Kennedy MB. Conserved and variable regions in the subunits of brain type II Ca2+/calmodulin-dependent protein kinase. Neuron 1: 63–72, 1988.

    PubMed  CAS  Google Scholar 

  30. Burgin KE, Waxham MN, Rickling S, Westgate SA, Mobley WC, and Kelly PT. In situ hybridization histochemistry of Ca 2+ calmodulin-dependent protein kinase in developing rat brain. J Neurosci 10: 1788–1798, 1990.

    PubMed  CAS  Google Scholar 

  31. Burkhardt C, Muller M, Badde A, Garner CC, Gundelfinger ED, and Puschel AW. Semaphorin 4B interacts with the post-synaptic density protein PSD-95/SAP90 and is recruited to synapses through a C-terminal PDZ-binding motif. FEBS Lett 579: 3821– 3828, 2005.

    PubMed  CAS  Google Scholar 

  32. Camera P, da Silva JS, Griffiths G, Giuffrida MG, Ferrara L, Schubert V, Imarisio S, Silengo L, Dotti CG, and Di Cunto F. Citron-N is a neuronal Rho-associated protein involved in Golgi organization through actin cytoskeleton regulation. Nat Cell Biol 5: 1071–1078, 2003.

    PubMed  CAS  Google Scholar 

  33. Carlin RK, Bartelt D, and Siekevitz P. Identification of fodrin as a major calmodulinbinding protein in postsynaptic density preparations. J Cell Biol 96: 443–448, 1983.

    PubMed  CAS  Google Scholar 

  34. Carlisle HJ and Kennedy MB. Spine Architecture and Synaptic Plasticity. Trends in Neurosci 28: 182–187, 2005.

    CAS  Google Scholar 

  35. Chen H-J, Rojas-Soto M, Oguni A, and Kennedy MB. A synaptic Ras-GTPase activating protein (p135 SynGAP) inhibited by CaM Kinase II. Neuron 20: 895–904, 1998.

    PubMed  CAS  Google Scholar 

  36. Chen L, Chetkovich DM, Petralia RS, Sweeney NT, Kawasaki Y, Wenthold RJ, Bredt DS, and Nicoll RA. Stargazin regulates synaptic targeting of AMPA receptors by two distinct mechanisms. Nature 408: 936–943., 2000.

    PubMed  CAS  Google Scholar 

  37. Cho K-O, Hunt CA, and Kennedy MB. The rat brain postsynaptic density fraction contains a homolog of the Drosophila discs-large tumor suppressor protein. Neuron 9: 929– 942, 1992.

    PubMed  CAS  Google Scholar 

  38. Christopherson KS, Hillier BJ, Lim WA, and Bredt DS. PSD-95 assembles a ternary complex with the N-methyl-D-aspartic acid receptor and a bivalent neuronal NO synthase PDZ domain. J Biol Chem 274: 27467–27473, 1999.

    PubMed  CAS  Google Scholar 

  39. Chung HJ, Xia J, Scannevin RH, Zhang X, and Huganir RL. Phosphorylation of the AMPA receptor subunit GluR2 differentially regulates its interaction with PDZ domaincontaining proteins. J Neurosci 20: 7258–7267, 2000.

    PubMed  CAS  Google Scholar 

  40. Cohen RS, Blomberg F, Berzins K, and Siekevitz P. The structure of postsynaptic densities isolated from dog cerebral cortex I. overall morphology and protein composition. J Cell Biol 74: 181–203, 1977.

    PubMed  CAS  Google Scholar 

  41. Colledge M, Dean RA, Scott GK, Langeberg LK, Huganir RL, and Scott JD. Targeting of PKA to glutamate receptors through a MAGUK-AKAP complex. Neuron 27: 107–119, 2000.

    PubMed  CAS  Google Scholar 

  42. Cotman CW, Banker B, Churchill L, and Taylor D. Isolation of postsynaptic densities from rat brain. J Cell Biol 63: 441–455, 1974.

    PubMed  CAS  Google Scholar 

  43. Cummings JA, Mulkey RM, Nicoll RA, and Malenka RC. Ca2+ signaling requirements for long-term depression in the hippocampus. Neuron 16: 825–833, 1996.

    PubMed  CAS  Google Scholar 

  44. Czogalla A and Sikorski AF. Spectrin and calpain: a ’target’ and a ’sniper’ in the pathology of neuronal cells. Cell Mol Life Sci 62: 1913–1924, 2005.

    PubMed  CAS  Google Scholar 

  45. Dalva MB, Takasu MA, Lin MZ, Shamah SM, Hu L, Gale NW, and Greenberg ME. EphB receptors interact with NMDA receptors and regulate excitatory synapse formation. Cell 103: 945–956, 2000.

    PubMed  CAS  Google Scholar 

  46. Daly RJ. Cortactin signalling and dynamic actin networks. Biochem J 382: 13–25, 2004.

    PubMed  CAS  Google Scholar 

  47. Daw MI, Chittajallu R, Bortolotto ZA, Dev KK, Duprat F, Henley JM, Collingridge GL, and Isaac JT. PDZ proteins interacting with C-terminal GluR2/3 are involved in a PKCdependent regulation of AMPA receptors at hippocampal synapses. Neuron 28: 873–886, 2000.

    PubMed  CAS  Google Scholar 

  48. DeSouza S, Fu J, States BA, and Ziff EB. Differential palmitoylation directs the AMPA receptor-binding protein ABP to spines or to intracellular clusters. J Neurosci 22: 3493–3503, 2002.

    PubMed  CAS  Google Scholar 

  49. Dev KK, Nishimune A, Henley JM, and Nakanishi S. The protein kinase C alpha binding protein PICK1 interacts with short but not long form alternative splice variants of AMPA receptor subunits. Neuropharmacology 38: 635–644, 1999.

    PubMed  CAS  Google Scholar 

  50. Dingledine R, Borges K, Bowie D, and Traynelis SF. The glutamate receptor ion channels. Pharmacol Rev 51: 7–61, 1999.

    PubMed  CAS  Google Scholar 

  51. Dong H, O’Brien RJ, Fung ET, Lanahan AA, Worley PF, and Huganir RL. GRIP: a synaptic PDZ domain-containing protein that interacts with AMPA receptors [see comments]. Nature 386: 279–284, 1997.

    PubMed  CAS  Google Scholar 

  52. Dong H, Zhang P, Song I, Petralia RS, Liao D, and Huganir RL. Characterization of the glutamate receptor-interacting proteins GRIP1 and GRIP2. J Neurosci 19: 6930–6941, 1999.

    PubMed  CAS  Google Scholar 

  53. Dosemeci A, Tao-Cheng JH, Vinade L, Winters CA, Pozzo-Miller L, and Reese TS. Glutamate-induced transient modification of the postsynaptic density. Proc Natl Acad Sci USA 98: 10428–10432, 2001.

    PubMed  CAS  Google Scholar 

  54. Du Y, Weed SA, Xiong WC, Marshall TD, and Parsons JT. Identification of a novel cortactin SH3 domain-binding protein and its localization to growth cones of cultured neurons. Mol Cell Biol 18: 5838–5851, 1998.

    PubMed  CAS  Google Scholar 

  55. Dunah AW, Wyszynski M, Martin DM, Sheng M, and Standaert DG. alpha-actinin-2 in rat striatum: localization and interaction with NMDA glutamate receptor subunits. Brain Res Mol Brain Res 79: 77–87, 2000.

    PubMed  CAS  Google Scholar 

  56. Ehlers MD. Synapse structure: glutamate receptors connected by the shanks. Curr Biol 9: R848–850, 1999.

    PubMed  CAS  Google Scholar 

  57. Ehrlich I and Malinow R. Postsynaptic density 95 controls AMPA receptor incorporation during long-term potentiation and experience-driven synaptic plasticity. J Neurosci 24: 916–927, 2004.

    PubMed  CAS  Google Scholar 

  58. El-Husseini Ael D, Schnell E, Dakoji S, Sweeney N, Zhou Q, Prange O, Gauthier- Campbell C, Aguilera-Moreno A, Nicoll RA, and Bredt DS. Synaptic strength regulated by palmitate cycling on PSD-95. Cell 108: 849–863, 2002.

