Arsenic in Marine Mammals, Seabirds, and Sea Turtles

  • Takashi Kunito
  • Reiji Kubota
  • Junko Fujihara
  • Tetsuro Agusa
  • Shinsuke Tanabe
Part of the Reviews of Environmental Contamination and Toxicology book series (RECT, volume 195)

Arsenic, a chalcophilic element, is widespread in the environment. Although arsenic may possibly be an essential element for life (Cox 1995) and some microorganisms are known to use arsenic for energy generation (Oremland and Stolz 2003), no firm data are available on its essentiality for biological systems (Francesconi 2005). In contrast to its possible essentiality in life, many studies have focused on its high toxicity, which has been well known from various cases of poisoning throughout the ages (Nriagu 2002). The toxicity is especially high for inorganic arsenic; trivalent inorganic arsenic [arsenite; As(III)] is known to bind readily to sulfhydryl groups of enzymes leading to enzyme inhibition, whereas pentavalent inorganic arsenic [arsenate; As(V)], which is structurally similar to phosphate, may disrupt metabolic reactions that require phosphorylation (Cox 1995). Symptoms of acute intoxication in humans by inorganic arsenic include severe gastrointestinal disorders, hepatic and renal failure, and cardiovascular disturbances, whereas chronic exposure causes skin pigmentation, hyperkeratosis, and cancers in the lung, bladder, liver, and kidney as well as skin (Gorby 1994; WHO 2001). At present, arsenic contamination of groundwater is a worldwide problem (Mandai and Suzuki 2002), particularly in the Bengal Delta where chronic ingestion of arsenic in groundwater poses a significant health risk to about 36 million people (Nordstrom 2002). Thus, the development and use of techniques to remove arsenic from polluted groundwater is an urgent necessity (Chowdhury 2004). In contrast to the hazards of arsenic, it is useful in medicine. For example, arsenic trioxide (As2O3) has recently attracted considerable attention as a therapeutic agent for treatment of acute promyelocytic leukemia and other cancers, although the precise mechanisms by which it produces results are not fully understood (Zhu et al. 2002).


Marine Mammal Marine Alga Arsenic Species Marine Animal Green Turtle 
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  1. Agusa T, Matsumoto T, Ikemoto T, Anan Y, Kubota R, Yasunaga G, Kunito T, Tanabe S, Ogi H, Shibata Y (2005) Body distribution of trace elements in black-tailed gulls from Rishiri Island, Japan: age-dependent accumulation and transfer to feathers and eggs. Environ Toxicol Chem 24:2107–2120.CrossRefGoogle Scholar
  2. Agusa T, Takagi K, Kubota R, Anan Y, Iwata H, Tanabe S (2008) Specific accumulation of arsenic compounds in green turtles (Chelonia mydas) and hawksbill turtles (Eretmochelys imbricata) from Ishigaki Island, Japan. Environ Pollut (in press).Google Scholar
  3. Amlund H, Berntssen MHG (2004) Arsenobetaine in Atlantic salmon (Salmo salar L.): influence of seawater adaptation. Comp Biochem Physiol Part C 138:507–514.Google Scholar
  4. Amlund H, Ingebrigtsen K, Hylland K, Ruus A, Eriksen DØ, Berntssen MHG (2006a) Disposition of arsenobetaine in two marine fish species following administration of a single oral dose of [14C]arsenobetaine. Comp Biochem Physiol Part C 143:171–178.CrossRefGoogle Scholar
  5. Amlund H, Francesconi KA, Bethune C, Lundebye A-K, Berntssen MHG (2006b) Accumulation and elimination of dietary arsenobetaine in two species of fish, Atlantic salmon (Salmo salar L.) and Atlantic cod (Gadus morhua L.). Environ Toxicol Chem 25:1787–1794.CrossRefGoogle Scholar
  6. Anan Y, Kunito T, Watanabe I, Sakai H, Tanabe S (2001) Trace element accumulation in hawksbill turtle (Eretmochelys imbricata) and green turtle (Chelonia mydas) from Yaeyama Islands, Japan. Environ Toxicol Chem 20:2802–2814.Google Scholar
  7. Andrewes P, Demarini DM, Funasaka K, Wallace K, Lai VWM, Sun H, Cullen WR, Kitchin KT (2004) Do arsenosugars pose a risk to human health? The comparative toxicities of a trivalent and pentavalent arsenosugar. Environ Sci Technol 38:4140–4148.CrossRefGoogle Scholar
  8. Aposhian HV (1997) Enzymatic methylation of arsenic species and other new approaches to arsenic toxicity. Annu Rev Pharmacol Toxicol 37:397–419.CrossRefGoogle Scholar
  9. Aposhian HV, Aposhian MM (2006) Arsenic toxicology: five questions. Chem Res Toxicol 19:1–15.CrossRefGoogle Scholar
  10. Arai T, Ikemoto T, Hokura A, Terada Y, Kunito T, Tanabe S, Nakai I (2004) Chemical forms of mercury and cadmium accumulated in marine mammals and seabirds as determined by XAFS analysis. Environ Sci Technol 38:6468–6474.CrossRefGoogle Scholar
  11. Azcue JM, Nriagu JO (1994) Arsenic: historical perspectives. In: Nriagu JO (ed) Arsenic in the Environment, Part I: Cycling and Characterization. Wiley, New York, pp 1–15.Google Scholar
  12. Basu A, Som A, Ghoshal S, Mondal L, Chaubey RC, Bhilwade HN, Rahman MM, Giri AK (2005) Assessment of DNA damage in peripheral blood lymphocytes of individuals susceptible to arsenic induced toxicity in West Bengal, India. Toxicol Lett 159:100–112.CrossRefGoogle Scholar
