Abstract
NMDA receptors (NMDARs) play a distinct role at excitatory glutamatergic synapses, where they are usually localized with other ionotropic glutamate receptors, including tors. Two features are essential to their specialized roles in synaptic plasticity and the excitodependent magnesium block, the removal of which requires depolarization of the membrane potential. Second, upon activation, the NMDAR channel passes sodium and, importantly, calcium into the neuron. Calcium is the universal second messenger in numerous intracellular signaling cascades and is critical in synaptic plasticity and mechanisms of neurotoxicity (288).
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Abel, T., P.V. Nguyen, M. Barad, T.A. Deuel, E.R. Kandel, and R. Bourtchouladze. Genetic demonstration of a role for PKA in the late phase of LTP and in hippocampusbased long-term memory. Cell 88: 615–626, 1997.
Adesnik, H., R.A. Nicoll, and P.M. England. Photoinactivation of native AMPA receptors reveals their real-time trafficking. Neuron 48: 977–985, 2005.
Al-Hallaq, R.A., T.P. Conrads, T.D. Veenstra, and R.J. Wenthold. NMDA diheteromeric receptor populations and associated proteins in rat hippocampus. J Neurosci 27: 8334–8343, 2007.
Al-Hallaq, R.A., B.R. Jarabek, Z. Fu, S. Vicini, B.B. Wolfe, and R.P. Yasuda. Association of NR3A with the N-methyl-D-aspartate receptor NR1 and NR2 subunits. Mol Pharmacol 62: 1119–1127, 2002.
Allen, J.A., R.A. Halverson-Tamboli, and M.M. Rasenick. Lipid raft microdomains and neurotransmitter signalling. Nat Rev Neurosci 8: 128–140, 2007.
Amparan, D., D. Avram, C.G. Thomas, M.G. Lindahl, J. Yang, G. Bajaj, and J.E. Ishmael. Direct interaction of myosin regulatory light chain with the NMDA receptor. J Neurochem 92: 349–361, 2005.
Andrasfalvy, B.K., and J.C. Magee. Changes in AMPA receptor currents following LTP induction on rat CA1 pyramidal neurones. J Physiol 559: 543–554, 2004.
Andre, V.M., C. Cepeda, A. Venegas, Y. Gomez, and M.S. Levine. Altered cortical glutamate receptor function in the R6/2 model of Huntington’s disease. J Neurophysiol 95: 2108–2119, 2006.
Arbuthnott, G.W., C.A. Ingham, and J.R. Wickens. Dopamine and synaptic plasticity in the neostriatum. J Anat 196: 587–596, 2000.
Awobuluyi, M., J. Yang, Y. Ye, J.E. Chatterton, A. Godzik, S.A. Lipton, and D. Zhang. Subunit-specific roles of glycine-binding domains in activation of NR1/NR3 N-methyl- D-aspartate receptors. Mol Pharmacol 71: 112–122, 2007.
Bardoni, R., C. Torsney, C.K. Tong, M. Prandini, and A.B. MacDermott. Presynaptic NMDA receptors modulate glutamate release from primary sensory neurons in rat spinal cord dorsal horn. J Neurosci 24: 2774–2781, 2004.
Barria, A., and R. Malinow. Subunit-specific NMDA receptor trafficking to synapses. Neuron 35: 345–353, 2002.
Barria, A., and R. Malinow. NMDA receptor subunit composition controls synaptic plasticity by regulating binding to CaMKII. Neuron 48: 289–301, 2005.
Bashir, Z.I., S. Alford, S.N. Davies, A.D. Randall, and G.L. Collingridge. Long-term potentiation of NMDA receptor-mediated synaptic transmission in the hippocampus. Nature 349: 156–158, 1991.
Basselin, M., L. Chang, J.M. Bell, and S.I. Rapoport. Chronic lithium chloride administration attenuates brain NMDA receptor-initiated signaling via arachidonic acid in unanesthetized rats. Neuropsychopharmacology 31: 1659–1674, 2006.
Bayer, K.U., K. De, P., A.S. Leonard, J.W. Hell, and H. Schulman. Interaction with the NMDA receptor locks CaMKII in an active conformation. Nature 411: 801–805, 2001.
Becker, S., and J.M. Wojtowicz. A model of hippocampal neurogenesis in memory and mood disorders. Trends Cogn Sci 11: 70–76, 2007.
Behar, T.N., C.A. Scott, C.L. Greene, X. Wen, S.V. Smith, D. Maric, Q.Y. Liu, C.A. Colton, and J.L. Barker. Glutamate acting at NMDA receptors stimulates embryonic cortical neuronal migration. J Neurosci 19: 4449–4461, 1999.
Bendel, O., B. Meijer, Y. Hurd, and G. von Euler. Cloning and expression of the human NMDA receptor subunit NR3B in the adult human hippocampus. Neurosci Lett 377: 31–36, 2005.
Berberich, S., P. Punnakkal, V. Jensen, V. Pawlak, P.H. Seeburg, O. Hvalby, and G. Kohr. Lack of NMDA receptor subtype selectivity for hippocampal long-term potentiation. J Neurosci 25: 6907–6910, 2005.
Bernard-Trifilo, J.A., E.A. Kramar, R. Torp, C.Y. Lin, E.A. Pineda, G. Lynch, and C.M. Gall. Integrin signaling cascades are operational in adult hippocampal synapses and modulate NMDA receptor physiology. J Neurochem 93: 834–849, 2005.
Berretta, N., F. Berton, R. Bianchi, M. Brunelli, M. Capogna, and W. Francesconi. Longterm Potentiation of NMDA Receptor-mediated EPSP in Guinea-pig Hippocampal Slices. Eur J Neurosci 3: 850–854, 1991.
Betarbet, R., O. Poisik, T.B. Sherer, and J.T. Greenamyre. Differential expression and ser897 phosphorylation of striatal N-methyl-D-aspartate receptor subunit NR1 in animal models of Parkinson’s disease. Exp Neurol 187: 76–85, 2004.
Blanpied, T.A., D.B. Scott, and M.D. Ehlers. Dynamics and regulation of clathrin coats at specialized endocytic zones of dendrites and spines. Neuron 36: 435–449, 2002.
Bleakman, D., A. Alt, and E.S. Nisenbaum. Glutamate receptors and pain. Semin Cell Dev Biol 17: 592–604, 2006.
Blumer, J.B., L.J. Chandler, and S.M. Lanier. Expression analysis and subcellular distribution of the two G-protein regulators AGS3 and LGN indicate distinct functionality. Localization of LGN to the midbody during cytokinesis. J Biol Chem 277: 15897–15903, 2002.
Boyce-Rustay, J.M., and A. Holmes. Genetic inactivation of the NMDA receptor NR2A subunit has anxiolytic- and antidepressant-like effects in mice. Neuropsychopharmacology 31: 2405–2414, 2006.
Bresler, T., M. Shapira, T. Boeckers, T. Dresbach, M. Futter, C.C. Garner, K. Rosenblum, E.D. Gundelfinger, and N.E. Ziv. Postsynaptic density assembly is fundamentally different from presynaptic active zone assembly. J Neurosci 24: 1507–1520, 2004.
Brewer, G.J., and C.W. Cotman. NMDA receptor regulation of neuronal morphology in cultured hippocampal neurons. Neurosci Lett 99: 268–273, 1989.
Brickley, S.G., C. Misra, M.H. Mok, M. Mishina, and S.G. Cull-Candy. NR2B and NR2D subunits coassemble in cerebellar Golgi cells to form a distinct NMDA receptor subtype restricted to extrasynaptic sites. J Neurosci 23: 4958–4966, 2003.
Bukalo, O., N. Fentrop, A.Y. Lee, B. Salmen, J.W. Law, C.T. Wotjak, M. Schweizer, A. Dityatev, and M. Schachner. Conditional ablation of the neural cell adhesion molecule reduces precision of spatial learning, long-term potentiation, and depression in the CA1 subfield of mouse hippocampus. J Neurosci 24: 1565–1577, 2004.
Calabresi, P., D. Centonze, and G. Bernardi. Electrophysiology of dopamine in normal and denervated striatal neurons. Trends Neurosci 23: S57–S63, 2000.
Calabresi, P., P. Giacomini, D. Centonze, and G. Bernardi. Levodopa-induced dyskinesia: a pathological form of striatal synaptic plasticity? Ann Neurol 47: S60–S68; discussion S68–S69, 2000.
Calabresi, P., N.B. Mercuri, G. Sancesario, and G. Bernardi. Electrophysiology of dopamine- denervated striatal neurons. Implications for Parkinson’s disease. Brain 116: 433–452, 1993.
Calon, F., A.H. Rajput, O. Hornykiewicz, P.J. Bedard, and T. Di Paolo. Levodopainduced motor complications are associated with alterations of glutamate receptors in Parkinson’s disease. Neurobiol Dis 14: 404–416, 2003.
Cao, J., J.I. Viholainen, C. Dart, H.K. Warwick, M.L. Leyland, and M.J. Courtney. The PSD95-nNOS interface: a target for inhibition of excitotoxic p38 stress-activated protein kinase activation and cell death. J Cell Biol 168: 117–126, 2005.
Carleton, A., L.T. Petreanu, R. Lansford, A. Alvarez-Buylla, and P.M. Lledo. Becoming a new neuron in the adult olfactory bulb. Nat Neurosci 6: 507–518, 2003.
Casado, M., P. Isope, and P. Ascher. Involvement of presynaptic N-methyl-D-aspartate receptors in cerebellar long-term depression. Neuron 33: 123–130, 2002.
Charriaut-Marlangue, C., S. Otani, C. Creuzet, Y. Ben-Ari, and J. Loeb. Rapid activation of hippocampal casein kinase II during long-term potentiation. Proc Natl Acad Sci USA 88: 10232–10236, 1991.
Chatterton, J.E., M. Awobuluyi, L.S. Premkumar, H. Takahashi, M. Talantova, Y. Shin, J. Cui, S. Tu, K.A. Sevarino, N. Nakanishi, G. Tong, S.A. Lipton, and D. Zhang. Excitatory glycine receptors containing the NR3 family of NMDA receptor subunits. Nature 415: 793–798, 2002.
Chavis, P., and G. Westbrook. Integrins mediate functional pre- and postsynaptic maturation at a hippocampal synapse. Nature 411: 317–321, 2001.
Chazot, P.L., and F.A. Stephenson. Biochemical evidence for the existence of a pool of unassembled C2 exon-containing NR1 subunits of the mammalian forebrain NMDA receptor. J Neurochem 68: 507–516, 1997.
Chen, L., and L.Y. Huang. Protein kinase C reduces Mg2+ block of NMDA-receptor channels as a mechanism of modulation. Nature 356: 521–523, 1992.
Chen, N., T. Luo, C. Wellington, M. Metzler, K. McCutcheon, M.R. Hayden, and L.A. Raymond. Subtype-specific enhancement of NMDA receptor currents by mutant huntingtin. J Neurochem 72: 1890–1898, 1999.
Chen, W., and A. Helenius. Role of ribosome and translocon complex during folding of influenza hemagglutinin in the endoplasmic reticulum of living cells. Mol Biol Cell 11: 765–772, 2000.
Cheng, C., D.M. Fass, and I.J. Reynolds. Emergence of excitotoxicity in cultured forebrain neurons coincides with larger glutamate-stimulated [Ca(2+)](i) increases and NMDA receptor mRNA levels. Brain Res 849: 97–108, 1999.
Choi, Y.B., L. Tenneti, D.A. Le, J. Ortiz, G. Bai, H.S. Chen, and S.A. Lipton. Molecular basis of NMDA receptor-coupled ion channel modulation by S-nitrosylation. Nat Neurosci 3: 15–21, 2000.
Christopherson, K.S., B.J. Hillier, W.A. Lim, and D.S. Bredt. PSD-95 assembles a ternary complex with the N-methyl-D-aspartic acid receptor and a bivalent neuronal NO synthase PDZ domain. J Biol Chem 274: 27467–27473, 1999.
Chung, H.J., Y.H. Huang, L.F. Lau, and R.L. Huganir. Regulation of the NMDA receptor complex and trafficking by activity-dependent phosphorylation of the NR2B subunit PDZ ligand. J Neurosci 24: 10248–10259, 2004.