    Google Scholar 

  59. Elias GM, Funke L, Stein V, Grant SG, Bredt DS, and Nicoll RA. Synapse-specific and developmentally regulated targeting of AMPA receptors by a family of MAGUK scaffolding proteins. Neuron 52: 307–320, 2006.

    PubMed  CAS  Google Scholar 

  60. Erondu NE and Kennedy MB. Regional distribution of type II Ca2+/calmodulindependent protein kinase in rat brain. J Neurosci 5: 3270–3277, 1985.

    PubMed  CAS  Google Scholar 

  61. Fagni L, Worley PF, and Ango F. Homer as both a scaffold and transduction molecule. Sci STKE 2002: RE8, 2002.

    Article  PubMed  Google Scholar 

  62. Farnsworth CL, Freshney NW, Rosen LB, Ghosh A, Greenberg ME, and Feig LA. Calcium activation of Ras mediated by neuronal exchange factor Ras-GRF. Nature 376: 524–527, 1995.

    PubMed  CAS  Google Scholar 

  63. Fifkova E and Delay RJ. Cytoplasmic actin in neuronal processes as a possible mediator of synaptic plasticity. J Cell Biol 95: 345–350, 1982.

    PubMed  CAS  Google Scholar 

  64. Franks KM, Keller DX, Bartol TMJ, and Sejnowski TJ. Subcellular spatial compartmentalization of calcium sources within a dendritic spine. submitted for publication, 2006.

    Google Scholar 

  65. Franks KM and Sejnowski TJ. Complexity of calcium signaling in synaptic spines. Bioessays 24: 1130–1144, 2002.

    PubMed  CAS  Google Scholar 

  66. Fu J, deSouza S, and Ziff EB. Intracellular membrane targeting and suppression of Ser880 phosphorylation of glutamate receptor 2 by the linker I-set II domain of AMPA receptor-binding protein. J Neurosci 23: 7592–7601, 2003.

    PubMed  CAS  Google Scholar 

  67. Fukata Y, Tzingounis AV, Trinidad JC, Fukata M, Burlingame AL, Nicoll RA, and Bredt DS. Molecular constituents of neuronal AMPA receptors. J Cell Biol 169: 399– 404, 2005.

    PubMed  CAS  Google Scholar 

  68. Furuyashiki T, Fujisawa K, Fujita A, Madaule P, Uchino S, Mishina M, Bito H, and Narumiya S. Citron, a rho-target, interacts with PSD-95/SAP-90 at glutamatergic synapses in the thalamus. J Neurosci 19: 109–118, 1999.

    PubMed  CAS  Google Scholar 

  69. Futai K, Kim MJ, Hashikawa T, Scheiffele P, Sheng M, and Hayashi Y. Retrograde modulation of presynaptic release probability through signaling mediated by PSD-95- neuroligin. Nat Neurosci 10: 186–195, 2007.

    PubMed  CAS  Google Scholar 

  70. Garcia EP, Mehta S, Blair LA, Wells DG, Shang J, Fukushima T, Fallon JR, Garner CC, and Marshall J. SAP90 binds and clusters kainate receptors causing incomplete desensitization. Neuron 21: 727–739, 1998.

    PubMed  CAS  Google Scholar 

  71. Garcia RA, Vasudevan K, and Buonanno A. The neuregulin receptor ErbB-4 interacts with PDZ-containing proteins at neuronal synapses. Proc Natl Acad Sci USA 97: 3596– 3601, 2000.

    PubMed  CAS  Google Scholar 

  72. Gardoni F, Bellone C, Cattabeni F, and Di Luca M. Protein kinase C activation modulates alpha-calmodulin kinase II binding to NR2A subunit of N-methyl-D-aspartate receptor complex. J Biol Chem 276: 7609–7613, 2001.

    PubMed  CAS  Google Scholar 

  73. Gardoni F, Caputi A, Cimino M, Pastorino L, Cattabeni F, and Di Luca M. Calcium/ calmodulin-dependent protein kinase II is associated with NR2A/B subunits of NMDA receptor in postsynaptic densities. J Neurochem 71: 1733–1741, 1998.

    PubMed  CAS  Google Scholar 

  74. Gardoni F, Schrama LH, van Dalen JJ, Gispen WH, Cattabeni F, and Di Luca M. AlphaCaMKII binding to the C-terminal tail of NMDA receptor subunit NR2A and its modulation by autophosphorylation. FEBS Lett 456: 394–398, 1999.

    PubMed  CAS  Google Scholar 

  75. Giese KP, Friedman E, Telliez JB, Fedorov NB, Wines M, Feig LA, and Silva AJ. Hippocampus- dependent learning and memory is impaired in mice lacking the Ras-guaninenucleotide releasing factor 1 (Ras-GRF1). Neuropharmacology 41: 791–800, 2001.

    PubMed  CAS  Google Scholar 

  76. Gleason MR, Higashijima S, Dallman J, Liu K, Mandel G, and Fetcho JR. Translocation of CaM kinase II to synaptic sites in vivo. Nat Neurosci 6: 217–218, 2003.

    PubMed  CAS  Google Scholar 

  77. Goodman SR, Zimmer WE, Clark MB, Zagon IS, Barker JE, and Bloom ML. Brain spectrin: of mice and men. Brain Res Bull 36: 593–606, 1995.

    PubMed  CAS  Google Scholar 

  78. Gray NW, Weimer RM, Bureau I, and Svoboda K. Rapid redistribution of synaptic PSD- 95 in the neocortex in vivo. PLoS Biol 4: e370, 2006.

    PubMed  Google Scholar 

  79. Hanson PI, Meyer T, Stryer L, and Schulman H. Dual role of calmodulin in autophosphorylation of multifunctional CaM kinase may underlie decoding of calcium signals. Neuron 12: 943–956, 1994.

    PubMed  CAS  Google Scholar 

  80. Hardingham GE, Arnold FJ, and Bading H. A calcium microdomain near NMDA receptors: on switch for ERK-dependent synapse-to-nucleus communication. Nat Neurosci 4: 565–566, 2001.

    PubMed  CAS  Google Scholar 

  81. Hayashi MK, Ames HM, and Hayashi Y. Tetrameric hub structure of postsynaptic scaffolding protein homer. J Neurosci 26: 8492–8501, 2006.

    PubMed  CAS  Google Scholar 

  82. Hayashi Y, Shi SH, Esteban JA, Piccini A, Poncer JC, and Malinow R. Driving AMPA receptors into synapses by LTP and CaMKII: requirement for GluR1 and PDZ domain interaction. Science 287: 2262–2267, 2000.

    PubMed  CAS  Google Scholar 

  83. Heidinger V, Manzerra P, Wang XQ, Strasser U, Yu S-P, Choi DW, and Behrens MM. Metabotropic glutamate receptor 1-induced upregulation of NMDA receptor current: mediation through the Pyk2/Src-family kinase pathway in cortical neurons. J Neurosci 22: 5452–5461, 2002.

    PubMed  CAS  Google Scholar 

  84. Hering H and Sheng M. Activity-dependent redistribution and essential role of cortactin in dendritic spine morphogenesis. J Neurosci 23: 11759–11769, 2003.

    PubMed  CAS  Google Scholar 

  85. Hirbec H, Francis JC, Lauri SE, Braithwaite SP, Coussen F, Mulle C, Dev KK, Coutinho V, Meyer G, Isaac JT, Collingridge GL, and Henley JM. Rapid and differential regulation of AMPA and kainate receptors at hippocampal mossy fibre synapses by PICK1 and GRIP. Neuron 37: 625–638, 2003.

    PubMed  CAS  Google Scholar 

  86. Hollmann M and Heinemann S. Cloned glutamate receptors. Annu Rev Neurosci 17: 31–108, 1994.

    PubMed  CAS  Google Scholar 

  87. Hoogenraad CC, Milstein AD, Ethell IM, Henkemeyer M, and Sheng M. GRIP1 controls dendrite morphogenesis by regulating EphB receptor trafficking. Nat Neurosci 8: 906– 915, 2005.

    PubMed  CAS  Google Scholar 

  88. Huang YZ, Won S, Ali DW, Wang Q, Tanowitz M, Du QS, Pelkey KA, Yang DJ, Xiong WC, Salter MW, and Mei L. Regulation of neuregulin signaling by PSD-95 interacting with ErbB4 at CNS synapses. Neuron 26: 443–455, 2000.