  13. Berry JP, Galle P (1994) Selenium–arsenic interaction in renal cells: role of lysosomes. Electron microprobe study. J Submicrosc Cytol Pathol 26:203–210.Google Scholar
  14. Bjorndal KA (1997) Foraging ecology and nutrition of sea turtles. In: Lutz PL, Musick JA (eds) The Biology of Sea Turtles. CRC Press, Boca Raton, FL, pp 199–231.Google Scholar
  15. Bodwell JE, Kingsley LA, Hamilton JW (2004) Arsenic at very low concentrations alters glucocorticoid receptor (GR)-mediated gene activation but not GR-mediated gene repression: complex dose–response effects are closely correlated with levels of activated GR and require a functional GR DNA binding domain. Chem Res Toxicol 17:1064–1076.CrossRefGoogle Scholar
  16. Bodwell JE, Gosse JA, Nomikos AP, Hamilton JW (2006) Arsenic disruption of steroid receptor gene activation: complex dose–response effects are shared by several steroid receptors. Chem Res Toxicol 19:1619–1629.CrossRefGoogle Scholar
  17. Braune BM, Outridge PM, Fisk AT, Muir DCG, Helm PA, Hobbs K, Hoekstra PF, Kuzyk ZA, Kwan M, Letcher RJ, Lockhart WL, Norstrom RJ, Stern GA, Stirling I (2005) Persistent organic pollutants and mercury in marine biota of the Canadian Arctic: an overview of spatial and temporal trends. Sci Total Environ 351–352:4–56.Google Scholar
  18. Burg MB, Kwon ED, Kültz D (1997) Regulation of gene expression by hypertonicity. Annu Rev Physiol 59:437–455.CrossRefGoogle Scholar
  19. Chowdhury AMR (2004) Arsenic crisis in Bangladesh. Sci Am 291:86–91.Google Scholar
  20. Clowes LA, Francesconi KA (2004) Uptake and elimination of arsenobetaine by the mussel Mytilus edulis is related to salinity. Comp Biochem Physiol Part C 137:35–42.Google Scholar
  21. Concha G, Vogler G, Lezcano D, Nermell B, Vahter M (1998) Exposure to inorganic arsenic metabolites during early human development. Toxicol Sci 44:185–190.CrossRefGoogle Scholar
  22. Conklin SD, Ackerman AH, Fricke MW, Creed PA, Creed JT, Kohan MC, Herbin-Davis K, Thomas DJ (2006) In vitro biotransformation of an arsenosugar by mouse anaerobic cecal microflora and cecal tissue as examined using IC-ICP-MS and LC-ESI-MS/MS. Analyst 131:648–655.CrossRefGoogle Scholar
  23. Cox PA (1995) The Elements on Earth: Inorganic Chemistry in the Environment. Oxford University Press, Oxford, pp 287.Google Scholar
  24. Cullen WR, Reimer KJ (1989) Arsenic speciation in the environment. Chem Rev 89:713–764.CrossRefGoogle Scholar
  25. Darbre PD (2006) Metalloestrogens: an emerging class of inorganic xenoestrogens with potential to add to the oestrogenic burden of the human breast. J Appl Toxicol 26:191–197.CrossRefGoogle Scholar
  26. Devalla S, Feldmann J (2003) Determination of lipid-soluble arsenic species in seaweed-eating sheep from Orkney. Appl Organomet Chem 17:906–912.CrossRefGoogle Scholar
  27. Devesa V, Loos A, Súñer MA, Vélez D, Feria A, Martínez A, Montoro R, Sanz Y (2005) Transformation of organoarsenical species by the microflora of freshwater crayfish. J Agric Food Chem 53:10297–10305.CrossRefGoogle Scholar
  28. Ebisuda K, Kunito T, Kubota R, Tanabe S (2002) Arsenic concentrations and speciation in the tissues of the ringed seals (Phoca hispida) from Pangnirtung, Canada. Appl Organomet Chem 16:451–457.CrossRefGoogle Scholar
  29. Ebisuda K, Kunito T, Fujihara J, Kubota R, Shibata Y, Tanabe S (2003) Lipid-soluble and water-soluble arsenic compounds in blubber of ringed seal (Pusa hispida). Talanta 61:779–787.CrossRefGoogle Scholar
  30. Edmonds JS (2000) Diastereoisomers of an ‘arsenomethionine’-based structure from Sargassum lacerifolium: the formation of the arsenic-carbon bond in arsenic-containing natural products. Bioorg Med Chem Lett 10:1105–1108.CrossRefGoogle Scholar
  31. Edmonds JS, Francesconi KA (1981) Arseno-sugars from brown kelp (Ecklonia radiata) as intermediates in cycling of arsenic in a marine ecosystem. Nature (Lond) 289:602–604.CrossRefGoogle Scholar
  32. Edmonds JS, Francesconi KA (2003) Organoarsenic compounds in the marine environment. In: Craig PJ (ed) Organometallic Compounds in the Environment. Wiley, New York, pp 195–222.CrossRefGoogle Scholar
  33. Edmonds JS, Francesconi KA, Cannon JR, Raston CL, Skelton BW, White AH (1977) Isolation, crystal structure and synthesis of arsenobetaine, the arsenical constituent of the western lock lobster Panulirus longipes cygnus George. Tetrahedron Lett 18:1543–1546.CrossRefGoogle Scholar
  34. Edmonds JS, Shibata Y, Francesconi KA, Yoshinaga J, Morita M (1992) Arsenic lipids in the digestive gland of the western rock lobster Panulirus cygnus: an investigation by HPLC ICP-MS. Sci Total Environ 122:321–335.CrossRefGoogle Scholar
  35. Edmonds JS, Francesconi KA, Stick RV (1993) Arsenic compounds from marine organisms. Nat Prod Rep 10:421–428.CrossRefGoogle Scholar
  36. Edmonds JS, Shibata Y, Prince RIT, Francesconi KA, Morita M (1994) Arsenic compounds in tissues of the leatherback turtle, Dermochelys coriacea. J Mar Biol Assoc U K 74:463–466.CrossRefGoogle Scholar
