Neurotoxicity in Neuropsychology



This chapter will provide definitions regarding neurotoxicity, general principles of neurotoxic damage, symptom presentation for common neurotoxic substances, a brief discussion of symptoms/features of the Neurotoxicity Syndrome, and assessment for neurotoxicity.


Neuropsychological Assessment Lead Poisoning Ergot Alkaloid Neuropsychological Evaluation Psychomotor Speed 


  1. Anger, W. K., & Johnson, B. (1985). Chemicals affecting behavior. In Neurotoxicity of Industrial and Commercial Chemicals. In J. O. Donoghue (Ed.), Neurotoxicity of Industrial and Commercial Chemicals (Vol. 1). Boca Raton: CRC Press.Google Scholar
  2. AITB (1944). Army Individual Test Battery, Manual of directions and scoring, War Department, Adjutant General’s Office, Washington, DC.Google Scholar
  3. Beck, A. T., and Steer, R. A. (1993). Beck Anxiety Inventory Manual. San Antonio, TX: The Psychological Corporation.Google Scholar
  4. Beck, A.T., Steer, R.A., and Brown, G.K. (1996). Manual for the Beck Depression Inventory-II. San Antonio, TX: Psychological CorporationGoogle Scholar
  5. Benton, A. L. (1974). Revised Visual Retention Test (4th ed.). New York: Psychological Corporation.Google Scholar
  6. Benton, A. L., & Hamsher, K. deS. (1989). Multilingual Aphasia Examination. Iowa City, IA: AJA Associates.Google Scholar
  7. Berent, S. (2005). Neurobehavioral toxicology: Neurobehavioral and neuropsychological perspectives, foundations, and methods (Studies on neuropsychology, development, and cognition). New York: Taylor & Francis.Google Scholar
  8. Bowler, R. M., Gysens, S., Diamond, E., Nakagawa, S., Drezgic, M., & Roels, H. A. (2006). Manganese exposure: Neuropsychological and neurological symptoms and effects in welders. Neurotoxicology, 27, 315–326.PubMedCrossRefGoogle Scholar
  9. Brown, J. S. (2002). Environmental and chemical toxins and psychiatric illness. Washington, DC: American Psychiatric Publishing.Google Scholar
  10. Bush, S. S., Ruff, R. M., Troster, A. I., Barth, J. T., Koffler, S. P., Pliskin, N. H., et al. (2005). For the NAN Policy & Planning Committee. (2005). NAN position paper. Symptom validity assessment: Practice issues andmedical necessity. Archives of Clinical Neuropsychology, 20, 419–426.PubMedCrossRefGoogle Scholar
  11. Calne, D. B., McGeer, E., Eisen, A., & Spencer, P. (1986). Alzheimer’s disease, Parkinson’s disease, and motoneurone disease: Abiotropic interaction between ageing and environment? Lancet, 2, 1067–70.PubMedCrossRefGoogle Scholar
  12. Chambers, C. A., Hopkins, R. O., Weaver, L. K., & Key, C. (2008). Cognitive and affective outcomes of more severe compared to less severe carbon monoxide poisoning. Brain Injury, 22, 387–395.PubMedCrossRefGoogle Scholar
  13. Costa, P. T., & McCrae, R. R. (1995). NEO Personality Inventory-Revised manual. Lutz, FL: Psychological Assessment Resources.Google Scholar
  14. Cunningham, C., Wilcockson, D. C., Campion, S., Lunnon, K., & Perry, V. H. (2005). Central and Systemic Endotoxin Challenges Exacerbate the Local Inflammatory Response and Increase Neuronal Death during Chronic Neurodegeneration. Journal of Neurosciences, 25, 9275–9284Google Scholar
  15. U.S. Congress, Office of Technology Assessment (1990, April). Neurotoxicity: Identifying and controlling poisons of the nervous system (OTA-BA-436). Washington, DC: U.S. Government Printing Office.Google Scholar
  16. Delis, D. C., Kaplan, E., & Kramer, J. H. (2001). The Delis-Kaplan Executive Function System (K-KEFS). San Antonio, TX: NCS Pearson.Google Scholar
  17. Ecobichon, D. J., & Joy, R. M. (1994). Pesticides and neurological diseases (2nd ed.). Boca Raton: CRC Press.Google Scholar