    PubMed  CAS  Google Scholar 

  89. Husi H, Ward MA, Choudhary JS, Blackstock WP, and Grant SGN. Proteomic analysis of NMDA receptor-adhesion protein signaling complexes. Nat Neurosci 3: 661–669, 2000.

    PubMed  CAS  Google Scholar 

  90. Im YJ, Lee JH, Park SH, Park SJ, Rho SH, Kang GB, Kim E, and Eom SH. Crystal structure of the Shank PDZ-ligand complex reveals a class I PDZ interaction and a novel PDZ-PDZ dimerization. J Biol Chem 278: 48099–48104, 2003.

    PubMed  CAS  Google Scholar 

  91. Irie M, Hata Y, Takeuchi M, Ichtchenko A, Toyoda A, Hirao K, Takai Y, Rosahl TW, and Sudhof TC. Binding of neuroligins to PSD-95. Science 277: 1511–1515, 1997.

    PubMed  CAS  Google Scholar 

  92. Isaac JTR, Nicoll RA, and Malenka RC. Evidence for silent synapses – implications for the expression of LTP. Neuron 15: 427–434, 1995.

    PubMed  CAS  Google Scholar 

  93. Kalia LV, Pitcher GM, Pelkey KA, and Salter MW. PSD-95 is a negative regulator of the tyrosine kinase Src in the NMDA receptor complex. EMBO J 25: 4971–4982, 2006.

    PubMed  CAS  Google Scholar 

  94. Kalia LV and Salter MW. Interactions between Src family protein tyrosine kinases and PSD-95. Neuropharmacology 45: 720–728, 2003.

    PubMed  CAS  Google Scholar 

  95. Kato A, Ozawa F, Saitoh Y, Fukazawa Y, Sugiyama H, and Inokuchi K. Novel members of the Vesl/Homer family of PDZ proteins that bind metabotropic glutamate receptors. J Biol Chem 273: 23969–23975, 1998.

    PubMed  CAS  Google Scholar 

  96. Kato A, Ozawa F, Saitoh Y, Hirai K, and Inokuchi K. vesl, a gene encoding VASP/Ena family related protein, is upregulated during seizure, long-term potentiation and synaptogenesis. FEBS Lett 412: 183–189, 1997.

    PubMed  CAS  Google Scholar 

  97. Kennedy MB. Signal-processing machines at the postsynaptic density. Science 290: 750– 754, 2000.

    PubMed  CAS  Google Scholar 

  98. Kennedy MB. The postsynaptic density at glutamatergic synapses. Trends Neurosci 20: 264–268, 1997.

    PubMed  CAS  Google Scholar 

  99. Kennedy MB, Beale HC, Carlisle HJ, and Washburn LR. Integration of biochemical signalling in spines. Nat Rev Neurosci 6: 423–434, 2005.

    PubMed  CAS  Google Scholar 

  100. Kennedy MB, Bennett MK, Bulleit RF, Erondu NE, Jennings VR, Miller SM, Molloy SS, Patton BL, and Schenker LJ. Structure and regulation of type II calcium/calmodulindependent protein kinase in central nervous system neurons. Cold Spring Harb Symp Quant Biol 55: 101–110, 1990.

    PubMed  CAS  Google Scholar 

  101. Kennedy MB, Bennett MK, and Erondu NE. Biochemical and immunochemical evidence that the "major postsynaptic density protein" is a subunit of a calmodulindependent protein kinase. Proc Natl Acad Sci USA 80: 7357–7361, 1983.

    PubMed  CAS  Google Scholar 

  102. Kim CH, Chung HJ, Lee HK, and Huganir RL. Interaction of the AMPA receptor subunit GluR2/3 with PDZ domains regulates hippocampal long-term depression. Proc Natl Acad Sci USA 98: 11725–11730, 2001.

    PubMed  CAS  Google Scholar 

  103. Kim E, Cho KO, Rothschild A, and Sheng M. Heteromultimerization and NMDA receptor- clustering activity of chapsyn-110, a member of the PSD-95 family of proteins. Neuron 17: 103–113, 1996.

    PubMed  CAS  Google Scholar 

  104. Kim E, Naisbitt S, Hsueh YP, Rao. A, Rothschild A, Craig AM, and Sheng M. GKAP, a novel synaptic protein that interacts with the guanylate kinase-like domain of the PSD- 95/SAP90 family of channel clustering molecules. J Cell Biol 136: 669–678, 1997.

    PubMed  CAS  Google Scholar 

  105. Kim E, Niethammer M, Rothschild A, Jan YN, and Sheng M. Clustering of shaker-type K+ channels by interaction with a family of membrane-associated guanylate kinases. Nature 378: 85–88, 1995.

    PubMed  CAS  Google Scholar 

  106. Kim E and Sheng M. PDZ domain proteins of synapses. Nat Rev Neurosci 5: 771–781, 2004.

    PubMed  CAS  Google Scholar 

  107. Kim JH, Liao D, Lau L-F, and Huganir RL. SynGAP: a synaptic RasGAP that associates with the PSD-95/SAP90 protein family. Neuron 20: 683–691, 1998.

    PubMed  CAS  Google Scholar 

  108. Kistner U, Garner CC, and Linial M. Nucleotide-binding by the synapse associated protein sap90. FEBS Lett 359: 159–163, 1995.

    PubMed  CAS  Google Scholar 

  109. Kistner U, Wenzel BM, Veh RW, Cases-Langhoff C, Garner AM, Appeltauer U, Voss B, Gundelfinger ED, and Garner CC. SAP90, a rat presynaptic protein related to the product of the Drosophila tumor suppressor gene dlg-A. J Biol Chem 268: 4580–4583, 1993.

    PubMed  CAS  Google Scholar 

  110. Knuesel I, Elliott A, Chen HJ, Mansuy IM, and Kennedy MB. A role for synGAP in regulating neuronal apoptosis. Eur J Neurosci 21: 611–621, 2005.

    PubMed  Google Scholar 

  111. Komiyama NH, Watabe AM, Carlisle HJ, Porter K, Charlesworth P, Monti J, Strathdee DJ, O’Carroll CM, Martin SJ, Morris RG, O’Dell TJ, and Grant SG. SynGAP regulates ERK/MAPK signaling, synaptic plasticity, and learning in the complex with postsynaptic density 95 and NMDA receptor. J Neurosci 22: 9721–9732, 2002.

    PubMed  CAS  Google Scholar 

  112. Korkin D, Davis FP, Alber F, Luong T, Shen MY, Lucic V, Kennedy MB, and Sali A. Structural modeling of protein interactions by analogy: application to PSD-95. PLoS Comput Biol 2: e153, 2006.

    PubMed  Google Scholar 

  113. Kornau H-C, Schenker LT, Kennedy MB, and Seeburg PH. Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95. Science 269: 1737–1740, 1995.

    PubMed  CAS  Google Scholar 

  114. Kornau H-C, Seeburg PH, and Kennedy MB. Interaction of ion channels and receptors with PDZ domain proteins. Curr Opin Neurobiol 7: 368–373, 1997.

    PubMed  CAS  Google Scholar 

  115. Krapivinsky G, Krapivinsky L, Manasian Y, Ivanov A, Tyzio R, Pellegrino C, Ben-Ari Y, Clapham DE, and Medina I. The NMDA receptor is coupled to the ERK pathway by a direct interaction between NR2B and RasGRF1. Neuron 40: 775–784, 2003.

    PubMed  CAS  Google Scholar 

  116. Krapivinsky G, Medina I, Krapivinsky L, Gapon S, and Clapham DE. SynGAP-MUPP1- CaMKII synaptic complexes regulate p38 MAP kinase activity and NMDA receptordependent synaptic AMPA receptor potentiation. Neuron 43: 563–574, 2004.

    PubMed  CAS  Google Scholar 

  117. Krupp JJ, Vissel B, Thomas CG, Heinemann SF, and Westbrook GL. Interactions of calmodulin and alpha-actinin with the NR1 subunit modulate Ca2+-dependent inactivation of NMDA receptors. J Neurosci 19: 1165–1178, 1999.