  37. Edmonds JS, Shibata Y, Francesconi KA, Rippingale RJ, Morita M (1997) Arsenic transformations in short marine food chains studied by HPLC-ICP MS. Appl Organomet Chem 11:281–287.CrossRefGoogle Scholar
  38. Eisler R (1994) A review of arsenic hazards to plants and animals with emphasis on fishery and wildlife resources. In: Nriagu JO (ed) Arsenic in the Environment, Part II: Human Health and Ecosystem Effects. Wiley, New York, pp 185–259.Google Scholar
  39. Feng Z, Xia Y, Tian D, Wu K, Schmitt M, Kwok RK, Mumford JL (2001) DNA damage in buccal epithelial cells from individuals chronically exposed to arsenic via drinking water in Inner Mongolia, China. Anticancer Res 21:51–58.Google Scholar
  40. Francesconi KA (2005) Current perspectives in arsenic environmental and biological research. Environ Chem 2:141–145.CrossRefGoogle Scholar
  41. Francesconi KA, Edmonds JS (1993) Arsenic in the sea. Oceanogr Mar Biol Annu Rev 31:111–151.Google Scholar
  42. Francesconi KA, Kuehnelt D (2002) Arsenic compounds in the environment. In: Frankenberger WT Jr (ed) Environmental Chemistry of Arsenic. Dekker, New York, pp 51–94.Google Scholar
  43. Francesconi KA, Kuehnelt D (2004) Determination of arsenic species: a critical review of methods and applications, 2000–2003. Analyst 129:373–395.CrossRefGoogle Scholar
  44. Fricke MW, Creed PA, Parks AN, Shoemaker JA, Schwegel CA, Creed JT (2004) Extraction and detection of a new arsine sulfide containing arsenosugar in molluscs by IC-ICP-MS and IC-ESI-MS/MS. J Anal At Spectrom 19:1454–1459.CrossRefGoogle Scholar
  45. Fujihara J, Kunito T, Kubota R, Tanabe S (2003) Arsenic accumulation in livers of pinnipeds, seabirds, and sea turtles: subcellular distribution and interaction between arsenobetaine and glycine betaine. Comp Biochem Physiol Part C 136:287–296.Google Scholar
  46. Fujihara J, Kunito T, Kubota R, Tanaka H, Tanabe S (2004) Arsenic accumulation and distribution in tissues of black-footed albatrosses. Mar Pollut Bull 48:1153–1160.CrossRefGoogle Scholar
  47. Gailer J (2007) Arsenic-selenium and mercury-selenium bonds in biology. Coord Chem Rev 251:234–254.CrossRefGoogle Scholar
  48. Gailer J, Francesconi KA, Edmonds JS, Irgolic KJ (1995) Metabolism of arsenic compounds by the blue mussel Mytilus edulis after accumulation from seawater spiked with arsenic compounds. Appl Organomet Chem 9:341–355.CrossRefGoogle Scholar
  49. Gailer J, George GN, Pickering IJ, Prince RC, Ringwald SC, Pemberton JE, Glass RS, Younis HS, DeYoung DW, Aposhian HV (2000) A metabolic link between arsenite and selenite: the seleno-bis(S-glutathionyl) arsinium ion. J Am Chem Soc 122:4637–4639.CrossRefGoogle Scholar
  50. Gailer J, George GN, Pickering IJ, Prince RC, Younis HS, Winzerling JJ (2002a) Biliary excretion of [(GS)2AsSe] after intravenous injection of rabbits with arsenite and selenate. Chem Res Toxicol 15:1466–1471.CrossRefGoogle Scholar
  51. Gailer J, George GN, Harris HH, Pickering IJ, Prince RC, Somogyi A, Buttigieg GA, Glass RS, Denton MB (2002b) Synthesis, purification, and structural characterization of the dimethyldiselenoarsinate anion. Inorg Chem 41:5426–5432.CrossRefGoogle Scholar
  52. Geiszinger A, Goessler W, Kuehnelt D, Francesconi K, Kosmus W (1998) Determination of arsenic compounds in earthworms. Environ Sci Technol 32:2238–2243.CrossRefGoogle Scholar
  53. Geiszinger A, Khokiattiwong S, Goessler W, Francesconi KA (2002) Identification of the new arsenic-containing betaine, trimethylarsoniopropionate, in tissues of a stranded sperm whale Physeter catodon. J Mar Biol Assoc U K 82:165–168.Google Scholar
  54. Gibbs PE, Langston WJ, Burt GR, Pascoe PL (1983) Tharyx marioni (Polychaeta): a remarkable accumulator of arsenic. J Mar Biol Assoc U K 63:313–325.CrossRefGoogle Scholar
  55. Goessler W, Rudorfer A, Mackey EA, Becker PR, Irgolic KJ (1998) Determination of arsenic compounds in marine mammals with high-performance liquid chromatography and an inductively coupled plasma mass spectrometer as element-specific detector. Appl Organomet Chem 12:491–501.CrossRefGoogle Scholar
  56. Gómes-Ariza JL, Sánchez-Rodas D, Giráldez I, Morales E (2000) A comparison between ICP-MS and AFS detection for arsenic speciation in environmental samples. Talanta 51:257–268.CrossRefGoogle Scholar
  57. Gorby MS (1994) Arsenic in human medicine. In: Nriagu JO (ed) Arsenic in the Environment, Part II: Human Health and Ecosystem Effects. Wiley, New York, pp 1–16.Google Scholar
  58. Hanaoka K, Kaise T (1999) Microbial degradation of arsenobetaine accumulated in marine animals. J Natl Fish Univ 48:41–47.Google Scholar
  59. Hanaoka K, Tagawa S, Kaise T (1992) The fate of organoarsenic compounds in marine ecosystems. Appl Organomet Chem 6:139–146.CrossRefGoogle Scholar
  60. Hanaoka K, Kaise T, Kai N, Kawasaki Y, Miyashita H, Kakimoto K, Tagawa S (1997) Arsenobetaine-decomposing ability of marine microorganisms occurring in particles collected at depths of 1100 and 3500 meters. Appl Organomet Chem 11:265–271.CrossRefGoogle Scholar
