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The Little Black Book of Neuropsychology pp 813–838Cite as

Neurotoxicity in Neuropsychology

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Abstract

This chapter will provide definitions regarding neurotoxicity, general principles of neurotoxic damage, symptom presentation for common neurotoxic substances, a brief discussion of symptoms/features of the Neurotoxicity Syndrome, and assessment for neurotoxicity.

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References

  • Anger, W. K., & Johnson, B. (1985). Chemicals affecting behavior. In Neurotoxicity of Industrial and Commercial Chemicals. In J. O. Donoghue (Ed.), Neurotoxicity of Industrial and Commercial Chemicals (Vol. 1). Boca Raton: CRC Press.

    Google Scholar 

  • AITB (1944). Army Individual Test Battery, Manual of directions and scoring, War Department, Adjutant General’s Office, Washington, DC.

    Google Scholar 

  • Beck, A. T., and Steer, R. A. (1993). Beck Anxiety Inventory Manual. San Antonio, TX: The Psychological Corporation.

    Google Scholar 

  • Beck, A.T., Steer, R.A., and Brown, G.K. (1996). Manual for the Beck Depression Inventory-II. San Antonio, TX: Psychological Corporation

    Google Scholar 

  • Benton, A. L. (1974). Revised Visual Retention Test (4th ed.). New York: Psychological Corporation.

    Google Scholar 

  • Benton, A. L., & Hamsher, K. deS. (1989). Multilingual Aphasia Examination. Iowa City, IA: AJA Associates.

    Google Scholar 

  • Berent, S. (2005). Neurobehavioral toxicology: Neurobehavioral and neuropsychological perspectives, foundations, and methods (Studies on neuropsychology, development, and cognition). New York: Taylor & Francis.

    Google Scholar 

  • Bowler, R. M., Gysens, S., Diamond, E., Nakagawa, S., Drezgic, M., & Roels, H. A. (2006). Manganese exposure: Neuropsychological and neurological symptoms and effects in welders. Neurotoxicology, 27, 315–326.

    Article  PubMed  Google Scholar 

  • Brown, J. S. (2002). Environmental and chemical toxins and psychiatric illness. Washington, DC: American Psychiatric Publishing.

    Google Scholar 

  • Bush, S. S., Ruff, R. M., Troster, A. I., Barth, J. T., Koffler, S. P., Pliskin, N. H., et al. (2005). For the NAN Policy & Planning Committee. (2005). NAN position paper. Symptom validity assessment: Practice issues andmedical necessity. Archives of Clinical Neuropsychology, 20, 419–426.

    Article  PubMed  Google Scholar 

  • Calne, D. B., McGeer, E., Eisen, A., & Spencer, P. (1986). Alzheimer’s disease, Parkinson’s disease, and motoneurone disease: Abiotropic interaction between ageing and environment? Lancet, 2, 1067–70.

    Article  PubMed  Google Scholar 

  • Chambers, C. A., Hopkins, R. O., Weaver, L. K., & Key, C. (2008). Cognitive and affective outcomes of more severe compared to less severe carbon monoxide poisoning. Brain Injury, 22, 387–395.

    Article  PubMed  Google Scholar 

  • Costa, P. T., & McCrae, R. R. (1995). NEO Personality Inventory-Revised manual. Lutz, FL: Psychological Assessment Resources.

    Google Scholar 

  • Cunningham, C., Wilcockson, D. C., Campion, S., Lunnon, K., & Perry, V. H. (2005). Central and Systemic Endotoxin Challenges Exacerbate the Local Inflammatory Response and Increase Neuronal Death during Chronic Neurodegeneration. Journal of Neurosciences, 25, 9275–9284

    Google Scholar 

  • U.S. Congress, Office of Technology Assessment (1990, April). Neurotoxicity: Identifying and controlling poisons of the nervous system (OTA-BA-436). Washington, DC: U.S. Government Printing Office.

    Google Scholar 

  • Delis, D. C., Kaplan, E., & Kramer, J. H. (2001). The Delis-Kaplan Executive Function System (K-KEFS). San Antonio, TX: NCS Pearson.

    Google Scholar 

  • Ecobichon, D. J., & Joy, R. M. (1994). Pesticides and neurological diseases (2nd ed.). Boca Raton: CRC Press.

    Google Scholar 

  • Edling, C., Lindberg, A., & Ulfberg, J. (1993). Occupational exposure to organic solvents as a cause of sleep apnoea. Br J Ind Med., 50, 276–279.

    PubMed  Google Scholar 

  • Fahn, S. (2002). The case of the frozen addicts: How the solution of an extraordinary medical mystery spawned a revolution in the understanding and treatment of Parkinson’s disease. The New England Journal of Medicine, 335, 2002.

    Article  Google Scholar 

  • Golden, C. J. (1978). Stroop color and Word Test. Chicago, IL: Stoelting.