Ciabarra, A.M., J.M. Sullivan, L.G. Gahn, G. Pecht, S. Heinemann, and K.A. Sevarino. Cloning and characterization of chi-1: a developmentally regulated member of a novel class of the ionotropic glutamate receptor family. J Neurosci 15: 6498–6508, 1995.
Cleary, J., J.M. Hittner, M. Semotuk, P. Mantyh, and E. O’Hare. Beta-amyloid(1–40) effects on behavior and memory. Brain Res 682: 69–74, 1995.
Colonnese, M.T., J.P. Zhao, and M. Constantine-Paton. NMDA receptor currents suppress synapse formation on sprouting axons in vivo. J Neurosci 25: 1291–1303, 2005.
Cottrell, J.R., E. Borok, T.L. Horvath, and E. Nedivi. CPG2: a brain- and synapsespecific protein that regulates the endocytosis of glutamate receptors. Neuron 44: 677–690, 2004.
Crump, F.T., K.S. Dillman, and A.M. Craig. cAMP-dependent protein kinase mediates activity-regulated synaptic targeting of NMDA receptors. J Neurosci 21: 5079–5088, 2001.
Cull-Candy, S., S. Brickley, and M. Farrant. NMDA receptor subunits: diversity, development and disease. Curr Opin Neurobiol 11: 327–335, 2001.
Dalva, M.B., A.C. McClelland, and M.S. Kayser. Cell adhesion molecules: signalling functions at the synapse. Nat Rev Neurosci 8: 206–220, 2007.
Dalva, M.B., M.A. Takasu, M.Z. Lin, S.M. Shamah, L. Hu, N.W. Gale, and M.E. Greenberg. EphB receptors interact with NMDA receptors and regulate excitatory synapse formation. Cell 103: 945–956, 2000.
Das, S., Y.F. Sasaki, T. Rothe, L.S. Premkumar, M. Takasu, J.E. Crandall, P. Dikkes, D.A. Conner, P.V. Rayudu, W. Cheung, H.S. Chen, S.A. Lipton, and N. Nakanishi. Increased NMDA current and spine density in mice lacking the NMDA receptor subunit NR3A. Nature 393: 377–381, 1998.
Davey, F., M. Hill, J. Falk, N. Sans, and F. J. Gunn-Moore. Synapse associated protein 102 is a novel binding partner to the cytoplasmic terminus of neurone-glial related cell adhesion molecule. J Neurochem 94: 1243–1253, 2005.
Davies, C.A., D.M. Mann, P.Q. Sumpter, and P.O. Yates. A quantitative morphometric analysis of the neuronal and synaptic content of the frontal and temporal cortex in patients with Alzheimer’s disease. J Neurol Sci 78: 151–164, 1987.
DeGiorgio, L.A., K.N. Konstantinov, S.C. Lee, J.A. Hardin, B.T. Volpe, and B. Diamond. A subset of lupus anti-DNA antibodies cross-reacts with the NR2 glutamate receptor in systemic lupus erythematosus. Nat Med 7: 1189–1193, 2001.
Demyanenko, G.P., M. Schachner, E. Anton, R. Schmid, G. Feng, J. Sanes, and P.F. Maness. Close homolog of L1 modulates area-specific neuronal positioning and dendrite orientation in the cerebral cortex. Neuron 44: 423–437, 2004.
Derkach, V., A. Barria, and T.R. Soderling. Ca2+/calmodulin-kinase II enhances channel conductance of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate type glutamate receptors. Proc Natl Acad Sci USA 96: 3269–3274, 1999.
deSouza, S., and E.B. Ziff. AMPA receptors do the electric slide. Sci STKE2002: PE45, 2002.
DiFiglia, M. Excitotoxic injury of the neostriatum: a model for Huntington’s disease. Trends Neurosci 13: 286–289, 1990.
Dingledine, R., K. Borges, D. Bowie, and S.F. Traynelis. The glutamate receptor ion channels. Pharmacol Rev 51: 7–61, 1999.
Dosemeci, A., J.H. Tao-Cheng, L. Vinade, C.A. Winters, L. Pozzo-Miller, and T.S. Reese. Glutamate-induced transient modification of the postsynaptic density. Proc Natl Acad Sci USA 98: 10428–10432, 2001.
Dracheva, S., S.A. Marras, S.L. Elhakem, F.R. Kramer, K.L. Davis, and V. Haroutunian. N-methyl-D-aspartic acid receptor expression in the dorsolateral prefrontal cortex of elderly patients with schizophrenia. Am J Psychiatry 158: 1400–1410, 2001.
Du, Q., P.T. Stukenberg, and I.G. Macara. A mammalian partner of inscuteable binds NuMA and regulates mitotic spindle organization. Nat Cell Biol 3: 1069–1075, 2001.
Dudman, J.T., M.E. Eaton, A. Rajadhyaksha, W. Macias, M. Taher, A. Barczak, K. Kameyama, R. Huganir, and C. Konradi. Dopamine D1 receptors mediate CREB phosphorylation via phosphorylation of the NMDA receptor at Ser897-NR1. J Neurochem 87: 922–934, 2003.
Duguid, I.C., and T.G. Smart. Retrograde activation of presynaptic NMDA receptors enhances GABA release at cerebellar interneuron-Purkinje cell synapses. Nat Neurosci 7: 525–533, 2004.
Dunah, A.W., A.C. Sirianni, A.A. Fienberg, E. Bastia, M.A. Schwarzschild, and D.G. Standaert. Dopamine D1-dependent trafficking of striatal N-methyl-D-aspartate glutamate receptors requires Fyn protein tyrosine kinase but not DARPP-32. Mol Pharmacol 65: 121–129, 2004.
Dunah, A.W., and D.G. Standaert. Dopamine D1 receptor-dependent trafficking of striatal NMDA glutamate receptors to the postsynaptic membrane. J Neurosci 21: 5546–5558, 2001.
Dunah, A.W., Y. Wang, R.P. Yasuda, K. Kameyama, R.L. Huganir, B.B. Wolfe, and D.G. Standaert. Alterations in subunit expression, composition, and phosphorylation of striatal N-methyl-D-aspartate glutamate receptors in a rat 6-hydroxydopamine model of Parkinson’s disease. Mol Pharmacol 57: 342–352, 2000.
Dunah, A.W., R.P. Yasuda, Y.H. Wang, J. Luo, M. Davila-Garcia, M. Gbadegesin, S. Vicini, and B.B. Wolfe. Regional and ontogenic expression of the NMDA receptor subunit NR2D protein in rat brain using a subunit-specific antibody. J Neurochem 67: 2335–2345, 1996.
Durand, G.M., M.V. Bennett, and R.S. Zukin. Splice variants of the N-methyl-Daspartate receptor NR1 identify domains involved in regulation by polyamines and protein kinase C. Proc Natl Acad Sci USA 90: 6731–6735, 1993.
Durand, G.M., P. Gregor, X. Zheng, M.V. Bennett, G.R. Uhl, and R.S. Zukin. Cloning of an apparent splice variant of the rat N-methyl-D-aspartate receptor NMDAR1 with altered sensitivity to polyamines and activators of protein kinase C. Proc Natl Acad Sci USA 89: 9359–9363, 1992.
Ehlers, M.D. Activity level controls postsynaptic composition and signaling via the ubiquitin-proteasome system. Nat Neurosci 6: 231–242, 2003.
Ehrlich, I., M. Klein, S. Rumpel, and R. Malinow. PSD-95 is required for activity-driven synapse stabilization. Proc Natl Acad Sci USA 104: 4176–4181, 2007.
Eisen, A., and M. Weber. Treatment of amyotrophic lateral sclerosis. Drugs Aging 14: 173–196, 1999.
El-Husseini, A.E., E. Schnell, D.M. Chetkovich, R.A. Nicoll, and D.S. Bredt. PSD-95 involvement in maturation of excitatory synapses. Science 290: 1364–1368, 2000.
Elias, G.M., L. Funke, V. Stein, S.G. Grant, D.S. Bredt, and R.A. Nicoll. Synapsespecific and developmentally regulated targeting of AMPA receptors by a family of MAGUK scaffolding proteins. Neuron 52: 307–320, 2006.
Ellgaard, L., and A. Helenius. ER quality control: towards an understanding at the molecular level. Curr Opin Cell Biol 13: 431–437, 2001.
Erisir, A., and J.L. Harris. Decline of the critical period of visual plasticity is concurrent with the reduction of NR2B subunit of the synaptic NMDA receptor in layer 4. J Neurosci 23: 5208–5218, 2003.
Fan, M.M., and L.A. Raymond. N-Methyl-D-aspartate (NMDA) receptor function and excitotoxicity in Huntington’s disease. Prog Neurobiol 81: 272–293, 2007.
Fiebiger, E., D. Tortorella, M.H. Jouvin, J.P. Kinet, and H.L. Ploegh. Cotranslational endoplasmic reticulum assembly of FcepsilonRI controls the formation of functional IgE-binding receptors. J Exp Med 201: 267–277, 2005.
Fong, D.K., A. Rao, F.T. Crump, and A.M. Craig. Rapid synaptic remodeling by protein kinase C: reciprocal translocation of NMDA receptors and calcium/calmodulindependent kinase II. J Neurosci 22: 2153–2164, 2002.
Forrest, D., M. Yuzaki, H.D. Soares, L. Ng, D.C. Luk, M. Sheng, C.L. Stewart, J.I. Morgan, J.A. Connor, and T. Curran. Targeted disruption of NMDA receptor 1 gene abolishes NMDA response and results in neonatal death. Neuron 13: 325–338, 1994.
Friedman, H.V., T. Bresler, C.C. Garner, and N.E. Ziv. Assembly of new individual excitatory synapses: time course and temporal order of synaptic molecule recruitment. Neuron 27: 57–69, 2000.
Fu, Z., S.M. Logan, and S. Vicini. Deletion of the NR2A subunit prevents developmental changes of NMDA-mEPSCs in cultured mouse cerebellar granule neurones. J Physiol 563: 867–881, 2005.
Fukaya, M., A. Kato, C. Lovett, S. Tonegawa, and M. Watanabe. Retention of NMDA receptor NR2 subunits in the lumen of endoplasmic reticulum in targeted NR1 knockout mice. Proc Natl Acad Sci USA 100: 4855–4860, 2003.
Furukawa, H., S.K. Singh, R. Mancusso, and E. Gouaux. Subunit arrangement and function in NMDA receptors. Nature 438: 185–192, 2005.
Furuyashiki, T., K. Fujisawa, A. Fujita, P. Madaule, S. Uchino, M. Mishina, H. Bito, and S. Narumiya. Citron, a Rho-target, interacts with PSD-95/SAP-90 at glutamatergic synapses in the thalamus. J Neurosci 19: 109–118, 1999.
Futai, K., M.J. Kim, T. Hashikawa, P. Scheiffele, M. Sheng, and Y. Hayashi. Retrograde modulation of presynaptic release probability through signaling mediated by PSD-95- neuroligin. Nat Neurosci 10: 186–195, 2007.
Fux, C.M., M. Krug, A. Dityatev, T. Schuster, and M. Schachner. NCAM180 and glutamate receptor subtypes in potentiated spine synapses: an immunogold electron microscopic study. Mol Cell Neurosci 24: 939–950, 2003.
Gao, X.M., K. Sakai, R.C. Roberts, R.R. Conley, B. Dean, and C.A. Tamminga. Ionotropic glutamate receptors and expression of N-methyl-D-aspartate receptor subunits in subregions of human hippocampus: effects of schizophrenia. Am J Psychiatry 157: 1141–1149, 2000.
Garcia, R.A., K. Vasudevan, and A. Buonanno. The neuregulin receptor ErbB-4 interacts with PDZ-containing proteins at neuronal synapses. Proc Natl Acad Sci USA 97: 3596–3601, 2000.
Gardoni, F., and M. Di Luca. New targets for pharmacological intervention in the glutamatergic synapse. Eur J Pharmacol 545: 2–10, 2006.
Gardoni, F., L.H. Schrama, D. van, J.J., W.H. Gispen, F. Cattabeni, and L. Di, M. AlphaCaMKII binding to the C-terminal tail of NMDA receptor subunit NR2A and its modulation by autophosphorylation. FEBS Lett 456: 394–398, 1999.