  61. Hanaoka K, Goessler W, Yoshida K, Fujitaka Y, Kaise T, Irgolic KJ (1999) Arsenocholine- and dimethylated arsenic-containing lipids in starspotted shark Mustelus manazo. Appl Organomet Chem 13:765–770.CrossRefGoogle Scholar
  62. Hanaoka K, Ohno H, Wada N, Ueno S, Goessler W, Kuehnelt D, Schlagenhaufen C, Kaise T, Irgolic KJ (2001a) Occurrence of organo-arsenicals in jellyfishes and their mucus. Chemosphere 44:743–749.CrossRefGoogle Scholar
  63. Hanaoka K, Tanaka Y, Nagata Y, Yoshida K, Kaise T (2001b) Water-soluble arsenic residues from several arsenolipids occurring in the tissues of the starspotted shark Musterus manazo. Appl Organomet Chem 15:299–305.CrossRefGoogle Scholar
  64. Hansen HR, Raab A, Francesconi KA, Feldmann J (2003) Metabolism of arsenic by sheep chronically exposed to arsenosugars as a normal part of their diet. 1. Quantitative intake, uptake, and excretion. Environ Sci Technol 37:845–851.CrossRefGoogle Scholar
  65. Hansen HR, Pickford R, Thomas-Oates J, Jaspars M, Feldmann J (2004a) 2-Dimethylarsinothioyl acetic acid identified in a biological sample: the first occurrence of a mammalian arsinothioyl metabolite. Angew Chem 116:341–344.CrossRefGoogle Scholar
  66. Hansen HR, Raab A, Jaspars M, Milne BF, Feldmann J (2004b) Sulfur-containing arsenical mistaken for dimethylarsinous acid [DMA(III)] and identified as a natural metabolite in urine: major implications for studies on arsenic metabolism and toxicity. Chem Res Toxicol 17:1086–1091.CrossRefGoogle Scholar
  67. Hansen HR, Jaspars M, Feldmann J (2004c) Arsinothioyl-sugars produced by in vitro incubation of seaweed extract with liver cytosol analysed by HPLC coupled simultaneously to ES-MS and ICP-MS. Analyst 129:1058–1064.CrossRefGoogle Scholar
  68. Haraguchi H (2004) Metallomics as integrated biometal science. J Anal At Spectrom 19:4–15.CrossRefGoogle Scholar
  69. Hasegawa H (1996) Seasonal changes in methylarsenic distribution in Tosa Bay and Uranouchi Inlet. Appl Organomet Chem 10:733–740.CrossRefGoogle Scholar
  70. Hayakawa T, Kobayashi Y, Cui X, Hirano S (2005) A new metabolic pathway of arsenite: arsenic-glutathione complexes are substrates for human arsenic methyltransferase Cyt19. Arch Toxicol 79:183–191.CrossRefGoogle Scholar
  71. Hei TK, Filipic M (2004) Role of oxidative damage in the genotoxicity of arsenic. Free Radic Biol Med 37:574–581.CrossRefGoogle Scholar
  72. Hirata S, Toshimitsu H, Aihara M (2006) Determination of arsenic species in marine samples by HPLC-ICP-MS. Anal Sci 22:39–43.CrossRefGoogle Scholar
  73. Ikemoto T, Kunito T, Tanaka H, Baba N, Miyazaki N, Tanabe S (2004) Detoxification mechanism of heavy metals in marine mammals and seabirds: interaction of selenium with mercury, silver, copper, zinc, and cadmium in liver. Arch Environ Contam Toxicol 47:402–413.CrossRefGoogle Scholar
  74. Jankong P, Chalhoub C, Kienzl N, Goessler W, Francesconi KA, Visoottiviseth P (2007) Arsenic accumulation and speciation in freshwater fish living in arsenic-contaminated waters. Environ Chem 4:11–17.CrossRefGoogle Scholar
  75. Jenkins RO, Ritchie AW, Edmonds JS, Goessler W, Molenat N, Kuehnelt D, Harrington CF, Sutton PG (2003) Bacterial degradation of arsenobetaine via dimethylarsinoylacetate. Arch Microbiol 180:142–150.CrossRefGoogle Scholar
  76. Kaise T, Hanaoka K, Tagawa S, Hirayama T, Fukui S (1988) Distribution of inorganic arsenic and methylated arsenic in marine organisms. Appl Organomet Chem 2:539–546.CrossRefGoogle Scholar
  77. Kanaki K, Pergantis SA (2007) HPLC-ICP-MS and HPLC-ES-MS/MS characterization of synthetic seleno-arsenic compounds. Anal Bioanal Chem 387:2617–2622.CrossRefGoogle Scholar
  78. Khokiattiwong S, Goessler W, Pedersen SN, Cox R, Francesconi KA (2001) Dimethylarsinoylacetate from microbial demethylation of arsenobetaine in seawater. Appl Organomet Chem 15:481–489.CrossRefGoogle Scholar
  79. Kirby J, Maher W (2002) Tissue accumulation and distribution of arsenic compounds in three marine fish species: relationship to trophic position. Appl Organomet Chem 16:108–115.CrossRefGoogle Scholar
  80. Kirby J, Maher W, Spooner D (2005) Arsenic occurrence and species in near-shore macroalgae-feeding marine animals. Environ Sci Technol 39:5999–6005.CrossRefGoogle Scholar
  81. Kitchin KT (2001) Recent advances in arsenic carcinogenesis: modes of action, animal model systems, and methylated arsenic metabolites. Toxicol Appl Pharmacol 172:249–261.CrossRefGoogle Scholar
  82. Kitchin KT, Ahmad S (2003) Oxidative stress as a possible mode of action for arsenic carcinogenesis. Toxicol Lett 137:3–13.CrossRefGoogle Scholar
  83. Koch I, Mace JV, Reimer KJ (2005) Arsenic speciation in terrestrial birds from Yellowknife Northwest Territories, Canada: the unexpected finding of arsenobetaine. Environ Toxicol Chem 24:1468–1474.CrossRefGoogle Scholar
  84. Kohlmeyer U, Jakubik S, Kuballa J, Jantzen E (2005) Determination of arsenic species in fish oil after acid digestion. Microchim Acta 151:249–255.CrossRefGoogle Scholar