    PubMed  CAS  Google Scholar 

  118. Landis DMD and Reese TS. Cytoplasmic organization in cerebellar dendritic spines. J Cell Biol 97: 1169–1178, 1983.

    PubMed  CAS  Google Scholar 

  119. Lau LF, Mammen A, Ehlers MD, Kindler S, Chung WJ, Garner CC, and Huganir RL. Interaction of the N-methyl-D-aspartate receptor complex with a novel synapseassociated protein, sap102. J Biol Chem 271: 21622–21628, 1996.

    PubMed  CAS  Google Scholar 

  120. Lee SH, Liu L, Wang YT, and Sheng M. Clathrin adaptor AP2 and NSF interact with overlapping sites of GluR2 and play distinct roles in AMPA receptor trafficking and hippocampal LTD. Neuron 36: 661–674, 2002.

    PubMed  CAS  Google Scholar 

  121. Leonard AS, Bayer KU, Merrill MA, Lim IA, Shea MA, Schulman H, and Hell JW. Regulation of calcium/calmodulin-dependent protein kinase II docking to N-methyl-Daspartate receptors by calcium/calmodulin and alpha-actinin. J Biol Chem 277: 48441– 48448, 2002.

    PubMed  CAS  Google Scholar 

  122. Leonard AS, Davare MA, Horne MC, Garner CC, and Hell JW. SAP97 is associated with the alpha-amino-3-hydroxy-5-methylisoxazole-4- propionic acid receptor GluR1 subunit. J Biol Chem 273: 19518–19524, 1998.

    PubMed  CAS  Google Scholar 

  123. Leonard AS, Lim IA, Hemsworth DE, Horne MC, and Hell JW. Calcium/calmodulindependent protein kinase II is associated with the N- methyl-D-aspartate receptor. Proc Natl Acad Sci USA 96: 3239–3244, 1999.

    PubMed  CAS  Google Scholar 

  124. Letts VA, Felix R, Biddlecome GH, Arikkath J, Mahaffey CL, Valenzuela A, Bartlett FS, II, Mori Y, Campbell KP, and Frankel WN. The mouse stargazer gene encodes a neuronal Ca2+-channel gamma subunit. Nat Genet 19: 340–347, 1998.

    PubMed  CAS  Google Scholar 

  125. LeVine H and Sahyoun NE. Involvement of fodrin-binding proteins in the structure of the neuronal postsynaptic density and regulation by phosphorylation. Biochem Biophys Res Commun 138: 59–65, 1986.

    PubMed  CAS  Google Scholar 

  126. Li K, Hornshaw MP, van Minnen J, Smalla KH, Gundelfinger ED, and Smit AB. Organelle proteomics of rat synaptic proteins: correlation-profiling by isotope-coded affinity tagging in conjunction with liquid chromatography-tandem mass spectrometry to reveal post-synaptic density specific proteins. J Proteome Res 4: 725–733, 2005.

    PubMed  CAS  Google Scholar 

  127. Li KW, Hornshaw MP, Van Der Schors RC, Watson R, Tate S, Casetta B, Jimenez CR, Gouwenberg Y, Gundelfinger ED, Smalla KH, and Smit AB. Proteomics analysis of rat brain postsynaptic density. Implications of the diverse protein functional groups for the integration of synaptic physiology. J Biol Chem 279: 987–1002, 2004.

    PubMed  CAS  Google Scholar 

  128. Liao DZ, Hessler NA, and Malinow R. Activation of postsynaptically silent synapses during pairing-induced LTP in CA1 region of hippocampal slice. Nature 375: 400–404, 1995.

    PubMed  CAS  Google Scholar 

  129. Lim S, Naisbitt S, Yoon J, Hwang JI, Suh PG, Sheng M, and Kim E. Characterization of the Shank family of synaptic proteins. Multiple genes, alternative splicing, and differential expression in brain and development. J Biol Chem 274: 29510–29518, 1999.

    PubMed  CAS  Google Scholar 

  130. Lim S, Sala C, Yoon J, Park S, Kuroda S, Sheng M, and Kim E. Sharpin, a novel postsynaptic density protein that directly interacts with the shank family of proteins. Mol Cell Neurosci 17: 385–397, 2001.

    PubMed  CAS  Google Scholar 

  131. Lin Y, Jover-Mengual T, Wong J, Bennett MV, and Zukin RS. PSD-95 and PKC converge in regulating NMDA receptor trafficking and gating. Proc Natl Acad Sci USA 103: 19902–19907, 2006.

    PubMed  CAS  Google Scholar 

  132. Lisman J, Schulman H, and Cline H. The molecular basis of CaMKII function in synaptic and behavioural memory. Nat Rev Neurosci 3: 175–190, 2002.

    PubMed  CAS  Google Scholar 

  133. Lu W and Ziff EB. PICK1 interacts with ABP/GRIP to regulate AMPA receptor trafficking. Neuron 47: 407–421, 2005.

    PubMed  CAS  Google Scholar 

  134. Lue RA, Marfatia SM, Branton D, and Chishti AH. Cloning and characterization of hdlg – the human homolog of the drosophila disks large tumor-suppressor binds to protein- 4.1. Proc Natl Acad Sci USA 91: 9818–9822, 1994.

    PubMed  CAS  Google Scholar 

  135. Lujan R, Roberts JD, Shigemoto R, Ohishi H, and Somogyi P. Differential plasma membrane distribution of metabotropic glutamate receptors mGluR1 alpha, mGluR2 and mGluR5, relative to neurotransmitter release sites. J Chem Neuroanat 13: 219–241, 1997.

    PubMed  CAS  Google Scholar 

  136. Luscher C, Xia H, Beattie EC, Carroll RC, von Zastrow M, Malenka RC, and Nicoll RA. Role of AMPA receptor cycling in synaptic transmission and plasticity. Neuron 24: 649– 658, 1999.

    PubMed  CAS  Google Scholar 

  137. Lyons-Warren A, Chang JJ, Balkissoon R, Kamiya A, Garant M, Nurnberger J, Scheftner W, Reich T, McMahon F, Kelsoe J, Gershon E, Coryell W, Byerley W, Berrettini W, Depaulo R, McInnis M, and Sawa A. Evidence of association between bipolar disorder and Citron on chromosome 12q24. Mol Psychiatry 10: 807–809, 2005.

    PubMed  CAS  Google Scholar 

  138. Ma XM, Huang J, Wang Y, Eipper BA, and Mains RE. Kalirin, a multifunctional Rho guanine nucleotide exchange factor, is necessary for maintenance of hippocampal pyramidal neuron dendrites and dendritic spines. J Neurosci 23: 10593–10603, 2003.

    PubMed  CAS  Google Scholar 

  139. Malenka RC and Bear MF. LTP and LTD: an embarrassment of riches. Neuron 44: 5– 21, 2004.

    Google Scholar 

  140. Malinow R. AMPA receptor trafficking and long-term potentiation. Philos Trans R Soc Lond B Biol Sci 358: 707–714, 2003.

    PubMed  CAS  Google Scholar 

  141. Malinow R and Malenka RC. AMPA receptor trafficking and synaptic plasticity. Annu Rev Neurosci 25: 103–126, 2002.

    PubMed  CAS  Google Scholar 

  142. Marchesi VT and Steers E, Jr. Selective solubilization of a protein component of the red cell membrane. Science 159: 203–204, 1968.

    PubMed  CAS  Google Scholar 

  143. Markham JA and Fifkova E. Actin filament organization within dendrites and dendritic spines during development. Brain Res 392: 263–269, 1986.

    PubMed  CAS  Google Scholar 

  144. Matsuda S, Mikawa S, and Hirai H. Phosphorylation of serine-880 in GluR2 by protein kinase C prevents its C terminus from binding with glutamate receptor-interacting protein. J Neurochem 73: 1765–1768, 1999.

    PubMed  CAS  Google Scholar 

  145. Matsuzaki M, Honkura N, Ellis-Davies GC, and Kasai H. Structural basis of long-term potentiation in single dendritic spines. Nature 429: 761–766, 2004.

    PubMed  CAS  Google Scholar 

  146. Matus A. Actin-based plasticity in dendritic spines. Science 290: 754–758., 2000.

    PubMed  CAS  Google Scholar 

  147. Mayer ML. Glutamate receptor ion channels. Curr Opin Neurobiol 15: 282–288, 2005.

    PubMed  CAS  Google Scholar 

  148. Mayer ML and Armstrong N. Structure and function of glutamate receptor ion channels. Annu Rev Physiol 66: 161–181, 2004.