Gerber, G., I. Kangrga, P.D. Ryu, J.S. Larew, and M. Randic. Multiple effects of phorbol esters in the rat spinal dorsal horn. J Neurosci 9: 3606–3617, 1989.
Gerges, N.Z., D.S. Backos, C.N. Rupasinghe, M.R. Spaller, and J.A. Esteban. Dual role of the exocyst in AMPA receptor targeting and insertion into the postsynaptic membrane. EMBO J 25: 1623–1634, 2006.
Goto, Y., T. Niidome, A. Akaike, T. Kihara, and H. Sugimoto. Amyloid beta-peptide preconditioning reduces glutamate-induced neurotoxicity by promoting endocytosis of NMDA receptor. Biochem Biophys Res Commun 351: 259–265, 2006.
Frizelle, P.A., P.E. Chen, and D.J. Wyllie. Equilibrium constants for (R)-[(S)-1-(4-bromophenyl)- ethylamino]-(2,3-dioxo-1,2,3,4-tetrahydroquino xalin-5-yl)-methyl]-phosphonic acid (NVP-AAM077) acting at recombinant NR1/NR2A and NR1/NR2B N-methyl-Daspartate receptors: implications for studies of synaptic transmission. Mol Pharmacol 70: 1022–1032, 2006.
Groc, L., M. Heine, L. Cognet, K. Brickley, F.A. Stephenson, B. Lounis, and D. Choquet. Differential activity-dependent regulation of the lateral mobilities of AMPA and NMDA receptors. Nat Neurosci 7: 695–696, 2004.
Groc, L., M. Heine, S.L. Cousins, F.A. Stephenson, B. Lounis, L. Cognet, and D. Choquet. NMDA receptor surface mobility depends on NR2A-2B subunits. Proc Natl Acad Sci USA 103: 18769–18774, 2006.
Grosshans, D.R., D.A. Clayton, S.J. Coultrap, and M.D. Browning. LTP leads to rapid surface expression of NMDA but not AMPA receptors in adult rat CA1. Nat Neurosci 5: 27–33, 2002.
Grossman, S.D., L.J. Rosenberg, and J.R. Wrathall. Temporal-spatial pattern of acute neuronal and glial loss after spinal cord contusion. Exp Neurol 168: 273–282, 2001.
Grunwald, I.C., M. Korte, D. Wolfer, G.A. Wilkinson, K. Unsicker, H.P. Lipp, T. Bonhoeffer, and R. Klein. Kinase-independent requirement of EphB2 receptors in hippocampal synaptic plasticity. Neuron 32: 1027–1040, 2001.
Gu, Z., Q. Jiang, A.K. Fu, N.Y. Ip, and Z. Yan. Regulation of NMDA receptors by neuregulin signaling in prefrontal cortex. J Neurosci 25: 4974–4984, 2005.
Guillaud, L., M. Setou, and N. Hirokawa. KIF17 dynamics and regulation of NR2B trafficking in hippocampal neurons. J Neurosci 23: 131–140, 2003.
Hahn, C. G., H.Y. Wang, D.S. Cho, K. Talbot, R.E. Gur, W.H. Berrettini, K. Bakshi, J. Kamins, K.E. Borgmann-Winter, S.J. Siegel, R.J. Gallop, and S.E. Arnold. Altered neuregulin 1-erbB4 signaling contributes to NMDA receptor hypofunction in schizophrenia. Nat Med 12: 824–828, 2006.
Hallett, P.J., A.W. Dunah, P. Ravenscroft, S. Zhou, E. Bezard, A.R. Crossman, J.M. Brotchie, and D.G. Standaert. Alterations of striatal NMDA receptor subunits associated with the development of dyskinesia in the MPTP-lesioned primate model of Parkinson’s disease. Neuropharmacology 48: 503–516, 2005.
Hallett, P.J., and D.G. Standaert. Rationale for and use of NMDA receptor antagonists in Parkinson’s disease. Pharmacol Ther 102: 155–174, 2004.
Hantraye, P., D. Riche, M. Maziere, and O. Isacson. A primate model of Huntington’s disease: behavioral and anatomical studies of unilateral excitotoxic lesions of the caudate- putamen in the baboon. Exp Neurol 108: 91–104, 1990.
Hardingham, G.E., and H. Bading. The Yin and Yang of NMDA receptor signalling. Trends Neurosci 26: 81–89, 2003.
Hardingham, G.E., Y. Fukunaga, and H. Bading. Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways. Nat Neurosci 5: 405–414, 2002.
Harney, S.C., M. Rowan, and R. Anwyl. Long-term depression of NMDA receptormediated synaptic transmission is dependent on activation of metabotropic glutamate receptors and is altered to long-term potentiation by low intracellular calcium buffering. J Neurosci 26: 1128–1132, 2006.
Harper, P.S. The epidemiology of Huntington’s disease. Hum Genet 89: 365–376, 1992.
Hawkins, L.M., K. Prybylowski, K. Chang, C. Moussan, F.A. Stephenson, and R.J. Wenthold. Export from the endoplasmic reticulum of assembled N-methyl-D-aspartic acid receptors is controlled by a motif in the c terminus of the NR2 subunit. J Biol Chem 279: 28903–28910, 2004.
Henderson, J.T., J. Georgiou, Z. Jia, J. Robertson, S. Elowe, J.C. Roder, and T. Pawson. The receptor tyrosine kinase EphB2 regulates NMDA-dependent synaptic function. Neuron 32: 1041–1056, 2001.
Henkemeyer, M., O.S. Itkis, M. Ngo, P.W. Hickmott, and I.M. Ethell. Multiple EphB receptor tyrosine kinases shape dendritic spines in the hippocampus. J Cell Biol 163: 1313–1326, 2003.
Herin, G.A., and E. Aizenman. Amino terminal domain regulation of NMDA receptor function. Eur J Pharmacol500: 101–111, 2004.
Hering, H., C.C. Lin, and M. Sheng. Lipid rafts in the maintenance of synapses, dendritic spines, and surface AMPA receptor stability. J Neurosci 23: 3262–3271, 2003.
Hirai, H., J. Kirsch, B. Laube, H. Betz, and J. Kuhse. The glycine binding site of the Nmethyl- D-aspartate receptor subunit NR1: identification of novel determinants of coagonist potentiation in the extracellular M3-M4 loop region. Proc Natl Acad Sci USA 93: 6031–6036, 1996.
Hirao, K., Y. Hata, N. Ide, M. Takeuchi, M. Irie, I. Yao, M. Deguchi, A. Toyoda, T.C. Sudhof, and Y. Takai. A novel multiple PDZ domain-containing molecule interacting with N-methyl-D-aspartate receptors and neuronal cell adhesion proteins. J Biol Chem 273: 21105–21110, 1998.
Hsu, S.C., A.E. Ting, C.D. Hazuka, S. Davanger, J.W. Kenny, Y. Kee, and R.H. Scheller. The mammalian brain rsec6/8 complex. Neuron 17: 1209–1219, 1996.
Huh, K.H., and R.J. Wenthold. Turnover analysis of glutamate receptors identifies a rapidly degraded pool of the N-methyl-D-aspartate receptor subunit, NR1, in cultured cerebellar granule cells. J Biol Chem 274: 151–157, 1999.
Humeau, Y., H. Shaban, S. Bissiere, and A. Luthi. Presynaptic induction of heterosynaptic associative plasticity in the mammalian brain. Nature 426: 841–845, 2003.
Hynd, M.R., H.L. Scott, and P.R. Dodd. Glutamate(NMDA) receptor NR1 subunit mRNA expression in Alzheimer’s disease. J Neurochem 78: 175–182, 2001.
Hynd, M.R., H.L. Scott, and P.R. Dodd. Selective loss of NMDA receptor NR1 subunit isoforms in Alzheimer’s disease. J Neurochem 89: 240–247, 2004.
Hynd, M.R., H.L. Scott, and P.R. Dodd. Differential expression of N-methyl-Daspartate receptor NR2 isoforms in Alzheimer’s disease. J Neurochem 90: 913–919, 2004.
Hynd, M.R., H.L. Scott, and P.R. Dodd. Glutamate-mediated excitotoxicity and neurodegeneration in Alzheimer’s disease. Neurochem Int 45: 583–595, 2004.
Isaac, J.T., R.A. Nicoll, and R.C. Malenka. Evidence for silent synapses: implications for the expression of LTP. Neuron 15: 427–434, 1995.
Isaacson, J.S., and G.J. Murphy. Glutamate-mediated extrasynaptic inhibition: direct coupling of NMDA receptors to Ca(2+)-activated K+ channels. Neuron 31: 1027–1034, 2001.
Ishii, T., K. Moriyoshi, H. Sugihara, K. Sakurada, H. Kadotani, M. Yokoi, C. Akazawa, R. Shigemoto, N. Mizuno, M. Masu, et al. Molecular characterization of the family of the N-methyl-D-aspartate receptor subunits. J Biol Chem 268: 2836–2843, 1993.
Jarabek, B.R., R.P. Yasuda, and B.B. Wolfe. Regulation of proteins affecting NMDA receptor-induced excitotoxicity in a Huntington’s mouse model. Brain 127: 505–516, 2004.
Jason, G.W., O. Suchowersky, E.M. Pajurkova, L. Graham, M.L. Klimek, A.T. Garber, and D. Poirier-Heine. Cognitive manifestations of Huntington disease in relation to genetic structure and clinical onset. Arch Neurol 54: 1081–1088, 1997.
Jourdain, P., L.H. Bergersen, K. Bhaukaurally, P. Bezzi, M. Santello, M. Domercq, C. Matute, F. Tonello, V. Gundersen, and A. Volterra. Glutamate exocytosis from astrocytes controls synaptic strength. Nat Neurosci 10: 331–339, 2007.
Kadotani, H., T. Hirano, M. Masugi, K. Nakamura, K. Nakao, M. Katsuki, and S. Nakanishi. Motor discoordination results from combined gene disruption of the NMDA receptor NR2A and NR2C subunits, but not from single disruption of the NR2A or NR2C subunit. J Neurosci 16: 7859–7867, 1996.
Kamenetz, F., T. Tomita, H. Hsieh, G. Seabrook, D. Borchelt, T. Iwatsubo, S. Sisodia, and R. Malinow. APP processing and synaptic function. Neuron 37: 925–937, 2003.
Kanzaki, M., and J.E. Pessin. Insulin signaling: GLUT4 vesicles exit via the exocyst. Curr Biol 13: R574–R576, 2003.
Karavanova, I., K. Vasudevan, J. Cheng, and A. Buonanno. Novel regional and developmental NMDA receptor expression patterns uncovered in NR2C subunit-betagalactosidase knock-in mice. Mol Cell Neurosci 34: 468–480, 2007.
Kato, A., N. Rouach, R.A. Nicoll, and D.S. Bredt. Activity-dependent NMDA receptor degradation mediated by retrotranslocation and ubiquitination. Proc Natl Acad Sci USA 102: 5600–5605, 2005.
Kaul, M., and S.A. Lipton. Signaling pathways to neuronal damage and apoptosis in human immunodeficiency virus type 1-associated dementia: chemokine receptors, excitotoxicity, and beyond. J Neurovirol 10(Suppl 1): 97–101, 2004.
Kennedy, M.B., and P. Manzerra. Telling tails. Proc Natl Acad Sci USA 98: 12323–12324, 2001.
Kim, E., S. Naisbitt, Y.P. Hsueh, A. Rao, A. Rothschild, A.M. Craig, and M. Sheng. GKAP, a novel synaptic protein that interacts with the guanylate kinase-like domain of the PSD-95/SAP90 family of channel clustering molecules. J Cell Biol 136: 669–678, 1997.
Kim, E., and M. Sheng. PDZ domain proteins of synapses. Nat Rev Neurosci 5: 771–781, 2004.
Kim, J.H., D. Liao, L.F. Lau, and R.L. Huganir. SynGAP: a synaptic RasGAP that associates with the PSD-95/SAP90 protein family. Neuron 20: 683–691, 1998.
Kirkham, M., and R.G. Parton. Clathrin-independent endocytosis: new insights into caveolae and non-caveolar lipid raft carriers. Biochim Biophys Acta 1746: 349–363, 2005.