  85. Kubota R, Kunito T, Tanabe S (2001) Arsenic accumulation in the liver tissue of marine mammals. Environ Pollut 115:303–312.CrossRefGoogle Scholar
  86. Kubota R, Kunito T, Tanabe S (2002a) Chemical speciation of arsenic in the livers of higher trophic marine animals. Mar Pollut Bull 45:218–223.CrossRefGoogle Scholar
  87. Kubota R, Kunito T, Tanabe S, Ogi H, Shibata Y (2002b) Maternal transfer of arsenic to eggs of black-tailed gull (Larus crassirostis) from Rishiri Island, Japan. Appl Organomet Chem 16:463–468.CrossRefGoogle Scholar
  88. Kubota R, Kunito T, Tanabe S (2003a) Occurrence of several arsenic compounds in the liver of birds, cetaceans, pinnipeds, and sea turtles. Environ Toxicol Chem 22:1200–1207.CrossRefGoogle Scholar
  89. Kubota R, Kunito T, Tanabe S (2003b) Is arsenobetaine the major arsenic compound in the liver of birds, marine mammals, and sea turtles? J Phys IV 107:707–710.CrossRefGoogle Scholar
  90. Kubota R, Kunito T, Fujihara J, Tanabe S, Yang J, Miyazaki N (2005) Placental transfer of arsenic to fetus of Dall’s porpoises (Phocoenoides dalli). Mar Pollut Bull 51:845–849.CrossRefGoogle Scholar
  91. Kubota R, Kunito T, Agusa T, Fujihara J, Monirith I, Iwata H, Subramanian A, Tana TS, Tanabe S (2006) Urinary 8-hydroxy-2’-deoxyguanosine in inhabitants chronically exposed to arsenic in groundwater in Cambodia. J Environ Monit 8:293–299.CrossRefGoogle Scholar
  92. Kuehnelt D, Goessler W (2003) Organoarsenic compounds in the terrestrial environment. In: Craig PJ (ed) Organometallic Compounds in the Environment. Wiley, New York, pp 223–275.CrossRefGoogle Scholar
  93. Kuehnelt D, Goessler W, Irgolic KJ (1997a) Arsenic compounds in terrestrial organisms I: Collybia maculata, Collybia butyracea and Amanita muscaria from arsenic smelter sites in Austria. Appl Organomet Chem 11:289–296.CrossRefGoogle Scholar
  94. Kuehnelt D, Goessler W, Schlagenhaufen C, Irgolic KJ (1997b) Arsenic compounds in terrestrial organisms III: arsenic compounds in Formica sp. from an old arsenic smelter site. Appl Organomet Chem 11:859–867.CrossRefGoogle Scholar
  95. Lam JCW, Tanabe S, Chan SKF, Lam MHW, Martin M, Lam PKS (2006) Levels of trace elements in green turtle eggs collected from Hong Kong: evidence of risks due to selenium and nickel. Environ Pollut 144:790–801.CrossRefGoogle Scholar
  96. Langlois C, Langis R (1995) Presence of airborne contaminants in the wildlife of northern Quebec. Sci Total Environ 160/161:391–402.Google Scholar
  97. Langston WJ, Spence SK (1995) Biological factors involved in metal concentrations observed in aquatic organisms. In: Tessier A, Turner DR (eds) Metal Speciation and Bioavailability in Aquatic Systems. Wiley, Chichester, UK, pp 407–478.Google Scholar
  98. Larsen EH, Francesconi KA (2003) Arsenic concentrations correlate with salinity for fish taken from the North Sea and Baltic waters. J Mar Biol Assoc U K 83:283–284.CrossRefGoogle Scholar
  99. Law RJ (1996) Metals in marine mammals. In: Beyer WN, Heinz GH, Redmon-Norwood AW (eds) Environmental Contaminants in Wildlife: Interpreting Tissue Concentrations. CRC Press, Boca Raton, pp 357–376.Google Scholar
  100. Le XC, Lu X, Li X-F (2004) Arsenic speciation. Anal Chem 76:27A–33A.CrossRefGoogle Scholar
  101. Lien YHH, Pacelli MM, Braun EJ (1993) Characterization of organic osmolytes in avian renal medulla: a nonurea osmotic gradient system. Am J Physiol 264:R1045–R1049.Google Scholar
  102. Lunde G (1977) Occurrence and transformation of arsenic in the marine environment. Environ Health Perspect 19:47–52.CrossRefGoogle Scholar
  103. Mancini I, Guella G, Frostin M, Hnawia E, Laurent D, Debitus C, Pietra F (2006) On the first polyarsenic organic compound from nature: arsenicin A from the New Caledonian marine sponge Echinochalina bargibanti. Chem Eur J 12:8989–8994.CrossRefGoogle Scholar
  104. Mandal BK, Suzuki KT (2002) Arsenic round the world: a review. Talanta 58:201–235.CrossRefGoogle Scholar
  105. Manley SA, George GN, Pickering IJ, Glass RS, Prenner EJ, Yamdagni R, Wu Q, Gailer J (2006) The seleno bis(S-glutathionyl) arsinium ion is assembled in erythrocyte lysate. Chem Res Toxicol 19:601–607.CrossRefGoogle Scholar
  106. Martin SJ, Newcombe C, Raab A, Feldmann J (2005) Arsenosugar metabolism not unique to the sheep of North Ronaldsay. Environ Chem 2:190–197.CrossRefGoogle Scholar
  107. McSheehy S, Szpunar J, Lobinski R, Haldys V, Tortajada J, Edmonds JS (2002) Characterization of arsenic species in kidney of the clam Tridacna derasa by multidimensional liquid chromatography-ICPMS and electrospray time-of-flight tandem mass spectrometry. Anal Chem 74:2370–2378.CrossRefGoogle Scholar
  108. Meador JP, Varanasi U, Robisch PA, Chan SL (1993) Toxic metals in pilot whales (Globicephala melaena) from strandings in 1986 and 1990 on Cape Cod, Massachusetts. Can J Fish Aquat Sci 50:2698–2706.CrossRefGoogle Scholar
  109. Meier J, Kienzl N, Goessler W, Francesconi KA (2005) The occurrence of thio-arsenosugars in some samples of marine algae. Environ Chem 2:304–307.CrossRefGoogle Scholar