    PubMed  CAS  Google Scholar 

  149. McGee AW and Bredt DS. Identification of an intramolecular interaction between the SH3 and guanylate kinase domains of PSD-95. J Biol Chem 274: 17431–17436, 1999.

    PubMed  CAS  Google Scholar 

  150. McGee AW, Dakoji SR, Olsen O, Bredt DS, Lim WA, and Prehoda KE. Structure of the SH3-guanylate kinase module from PSD-95 suggests a mechanism for regulated assembly of MAGUK scaffolding proteins. Mol Cell 8: 1291–1301, 2001.

    PubMed  CAS  Google Scholar 

  151. Mehta S, Wu H, Garner CC, and Marshall J. Molecular mechanisms regulating the differential association of kainate receptor subunits with SAP90/PSD-95 and SAP97. J Biol Chem 276: 16092–16099, 2001.

    PubMed  CAS  Google Scholar 

  152. Merrill MA, Chen Y, Strack S, and Hell JW. Activity-driven postsynaptic translocation of CaMKII. Trends Pharmacol Sci 26: 645–653, 2005.

    PubMed  CAS  Google Scholar 

  153. Meyer RK and Aebi U. Bundling of actin filaments by alpha-actinin depends on its molecular length. J Cell Biol 110: 2013–2024, 1990.

    PubMed  CAS  Google Scholar 

  154. Migaud M, Charlesworth P, Dempster M, Webster LC, Watabe AM, Makhinson M, He Y, Ramsay MF, Morris RG, Morrison JH, O’Dell TJ, and Grant SG. Enhanced long-term potentiation and impaired learning in mice with mutant postsynaptic density-95 protein [see comments]. Nature 396: 433–439, 1998.

    PubMed  CAS  Google Scholar 

  155. Miller SG and Kennedy MB. Regulation of brain type II Ca2+/calmodulin-dependent protein kinase by autophosphorylation: a Ca2+-triggered molecular switch. Cell 44: 861–870, 1986.

    PubMed  CAS  Google Scholar 

  156. Muller BM, Kistner U, Kindler S, Chung WJ, Kuhlendahl S, Fenster SD, Lau LF, Veh RW, Huganir RL, Gundelfinger ED, and Garner CC. Sap102, a novel postsynaptic protein that interacts with NMDA receptor complexes in-vivo. Neuron 17: 255–265, 1996.

    PubMed  CAS  Google Scholar 

  157. Muller BM, Kistner U, Veh RW, Caseslanghoff C, Becker B, Gundelfinger ED, and Garner CC. Molecular characterization and spatial-distribution of sap97, a novel presynaptic protein homologous to sap90 and the drosophila disks-large tumor-suppressor protein. J Neurosci 15: 2354–2366, 1995.

    PubMed  CAS  Google Scholar 

  158. Naisbitt S, Kim E, Tu JC, Xiao B, Sala C, Valtschanoff J, Weinberg RJ, Worley PF, and Sheng M. Shank, a novel family of postsynaptic density proteins that binds to the NMDA receptor/PSD-95/GKAP complex and cortactin. Neuron 23: 569–582, 1999.

    PubMed  CAS  Google Scholar 

  159. Nakagawa T, Cheng Y, Ramm E, Sheng M, and Walz T. Structure and different conformational states of native AMPA receptor complexes. Nature 433: 545–549, 2005.

    PubMed  CAS  Google Scholar 

  160. Nakagawa T, Engler JA, and Sheng M. The dynamic turnover and functional roles of alpha-actinin in dendritic spines. Neuropharmacology 47: 734–745, 2004.

    PubMed  CAS  Google Scholar 

  161. Nehring RB, Wischmeyer E, Doring F, Veh RW, Sheng M, and Karschin A. Neuronal inwardly rectifying K(+) channels differentially couple to PDZ proteins of the PSD- 95/SAP90 family. J Neurosci 20: 156–162, 2000.

    PubMed  CAS  Google Scholar 

  162. Nicoll RA, Tomita S, and Bredt DS. Auxiliary subunits assist AMPA-type glutamate receptors. Science 311: 1253–1256, 2006.

    PubMed  CAS  Google Scholar 

  163. Nishimune A, Isaac JT, Molnar E, Noel J, Nash SR, Tagaya M, Collingridge GL, Nakanishi S, and Henley JM. NSF binding to GluR2 regulates synaptic transmission. Neuron 21: 87–97, 1998.

    PubMed  CAS  Google Scholar 

  164. Nourry C, Grant SG, and Borg JP. PDZ domain proteins: plug and play! Sci STKE 2003: RE7, 2003.

    PubMed  Google Scholar 

  165. Nusser Z, Mulvihill E, Streit P, and Somogyi P. Subsynaptic segregation of metabotropic and ionotropic glutamate receptors as revealed by immunogold localization. Neuroscience 61: 421–427, 1994.

    PubMed  CAS  Google Scholar 

  166. O’Connor JJ, Rowan MJ, and Anwyl R. Long-lasting enhancement of NMDA receptormediated synaptic transmission by metabotropic glutamate receptor activation. Nature 367: 557–559, 1994.

    PubMed  CAS  Google Scholar 

  167. Oh JS, Manzerra P, and Kennedy MB. Regulation of the neuron-specific Ras GTPase activating protein, synGAP, by Ca2+/calmodulin-dependent protein kinase II. J Biol Chem 279: 17980–17988, 2004.

    PubMed  CAS  Google Scholar 

  168. Ohta Y, Nishida E, and Sakai H. Type II Ca2+/calmodulin-dependent protein kinase binds to actin filaments in a calmodulin-sensitive manner. FEBS Lett 208: 423–426, 1986.

    PubMed  CAS  Google Scholar 

  169. Osten P, Khatri L, Perez JL, Kohr G, Giese G, Daly C, Schulz TW, Wensky A, Lee LM, and Ziff EB. Mutagenesis reveals a role for ABP/GRIP binding to GluR2 in synaptic surface accumulation of the AMPA receptor. Neuron 27: 313–325, 2000.

    PubMed  CAS  Google Scholar 

  170. Osten P, Srivastava S, Inman GJ, Vilim FS, Khatri L, Lee LM, States BA, Einheber S, Milner TA, Hanson PI, and Ziff EB. The AMPA receptor GluR2 C terminus can mediate a reversible, ATP-dependent interaction with NSF and alpha- and beta-SNAPs. Neuron 21: 99–110, 1998.

    PubMed  CAS  Google Scholar 

  171. Osten P and Stern-Bach Y. Learning from stargazin: the mouse, the phenotype and the unexpected. Curr Opin Neurobiol 16: 275–280, 2006.

    PubMed  CAS  Google Scholar 

  172. Otmakhov N, Tao-Cheng JH, Carpenter S, Asrican B, Dosemeci A, Reese TS, and Lisman J. Persistent accumulation of calcium/calmodulin-dependent protein kinase II in dendritic spines after induction of NMDA receptor-dependent chemical long-term potentiation. J Neurosci 24: 9324–9331, 2004.

    PubMed  CAS  Google Scholar 

  173. Ouyang Y, Rosenstein A, Kreiman G, Schuman EM, and Kennedy MB. Tetanic stimulation leads to increased accumulation of Ca(2+)/calmodulin-dependent protein kinase II via dendritic protein synthesis in hippocampal neurons. J Neurosci 19: 7823–7833, 1999.

    PubMed  CAS  Google Scholar 

  174. Pak DT, Yang S, Rudolph-Correia S, Kim E, and Sheng M. Regulation of dendritic spine morphology by SPAR, a PSD-95-associated RapGAP. Neuron 31: 289–303, 2001.

    PubMed  CAS  Google Scholar 

  175. Park M, Penick EC, Edwards JG, Kauer JA, and Ehlers MD. Recycling endosomes supply AMPA receptors for LTP. Science 305: 1972–1975, 2004.

    PubMed  CAS  Google Scholar 

  176. Payne ME, Fong YL, Ono T, Colbran RJ, Kemp BE, Soderling TR, and Means AR. Calcium/calmodulin-dependent protein kinase II. Characterization of distinct calmodulin binding and inhibitory domains. J Biol Chem 263: 7190–7195, 1988.