Kirson, E.D., C. Schirra, A. Konnerth, and Y. Yaari. Early postnatal switch in magnesium sensitivity of NMDA receptors in rat CA1 pyramidal cells. J Physiol 521(Pt 1): 99–111, 1999.
Kitamura, T., M. Mishina, and H. Sugiyama. Enhancement of neurogenesis by running wheel exercises is suppressed in mice lacking NMDA receptor epsilon 1 subunit. Neurosci Res 47: 55–63, 2003.
Kneussel, M. Postsynaptic scaffold proteins at non-synaptic sites. The role of postsynaptic scaffold proteins in motor-protein-receptor complexes. EMBO Rep 6: 22–27, 2005.
Ko, J., S. Kim, H.S. Chung, K. Kim, K. Han, H. Kim, H. Jun, B.K. Kaang, and E. Kim. SALM synaptic cell adhesion-like molecules regulate the differentiation of excitatory synapses. Neuron 50: 233–245, 2006.
Kohr, G. NMDA receptor function: subunit composition versus spatial distribution. Cell Tissue Res 326: 439–446, 2006.
Komuro, H., and P. Rakic. Modulation of neuronal migration by NMDA receptors. Science 260: 95–97, 1993.
Kornau, H.C., L.T. Schenker, M.B. Kennedy, and P.H. Seeburg. Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95. Science 269: 1737–1740, 1995.
Kowal, C., L.A. Degiorgio, J.Y. Lee, M.A. Edgar, P.T. Huerta, B.T. Volpe, and B. Diamond. Human lupus autoantibodies against NMDA receptors mediate cognitive impairment. Proc Natl Acad Sci USA 103: 19854–19859, 2006.
Kristiansen, L.V., and J.H. Meador-Woodruff. Abnormal striatal expression of transcripts encoding NMDA interacting PSD proteins in schizophrenia, bipolar disorder and major depression. Schizophr Res 78: 87–93, 2005.
Kumada, T., and H. Komuro. Completion of neuronal migration regulated by loss of Ca(2+) transients. Proc Natl Acad Sci USA 101: 8479–8484, 2004.
Kuppenbender, K.D., D.G. Standaert, T.J. Feuerstein, J.B.J. Penney, A.B. Young, and G.B. Landwehrmeyer. Expression of NMDA receptor subunit mRNAs in neurochemically identified projection and interneurons in the human striatum. J Comp Neurol 419: 407–421, 2000.
Kurschner, C., P.G. Mermelstein, W.T. Holden, and D.J. Surmeier. CIPP, a novel multivalent PDZ domain protein, selectively interacts with Kir4.0 family members, NMDA receptor subunits, neurexins, and neuroligins. Mol Cell Neurosci 11: 161–172, 1998.
Kuryatov, A., B. Laube, H. Betz, and J. Kuhse. Mutational analysis of the glycinebinding site of the NMDA receptor: structural similarity with bacterial amino acidbinding proteins. Neuron 12: 1291–1300, 1994.
Kusumi, A., and K. Suzuki. Toward understanding the dynamics of membrane-raftbased molecular interactions. Biochim Biophys Acta 1746: 234–251, 2005.
Kwon, O.B., M. Longart, D. Vullhorst, D.A. Hoffman, and A. Buonanno. Neuregulin-1 reverses long-term potentiation at CA1 hippocampal synapses. J Neurosci 25: 9378–9383, 2005.
Lacor, P.N., M.C. Buniel, P.W. Furlow, A.S. Clemente, P.T. Velasco, M. Wood, K.L. Viola, and W.L. Klein. Abeta oligomer-induced aberrations in synapse composition, shape, and density provide a molecular basis for loss of connectivity in Alzheimer’s disease. J Neurosci 27: 796–807, 2007.
Lambert, M.P., A.K. Barlow, B.A. Chromy, C. Edwards, R. Freed, M. Liosatos, T.E. Morgan, I. Rozovsky, B. Trommer, K.L. Viola, P. Wals, C. Zhang, C.E. Finch, G.A. Krafft, and W.L. Klein. Diffusible, nonfibrillar ligands derived from Abeta1–42 are potent central nervous system neurotoxins. Proc Natl Acad Sci USA 95: 6448–6453, 1998.
Lan, J.Y., V.A. Skeberdis, T. Jover, S.Y. Grooms, Y. Lin, R.C. Araneda, X. Zheng, M.V. Bennett, and R.S. Zukin. Protein kinase C modulates NMDA receptor trafficking and gating. Nat Neurosci 4: 382–390, 2001.
Landles, C., and G.P. Bates. Huntingtin and the molecular pathogenesis of Huntington’s disease. Fourth in molecular medicine review series. EMBO Rep 5: 958–963, 2004.
Landwehrmeyer, G.B., D.G. Standaert, C.M. Testa, J.B.J. Penney, and A.B. Young. NMDA receptor subunit mRNA expression by projection neurons and interneurons in rat striatum. J Neurosci 15: 5297–5307, 1995.
Lau, C.G., and R.S. Zukin. NMDA receptor trafficking in synaptic plasticity and neuropsychiatric disorders. Nat Rev Neurosci 8: 413–426, 2007.
Lau, L.F., A. Mammen, M.D. Ehlers, S. Kindler, W.J. Chung, C.C. Garner, and R.L. Huganir. Interaction of the N-methyl-D-aspartate receptor complex with a novel synapse- associated protein, SAP102. J Biol Chem 271: 21622–21628, 1996.
Laube, B., H. Hirai, M. Sturgess, H. Betz, and J. Kuhse. Molecular determinants of agonist discrimination by NMDA receptor subunits: analysis of the glutamate binding site on the NR2B subunit. Neuron 18: 493–503, 1997.
Laurie, D.J., I. Bartke, R. Schoepfer, K. Naujoks, and P.H. Seeburg. Regional, developmental and interspecies expression of the four NMDAR2 subunits, examined using monoclonal antibodies. Brain Res Mol Brain Res 51: 23–32, 1997.
Laurie, D.J., J. Putzke, W. Zieglgansberger, P.H. Seeburg, and T.R. Tolle. The distribution of splice variants of the NMDAR1 subunit mRNA in adult rat brain. Brain Res Mol Brain Res 32: 94–108, 1995.
Laurie, D.J., and P.H. Seeburg. Regional and developmental heterogeneity in splicing of the rat brain NMDAR1 mRNA. J Neurosci 14: 3180–3194, 1994.
Lavezzari, G., J. McCallum, C.M. Dewey, and K.W. Roche. Subunit-specific regulation of NMDA receptor endocytosis. J Neurosci 24: 6383–6391, 2004.
Lawrence, A.D., B.J. Sahakian, J.R. Hodges, A.E. Rosser, K.W. Lange, and T.W. Robbins. Executive and mnemonic functions in early Huntington’s disease. Brain 119: 1633–1645, 1996.
Leavitt, B.R., J.M. van Raamsdonk, J. Shehadeh, H. Fernandes, Z. Murphy, R.K. Graham, C.L. Wellington, L.A. Raymond, and M.R. Hayden. Wild-type huntingtin protects neurons from excitotoxicity. J Neurochem 96: 1121–1129, 2006.
Lei, S., E. Czerwinska, W. Czerwinski, M.P. Walsh, and J.F. MacDonald. Regulation of NMDA receptor activity by F-actin and myosin light chain kinase. J Neurosci 21: 8464–8472, 2001.
Leonard, A.S., I.A. Lim, D.E. Hemsworth, M.C. Horne, and J.W. Hell. Calcium/ calmodulin-dependent protein kinase II is associated with the N-methyl-Daspartate receptor. Proc Natl Acad Sci USA 96: 3239–3244, 1999.
Levine, M.S., C. Cepeda, M.A. Hickey, S.M. Fleming, and M.F. Chesselet. Genetic mouse models of Huntington’s and Parkinson’s diseases: illuminating but imperfect. Trends Neurosci 27: 691–697, 2004.
Levinson, J.N., N. Chery, K. Huang, T.P. Wong, K. Gerrow, R. Kang, O. Prange, Y.T. Wang, and A. El-Husseini. Neuroligins mediate excitatory and inhibitory synapse formation: involvement of PSD-95 and neurexin-1beta in neuroligin-induced synaptic specificity. J Biol Chem 280: 17312–17319, 2005.
Li, B., N. Chen, T. Luo, Y. Otsu, T.H. Murphy, and L.A. Raymond. Differential regulation of synaptic and extra-synaptic NMDA receptors. Nat Neurosci 5: 833–834, 2002.
Li, B.S., M.K. Sun, L. Zhang, S. Takahashi, W. Ma, L. Vinade, A.B. Kulkarni, R.O. Brady, and H.C. Pant. Regulation of NMDA receptors by cyclin-dependent kinase-5. Proc Natl Acad Sci USA 98: 12742–12747, 2001.
Li, L., M. Fan, C.D. Icton, N. Chen, B.R. Leavitt, M.R. Hayden, T.H. Murphy, and L.A. Raymond. Role of NR2B-type NMDA receptors in selective neurodegeneration in Huntington disease. Neurobiol Aging 24: 1113–1121, 2003.
Li, Z., and M. Sheng. Some assembly required: the development of neuronal synapses. Nat Rev Mol Cell Biol 4: 833–841, 2003.
Lieberman, D.N., and I. Mody. Casein kinase-II regulates NMDA channel function in hippocampal neurons. Nat Neurosci 2: 125–132, 1999.
Lien, C.C., Y. Mu, M. Vargas-Caballero, and M.M. Poo. Visual stimuli-induced LTD of GABAergic synapses mediated by presynaptic NMDA receptors. Nat Neurosci 9: 372–380, 2006.
Lillemeier, B.F., J.R. Pfeiffer, Z. Surviladze, B.S. Wilson, and M.M. Davis. Plasma membrane-associated proteins are clustered into islands attached to the cytoskeleton. Proc Natl Acad Sci USA 103: 18992–18997, 2006.
Lin, B., A.C. Arai, G. Lynch, and C.M. Gall. Integrins regulate NMDA receptormediated synaptic currents. J Neurophysiol 89: 2874–2878, 2003.
Lin, S.Y., and M. Constantine-Paton. Suppression of sprouting: an early function of NMDA receptors in the absence of AMPA/kainate receptor activity. J Neurosci 18: 3725–3737, 1998.
Lipton, S.A. The molecular basis of memantine action in Alzheimer’s disease and other neurologic disorders: low-affinity, uncompetitive antagonism. Curr Alzheimer Res 2: 155–165, 2005.
Liu, L., T.P. Wong, M.F. Pozza, K. Lingenhoehl, Y. Wang, M. Sheng, Y.P. Auberson, and Y.T. Wang. Role of NMDA receptor subtypes in governing the direction of hippocampal synaptic plasticity. Science 304: 1021–1024, 2004.
Liu, X.B., K.D. Murray, and E.G. Jones. Switching of NMDA receptor 2A and 2B subunits at thalamic and cortical synapses during early postnatal development. J Neurosci 24: 8885–8895, 2004.
Loschmann, P.A., C. De Groote, L. Smith, U. Wullner, G. Fischer, J.A. Kemp, P. Jenner, and T. Klockgether. Antiparkinsonian activity of Ro 25–6981, a NR2B subunit specific NMDA receptor antagonist, in animal models of Parkinson’s disease. Exp Neurol 187: 86–93, 2004.
Losi, G., K. Prybylowski, Z. Fu, J. Luo, R.J. Wenthold, and S. Vicini. PSD-95 regulates NMDA receptors in developing cerebellar granule neurons of the rat. J Physiol 548: 21–29, 2003.
LoTurco, J.J., M.G. Blanton, and A.R. Kriegstein. Initial expression and endogenous activation of NMDA channels in early neocortical development. J Neurosci 11: 792–799, 1991.
Low, C.M., F. Zheng, P. Lyuboslavsky, and S.F. Traynelis. Molecular determinants of coordinated proton and zinc inhibition of N-methyl-D-aspartate NR1/NR2A receptors. Proc Natl Acad Sci USA 97: 11062–11067, 2000.
Luby, E.D., B.D. Cohen, G. Rosenbaum, J.S. Gottlieb, and R. Kelley. Study of a new schizophrenomimetic drug; sernyl. AMA Arch Neurol Psychiatry 81: 363–369, 1959.