  110. Miyajima M, Hamada N, Yoshimura E, Okubo A, Yamazaki S, Toda S (1988) Lipophilic arsenic compound(s) in the liver of a tiger shark (Galeocerdo cuvier). Appl Organomet Chem 2:377–384.CrossRefGoogle Scholar
  111. Morita M, Shibata Y (1988) Isolation and identification of arseno-lipid from a brown alga, Undaria pinnatifida (Wakame). Chemosphere 17:1147–1152.CrossRefGoogle Scholar
  112. Morita M, Shibata Y (1990) Chemical form of arsenic in marine macroalgae. Appl Organomet Chem 4:181–190.CrossRefGoogle Scholar
  113. Morton WE, Dunnette DA (1994) Health effects of environmental arsenic. In: Nriagu JO (ed) Arsenic in the Environment, Part II: Human Health and Ecosystem Effects. Wiley, New York, pp 17–34.Google Scholar
  114. Nakazato T, Tao H (2006) A high-efficiency photooxidation reactor for speciation of organic arsenicals by liquid chromatography-hydride generation-ICPMS. Anal Chem 78:1665–1672.CrossRefGoogle Scholar
  115. Naranmandura H, Suzuki N, Suzuki KT (2006) Trivalent arsenicals are bound to proteins during reductive methylation. Chem Res Toxicol 19:1010–1018.CrossRefGoogle Scholar
  116. Neff JM (1997) Ecotoxicology of arsenic in the marine environment. Environ Toxicol Chem 16:917–927.Google Scholar
  117. Ng PS, Li H, Matsumoto K, Yamazaki S, Kogure T, Tagai T, Nagasawa H (2001) Striped dolphin detoxificates mercury as insoluble Hg(S, Se) in the liver. Proc Jpn Acad 77(Ser B):178–183.CrossRefGoogle Scholar
  118. Ninh TD, Nagashima Y, Shiomi K (2007) Water-soluble and lipid-soluble arsenic compounds in Japanese flying squid Todarodes pacificus. J Agric Food Chem 55:3196–3202.CrossRefGoogle Scholar
  119. Nischwitz V, Pergantis SA (2005a) First report on the detection and quantification of arsenobetaine in extracts of marine algae using HPLC-ES-MS/MS. Analyst 130:1348–1350.CrossRefGoogle Scholar
  120. Nischwitz V, Pergantis SA (2005b) Liquid chromatography online with selected reaction monitoring electrospray mass spectrometry for the determination of organoarsenic species in crude extracts of marine reference materials. Anal Chem 77:5551–5563.CrossRefGoogle Scholar
  121. Nischwitz V, Pergantis SA (2006) Optimisation of an HPLC selected reaction monitoring electrospray tandem mass spectrometry method for the detection of 50 arsenic species. J Anal At Spectrom 21:1277–1286.CrossRefGoogle Scholar
  122. Nischwitz V, Kanaki K, Pergantis SA (2006) Mass spectrometric identification of novel arsinothioyl-sugars in marine bivalves and algae. J Anal At Spectrom 21:33–40.CrossRefGoogle Scholar
  123. Nordstrom DK (2002) Worldwide occurrences of arsenic in ground water. Science 296:2143–2145.CrossRefGoogle Scholar
  124. Nriagu JO (1989) A global assessment of natural sources of atmospheric trace metals. Nature (Lond) 338:47–49.CrossRefGoogle Scholar
  125. Nriagu JO (2002) Arsenic poisoning through the ages. In: Frankenberger WT Jr (ed) Environmental Chemistry of Arsenic. Dekker, New York, pp 1–26.Google Scholar
  126. Oremland RS, Stolz JF (2003) The ecology of arsenic. Science 300:939–944.CrossRefGoogle Scholar
  127. O’Shea TJ (1999) Environmental contaminants and marine mammals. In: Reynolds JE III, Rommel SA (eds) Biology of Marine Mammals. Smithsonian Institution Press, Washington, pp 485–563.Google Scholar
  128. O’Shea TJ, Tanabe S (2003) Persistent ocean contaminants and marine mammals: a retrospective overview. In: Vos JG, Bossart GD, Fournier M, O’Shea TJ (eds) Toxicology of Marine Mammals. Taylor & Francis, London, pp 99–134.Google Scholar
  129. Pacyna JM, Pacyna EG (2001) An assessment of global and regional emissions of trace metals to the atmosphere from anthropogenic sources worldwide. Environ Rev 9:269–298.CrossRefGoogle Scholar
  130. Phillips DJH (1990) Arsenic in aquatic organisms: a review, emphasizing chemical speciation. Aquat Toxicol 16:151–186.CrossRefGoogle Scholar
  131. Pichereau V, Cosquer A, Gaumont AC, Bernard T (1997) Synthesis of trimethylated phosphonium and arsonium analogues of the osmoprotectant glycine betaine; contrasted biological activities in two bacterial species. Bioorg Med Chem Lett 7:2893–2896.CrossRefGoogle Scholar
  132. Plant JA, Kinniburgh DG, Smedley PL, Fordyce FM, Klinck BA (2005) Arsenic and selenium. In: Lollar BS (ed) Environmental Geochemistry. Elsevier, Amsterdam, pp 17–66.Google Scholar
  133. Raab A, Wright SH, Jaspars M, Meharg AA, Feldmann J (2007) Pentavalent arsenic can bind to biomolecules. Angew Chem Int Ed 46:2594–2597.CrossRefGoogle Scholar
  134. Raml R, Goessler W, Traar P, Ochi T, Francesconi KA (2005) Novel thioarsenic metabolites in human urine after ingestion of an arsenosugar, 2’, 3’-dihydroxypropyl 5-deoxy-5-dimethylarsinoyl-β-D-riboside. Chem Res Toxicol 18:1444–1450.CrossRefGoogle Scholar
  135. Raml R, Goessler W, Francesconi KA (2006) Improved chromatographic separation of thio-arsenic compounds by reversed-phase high performance liquid chromatography-inductively coupled plasma mass spectrometry. J Chromatogr A 1128:164–170.CrossRefGoogle Scholar