  18. Edling, C., Lindberg, A., & Ulfberg, J. (1993). Occupational exposure to organic solvents as a cause of sleep apnoea. Br J Ind Med., 50, 276–279.PubMedGoogle Scholar
  19. Fahn, S. (2002). The case of the frozen addicts: How the solution of an extraordinary medical mystery spawned a revolution in the understanding and treatment of Parkinson’s disease. The New England Journal of Medicine, 335, 2002.CrossRefGoogle Scholar
  20. Golden, C. J. (1978). Stroop color and Word Test. Chicago, IL: Stoelting.Google Scholar
  21. Goodglass, H., & Kaplan, E. (2000). The Boston Naming Test. Philadelphia: Lippincott Williams & Wilkins.Google Scholar
  22. Goodglass, H., Kaplan, E., & Barresi, B. (2000). The Boston Diagnostic Aphasia Examination (BDAE-3) (3rd Ed.). Philadelphia: Lippincott Williams & Wilkins.Google Scholar
  23. Grace, J., & Malloy, P. F. (2001). Frontal Systems Behavior Scale (FrSBe). Lutz, FL: Psychological Assessment Resources.Google Scholar
  24. Gronwall, D. M. A. (1977). Paced Auditory Serial Addition Task: A measure of recovery from concussion. Perceptual and Motor Skills, 44, 367–373.Google Scholar
  25. Haley, R. W., Spence, J. S., Carmack, P. S., Gunst, R. F., Schucany, W. R., Petty, F., et al. (2009). Abnormal brain response to cholinergic challenge in chronic encephalopathy from the 1991 Gulf War. Psychiatry Research, 171, 207–20.PubMedCrossRefGoogle Scholar
  26. Hartman, H. E. (1995). Neuropsychological toxicology. Identification and assessment of human neurotoxic syndromes (2nd ed.). New York: Plenum Press.Google Scholar
  27. Hojo, S., Kumano, H., Yoshino, H., Kakuta, K., & Ishikawa, S. (2003). Application of quick environment exposure sensitivity inventory (QEESI©) for Japanese population: study of reliability and validity of the questionnaire. Toxicology and Industrial Health, 19, 41–49.PubMedCrossRefGoogle Scholar
  28. Kertesz, A. (1982). Western Aphasia Battery. San Antonio, TX: Psychological Corporation.Google Scholar
  29. Kilburn, K. H. (2004). Endangered brains: How chemicals threaten our future. Birmingham: Princeton Scientific Publishers Co.Google Scholar
  30. Kilburn, K. H. (2009). Neurobehavioral and pulmonary impairment in 105 adults with indoor exposure to molds compared to 100 exposed to chemicals. Toxicology and Industrial Health, 25(9–10), 681–92.PubMedCrossRefGoogle Scholar
  31. Kimura, J. (2001). Electrodiagnosis of diseases of nerve and muscle: Principles and practice (3rd Ed.). New York: Oxford University Press.Google Scholar
  32. Kulig, K., Cetaruk, E., Palmer, R., & Brent, J. (2009). The methodology in the paper by Chambers et al., raises serious questions about their conclusions. Brain Injury, 32, 3–4.CrossRefGoogle Scholar
  33. Lezak, M. D., Howieson, D. B., & Loring, D. W. (2004). Neuropsychological assessment (4th ed.). New York: Oxford University Press.Google Scholar
  34. Lidsky, T. I., & Schneider, J. S. (2006). Adverse effects of childhood lead poisoning: The clinical neuropsychological perspective. Environmental Research, 100, 284–293.PubMedCrossRefGoogle Scholar
  35. Lucchini, R. G., Martin, C. J., & Doney, B. C. (2009). From manganism to manganese-induced parkinsonism: a conceptual model based on the evolution of exposure. Neuromol Med Dec, 11(4), 311–321.CrossRefGoogle Scholar
  36. Lutz, W. D. (2008). Toxicology Principles for the Industrial Hygienist. In W. E. Luttrell, W. W. Jederberg, & K. R. Still (Eds.), Toxicology of sensory organs. Fairfax: American Industrial Hygiene Association.Google Scholar
  37. Matthews, C.G., & Klove, H. (1964). Instruction manual for the Adult Neuropsychology Test Battery. University of Wisconsin Medical School, Madison, WI.Google Scholar
  38. Monstad, P., Mellgren, S. I., & Sulg, I. A. (1992). The clinical significance of sleep apnea in workers exposed to organic solvents: Implications for the diagnosis of organic solvent encephalopathy. J Neurol., 239, 195–198.PubMedCrossRefGoogle Scholar