Luthi-Carter, R., B.L. Apostol, A.W. Dunah, M.M. DeJohn, L.A. Farrell, G.P. Bates, A.B. Young, D.G. Standaert, L.M. Thompson, and J.H. Cha. Complex alteration of NMDA receptors in transgenic Huntington’s disease mouse brain: analysis of mRNA and protein expression, plasma membrane association, interacting proteins, and phosphorylation. Neurobiol Dis 14: 624–636, 2003.
Lynch, D.R., and R.P. Guttmann. Excitotoxicity: perspectives based on N-methyl-Daspartate receptor subtypes. J Pharmacol Exp Ther 300: 717–723, 2002.
MacDonald, J.F., S.A. Kotecha, W.Y. Lu, and M.F. Jackson. Convergence of PKCdependent kinase signal cascades on NMDA receptors. Curr Drug Targets 2: 299–312, 2001.
Mameli, M., M. Carta, L.D. Partridge, and C.F. Valenzuela. Neurosteroid-induced plasticity of immature synapses via retrograde modulation of presynaptic NMDA receptors. J Neurosci 25: 2285–2294, 2005.
Manent, J.B., M. Demarque, I. Jorquera, C. Pellegrino, Y. Ben-Ari, L. Aniksztejn, and A. Represa. A noncanonical release of GABA and glutamate modulates neuronal migration. J Neurosci 25: 4755–4765, 2005.
Manent, J.B., I. Jorquera, Y. Ben-Ari, L. Aniksztejn, and A. Represa. Glutamate acting on AMPA but not NMDA receptors modulates the migration of hippocampal interneurons. J Neurosci 26: 5901–5909, 2006.
Matsuda, K., M. Fletcher, Y. Kamiya, and M. Yuzaki. Specific assembly with the NMDA receptor 3B subunit controls surface expression and calcium permeability of NMDA receptors. J Neurosci 23: 10064–10073, 2003.
McCullumsmith, R.E., L.V. Kristiansen, M. Beneyto, E. Scarr, B. Dean, and J. H. Meador-Woodruff. Decreased NR1, NR2A, and SAP102 transcript expression in the hippocampus in bipolar disorder. Brain Res 1127: 108–118, 2007.
McGee, A.W., J.R. Topinka, K. Hashimoto, R.S. Petralia, S. Kakizawa, F.W. Kauer, A. Aguilera-Moreno, R.J. Wenthold, M. Kano, and D.S. Bredt. PSD-93 knock-out mice reveal that neuronal MAGUKs are not required for development or function of parallel fiber synapses in cerebellum. J Neurosci 21: 3085–3091, 2001.
McIlhinney, R.A., B. Le Bourdelles, E. Molnar, N. Tricaud, P. Streit, and P.J. Whiting. Assembly intracellular targeting and cell surface expression of the human N-methyl-Daspartate receptor subunits NR1a and NR2A in transfected cells. Neuropharmacology 37: 1355–1367, 1998.
McIlhinney, R.A., E. Philipps, B. Le Bourdelles, S. Grimwood, K. Wafford, S. Sandhu, and P. Whiting. Assembly of N-methyl-D-aspartate (NMDA) receptors. Biochem Soc Trans 31: 865–868, 2003.
McKinney, R.A., A. Luthi, C.E. Bandtlow, B.H. Gahwiler, and S.M. Thompson. Selective glutamate receptor antagonists can induce or prevent axonal sprouting in rat hippocampal slice cultures. Proc Natl Acad Sci USA 96: 11631–11636, 1999.
Meador-Woodruff, J.H., and D.J. Healy. Glutamate receptor expression in schizophrenic brain. Brain Res Brain Res Rev 31: 288–294, 2000.
Meddows, E., B. Le Bourdelles, S. Grimwood, K. Wafford, S. Sandhu, P. Whiting, and R.A. McIlhinney. Identification of molecular determinants that are important in the assembly of N-methyl-D-aspartate receptors. J Biol Chem 276: 18795–18803, 2001.
Medina, I. Extrasynaptic NMDA receptors reshape gene ranks. Sci STKE 2007: pe23, 2007.
Mehta, S.Q., P.R. Hiesinger, S. Beronja, R.G. Zhai, K.L. Schulze, P. Verstreken, Y. Cao, Y. Zhou, U. Tepass, M.C. Crair, and H.J. Bellen. Mutations in Drosophila sec15 reveal a function in neuronal targeting for a subset of exocyst components. Neuron 46: 219–232, 2005.
Menegoz, M., L.F. Lau, D. Herve, R.L. Huganir, and J.A. Girault. Tyrosine phosphorylation of NMDA receptor in rat striatum: effects of 6-OH-dopamine lesions. Neuroreport 7: 125–128, 1995.
Meoni, P., B.H. Bunnemann, A.E. Kingsbury, D.G. Trist, and N.G. Bowery. NMDA NR1 subunit mRNA and glutamate NMDA-sensitive binding are differentially affected in the striatum and pre-frontal cortex of Parkinson’s disease patients. Neuropharmacology 38: 625–633, 1999.
Migaud, M., P. Charlesworth, M. Dempster, L.C. Webster, A.M. Watabe, M. Makhinson, Y. He, M.F. Ramsay, R.G. Morris, J.H. Morrison, T.J. O’Dell, and S.G. Grant. Enhanced long-term potentiation and impaired learning in mice with mutant postsynaptic density-95 protein. Nature 396: 433–439, 1998.
Mishizen-Eberz, A.J., R.A. Rissman, T.L. Carter, M.D. Ikonomovic, B.B. Wolfe, and D.M. Armstrong. Biochemical and molecular studies of NMDA receptor subunits NR1/2A/2B in hippocampal subregions throughout progression of Alzheimer’s disease pathology. Neurobiol Dis 15: 80–92, 2004.
Miskevich, F., W. Lu, S.Y. Lin, and M. Constantine-Paton. Interaction between metabotropic and NMDA subtypes of glutamate receptors in sprout suppression at young synapses. J Neurosci 22: 226–238, 2002.
Misra, C., and E.B. Ziff. EphB2 gets a GRIP on the dendritic arbor. Nat Neurosci 8: 848–850, 2005.
Miyamoto, Y., K. Yamada, Y. Noda, H. Mori, M. Mishina, and T. Nabeshima. Lower sensitivity to stress and altered monoaminergic neuronal function in mice lacking the NMDA receptor epsilon 4 subunit. J Neurosci 22: 2335–2342, 2002.
Mohn, A.R., R.R. Gainetdinov, M.G. Caron, and B.H. Koller. Mice with reduced NMDA receptor expression display behaviors related to schizophrenia. Cell 98: 427–436, 1999.
Mok, H., H. Shin, S. Kim, J.R. Lee, J. Yoon, and E. Kim. Association of the kinesin superfamily motor protein KIF1Balpha with postsynaptic density-95 (PSD-95), synapseassociated protein-97, and synaptic scaffolding molecule PSD-95/discs large/zona occludens- 1 proteins. J Neurosci 22: 5253–5258, 2002.
Montgomery, J.M., and D.V. Madison. State-dependent heterogeneity in synaptic depression between pyramidal cell pairs. Neuron 33: 765–777, 2002.
Monyer, H., N. Burnashev, D.J. Laurie, B. Sakmann, and P.H. Seeburg. Developmental and regional expression in the rat brain and functional properties of four NMDA receptors. Neuron 12: 529–540, 1994.
Moya, F., and M. Valdeolmillos. Polarized increase of calcium and nucleokinesis in tangentially migrating neurons. Cereb Cortex 14: 610–618, 2004.
Mu, Y., T. Otsuka, A.C. Horton, D.B. Scott, and M.D. Ehlers. Activity-dependent mRNA splicing controls ER export and synaptic delivery of NMDA receptors. Neuron 40: 581–594, 2003.
Mueller, H.T., and J.H. Meador-Woodruff. NR3A NMDA receptor subunit mRNA expression in schizophrenia, depression and bipolar disorder. Schizophr Res 71: 361–370, 2004.
Naisbitt, S., E. Kim, J.C. Tu, B. Xiao, C. Sala, J. Valtschanoff, R.J. Weinberg, P.F. Worley, and M. Sheng. Shank, a novel family of postsynaptic density proteins that binds to the NMDA receptor/PSD-95/GKAP complex and cortactin. Neuron 23: 569–582, 1999.
Nakazawa, T., S. Komai, T. Tezuka, C. Hisatsune, H. Umemori, K. Semba, M. Mishina, T. Manabe, and T. Yamamoto. Characterization of Fyn-mediated tyrosine phosphorylation sites on GluR epsilon 2 (NR2B) subunit of the N-methyl-D-aspartate receptor. J Biol Chem 276: 693–699, 2001.
Nash, J.E., S.H. Fox, B. Henry, M.P. Hill, D. Peggs, S. McGuire, Y. Maneuf, C. Hille, J.M. Brotchie, and A.R. Crossman. Antiparkinsonian actions of ifenprodil in the MPTP-lesioned marmoset model of Parkinson’s disease. Exp Neurol 165: 136–142, 2000.
Neyton, J., and P. Paoletti. Relating NMDA receptor function to receptor subunit composition: limitations of the pharmacological approach. J Neurosci 26: 1331–1333, 2006.
Nichols, B.J., and J. Lippincott-Schwartz. Endocytosis without clathrin coats. Trends Cell Biol 11: 406–412, 2001.
Niethammer, M., E. Kim, and M. Sheng. Interaction between the C terminus of NMDA receptor subunits and multiple members of the PSD-95 family of membrane-associated guanylate kinases. J Neurosci 16: 2157–2163, 1996.
Nishimura, W., I. Yao, J. Iida, N. Tanaka, and Y. Hata. Interaction of synaptic scaffolding molecule and Beta -catenin. J Neurosci 22: 757–765, 2002.
Nong, Y., Y.Q. Huang, and M.W. Salter. NMDA receptors are movin’ in. Curr Opin Neurobiol 14: 353–361, 2004.
O’Connor, J.J., M.J. Rowan, and R. Anwyl. Long-lasting enhancement of NMDA receptor-mediated synaptic transmission by metabotropic glutamate receptor activation. Nature 367: 557–559, 1994.
Obrietan, K., and K.R. Hoyt. CRE-mediated transcription is increased in Huntington’s disease transgenic mice. J Neurosci 24: 791–796, 2004.
Oh, J.D., D.S. Russell, C.L. Vaughan, and T.N. Chase. Enhanced tyrosine phosphorylation of striatal NMDA receptor subunits: effect of dopaminergic denervation and LDOPA administration. Brain Res 813: 150–159, 1998.
Oh, J.D., C.L. Vaughan, and T.N. Chase. Effect of dopamine denervation and dopamine agonist administration on serine phosphorylation of striatal NMDA receptor subunits. Brain Res 821: 433–442, 1999.
Ohtakara, K., M. Nishizawa, I. Izawa, Y. Hata, S. Matsushima, W. Taki, H. Inada, Y. Takai, and M. Inagaki. Densin-180, a synaptic protein, links to PSD-95 through its direct interaction with MAGUIN-1. Genes Cells 7: 1149–1160, 2002.
Okabe, S., C. Collin, J.M. Auerbach, N. Meiri, J. Bengzon, M.B. Kennedy, M. Segal, and R.D. McKay. Hippocampal synaptic plasticity in mice overexpressing an embryonic subunit of the NMDA receptor. J Neurosci 18: 4177–4188, 1998.
Okabe, S., A. Miwa, and H. Okado. Alternative splicing of the C-terminal domain regulates cell surface expression of the NMDA receptor NR1 subunit. J Neurosci 19: 7781–7792, 1999.
Oshima, S., M. Fukaya, N. Masabumi, T. Shirakawa, H. Oguchi, and M. Watanabe. Early onset of NMDA receptor GluR epsilon 1 (NR2A) expression and its abundant postsynaptic localization in developing motoneurons of the mouse hypoglossal nucleus. Neurosci Res 43: 239–250, 2002.
Ozaki, M., M. Sasner, R. Yano, H.S. Lu, and A. Buonanno. Neuregulin-beta induces expression of an NMDA-receptor subunit. Nature 390: 691–694, 1997.