    Google Scholar 

  • Goodglass, H., & Kaplan, E. (2000). The Boston Naming Test. Philadelphia: Lippincott Williams & Wilkins.

    Google Scholar 

  • Goodglass, H., Kaplan, E., & Barresi, B. (2000). The Boston Diagnostic Aphasia Examination (BDAE-3) (3rd Ed.). Philadelphia: Lippincott Williams & Wilkins.

    Google Scholar 

  • Grace, J., & Malloy, P. F. (2001). Frontal Systems Behavior Scale (FrSBe). Lutz, FL: Psychological Assessment Resources.

    Google Scholar 

  • Gronwall, D. M. A. (1977). Paced Auditory Serial Addition Task: A measure of recovery from concussion. Perceptual and Motor Skills, 44, 367–373.

    Google Scholar 

  • Haley, R. W., Spence, J. S., Carmack, P. S., Gunst, R. F., Schucany, W. R., Petty, F., et al. (2009). Abnormal brain response to cholinergic challenge in chronic encephalopathy from the 1991 Gulf War. Psychiatry Research, 171, 207–20.

    Article  PubMed  Google Scholar 

  • Hartman, H. E. (1995). Neuropsychological toxicology. Identification and assessment of human neurotoxic syndromes (2nd ed.). New York: Plenum Press.

    Google Scholar 

  • Hojo, S., Kumano, H., Yoshino, H., Kakuta, K., & Ishikawa, S. (2003). Application of quick environment exposure sensitivity inventory (QEESI©) for Japanese population: study of reliability and validity of the questionnaire. Toxicology and Industrial Health, 19, 41–49.

    Article  PubMed  Google Scholar 

  • Kertesz, A. (1982). Western Aphasia Battery. San Antonio, TX: Psychological Corporation.

    Google Scholar 

  • Kilburn, K. H. (2004). Endangered brains: How chemicals threaten our future. Birmingham: Princeton Scientific Publishers Co.

    Google Scholar 

  • Kilburn, K. H. (2009). Neurobehavioral and pulmonary impairment in 105 adults with indoor exposure to molds compared to 100 exposed to chemicals. Toxicology and Industrial Health, 25(9–10), 681–92.

    Article  PubMed  Google Scholar 

  • Kimura, J. (2001). Electrodiagnosis of diseases of nerve and muscle: Principles and practice (3rd Ed.). New York: Oxford University Press.

    Google Scholar 

  • Kulig, K., Cetaruk, E., Palmer, R., & Brent, J. (2009). The methodology in the paper by Chambers et al., raises serious questions about their conclusions. Brain Injury, 32, 3–4.

    Article  Google Scholar 

  • Lezak, M. D., Howieson, D. B., & Loring, D. W. (2004). Neuropsychological assessment (4th ed.). New York: Oxford University Press.

    Google Scholar 

  • Lidsky, T. I., & Schneider, J. S. (2006). Adverse effects of childhood lead poisoning: The clinical neuropsychological perspective. Environmental Research, 100, 284–293.

    Article  PubMed  Google Scholar 

  • Lucchini, R. G., Martin, C. J., & Doney, B. C. (2009). From manganism to manganese-induced parkinsonism: a conceptual model based on the evolution of exposure. Neuromol Med Dec, 11(4), 311–321.

    Article  Google Scholar 

  • Lutz, W. D. (2008). Toxicology Principles for the Industrial Hygienist. In W. E. Luttrell, W. W. Jederberg, & K. R. Still (Eds.), Toxicology of sensory organs. Fairfax: American Industrial Hygiene Association.

    Google Scholar 

  • Matthews, C.G., & Klove, H. (1964). Instruction manual for the Adult Neuropsychology Test Battery. University of Wisconsin Medical School, Madison, WI.

    Google Scholar 

  • Monstad, P., Mellgren, S. I., & Sulg, I. A. (1992). The clinical significance of sleep apnea in workers exposed to organic solvents: Implications for the diagnosis of organic solvent encephalopathy. J Neurol., 239, 195–198.

    Article  PubMed  Google Scholar 

  • Packer, S. (1998). Jewish mystical movements and the European ergot epidemics. Isr J Psychiatry Relat Sci., 35(3), 227–39.

    PubMed  Google Scholar 

  • Panaccione, D. G., & Coyle, C. M. (2005). Abundant respirable ergot alkaloids from the common airborne fungus Aspergillus fumigates. Appl. Environ. Microbiol, 71, 3106–3111.

    Article  PubMed  Google Scholar 

  • Racette, B. A., McGee-Minnich, L., Moerlein, S. M., Mink, J. W., & Perlmuter, J. S. (2001). Welding related Parkinsonism: Clinical features, treatment, and pathophysiology. Neurology, 56, 8–13.