    PubMed  CAS  Google Scholar 

  177. Peng J, Kim MJ, Cheng D, Duong DM, Gygi SP, and Sheng M. Semiquantitative proteomic analysis of rat forebrain postsynaptic density fractions by mass spectrometry. J Biol Chem 279: 21003–21011, 2004.

    PubMed  CAS  Google Scholar 

  178. Penzes P, Beeser A, Chernoff J, Schiller MR, Eipper BA, Mains RE, and Huganir RL. Rapid induction of dendritic spine morphogenesis by trans-synaptic ephrinB-EphB receptor activation of the Rho-GEF kalirin. Neuron 37: 263–274, 2003.

    PubMed  CAS  Google Scholar 

  179. Penzes P, Johnson RC, Alam MR, Kambampati V, Mains RE, and Eipper BA. An isoform of kalirin, a brain-specific GDP/GTP exchange factor, is enriched in the postsynaptic density fraction. J Biol Chem 275: 6395–6403, 2000.

    PubMed  CAS  Google Scholar 

  180. Penzes P, Johnson RC, Sattler R, Zhang X, Huganir RL, Kambampati V, Mains RE, and Eipper BA. The neuronal Rho-GEF Kalirin-7 interacts with PDZ domain-containing proteins and regulates dendritic morphogenesis. Neuron 29: 229–242, 2001.

    PubMed  CAS  Google Scholar 

  181. Perez JL, Khatri L, Chang C, Srivastava S, Osten P, and Ziff EB. PICK1 targets activated protein kinase Calpha to AMPA receptor clusters in spines of hippocampal neurons and reduces surface levels of the AMPA-type glutamate receptor subunit 2. J Neurosci 21: 5417–5428, 2001.

    PubMed  CAS  Google Scholar 

  182. Peter BJ, Kent HM, Mills IG, Vallis Y, Butler PJ, Evans PR, and McMahon HT. BAR domains as sensors of membrane curvature: the amphiphysin BAR structure. Science 303: 495–499, 2004.

    PubMed  CAS  Google Scholar 

  183. Petersen JD, Chen X, Vinade L, Dosemeci A, Lisman JE, and Reese TS. Distribution of postsynaptic density (PSD)-95 and Ca2+/calmodulin-dependent protein kinase II at the PSD. J Neurosci 23: 11270–11278, 2003.

    PubMed  CAS  Google Scholar 

  184. Petralia RS, Sans N, Wang YX, and Wenthold RJ. Ontogeny of postsynaptic density proteins at glutamatergic synapses. Mol Cell Neurosci 29: 436–452, 2005.

    PubMed  CAS  Google Scholar 

  185. Prange O, Wong TP, Gerrow K, Wang YT, and El-Husseini A. A balance between excitatory and inhibitory synapses is controlled by PSD-95 and neuroligin. Proc Natl Acad Sci USA 101: 13915–13920, 2004.

    PubMed  CAS  Google Scholar 

  186. Qualmann B, Boeckers TM, Jeromin M, Gundelfinger ED, and Kessels MM. Linkage of the actin cytoskeleton to the postsynaptic density via direct interactions of Abp1 with the ProSAP/Shank family. J Neurosci 24: 2481–2495, 2004.

    PubMed  CAS  Google Scholar 

  187. Rabiner CA, Mains RE, and Eipper BA. Kalirin: a dual Rho guanine nucleotide exchange factor that is so much more than the sum of its many parts. Neuroscientist 11: 148–160, 2005.

    PubMed  CAS  Google Scholar 

  188. Racz B and Weinberg RJ. The subcellular organization of cortactin in hippocampus. J Neurosci 24: 10310–10317, 2004.

    PubMed  CAS  Google Scholar 

  189. Rosenberg OS, Deindl S, Comolli LR, Hoelz A, Downing KH, Nairn AC, and Kuriyan J. Oligomerization states of the association domain and the holoenyzme of Ca/CaM kinase II. Febs J 273: 682–694, 2006.

    PubMed  CAS  Google Scholar 

  190. Rosenberg OS, Deindl S, Sung RJ, Nairn AC, and Kuriyan J. Structure of the autoinhibited kinase domain of CaMKII and SAXS analysis of the holoenzyme. Cell 123: 849– 860, 2005.

    PubMed  CAS  Google Scholar 

  191. Rosenmund C and Westbrook GL. Calcium-induced actin depolymerization reduces NMDA channel activity. Neuron 10: 805–814, 1993.

    PubMed  CAS  Google Scholar 

  192. Rumbaugh G, Adams JP, Kim JH, and Huganir RL. SynGAP regulates synaptic strength and mitogen-activated protein kinases in cultured neurons. Proc Natl Acad Sci USA 103: 4344–4351, 2006.

    PubMed  CAS  Google Scholar 

  193. Sabatini BL, Maravall M, and Svoboda K. Ca2+ signaling in dendritic spines. Curr Opin Neurobiol 11: 349–356, 2001.

    PubMed  CAS  Google Scholar 

  194. Sala C, Futai K, Yamamoto K, Worley PF, Hayashi Y, and Sheng M. Inhibition of dendritic spine morphogenesis and synaptic transmission by activity-inducible protein Homer1a. J Neurosci 23: 6327–6337, 2003.

    PubMed  CAS  Google Scholar 

  195. Sala C, Piech V, Wilson NR, Passafaro M, Liu G, and Sheng M. Regulation of dendritic spine morphology and synaptic function by Shank and Homer. Neuron 31: 115–130, 2001.

    PubMed  CAS  Google Scholar 

  196. Sala C, Roussignol G, Meldolesi J, and Fagni L. Key role of the postsynaptic density scaffold proteins Shank and Homer in the functional architecture of Ca2+ homeostasis at dendritic spines in hippocampal neurons. J Neurosci 25: 4587–4592, 2005.

    PubMed  CAS  Google Scholar 

  197. Sans N, Racca C, Petralia RS, Wang YX, McCallum J, and Wenthold RJ. Synapseassociated protein 97 selectively associates with a subset of AMPA receptors early in their biosynthetic pathway. J Neurosci 21: 7506–7516, 2001.

    PubMed  CAS  Google Scholar 

  198. Satoh K, Yanai H, Senda T, Kohu K, Nakamura T, Okumura N, Matsumine A, Kobayashi S, Toyoshima K, and Akiyama T. DAP-1, a novel protein that interacts with the guanylate kinase-like domains of hDLG and PSD-95. Genes Cells 2: 415–424, 1997.

    PubMed  CAS  Google Scholar 

  199. Schnell E, Sizemore M, Karimzadegan S, Chen L, Bredt DS, and Nicoll RA. Direct interactions between PSD-95 and stargazin control synaptic AMPA receptor number. Proc Natl Acad Sci USA 99: 13902–13907, 2002.

    PubMed  CAS  Google Scholar 

  200. Schulman H. Activity-dependent regulation of calcium/calmodulin-dependent protein kinase II localization. J Neurosci 24: 8399–8403, 2004.

    PubMed  CAS  Google Scholar 

  201. Schultze W, Eulenburg V, Lessmann V, Herrmann L, Dittmar T, Gundelfinger ED, Heumann R, and Erdmann KS. Semaphorin4F interacts with the synapse-associated protein SAP90/PSD-95. J Neurochem 78: 482–489, 2001.

    PubMed  CAS  Google Scholar 

  202. Seidenman KJ, Steinberg JP, Huganir R, and Malinow R. Glutamate receptor subunit 2 Serine 880 phosphorylation modulates synaptic transmission and mediates plasticity in CA1 pyramidal cells. J Neurosci 23: 9220–9228, 2003.

    PubMed  CAS  Google Scholar 

  203. Shen K and Meyer T. Dynamic control of CaMKII translocation and localization in hippocampal neurons by NMDA receptor stimulation. Science 284: 162–166, 1999.

    PubMed  CAS  Google Scholar 

  204. Shen K, Teruel MN, Connor JH, Shenolikar S, and Meyer T. Molecular memory by reversible translocation of calcium/calmodulin-dependent protein kinase II. Nat Neurosci 3: 881–886, 2000.

    PubMed  CAS  Google Scholar 

  205. Shen K, Teruel MN, Subramanian K, and Meyer T. CaMKIIbeta functions as an F-actin targeting module that localizes CaMKIIalpha/beta heterooligomers to dendritic spines. Neuron 21: 593–606, 1998.