  136. Raml R, Rumpler A, Goessler W, Vahter M, Li L, Ochi T, Francesconi KA (2007) Thio-dimethylarsinate is a common metabolite in urine samples from arsenic-exposed women in Bangladesh. Toxicol Appl Pharmacol 222:374–380.CrossRefGoogle Scholar
  137. Randall K, Lever M, Peddie BA, Chambers ST (1995) Competitive accumulation of betaines by Escherichia coli K-12 and derivative strains lacking betaine porters. Biochim Biophys Acta 1245:116–120.Google Scholar
  138. Randall K, Lever M, Peddie BA, Chambers ST (1996) Accumulation of natural and synthetic betaines by a mammalian renal cell line. Biochem Cell Biol 74:283–287.CrossRefGoogle Scholar
  139. Ritchie AW, Edmonds JS, Goessler W, Jenkins RO (2004) An origin for arsenobetaine involving bacterial formation of an arsenic-carbon bond. FEMS Microbiol Lett 235:95–99.Google Scholar
  140. Saeki K, Sakakibara H, Sakai H, Kunito T, Tanabe S (2000) Arsenic accumulation in three species of sea turtles. BioMetals 13:241–250.CrossRefGoogle Scholar
  141. Santosa SJ, Mokudai H, Takahashi M, Tanaka S (1996) The distribution of arsenic compounds in the ocean: biological activity in the surface zone and removal processes in the deep zone. Appl Organomet Chem 10:697–705.CrossRefGoogle Scholar
  142. Schaeffer R, Francesconi KA, Kienzl N, Soeroes C, Fodor P, Váradi L, Raml R, Goessler W, Kuehnelt D (2006) Arsenic speciation in freshwater organisms from the river Danube in Hungary. Talanta 69:856–865.CrossRefGoogle Scholar
  143. Schmeisser E, Raml R, Francesconi KA, Kuehnelt D, Lindberg AL, Sörös C, Goessler W (2004) Thio arsenosugars identified as natural constituents of mussels by liquid chromatography-mass spectrometry. Chem Commun 2004:1824–1825.CrossRefGoogle Scholar
  144. Schmeisser E, Goessler W, Kienzl N, Francesconi KA (2005) Direct measurement of lipid-soluble arsenic species in biological samples with HPLC-ICPMS. Analyst 130:948–955.CrossRefGoogle Scholar
  145. Schmeisser E, Rumpler A, Kollroser M, Rechberger G, Goessler W, Francesconi KA (2006a) Arsenic fatty acids are human urinary metabolites of arsenolipids present in cod liver. Angew Chem Int Ed 45:150–154.CrossRefGoogle Scholar
  146. Schmeisser E, Goessler W, Francesconi KA (2006b) Human metabolism of arsenolipids present in cod liver. Anal Bioanal Chem 385:367–376.CrossRefGoogle Scholar
  147. Schwerdtle T, Walter I, Mackiw I, Hartwig A (2003) Induction of oxidative DNA damage by arsenite and its trivalent and pentavalent methylated metabolites in cultured human cells and isolated DNA. Carcinogenesis 24:967–974.CrossRefGoogle Scholar
  148. Shaw JR, Gabor K, Hand E, Lankowski A, Durant L, Thibodeau R, Stanton CR, Barnaby R, Coutermarsh B, Karlson KH, Sato JD, Hamilton JW, Stanton BA (2007) Role of glucocorticoid receptor in acclimation of killifish (Fundulus heteroclitus) to seawater and effects of arsenic. Am J Physiol Regul Integr Comp Physiol 292:R1052–R1060.Google Scholar
  149. Shibata Y, Morita M (1992) Characterization of organic arsenic compounds in bivalves. Appl Organomet Chem 6:343–349.CrossRefGoogle Scholar
  150. Shibata Y, Morita M (2000) Chemical forms of arsenic in the environment. Biomed Res Trace Elements 11:1–24 (in Japanese).Google Scholar
  151. Shibata Y, Morita M, Fuwa K (1992) Selenium and arsenic in biology: their chemical forms and biological functions. Adv Biophys 28:31–80.CrossRefGoogle Scholar
  152. Shinagawa A, Shiomi K, Yamanaka H, Kikuchi T (1983) Selective determination of inorganic arsenic (III), (V) and organic arsenic in marine organisms. Bull Jpn Soc Sci Fish 49:75–78.Google Scholar
  153. Shiomi K (1994) Arsenic in marine organisms: chemical forms and toxicological aspects. In: Nriagu JO (ed) Arsenic in the Environment, Part II: Human Health and Ecosystem Effects. Wiley, New York, pp 261–282.Google Scholar
  154. Shiomi K, Sugiyama Y, Shimakura K, Nagashima Y (1996) Retention and biotransformation of arsenic compounds administered intraperitoneally to carp. Fish Sci 62:261–266.Google Scholar
  155. Šlejkovec Z, Bajc Z, Doganoc DZ (2004) Arsenic speciation patterns in freshwater fish. Talanta 62:931–936.CrossRefGoogle Scholar
  156. Sloth JJ, Larsen EH, Julshamn K (2003) Determination of organoarsenic species in marine samples using gradient elution cation exchange HPLC-ICP-MS. J Anal At Spectrom 18:452–459.CrossRefGoogle Scholar
  157. Sloth JJ, Larsen EH, Julshamn K (2005a) Report on three aliphatic dimethylarsinoyl compounds as common minor constituents in marine samples. An investigation using high-performance liquid chromatography/inductively coupled plasma mass spectrometry and electrospray ionisation tandem mass spectrometry. Rapid Commun Mass Spectrom 19:227–235.CrossRefGoogle Scholar
  158. Sloth JJ, Larsen EH, Julshamn K (2005b) Survey of inorganic arsenic in marine animals and marine certified reference materials by anion exchange high-performance liquid chromatography–inductively coupled plasma mass spectrometry. J Agric Food Chem 53:6011–6018.CrossRefGoogle Scholar