Pak, D.T., S. Yang, S. Rudolph-Correia, E. Kim, and M. Sheng. Regulation of dendritic spine morphology by SPAR, a PSD-95-associated RapGAP. Neuron 31: 289–303, 2001.
Passafaro, M., V. Piech, and M. Sheng. Subunit-specific temporal and spatial patterns of AMPA receptor exocytosis in hippocampal neurons. Nat Neurosci 4: 917–926, 2001.
Paulsen, J.S., R.E. Ready, J.M. Hamilton, M.S. Mega, and J.L. Cummings. Neuropsychiatric aspects of Huntington’s disease. J Neurol Neurosurg Psychiatry 71: 310–314, 2001.
Pavlov, I., R. Riekki, and T. Taira. Synergistic action of GABA-A and NMDA receptors in the induction of long-term depression in glutamatergic synapses in the newborn rat hippocampus. Eur J Neurosci 20: 3019–3026, 2004.
Pearce, I.A., M.A. Cambray-Deakin, and R.D. Burgoyne. Glutamate acting on NMDA receptors stimulates neurite outgrowth from cerebellar granule cells. FEBS Lett 223: 143–147, 1987.
Perez-Otano, I., and M.D. Ehlers. Learning from NMDA receptor trafficking: clues to the development and maturation of glutamatergic synapses. Neurosignals 13: 175–189, 2004.
Perez-Otano, I., R. Lujan, S.J. Tavalin, M. Plomann, J. Modregger, X.B. Liu, E.G. Jones, S.F. Heinemann, D.C. Lo, and M.D. Ehlers. Endocytosis and synaptic removal of NR3A-containing NMDA receptors by PACSIN1/syndapin1. Nat Neurosci 9: 611–621, 2006.
Perez-Otano, I., C.T. Schulteis, A. Contractor, S.A. Lipton, J.S. Trimmer, N.J. Sucher, and S.F. Heinemann. Assembly with the NR1 subunit is required for surface expression of NR3A-containing NMDA receptors. J Neurosci 21: 1228–1237, 2001.
Perez-Otano, I., and M.D. Ehlers. Homeostatic plasticity and NMDA receptor trafficking. Trends Neurosci 28: 229–238, 2005.
Perin-Dureau, F., J. Rachline, J. Neyton, and P. Paoletti. Mapping the binding site of the neuroprotectant ifenprodil on NMDA receptors. J Neurosci 22: 5955–5965, 2002.
Petralia, R.S., N. Sans, Y.X. Wang, and R.J. Wenthold. Ontogeny of postsynaptic density proteins at glutamatergic synapses. Mol Cell Neurosci 29: 436–452, 2005.
Petralia, R.S., Y.X. Wang, and R.J. Wenthold. Internalization at glutamatergic synapses during development. Eur J Neurosci 18: 3207–3217, 2003.
Petralia, R.S., L.A. Dunbar, Y.-X. Wang, and R.J. Wenthold. Morphological correlates of glutamate receptor trafficking to synapses. Soc Neurosci Abstr 843.2, 2004.
Petralia, R.S., L.A. Dunbar, Y.-X. Wang, and R.J. Wenthold. Specific endosomal associations during the trafficking of synaptic glutamate receptors. Soc Neurosci Abs 949.1, 2005.
Petralia, R.S., J.A. Esteban, Y.X. Wang, J.G. Partridge, H.M. Zhao, R.J. Wenthold, and R. Malinow. Selective acquisition of AMPA receptors over postnatal development suggests a molecular basis for silent synapses. Nat Neurosci 2: 31–36, 1999.
Petralia, R.S., Y.X. Wang, and R.J. Wenthold. NMDA receptors and PSD-95 are found in attachment plaques in cerebellar granular layer glomeruli. Eur J Neurosci 15: 583–587, 2002.
Philpot, B.D., A.K. Sekhar, H.Z. Shouval, and M.F. Bear. Visual experience and deprivation bidirectionally modify the composition and function of NMDA receptors in visual cortex. Neuron 29: 157–169, 2001.
Philpot, B.D., K.K. Cho, and M.F. Bear. Obligatory Role of NR2A for Metaplasticity in Visual Cortex. Neuron 53: 495–502, 2007.
Picconi, B., F. Gardoni, D. Centonze, D. Mauceri, M.A. Cenci, G. Bernardi, P. Calabresi, and M. Di Luca. Abnormal Ca2+-calmodulin-dependent protein kinase II function mediates synaptic and motor deficits in experimental parkinsonism. J Neurosci 24: 5283–5291, 2004.
Polo-Parada, L., C.M. Bose, F. Plattner, and L.T. Landmesser. Distinct roles of different neural cell adhesion molecule (NCAM) isoforms in synaptic maturation revealed by analysis of NCAM 180 kDa isoform-deficient mice. J Neurosci 24: 1852–1864, 2004.
Prybylowski, K., K. Chang, N. Sans, L. Kan, S. Vicini, and R.J. Wenthold. The synaptic localization of NR2B-containing NMDA receptors is controlled by interactions with PDZ proteins and AP-2. Neuron 47: 845–857, 2005.
Prybylowski, K., Z. Fu, G. Losi, L.M. Hawkins, J. Luo, K. Chang, R.J. Wenthold, and S. Vicini. Relationship between availability of NMDA receptor subunits and their expression at the synapse. J Neurosci 22: 8902–8910, 2002.
Prybylowski, K.L., and B.B. Wolfe. Developmental differences in alternative splicing of the NR1 protein in rat cortex and cerebellum. Brain Res Dev Brain Res 123: 143–150, 2000.
Quinlan, E.M., D. Lebel, I. Brosh, and E. Barkai. A molecular mechanism for stabilization of learning-induced synaptic modifications. Neuron 41: 185–192, 2004.
Quinlan, E.M., D.H. Olstein, and M.F. Bear. Bidirectional, experience-dependent regulation of N-methyl-D-aspartate receptor subunit composition in the rat visual cortex during postnatal development. Proc Natl Acad Sci USA 96: 12876–12880, 1999.
Quinlan, E.M., B.D. Philpot, R.L. Huganir, and M.F. Bear. Rapid, experiencedependent expression of synaptic NMDA receptors in visual cortex in vivo. Nat Neurosci 2: 352–357, 1999.
Racz, B., T.A. Blanpied, M.D. Ehlers, and R.J. Weinberg. Lateral organization of endocytic machinery in dendritic spines. Nat Neurosci 7: 917–918, 2004.
Rajan, I., and H.T. Cline. Glutamate receptor activity is required for normal development of tectal cell dendrites in vivo. J Neurosci 18: 7836–7846, 1998.
Rampon, C., Y.P. Tang, J. Goodhouse, E. Shimizu, M. Kyin, and J.Z. Tsien. Enrichment induces structural changes and recovery from nonspatial memory deficits in CA1 NMDAR1-knockout mice. Nat Neurosci 3: 238–244, 2000.
Rao, A., E. Kim, M. Sheng, and A.M. Craig. Heterogeneity in the molecular composition of excitatory postsynaptic sites during development of hippocampal neurons in culture. J Neurosci 18: 1217–1229, 1998.
Rashid, N.A., and M.A. Cambray-Deakin. N-methyl-D-aspartate effects on the growth, morphology and cytoskeleton of individual neurons in vitro. Brain Res Dev Brain Res 67: 301–308, 1992.
Regalado, M.P., R.T. Terry-Lorenzo, C.L. Waites, C.C. Garner, and R.C. Malenka. Transsynaptic signaling by postsynaptic synapse-associated protein 97. J Neurosci 26: 2343–2357, 2006.
Roche, K.W., S. Standley, J. McCallum, L. Dune, C., M.D. Ehlers, and R.J. Wenthold. Molecular determinants of NMDA receptor internalization. Nat Neurosci 4: 794–802, 2001.
Rumbaugh, G., K. Prybylowski, J.F. Wang, and S. Vicini. Exon 5 and spermine regulate deactivation of NMDA receptor subtypes. J Neurophysiol 83: 1300–1306, 2000.
Rumbaugh, G., and S. Vicini. Distinct synaptic and extrasynaptic NMDA receptors in developing cerebellar granule neurons. J Neurosci 19: 10603–10610, 1999.
Ruthazer, E.S., C.J. Akerman, and H.T. Cline. Control of axon branch dynamics by correlated activity in vivo. Science 301: 66–70, 2003.
Salter, M.W., and L.V. Kalia. Src kinases: a hub for NMDA receptor regulation. Nat Rev Neurosci 5: 317–328, 2004. Molecular Properties and Cell Biology of the NMDA
Sampo, B., S. Kaech, S. Kunz, and G. Banker. Two distinct mechanisms target membrane proteins to the axonal surface. Neuron 37: 611–624, 2003.
Sans, N., K. Prybylowski, R.S. Petralia, K. Chang, Y.X. Wang, C. Racca, S. Vicini, and R.J. Wenthold. NMDA receptor trafficking through an interaction between PDZ proteins and the exocyst complex. Nat Cell Biol 5: 520–530, 2003.
Sans, N., P.Y. Wang, Q. Du, R.S. Petralia, Y.X. Wang, S. Nakka, J.B. Blumer, I.G. Macara, and R.J. Wenthold. mPins modulates PSD-95 and SAP102 trafficking and influences NMDA receptor surface expression. Nat Cell Biol 7: 1179–1190, 2005.
Sans, N., R.S. Petralia, Y.X. Wang, J. Blahos, 2nd, J.W. Hell, and R.J. Wenthold. A developmental change in NMDA receptor-associated proteins at hippocampal synapses. J Neurosci 20: 1260–1271, 2000.
Sattler, R., and M. Tymianski. Molecular mechanisms of calcium-dependent excitotoxicity. J Mol Med 78: 3–13, 2000.
Scarpini, E., P. Scheltens, and H. Feldman. Treatment of Alzheimer’s disease: current status and new perspectives. Lancet Neurol 2: 539–547, 2003.
Schnell, E., M. Sizemore, S. Karimzadegan, L. Chen, D.S. Bredt, and R.A. Nicoll. Direct interactions between PSD-95 and stargazin control synaptic AMPA receptor number. Proc Natl Acad Sci USA 99: 13902–13907, 2002.
Schorge, S., and D. Colquhoun. Studies of NMDA receptor function and stoichiometry with truncated and tandem subunits. J Neurosci 23: 1151–1158, 2003.
Schwarcz, R., and C. Kohler. Differential vulnerability of central neurons of the rat to quinolinic acid. Neurosci Lett 38: 85–90, 1983.
Scott, D.B., T.A. Blanpied, and M.D. Ehlers. Coordinated PKA and PKC phoshorylation suppresses RXR-mediated ER retention and regulates the surface delivery of NMDA receptors. Neuropharmacology 45: 755–767, 2003.
Scott, D.B., I. Michailidis, Y. Mu, D. Logothetis, and M.D. Ehlers. Endocytosis and degradative sorting of NMDA receptors by conserved membrane-proximal signals. J Neurosci 24: 7096–7109, 2004.
Scott, D.B., T.A. Blanpied, G.T. Swanson, C. Zhang, and M.D. Ehlers. An NMDA receptor ER retention signal regulated by phosphorylation and alternative splicing. J Neurosci 21: 3063–3072, 2001.
Selkoe, D.J. Alzheimer’s disease is a synaptic failure. Science 298: 789–791, 2002.
Setou, M., T. Nakagawa, D.H. Seog, and N. Hirokawa. Kinesin superfamily motor protein KIF17 and mLin-10 in NMDA receptor-containing vesicle transport. Science 288: 1796–1802, 2000.
Shankar, G. M., B.L. Bloodgood, M. Townsend, D.M. Walsh, D.J. Selkoe, and B.L. Sabatini. Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway. J Neurosci 27: 2866–2875, 2007.
Shen, K., and T. Meyer. Dynamic control of CaMKII translocation and localization in hippocampal neurons by NMDA receptor stimulation. Science 284: 162–166, 1999.
Sheng, M., J. Cummings, L.A. Roldan, Y.N. Jan, and L.Y. Jan. Changing subunit composition of heteromeric NMDA receptors during development of rat cortex. Nature 368: 144–147, 1994.