    Article  PubMed  Google Scholar 

  • Reynolds, C. R., & Joress, J. K. (2007). Test of Memory and Learning-2nd ed. (TOML-II). Austin, TX: PRO-ED.

    Google Scholar 

  • Ruff, R. M., & Allen, C. C. (1996). Ruff 2 & 7 selective attention test, professional manual. Lutz, FL: Psychological Assessment Resources.

    Google Scholar 

  • Russell, R. W., Flattau, P.E., & MacPherson-Pope, A. (1990). Behavioral measures of neurotoxicity: Report of a symposium, U.S. National Committee for the International Union of Psychological Science, National Research Council, National Research Council (U.S.). Commission on Behavioral and Social Sciences and Education, National Research Council (U.S.). Washington, DC: National Academies Press, p. 48.

    Google Scholar 

  • Ryan, C. M., Morrow, L. A., Bromet, E. J., & Parkinson, D. K. (1987). Assessment of neuropsychological dysfunction in the workplace: Normative data from the Pittsburgh occupational exposures test battery. Journal of Clinical and Experimental Neuropsychology, 9(6), 665–679. doi:10.1080/01688638708405209.

    Article  PubMed  Google Scholar 

  • Sbordonne, et al. (2000). The use of significant others to enhance the detection of malingerers from traumatically brain-injured patients. Archives of Clinical Neuropsychology, 15, 465–477.

    Google Scholar 

  • Seppalainen, A. M. (1989). Electrophysiological approaches to occupational neurotoicology. In L. G. Costa & L. Manzo (Eds.), Occupational neurotoxicology. Boca Raton: CRC Press.

    Google Scholar 

  • Singer, R. (1990a). Neurotoxicity guidebook. New York: Van Nostrand Reinhold Co.

    Google Scholar 

  • Singer, R. (1990b). Neurotoxicity can produce “MS-like” symptoms. Journal of Clinical and Experimental Neuropsychology, 12, 68.

    Google Scholar 

  • Singer, R. (1996). Neurobehavioral screening of breast implant women. Archives of Clinical Neuropsychology, 11, 5.

    Google Scholar 

  • Singer, R. (1997). Wood-preserving chemicals, multiple sclerosis, and neuropsychological function. Archives of Clinical Neuropsychology, 12, 404.

    Article  Google Scholar 

  • Singer, R. (2001). Neurotoxicity evaluation of a new solvent. Archives of Clinical Neuropsychology, 16, 697.

    Google Scholar 

  • Singer, R. (2002a). Neurobehavioral evaluation of residual effects of low-level bystander organophosphate pesticide exposure. Fundamental and Applied Toxicology, Supplement: The Toxicologist, 55, 311.

    Google Scholar 

  • Singer, R. (2002b). Panic disorder can be caused by neurotoxicity. Archives of Clinical Neuropsychology, 17, 813–814.

    Google Scholar 

  • Singer, R. (2002c, April 21st). Death penalty mitigation factors: Neurotoxicity. 18th Annual Symposium of the American College of Forensic Psychology, San Francisco.

    Google Scholar 

  • Singer, R. (2005a). Forensic evaluation of a mold (repeated water intrusions) neurotoxicity case. Archives of Clinical Neuropsychology, 20, 808.

    Google Scholar 

  • Singer, R. (2005b). Clinical evaluation of suspected mold neurotoxicity. Proceedings of the Fifth International Conference on Bioaerosols, Fungi, Bacteria, Mycotoxins and Human Health. Albany, NY: Boyd Printing.

    Google Scholar 

  • Singer, R. (2006). Forensic neuropsychological autopsy of a suicide following occupational ­solvent exposure. Archives of Clinical Neuropsychology, 21, 606.

    Google Scholar 

  • Singer, R. (2007). Neuropsychological assessment of toxic exposures. In The neuropsychology handbook (3rd ed., Vol. 2). New York: Springer.

    Google Scholar 

  • Singer, R. (2008). Forensic evaluation of neuropsychological decline following solvent exposure. Archives of Clinical Neuropsychology, 23, 746.

    Google Scholar 

  • Singer, R. (2010). Forensic neurotoxicology. In A. MacNeill Horton and L. C. Hartlage (Eds.). The Handbook of Forensic Neuropsychology (2nd ed.). (pp. 541–560) New York: Springer.

    Google Scholar 

  • Singer, R., & Gray, M. (2007). Neuropsychological evaluation of a practicing physician with mold exposure. Archives of Clinical Neuropsychology, 22, 892.

    Google Scholar 

  • Smith, A. (1982). Symbol Digit Modalities Test (SDMT) manual (revised). Los Angeles: Western Psychological Services.

    Google Scholar 

  • Stampfer, M. (2009). Welding occupations and mortality from Parkinson’s disease and other neurodegenerative diseases among United States men, 1985-1999. Journal of Occupational and Environmental Hygiene, 6, 267–272.