  159. Soeroes C, Goessler W, Francesconi KA, Kienzl N, Schaeffer R, Fodor P, Kuehnelt D (2005) Arsenic speciation in farmed Hungarian freshwater fish. J Agric Food Chem 53:9238–9243.CrossRefGoogle Scholar
  160. Stanton CR, Thibodeau R, Lankowski A, Shaw JR, Hamilton JW, Stanton BA (2006) Arsenic inhibits CFTR-mediated chloride secretion by killifish (Fundulus heteroclitus) opercular membrane. Cell Physiol Biochem 17:269–278.CrossRefGoogle Scholar
  161. Stoica A, Pentecost E, Martin MB (2000) Effects of arsenite on estrogen receptor-S expression and activity in MCF-7 breast cancer cells. Endocrinology 141:3595–3602.CrossRefGoogle Scholar
  162. Storelli MM, Marcotrigiano GO (2000) Total organic and inorganic arsenic from marine turtles (Caretta caretta) beached along the Italian coast (South Adriatic Sea). Bull Environ Contam Toxicol 65:732–739.CrossRefGoogle Scholar
  163. Styblo M, Thomas DJ (1997) Binding of arsenicals to proteins in an in vitro methylation system. Toxicol Appl Pharmacol 147:1–8.CrossRefGoogle Scholar
  164. Styblo M, Delnomdedieu M, Thomas DJ (1996) Mono- and dimethylation of arsenic in rat liver cytosol in vitro. Chem-Biol Interact 99:147–164.CrossRefGoogle Scholar
  165. Suedel BC, Boraczek JA, Peddicord RK, Clifford PA, Dillon TM (1994) Trophic transfer and biomagnification potential of contaminants in aquatic ecosystems. Rev Environ Contam Toxicol 136:21–89.Google Scholar
  166. Suzuki KT (2005) Metabolomics of arsenic based on speciation studies. Anal Chim Acta 540:71–76.CrossRefGoogle Scholar
  167. Tanabe S, Subramanian A (2006) Bioindicators of POPs: Monitoring in Developing Countries. Kyoto University Press, Kyoto, Japan, pp 190.Google Scholar
  168. Tanabe S, Tatsukawa R, Maruyama K, Miyazaki N (1982) Transplacental transfer of PCBs and chlorinated hydrocarbon pesticides from the pregnant striped dolphin (Stenella coeruleoalba) to her fetus. Agric Biol Chem 46:1249–1254.Google Scholar
  169. Thompson DR (1990) Metal levels in marine vertebrates. In: Furness RW, Rainbow PS (eds) Heavy Metals in the Marine Environment. CRC Press, Boca Raton, pp 143–182.Google Scholar
  170. Vahter M (1999) Methylation of inorganic arsenic in different mammalian species and population groups. Sci Prog 82:69–88.Google Scholar
  171. Vahter M, Marafante E, Dencker L (1983) Metabolism of arsenobetaine in mice, rats and rabbits. Sci Total Environ 30:197–211.CrossRefGoogle Scholar
  172. Waalkes MP, Liu J, Chen H, Xie Y, Achanzar WE, Zhou Y-S, Cheng M-L, Diwan BA (2004) Estrogen signaling in livers of male mice with hepatocellular carcinoma induced by exposure to arsenic in utero. J Natl Cancer Inst 96:466–474.CrossRefGoogle Scholar
  173. Wahlen R, McSheehy S, Scriver C, Mester Z (2004) Arsenic speciation in marine certified reference materials. Part 2. The quantification of water-soluble arsenic species by high-performance liquid chromatography-inductively coupled plasma mass spectrometry. J Anal At Spectrom 19:876–882.CrossRefGoogle Scholar
  174. Watanabe I, Kunito T, Tanabe S, Amano M, Koyama Y, Miyazaki N, Petrov EA, Tatsukawa R (2002) Accumulation of heavy metals in Caspian seals (Phoca caspica). Arch Environ Contam Toxicol 43:109–120.CrossRefGoogle Scholar
  175. WHO (2001) Environmental Health Criteria 224: Arsenic and Arsenic Compounds, 2nd Ed. World Health Organization, Geneva.Google Scholar
  176. Yamanaka K, Kato K, Mizoi M, An Y, Takabayashi F, Nakano M, Hoshino M, Okada S (2004) The role of active arsenic species produced by metabolic reduction of dimethylarsinic acid in genotoxicity and tumorigenesis. Toxicol Appl Pharmacol 198:385–393.CrossRefGoogle Scholar
  177. Yancey PH, Clark ME, Hand SC, Bowlus RD, Somero GN (1982) Living with water stress: evolution of osmolyte systems. Science 217:1214–1222.CrossRefGoogle Scholar
  178. Yoshida K, Kuroda K, Inoue Y, Chen H, Wanibuchi H, Fukushima S, Endo G (2001) Metabolites of arsenobetaine in rats: does decomposition of arsenobetaine occur in mammals? Appl Organomet Chem 15:271–276.CrossRefGoogle Scholar
  179. Yoshitome R, Kunito T, Ikemoto T, Tanabe S, Zenke H, Yamauchi M, Miyazaki N (2003) Global distribution of radionuclides (137Cs and 40K) in marine mammals. Environ Sci Technol 37:4597–4602.CrossRefGoogle Scholar
  180. Zhu J, Chen Z, Lallemand-Breitenbach V, de Thé H (2002) How acute promyelocytic leukaemia revived arsenic. Nat Rev Cancer 2:705–713.CrossRefGoogle Scholar

Copyright information

© Springer 2008

Authors and Affiliations

  • Takashi Kunito
    • 1
    • 2
  • Reiji Kubota
    • 1
    • 3
  • Junko Fujihara
    • 1
    • 4
  • Tetsuro Agusa
    • 1
  • Shinsuke Tanabe
    • 1
  1. 1.Center for Marine Environmental Studies (CMES)Ehime UniversityMatsuyamaJapan
  2. 2.Department of Environmental Sciences, Faculty of ScienceShinshu UniversityMatsumotoJapan
  3. 3.Division of Environmental ChemistryNational Institute of Health SciencesTokyoJapan
  4. 4.Department of Legal MedicineShimane University School of MedicineShimaneJapan

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