Shrestha, B.R., O.V. Vitolo, P. Joshi, T. Lordkipanidze, M. Shelanski, and A. Dunaevsky. Amyloid beta peptide adversely affects spine number and motility in hippocampal neurons. Mol Cell Neurosci 33: 274–282, 2006.
Sigismund, S., T. Woelk, C. Puri, E. Maspero, C. Tacchetti, P. Transidico, F. Di, P. P., and S. Polo. Clathrin-independent endocytosis of ubiquitinated cargos. Proc Natl Acad Sci USA 102: 2760–2765, 2005.
Simonian, S.X., and A.E. Herbison. Differing, spatially restricted roles of ionotropic glutamate receptors in regulating the migration of gnrh neurons during embryogenesis. J Neurosci 21: 934–943, 2001.
Sjostrom, P.J., G.G. Turrigiano, and S.B. Nelson. Neocortical LTD via coincident activation of presynaptic NMDA and cannabinoid receptors. Neuron 39: 641–654, 2003.
Skeberdis, V.A., V. Chevaleyre, C.G. Lau, J.H. Goldberg, D.L. Pettit, S.O. Suadicani, Y. Lin, M.V. Bennett, R. Yuste, P.E. Castillo, and R.S. Zukin. Protein kinase A regulates calcium permeability of NMDA receptors. Nat Neurosci 9: 501–510, 2006.
Small, D.H., S.S. Mok, and J.C. Bornstein. Alzheimer’s disease and Abeta toxicity: from top to bottom. Nat Rev Neurosci 2: 595–598, 2001.
Snyder, E.M., B.D. Philpot, K.M. Huber, X. Dong, J.R. Fallon, and M.F. Bear. Internalization of ionotropic glutamate receptors in response to mGluR activation. Nat Neurosci 4: 1079–1085, 2001.
Snyder, E.M., Y. Nong, C.G. Almeida, S. Paul, T. Moran, E.Y. Choi, A.C. Nairn, M.W. Salter, P.J. Lombroso, G.K. Gouras, and P. Greengard. Regulation of NMDA receptor trafficking by amyloid-beta. Nat Neurosci 8: 1051–1058, 2005.
Song, C., Y. Zhang, C.G. Parsons, and Y.F. Liu. Expression of polyglutamineexpanded huntingtin induces tyrosine phosphorylation of N-methyl-D-aspartate receptors. J Biol Chem 278: 33364–33369, 2003.
Soriano, F. X., S. Papadia, F. Hofmann, N.R. Hardingham, H. Bading, and G.E. Hardingham. Preconditioning doses of NMDA promote neuroprotection by enhancing neuronal excitability. J Neurosci 26: 4509–4518, 2006.
Spacek, J., and K.M. Harris. Three-dimensional organization of smooth endoplasmic reticulum in hippocampal CA1 dendrites and dendritic spines of the immature and mature rat. J Neurosci 17: 190–203, 1997.
Sprengel, R., B. Suchanek, C. Amico, R. Brusa, N. Burnashev, A. Rozov, O. Hvalby, V. Jensen, O. Paulsen, P. Andersen, J.J. Kim, R.F. Thompson, W. Sun, L.C. Webster, S.G. Grant, J. Eilers, A. Konnerth, J. Li, J.O. McNamara, and P.H. Seeburg. Importance of the intracellular domain of NR2 subunits for NMDA receptor function in vivo. Cell 92: 279–289, 1998.
Stahl, S.M. Beyond the dopamine hypothesis to the NMDA glutamate receptor hypofunction hypothesis of schizophrenia. CNS Spectr 12: 265–268, 2007.
Standley, S., K.W. Roche, J. McCallum, N. Sans, and R.J. Wenthold. PDZ domain suppression of an ER retention signal in NMDA receptor NR1 splice variants. Neuron 28: 887–898, 2000.
Starling, A.J., V.M. Andre, C. Cepeda, M. de Lima, S.H. Chandler, and M.S. Levine. Alterations in N-methyl-D-aspartate receptor sensitivity and magnesium blockade occur early in development in the R6/2 mouse model of Huntington’s disease. J Neurosci Res 82: 377–386, 2005.
Stefansson, H., E. Sigurdsson, V. Steinthorsdottir, S. Bjornsdottir, T. Sigmundsson, S. Ghosh, J. Brynjolfsson, S. Gunnarsdottir, O. Ivarsson, T.T. Chou, O. Hjaltason, B. Birgisdottir, H. Jonsson, V.G. Gudnadottir, E. Gudmundsdottir, A. Bjornsson, B. Ingvarsson, A. Ingason, S. Sigfusson, H. Hardardottir, R.P. Harvey, D. Lai, M. Zhou, D. Brunner, V. Mutel, A. Gonzalo, G. Lemke, J. Sainz, G. Johannesson, T. Andresson, D. Gudbjartsson, A. Manolescu, M.L. Frigge, M.E. Gurney, A. Kong, J.R. Gulcher, H. Petursson, and K. Stefansson. Neuregulin 1 and susceptibility to schizophrenia. Am J Hum Genet 71: 877–892, 2002.
Steigerwald, F., T.W. Schulz, L.T. Schenker, M.B. Kennedy, P.H. Seeburg, and G. Kohr. C-Terminal truncation of NR2A subunits impairs synaptic but not extrasynaptic localization of NMDA receptors. J Neurosci 20: 4573–4581, 2000.
Stern-Bach, Y., B. Bettler, M. Hartley, P.O. Sheppard, P.J. O’Hara, and S.F. Heinemann. Agonist selectivity of glutamate receptors is specified by two domains structurally related to bacterial amino acid-binding proteins. Neuron 13: 1345–1357, 1994.
Stocca, G., and S. Vicini. Increased contribution of NR2A subunit to synaptic NMDA receptors in developing rat cortical neurons. J Physiol 507: 13–24, 1998.
Strack, S., and R.J. Colbran. Autophosphorylation-dependent targeting of calcium/ calmodulin-dependent protein kinase II by the NR2B subunit of the N-methyl-Daspartate receptor. J Biol Chem 273: 20689–20692, 1998.
Sucher, N.J., S. Akbarian, C.L. Chi, C.L. Leclerc, M. Awobuluyi, D.L. Deitcher, M.K. Wu, J.P. Yuan, E.G. Jones, and S.A. Lipton. Developmental and regional expression pattern of a novel NMDA receptor-like subunit (NMDAR-L) in the rodent brain. J Neurosci 15: 6509–6520, 1995.
Sun, Y., A. Savanenin, P.H. Reddy, and Y.F. Liu. Polyglutamine-expanded huntingtin promotes sensitization of N-methyl-D-aspartate receptors via post-synaptic density 95. J Biol Chem 276: 24713–24718, 2001.
Sytnyk, V., I. Leshchyns’ka, M. Delling, G. Dityateva, A. Dityatev, and M. Schachner. Neural cell adhesion molecule promotes accumulation of TGN organelles at sites of neuron- to-neuron contacts. J Cell Biol 159: 649–661, 2002.
Takahashi, T., D. Feldmeyer, N. Suzuki, K. Onodera, S.G. Cull-Candy, K. Sakimura, and M. Mishina. Functional correlation of NMDA receptor epsilon subunits expression with the properties of single-channel and synaptic currents in the developing cerebellum. J Neurosci 16: 4376–4382, 1996.
Takasu, M.A., M.B. Dalva, R.E. Zigmond, and M.E. Greenberg. Modulation of NMDA receptor-dependent calcium influx and gene expression through EphB receptors. Science 295: 491–495, 2002.
Tang, Y.P., E. Shimizu, G.R. Dube, C. Rampon, G.A. Kerchner, M. Zhuo, G. Liu, and J.Z. Tsien. Genetic enhancement of learning and memory in mice. Nature 401: 63–69, 1999.
Thomas, C.G., A.J. Miller, and G.L. Westbrook. Synaptic and extrasynaptic NMDA receptor NR2 subunits in cultured hippocampal neurons. J Neurophysiol 95: 1727–1734, 2006.
Thompson, C.L., D.L. Drewery, H.D. Atkins, F.A. Stephenson, and P.L. Chazot. Immunohistochemical localization of N-methyl-D-aspartate receptor subunits in the adult murine hippocampal formation: evidence for a unique role of the NR2D subunit. Brain Res Mol Brain Res 102: 55–61, 2002.
Tingley, W.G., M.D. Ehlers, K. Kameyama, C. Doherty, J.B. Ptak, C.T. Riley, and R.L. Huganir. Characterization of protein kinase A and protein kinase C phosphorylation of the N-methyl-D-aspartate receptor NR1 subunit using phosphorylation site-specific antibodies. J Biol Chem 272: 5157–5166, 1997.
Tolias, K.F., J.B. Bikoff, A. Burette, S. Paradis, D. Harrar, S. Tavazoie, R.J. Weinberg, and M.E. Greenberg. The Rac1-GEF Tiam1 couples the NMDA receptor to the activitydependent development of dendritic arbors and spines. Neuron 45: 525–538, 2005.
Tolias, K.F., J.B. Bikoff, C.G. Kane, C.S. Tolias, L. Hu, and M.E. Greenberg. The Rac1 guanine nucleotide exchange factor Tiam1 mediates EphB receptor-dependent dendritic spine development. Proc Natl Acad Sci USA 104: 7265–7270, 2007.
Tomita, S., L. Chen, Y. Kawasaki, R.S. Petralia, R.J. Wenthold, R.A. Nicoll, and D.S. Bredt. Functional studies and distribution define a family of transmembrane AMPA receptor regulatory proteins. J Cell Biol 161: 805–816, 2003.
Tovar, K.R., and G.L. Westbrook. The incorporation of NMDA receptors with a distinct subunit composition at nascent hippocampal synapses in vitro. J Neurosci 19: 4180–4188, 1999.
Tovar, K.R., and G.L. Westbrook. Mobile NMDA receptors at hippocampal synapses. Neuron 34: 255–264, 2002.
Townsend, M., J.P. Cleary, T. Mehta, J. Hofmeister, S. Lesne, E. O’Hare, D.M. Walsh, and D.J. Selkoe. Orally available compound prevents deficits in memory caused by the Alzheimer amyloid-beta oligomers. Ann Neurol 60: 668–676, 2006.
Townsend, M., A. Yoshii, M. Mishina, and M. Constantine-Paton. Developmental loss of miniature N-methyl-D-aspartate receptor currents in NR2A knockout mice. Proc Natl Acad Sci USA 100: 1340–1345, 2003.
Traynelis, S.F., M. Hartley, and S.F. Heinemann. Control of proton sensitivity of the NMDA receptor by RNA splicing and polyamines. Science 268: 873–876, 1995.
Triller, A., and D. Choquet. Surface trafficking of receptors between synaptic and extrasynaptic membranes: and yet they do move!. Trends Neurosci 28: 133–139, 2005.
Tu, J.C., B. Xiao, S. Naisbitt, J.P. Yuan, R.S. Petralia, P. Brakeman, A. Doan, V.K. Aakalu, A.A. Lanahan, M. Sheng, and P.F. Worley. Coupling of mGluR/Homer and PSD-95 complexes by the Shank family of postsynaptic density proteins. Neuron 23: 583–592, 1999.
Turrigiano, G.G., K.R. Leslie, N.S. Desai, L.C. Rutherford, and S.B. Nelson. Activity- dependent scaling of quantal amplitude in neocortical neurons. Nature 391: 892–896, 1998.
Tymianski, M., M.P. Charlton, P.L. Carlen, and C.H. Tator. Source specificity of early calcium neurotoxicity in cultured embryonic spinal neurons. J Neurosci 13: 2085–2104, 1993.
Tyzio, R., A. Represa, I. Jorquera, Y. Ben-Ari, H. Gozlan, and L. Aniksztejn. The establishment of GABAergic and glutamatergic synapses on CA1 pyramidal neurons is sequential and correlates with the development of the apical dendrite. J Neurosci 19: 10372–10382, 1999.
Uitti, R.J., A.H. Rajput, J.E. Ahlskog, K.P. Offord, D.R. Schroeder, M.M. Ho, M. Prasad, A. Rajput, and P. Basran. Amantadine treatment is an independent predictor of improved survival in Parkinson’s disease. Neurology 46: 1551–1556, 1996.