    PubMed  CAS  Google Scholar 

  206. Sheng M and Kim E. The Shank family of scaffold proteins. J Cell Sci 113: 1851–1856, 2000.

    PubMed  CAS  Google Scholar 

  207. Shi S, Hayashi Y, Esteban JA, and Malinow R. Subunit-specific rules governing AMPA receptor trafficking to synapses in hippocampal pyramidal neurons. Cell 105: 331–343, 2001.

    PubMed  CAS  Google Scholar 

  208. Shi SH, Hayashi Y, Petralia RS, Zaman SH, Wenthold RJ, Svoboda K, and Malinow R. Rapid spine delivery and redistribution of AMPA receptors after synaptic NMDA receptor activation [see comments]. Science 284: 1811–1816, 1999.

    PubMed  CAS  Google Scholar 

  209. Shin H, Hsueh YP, Yang F-C, Kim E, and Sheng M. An intramolecular interaction between src homology 3 domain and guanylate kinase-like domain required for channel clustering by postsynaptic density-95/SAP90. J Neurosci 20: 3580–3587, 2000.

    PubMed  CAS  Google Scholar 

  210. Song I and Huganir RL. Regulation of AMPA receptors during synaptic plasticity. Trends Neurosci 25: 578–588, 2002.

    PubMed  CAS  Google Scholar 

  211. Song I, Kamboj S, Xia J, Dong H, Liao D, and Huganir RL. Interaction of the Nethylmaleimide- sensitive factor with AMPA receptors. Neuron 21: 393–400, 1998.

    PubMed  CAS  Google Scholar 

  212. Song JY, Ichtchenko K, Sudhof TC, and Brose N. Neuroligin 1 is a postsynaptic celladhesion molecule of excitatory synapses. Proc Natl Acad Sci USA 96: 1100–1105, 1999.

    PubMed  CAS  Google Scholar 

  213. Srivastava S, Osten P, Vilim FS, Khatri L, Inman G, States B, Daly C, DeSouza S, Abagyan R, Valtschanoff JG, Weinberg RJ, and Ziff EB. Novel anchorage of GluR2/3 to the postsynaptic density by the AMPA receptor-binding protein ABP. Neuron 21: 581– 591, 1998.

    PubMed  CAS  Google Scholar 

  214. Staudinger J, Lu J, and Olson EN. Specific interaction of the PDZ domain protein PICK1 with the COOH terminus of protein kinase C-alpha. J Biol Chem 272: 32019–32024, 1997.

    PubMed  CAS  Google Scholar 

  215. Stein V, House DR, Bredt DS, and Nicoll RA. Postsynaptic density-95 mimics and occludes hippocampal long-term potentiation and enhances long-term depression. J Neurosci 23: 5503–5506, 2003.

    PubMed  CAS  Google Scholar 

  216. Strack S and Colbran RJ. Autophosphorylation-dependent targeting of calcium/ calmodulin- dependent protein kinase II by the NR2B subunit of the N-methyl- D- aspartate receptor. J Biol Chem 273: 20689–20692, 1998.

    PubMed  CAS  Google Scholar 

  217. Strack S, McNeill RB, and Colbran RJ. Mechanism and regulation of calcium/ calmodulin-dependent protein kinase II targeting to the NR2B subunit of the Nmethyl- D-aspartate receptor. J Biol Chem 275: 23798–23806, 2000.

    PubMed  CAS  Google Scholar 

  218. Suzuki T, Okumuranoji K, Tanaka R, and Tada T. Rapid translocation of cytosolic Ca2+/calmodulin-dependent protein kinase II into postsynaptic density after decapitation. J Neurochem 63: 1529–1537, 1994.

    Article  PubMed  CAS  Google Scholar 

  219. Sweatt JD. Mitogen-activated protein kinases in synaptic plasticity and memory. Curr Opin Neurobiol 14: 311–317, 2004.

    PubMed  CAS  Google Scholar 

  220. Tadokoro S, Tachibana T, Imanaka T, Nishida W, and Sobue K. Involvement of unique leucine-zipper motif of PSD-Zip45 (Homer 1c/vesl-1L) in group 1 metabotropic glutamate receptor clustering. Proc Natl Acad Sci USA 96: 13801–13806, 1999.

    PubMed  CAS  Google Scholar 

  221. Takasu MA, Dalva MB, Zigmond RE, and Greenberg ME. Modulation of NMDA receptor- dependent calcium influx and gene expression through EphB receptors. Science 295: 491–495, 2002.

    PubMed  CAS  Google Scholar 

  222. Takeuchi M, Hata Y, Hirao K, Toyoda A, Irie M, and Takai Y. SAPAPs. A family of PSD-95/SAP90-associated proteins localized at postsynaptic density. J Biol Chem 272: 11943–11951, 1997.

    PubMed  CAS  Google Scholar 

  223. Tavares GA, Panepucci EH, and Brunger AT. Structural characterization of the intramolecular interaction between the SH3 and guanylate kinase domains of PSD-95. Mol Cell 8: 1313–1325, 2001.

    PubMed  CAS  Google Scholar 

  224. Tezuka T, Umemori H, Akiyama T, Nakanishi S, and Yamamoto T. PSD-95 promotes Fyn-mediated tyrosine phosphorylation of the N-methyl-D- aspartate receptor subunit NR2A. Proc Natl Acad Sci USA 96: 435–440, 1999.

    PubMed  CAS  Google Scholar 

  225. Tomita S, Chen L, Kawasaki Y, Petralia RS, Wenthold RJ, Nicoll RA, and Bredt DS. Functional studies and distribution define a family of transmembrane AMPA receptor regulatory proteins. J Cell Biol 161: 805–816, 2003.

    PubMed  CAS  Google Scholar 

  226. Tomita S, Fukata M, Nicoll RA, and Bredt DS. Dynamic interaction of stargazin-like TARPs with cycling AMPA receptors at synapses. Science 303: 1508–1511, 2004.

    PubMed  CAS  Google Scholar 

  227. Torres R, Firestein BL, Dong H, Staudinger J, Olson EN, Huganir RL, Bredt DS, Gale NW, and Yancopoulos GD. PDZ proteins bind, cluster, and synaptically colocalize with Eph receptors and their ephrin ligands. Neuron 21: 1453–1463, 1998.

    PubMed  CAS  Google Scholar 

  228. Tu JC, Xiao B, Naisbitt S, Yuan JP, Petralia RS, Brakeman P, Doan A, Aakalu VK, Lanahan AA, Sheng M, and Worley PF. Coupling of mGluR/Homer and PSD-95 complexes by the Shank family of postsynaptic density proteins. Neuron 23: 583–592, 1999.

    PubMed  CAS  Google Scholar 

  229. Tu JC, Xiao B, Yuan JP, Lanahan AA, Leoffert K, Li M, Linden DJ, and Worley PF. Homer binds a novel proline-rich motif and links group 1 metabotropic glutamate receptors with IP3 receptors. Neuron 21: 717–726, 1998.

    PubMed  CAS  Google Scholar 

  230. Uchino S, Wada H, Honda S, Nakamura Y, Ondo Y, Uchiyama T, Tsutsumi M, Suzuki E, Hirasawa T, and Kohsaka S. Direct interaction of post-synaptic density-95/Dlg/ZO-1 domain-containing synaptic molecule Shank3 with GluR1 alpha-amino-3-hydroxy-5- methyl-4-isoxazole propionic acid receptor. J Neurochem 97: 1203–1214, 2006.

    PubMed  CAS  Google Scholar 

  231. Uruno T, Liu J, Zhang P, Fan Y, Egile C, Li R, Mueller SC, and Zhan X. Activation of Arp2/3 complex-mediated actin polymerization by cortactin. Nat Cell Biol 3: 259–266, 2001.

    PubMed  CAS  Google Scholar 

  232. Valtschanoff JG and Weinberg RJ. Laminar organization of the NMDA receptor complex within the postsynaptic density. J Neurosci 21: 1211–1217, 2001.

    PubMed  CAS  Google Scholar 

  233. Vandenberghe W, Nicoll RA, and Bredt DS. Stargazin is an AMPA receptor auxiliary subunit. Proc Natl Acad Sci USA 102: 485–490, 2005.