    Article  PubMed  Google Scholar 

  • Spreen, O., & Strauss, E. (1998). A Compendium of Neuropsychological Tests (2nd ed.). New York: Oxford University Press.

    Google Scholar 

  • Suner, S., Partridge, R., Sucov, A., Valente, J., Chee, K., Hughes, A., et al. (2008). Non-invasive pulse CO-oximetry screening in the emergency department identifies occult carbon monoxide toxicity. Journal of Emergency Medicine, 34, 441–450.

    Article  PubMed  Google Scholar 

  • Thrasher, J. D., & Crawley, S. (2009). The biocontaminants and complexity of damp indoor spaces: more than what meets the eyes. Toxicol Ind Health, 25, 583–615.

    Google Scholar 

  • Thorne, D. R., Genser, S. G., Sing, H. C., & Hegge, F. W. (1985). The Walter Reed performance assessment battery. Neurobehav Toxicol Teratol, 7(4), 415–8.

    PubMed  Google Scholar 

  • Trenerry, M. R., Crosson, B., DeBoe, J., & Leber, W. R. (1990). Visual Search and Attention Test. Lutz, FL: Psychological Assessment Resources.

    Google Scholar 

  • Valciukas, J., & Singer, R. (1982). The embedded figures test in epidemiological studies of environmental neurotoxic agents. Environmental Research, 28, 183–198.

    Article  Google Scholar 

  • Valciukas, J., Lilis, R., Singer, R., Fischbein, A., Anderson, H. A., & Glickman, L. (1980). Lead exposure and behavioral changes: Comparisons of four occupational groups with different levels of lead absorption. American Journal of Industrial Medicine, 1, 421–426.

    Article  PubMed  Google Scholar 

  • Valciukas, J., Lilis, R., Singer, R., Glickman, L., & Nicholson, W. J. (1985). Neurobehavioral changes among shipyard painters exposed to solvents. Archives of Environmental Health, 40(1), 47–52.

    PubMed  Google Scholar 

  • Wanamaker, R. W., & Wiener, S. L. (1997). Tricholthecene mycotoxin. In R. Zajtchuk (Ed.), Textbook of military medicine (Medical aspects of chemical and biological warfare). Washington, DC: Office of the Surgeon General, Borden Institute, Walter Reed Army Medical Center, Office of the Surgeon General United States Army. Chapter 34.

    Google Scholar 

  • Wechsler, D. (1981). Wechsler Adult Intelligence Scale-Revised. New York: The Psychological Corporation.

    Google Scholar 

  • Wechsler, D. (1997a). Wechsler Adult Intelligence Scale-3rd ed. (WAIS-III). San Antonio, TX: The Psychological Corporation.

    Google Scholar 

  • Wechsler, D. (1997b). Wechsler Memory Scale-3rd ed. (WAIS-III). San Antonio, TX: The Psychological Corporation.

    Google Scholar 

  • Wechsler, D. (2001). Wechsler Abbreviated Scales of Intelligence (WASI). San Antonio, TX: The Psychological Corporation.

    Google Scholar 

  • Wechsler, D. (2008). Wechsler Adult Intelligence Scale-4th ed. (WAIS-IV). San Antonio, TX: NCS Pearson.

    Google Scholar 

  • Wechsler, D. (2010). Wechsler Individual Achievement Test-3rd ed. (WIAT-III). San Antonio, TX: NCS Pearson.

    Google Scholar 

  • Wilkinson, G. S., & Robertson, G. J. (2006). Wide Range Achievement Test-Fourth Edition. Lutz, FL: Psychological Assessment Resources.

    Google Scholar 

  • Woodcock, R. W., McGrew, K. W., & Mather, N. (2001). Woodcock-Johnson III. Itasca, IL: Riverside Publishing.

    Google Scholar 

  • World Health Organization (1992). The International Classification of Mental and Behavioral Disorders: Clinical Descriptions and Diagnostic Guidelines (10th ed.). Author: Geneva.

    Google Scholar 

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Authors and Affiliations

  1. National Academy of Neuropsychology, Association for Psychological Science, American Psychological Association, Santa Fe, NM, USA

    Raymond Singer

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  1. Raymond Singer
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Correspondence to Raymond Singer .

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Editors and Affiliations

  1. School of Medicine, Dept. Neurology, University of South Florida, Euclid Avenue 11100, Tampa, 44106, Florida, USA

    Mike R. Schoenberg

  2. Dept. Psychiatry & Behavioral Health, Health Sciences Center, University of Oklahoma, Oklahoma, Oklahoma, USA

    James G. Scott

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Singer, R. (2011). Neurotoxicity in Neuropsychology. In: Schoenberg, M., Scott, J. (eds) The Little Black Book of Neuropsychology. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-76978-3_27

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