Van de Ven, T.J., H.M. VanDongen, and A.M. VanDongen. The nonkinase phorbol ester receptor alpha 1-chimerin binds the NMDA receptor NR2A subunit and regulates dendritic spine density. J Neurosci 25: 9488–9496, 2005.
van Zundert, B., A. Yoshii, and M. Constantine-Paton. Receptor compartmentalization and trafficking at glutamate synapses: a developmental proposal. Trends Neurosci 27: 428–437, 2004.
Vanhoutte, P., and H. Bading. Opposing roles of synaptic and extrasynaptic NMDA receptors in neuronal calcium signalling and BDNF gene regulation. Curr Opin Neurobiol 13: 366–371, 2003.
Vicini, S., J.F. Wang, J.H. Li, W.J. Zhu, Y.H. Wang, J.H. Luo, B.B. Wolfe, and D.R. Grayson. Functional and pharmacological differences between recombinant Nmethyl- D-aspartate receptors. J Neurophysiol 79: 555–566, 1998.
Vissel, B., J.J. Krupp, S.F. Heinemann, and G.L. Westbrook. A use-dependent tyrosine dephosphorylation of NMDA receptors is independent of ion flux. Nat Neurosci 4: 587–596, 2001.
Vonsattel, J.P., and M. DiFiglia. Huntington disease. J Neuropathol Exp Neurol 57: 369–384, 1998.
Wafford, K.A., M. Kathoria, C.J. Bain, G. Marshall, B. Le Bourdelles, J.A. Kemp, and P.J. Whiting. Identification of amino acids in the N-methyl-D-aspartate receptor NR1 subunit that contribute to the glycine binding site. Mol Pharmacol 47: 374–380, 1995.
Walsh, D.M., and D.J. Selkoe. Deciphering the molecular basis of memory failure in Alzheimer’s disease. Neuron 44: 181–193, 2004.
Waltereit, R., and M. Weller. Signaling from cAMP/PKA to MAPK and synaptic plasticity. Mol Neurobiol 27: 99–106, 2003.
Wang, C.Y., K. Chang, R.S. Petralia, Y.X. Wang, G.K. Seabold, and R.J. Wenthold. A novel family of adhesion-like molecules that interacts with the NMDA receptor. J Neurosci 26: 2174–2183, 2006.
Wang, C.X., and A. Shuaib. NMDA/NR2B selective antagonists in the treatment of ischemic brain injury. Curr Drug Targets CNS Neurol Disord 4: 143–151, 2005.
Wang, J., S. Liu, Y. Fu, J.H. Wang, and Y. Lu. Cdk5 activation induces hippocampal CA1 cell death by directly phosphorylating NMDA receptors. Nat Neurosci 6: 1039–1047, 2003.
Wang, J.K., and V. Thukral. Presynaptic NMDA receptors display physiological characteristics of homomeric complexes of NR1 subunits that contain the exon 5 insert in the N-terminal domain. J Neurochem 66: 865–868, 1996.
Wang, Y.T., and M.W. Salter. Regulation of NMDA receptors by tyrosine kinases and phosphatases. Nature 369: 233–235, 1994.
Washbourne, P., J.E. Bennett, and A.K. McAllister. Rapid recruitment of NMDA receptor transport packets to nascent synapses. Nat Neurosci 5: 751–759, 2002.
Washbourne, P., X.B. Liu, E.G. Jones, and A.K. McAllister. Cycling of NMDA receptors during trafficking in neurons before synapse formation. J Neurosci 24: 8253–8264, 2004.
Watanabe, M., Y. Inoue, K. Sakimura, and M. Mishina. Developmental changes in distribution of NMDA receptor channel subunit mRNAs. Neuroreport 3: 1138–1140, 1992.
Wei, F., G.D. Wang, G.A. Kerchner, S.J. Kim, H.M. Xu, Z.F. Chen, and M. Zhuo. Genetic enhancement of inflammatory pain by forebrain NR2B overexpression. Nat Neurosci 4: 164–169, 2001.
Weissman, A.M. Themes and variations on ubiquitylation. Nat Rev Mol Cell Biol 2: 169–178, 2001.
Weitlauf, C., Y. Honse, Y.P. Auberson, M. Mishina, D.M. Lovinger, and D.G. Winder. Activation of NR2A-containing NMDA receptors is not obligatory for NMDA receptordependent long-term potentiation. J Neurosci 25: 8386–8390, 2005.
Wenthold, R.J., K. Prybylowski, S. Standley, N. Sans, and R.S. Petralia. Trafficking of NMDA receptors. Annu Rev Pharmacol Toxicol 43: 335–358, 2003.
Wenzel, A., D. Benke, H. Mohler, and J.M. Fritschy. N-methyl-D-aspartate receptors containing the NR2D subunit in the retina are selectively expressed in rod bipolar cells. Neuroscience 78: 1105–1112, 1997.
Westphal, R.S., S.J. Tavalin, J.W. Lin, N.M. Alto, I.D. Fraser, L.K. Langeberg, M. Sheng, and J.D. Scott. Regulation of NMDA receptors by an associated phosphatasekinase signaling complex. Science 285: 93–96, 1999.
Willard, F.S., R.J. Kimple, and D.P. Siderovski. Return of the GDI: the GoLoco motif in cell division. Annu Rev Biochem 73: 925–951, 2004.
Wong, R.W., M. Setou, J. Teng, Y. Takei, and N. Hirokawa. Overexpression of motor protein KIF17 enhances spatial and working memory in transgenic mice. Proc Natl Acad Sci USA 99: 14500–14505, 2002.
Woo, N.H., H.K. Teng, C.J. Siao, C. Chiaruttini, P.T. Pang, T.A. Milner, B.L. Hempstead, and B. Lu. Activation of p75NTR by proBDNF facilitates hippocampal long-term depression. Nat Neurosci 8: 1069–1077, 2005.
Woo, T.U., J.P. Walsh, and F.M. Benes. Density of glutamic acid decarboxylase 67 messenger RNA-containing neurons that express the N-methyl-D-aspartate receptor subunit NR2A in the anterior cingulate cortex in schizophrenia and bipolar disorder. Arch Gen Psychiatry 61: 649–657, 2004.
Wu, H. Y., E.Y. Yuen, Y.F. Lu, M. Matsushita, H. Matsui, Z. Yan, and K. Tomizawa. Regulation of N-methyl-D-aspartate receptors by calpain in cortical neurons. J Biol Chem 280: 21588–21593, 2005.
Wyszynski, M., J. Lin, A. Rao, E. Nigh, A.H. Beggs, A.M. Craig, and M. Sheng. Competitive binding of alpha-actinin and calmodulin to the NMDA receptor. Nature 385: 439–442, 1997.
Xia, H., Z.D. Hornby, and R.C. Malenka. An ER retention signal explains differences in surface expression of NMDA and AMPA receptor subunits. Neuropharmacology 41: 714–723, 2001.
Xiong, Z.G., R. Raouf, W.Y. Lu, L.Y. Wang, B.A. Orser, E.M. Dudek, M.D. Browning, and J.F. MacDonald. Regulation of N-methyl-D-aspartate receptor function by constitutively active protein kinase C. Mol Pharmacol 54: 1055–1063, 1998.
Yang, J., G.L. Woodhall, and R.S. Jones. Tonic facilitation of glutamate release by presynaptic NR2B-containing NMDA receptors is increased in the entorhinal cortex of chronically epileptic rats. J Neurosci 26: 406–410, 2006.
Yang, W., C. Zheng, Q. Song, X. Yang, S. Qiu, C. Liu, Z. Chen, S. Duan, and J. Luo. A three amino acid tail following the TM4 region of the N-methyl-D-aspartate receptor (NR) 2 subunits is sufficient to overcome endoplasmic reticulum retention of NR1-1a subunit. J Biol Chem 282: 9269–9278, 2007.
Yao, I., Y. Hata, N. Ide, K. Hirao, M. Deguchi, H. Nishioka, A. Mizoguchi, and Y. Takai. MAGUIN, a novel neuronal membrane-associated guanylate kinase-interacting protein. J Biol Chem 274: 11889–11896, 1999.
Yeaman, C., K.K. Grindstaff, J.R. Wright, and W.J. Nelson. Sec6/8 complexes on trans-Golgi network and plasma membrane regulate late stages of exocytosis in mammalian cells. J Cell Biol 155: 593–604, 2001.
Yi, Z., R.S. Petralia, K. Prybylowski, N. Sans, Y.-X. Wang, and R.J. Wenthold. GIPC, a single PDZ domain-containing protein, interacts with the NMDA receptor and regulates its surface expression. Soc Neurosci Abs 31.14, 2006.
Yi, Z., R.S. Petralia, N. Sans, and W. RJ. NMDA receptors interact with GIPC. Soc Neurosci Abs 487.10, 2005.
Yoshii, A., M.H. Sheng, and M. Constantine-Paton. Eye opening induces a rapid dendritic localization of PSD-95 in central visual neurons. Proc Natl Acad Sci USA 100: 1334–1339, 2003.
Young, A.B., J.T. Greenamyre, Z. Hollingsworth, R. Albin, C. D’Amato, I. Shoulson, and J.B. Penney. NMDA receptor losses in putamen from patients with Huntington’s disease. Science 241: 981–983, 1988.
Yuen, E.Y., Q. Jiang, J. Feng, and Z. Yan. Microtubule regulation of N-methyl-Daspartate receptor channels in neurons. J Biol Chem 280: 29420–29427, 2005.
Zarate, C.A., J. Quiroz, J. Payne, and H.K. Manji. Modulators of the glutamatergic system: implications for the development of improved therapeutics in mood disorders. Psychopharmacol Bull 36: 35–83, 2002.
Zarate, C.A.J., J.B. Singh, P.J. Carlson, N.E. Brutsche, R. Ameli, D.A. Luckenbaugh, D.S. Charney, and H.K. Manji. A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression. Arch Gen Psychiatry 63: 856–864, 2006.
Zeron, M.M., N. Chen, A. Moshaver, A.T. Lee, C.L. Wellington, M.R. Hayden, and L.A. Raymond. Mutant huntingtin enhances excitotoxic cell death. Mol Cell Neurosci 17: 41–53, 2001.
Zeron, M.M., O. Hansson, N. Chen, C.L. Wellington, B.R. Leavitt, P. Brundin, M.R. Hayden, and L.A. Raymond. Increased sensitivity to N-methyl-D-aspartate receptormediated excitotoxicity in a mouse model of Huntington’s disease. Neuron 33: 849–860, 2002.
Zhang, S.J., M.N. Steijaert, D. Lau, G. Schutz, C. Delucinge-Vivier, P. Descombes, and H. Bading. Decoding NMDA Receptor Signaling: identification of Genomic Programs Specifying Neuronal Survival and Death. Neuron 53: 549–562, 2007.
Zhang, W., L. Vazquez, M. Apperson, and M.B. Kennedy. Citron binds to PSD-95 at glutamatergic synapses on inhibitory neurons in the hippocampus. J Neurosci 19: 96–108, 1999.
Zheng, X., L. Zhang, A.P. Wang, M.V. Bennett, and R.S. Zukin. Protein kinase C potentiation of N-methyl-D-aspartate receptor activity is not mediated by phosphorylation of N-methyl-D-aspartate receptor subunits. Proc Natl Acad Sci USA 96: 15262–15267, 1999.
Ziv, N.E., and C.C. Garner. Cellular and molecular mechanisms of presynaptic assembly. Nat Rev Neurosci 5: 385–399, 2004.
Zukin, R.S., and M.V. Bennett. Alternatively spliced isoforms of the NMDARI receptor subunit. Trends Neurosci 18: 306–313, 1995.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2008 Springer Science+Business Media, LLC
About this chapter
Cite this chapter
Wenthold, R.J., Al-Hallaq, R.A., Swanwick, C.C., Petralia, R.S. (2008). Molecular Properties and Cell Biology of the NMDA Receptor. In: Hell, J.W., Ehlers, M.D. (eds) Structural And Functional Organization Of The Synapse. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-77232-5_12
Download citation
DOI: https://doi.org/10.1007/978-0-387-77232-5_12
Publisher Name: Springer, Boston, MA
Print ISBN: 978-0-387-77231-8
Online ISBN: 978-0-387-77232-5
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)