    PubMed  CAS  Google Scholar 

  234. Vazquez LE, Chen HJ, Sokolova I, Knuesel I, and Kennedy MB. SynGAP regulates spine formation. J Neurosci 24: 8796–8805, 2004.

    Google Scholar 

  235. Walikonis RS, Jensen ON, Mann M, Provance DWJ, Mercer JA, and Kennedy MB. Identification of proteins in the postsynaptic density fraction by mass spectrometry. J Neurosci 20: 4069–4080, 2000.

    PubMed  CAS  Google Scholar 

  236. Walikonis RS, Oguni A, Khorosheva EM, Jeng C-J, Asuncion FJ, and Kennedy MB. Densin-180 forms a ternary complex with the α -subunit of CaMKII and α -actinin. J Neurosci 21: 423–433, 2001.

    PubMed  CAS  Google Scholar 

  237. Wang YT and Salter MW. Regulation of NMDA receptors by tyrosine kinases and phosphatases. Nature 369: 233–235, 1994.

    PubMed  CAS  Google Scholar 

  238. Weaver AM, Karginov AV, Kinley AW, Weed SA, Li Y, Parsons JT, and Cooper JA. Cortactin promotes and stabilizes Arp2/3-induced actin filament network formation. Curr Biol 11: 370–374, 2001.

    PubMed  CAS  Google Scholar 

  239. Wechsler A and Teichberg VI. Brain spectrin binding to the NMDA receptor is regulated by phosphorylation, calcium and calmodulin. EMBO J 17: 3931–3939, 1998.

    PubMed  CAS  Google Scholar 

  240. Weed SA, Karginov AV, Schafer DA, Weaver AM, Kinley AW, Cooper JA, and Parsons JT. Cortactin localization to sites of actin assembly in lamellipodia requires interactions with F-actin and the Arp2/3 complex. J Cell Biol 151: 29–40, 2000.

    PubMed  CAS  Google Scholar 

  241. Wendholt D, Spilker C, Schmitt A, Dolnik A, Smalla KH, Proepper C, Bockmann J, Sobue K, Gundelfinger ED, Kreutz MR, and Boeckers TM. ProSAP-interacting protein 1 (ProSAPiP1), a novel protein of the postsynaptic density that links the spine-associated Rap-Gap (SPAR) to the scaffolding protein ProSAP2/Shank3. J Biol Chem 281: 13805– 13816, 2006.

    PubMed  CAS  Google Scholar 

  242. Westphal RS, Tavalin SJ, Lin JW, Alto NM, Fraser ID, Langeberg LK, Sheng M, and Scott JD. Regulation of NMDA receptors by an associated phosphatase-kinase signaling complex. Science 285: 93–96, 1999.

    PubMed  CAS  Google Scholar 

  243. Witke W, Hofmann A, Koppel B, Schleicher M, and Noegel AA. The Ca(2+)-binding domains in non-muscle type alpha-actinin: biochemical and genetic analysis. J Cell Biol 121: 599–606, 1993.

    PubMed  CAS  Google Scholar 

  244. Wu H, Nash JE, Zamorano P, and Garner CC. Interaction of SAP97 with minus-enddirected actin motor myosin VI. Implications for AMPA receptor trafficking. J Biol Chem 277: 30928–30934, 2002.

    PubMed  CAS  Google Scholar 

  245. Wu H and Parsons JT. Cortactin, an 80/85-kilodalton pp60src substrate, is a filamentous actin-binding protein enriched in the cell cortex. J Cell Biol 120: 1417–1426, 1993.

    PubMed  CAS  Google Scholar 

  246. Wyszynski M, Kharazia V, Shanghvi R, Rao A, Beggs AH, Craig AM, Weinberg R, and Sheng M. Differential regional expression and ultrastructural localization of alphaactinin- 2, a putative NMDA receptor-anchoring protein, in rat brain. J Neurosci 18: 1383–1392, 1998.

    PubMed  CAS  Google Scholar 

  247. Wyszynski M, Kim E, Dunah AW, Passafaro M, Valtschanoff JG, Serra-Pages C, Streuli M, Weinberg RJ, and Sheng M. Interaction between GRIP and liprin-alpha/SYD2 is required for AMPA receptor targeting. Neuron 34: 39–52, 2002.

    PubMed  CAS  Google Scholar 

  248. Wyszynski M, Lin J, Rao A, Nigh E, Beggs AH, Craig AM, and Sheng M. Competitive binding of α -actinin and calmodulin to the NMDA receptor. Nature 385: 439–442, 1997.

    PubMed  CAS  Google Scholar 

  249. Wyszynski M, Valtschanoff JG, Naisbitt S, Dunah AW, Kim E, Standaert DG, Weinberg R, and Sheng M. Association of AMPA receptors with a subset of glutamate receptorinteracting protein in vivo. J Neurosci 19: 6528–6537, 1999.

    PubMed  CAS  Google Scholar 

  250. Xiao B, Tu JC, Petralia RS, Yuan JP, Doan A, Breder CD, Ruggiero A, Lanahan AA, Wenthold RJ, and Worley PF. Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of homer-related, synaptic proteins. Neuron 21: 707–716, 1998.

    PubMed  CAS  Google Scholar 

  251. Xiao B, Tu JC, and Worley PF. Homer: a link between neural activity and glutamate receptor function. Curr Opin Neurobiol 10: 370–374, 2000.

    PubMed  CAS  Google Scholar 

  252. Yamada Y, Chochi Y, Takamiya K, Sobue K, and Inui M. Modulation of the channel activity of the epsilon2/zeta1-subtype N-methyl D-aspartate receptor by PSD-95. J Biol Chem 274: 6647–6652, 1999.

    PubMed  CAS  Google Scholar 

  253. Yamazaki M, Fukaya M, Abe M, Ikeno K, Kakizaki T, Watanabe M, and Sakimura K. Differential palmitoylation of two mouse glutamate receptor interacting protein 1 forms with different N-terminal sequences. Neurosci Lett 304: 81–84, 2001.

    PubMed  CAS  Google Scholar 

  254. Yao I, Hata Y, Hirao K, Deguchi M, Ide N, Takeuchi M, and Takai Y. Synamon, a novel neuronal protein interacting with synapse-associated protein 90/postsynaptic density-95- associated protein. J Biol Chem 274: 27463–27466, 1999.

    PubMed  CAS  Google Scholar 

  255. Ye B, Liao D, Zhang X, Zhang P, Dong H, and Huganir RL. GRASP-1: a neuronal RasGEF associated with the AMPA receptor/GRIP complex. Neuron 26: 603–617, 2000.

    PubMed  CAS  Google Scholar 

  256. Yu XM, Askalan R, Keil GJ, 2nd, and Salter MW. NMDA channel regulation by channel- associated protein tyrosine kinase Src. Science 275: 674–678, 1997.

    PubMed  CAS  Google Scholar 

  257. Zhang S, Ehlers MD, Bernhardt JP, Su CT, and Huganir RL. Calmodulin mediates calcium- dependent inactivation of N-methyl-D- aspartate receptors. Neuron 21: 443–453, 1998.

    PubMed  CAS  Google Scholar 

  258. Zhang W and Benson DL. Targeting and clustering citron to synapses. Mol Cell Neurosci 31: 26–36, 2006.

    PubMed  Google Scholar 

  259. Zhang W, Vazquez L, Apperson M, and Kennedy MB. Citron binds to PSD-95 at glutamatergic synapses on inhibitory neurons in the hippocampus. J Neurosci 19: 96–108, 1999.

    PubMed  CAS  Google Scholar 

  260. Zhu JJ, Qin Y, Zhao M, Van Aelst L, and Malinow R. Ras and Rap control AMPA receptor trafficking during synaptic plasticity. Cell 110: 443–455, 2002.

    PubMed  CAS  Google Scholar 

  261. Zucker RS. Calcium- and activity-dependent synaptic plasticity. Curr Opin Neurobiol 9: 305–313, 1999.

    PubMed  CAS  Google Scholar 

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Kennedy, M.B., Marcora, E., Carlisle, H.J. (2008). Scaffold Proteins in the Postsynaptic Density. In: Hell, J.W., Ehlers, M.D. (eds) Structural And Functional Organization Of The Synapse. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-77232-5_14

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