  39. Packer, S. (1998). Jewish mystical movements and the European ergot epidemics. Isr J Psychiatry Relat Sci., 35(3), 227–39.PubMedGoogle Scholar
  40. Panaccione, D. G., & Coyle, C. M. (2005). Abundant respirable ergot alkaloids from the common airborne fungus Aspergillus fumigates. Appl. Environ. Microbiol, 71, 3106–3111.PubMedCrossRefGoogle Scholar
  41. Racette, B. A., McGee-Minnich, L., Moerlein, S. M., Mink, J. W., & Perlmuter, J. S. (2001). Welding related Parkinsonism: Clinical features, treatment, and pathophysiology. Neurology, 56, 8–13.PubMedCrossRefGoogle Scholar
  42. Reynolds, C. R., & Joress, J. K. (2007). Test of Memory and Learning-2nd ed. (TOML-II). Austin, TX: PRO-ED.Google Scholar
  43. Ruff, R. M., & Allen, C. C. (1996). Ruff 2 & 7 selective attention test, professional manual. Lutz, FL: Psychological Assessment Resources.Google Scholar
  44. Russell, R. W., Flattau, P.E., & MacPherson-Pope, A. (1990). Behavioral measures of neurotoxicity: Report of a symposium, U.S. National Committee for the International Union of Psychological Science, National Research Council, National Research Council (U.S.). Commission on Behavioral and Social Sciences and Education, National Research Council (U.S.). Washington, DC: National Academies Press, p. 48.Google Scholar
  45. Ryan, C. M., Morrow, L. A., Bromet, E. J., & Parkinson, D. K. (1987). Assessment of neuropsychological dysfunction in the workplace: Normative data from the Pittsburgh occupational exposures test battery. Journal of Clinical and Experimental Neuropsychology, 9(6), 665–679. doi: 10.1080/01688638708405209.PubMedCrossRefGoogle Scholar
  46. Sbordonne, et al. (2000). The use of significant others to enhance the detection of malingerers from traumatically brain-injured patients. Archives of Clinical Neuropsychology, 15, 465–477.Google Scholar
  47. Seppalainen, A. M. (1989). Electrophysiological approaches to occupational neurotoicology. In L. G. Costa & L. Manzo (Eds.), Occupational neurotoxicology. Boca Raton: CRC Press.Google Scholar
  48. Singer, R. (1990a). Neurotoxicity guidebook. New York: Van Nostrand Reinhold Co.Google Scholar
  49. Singer, R. (1990b). Neurotoxicity can produce “MS-like” symptoms. Journal of Clinical and Experimental Neuropsychology, 12, 68.Google Scholar
  50. Singer, R. (1996). Neurobehavioral screening of breast implant women. Archives of Clinical Neuropsychology, 11, 5.Google Scholar
  51. Singer, R. (1997). Wood-preserving chemicals, multiple sclerosis, and neuropsychological function. Archives of Clinical Neuropsychology, 12, 404.CrossRefGoogle Scholar
  52. Singer, R. (2001). Neurotoxicity evaluation of a new solvent. Archives of Clinical Neuropsychology, 16, 697.Google Scholar
  53. Singer, R. (2002a). Neurobehavioral evaluation of residual effects of low-level bystander organophosphate pesticide exposure. Fundamental and Applied Toxicology, Supplement: The Toxicologist, 55, 311.Google Scholar
  54. Singer, R. (2002b). Panic disorder can be caused by neurotoxicity. Archives of Clinical Neuropsychology, 17, 813–814.Google Scholar
  55. Singer, R. (2002c, April 21st). Death penalty mitigation factors: Neurotoxicity. 18th Annual Symposium of the American College of Forensic Psychology, San Francisco.Google Scholar
  56. Singer, R. (2005a). Forensic evaluation of a mold (repeated water intrusions) neurotoxicity case. Archives of Clinical Neuropsychology, 20, 808.Google Scholar
  57. Singer, R. (2005b). Clinical evaluation of suspected mold neurotoxicity. Proceedings of the Fifth International Conference on Bioaerosols, Fungi, Bacteria, Mycotoxins and Human Health. Albany, NY: Boyd Printing.Google Scholar
  58. Singer, R. (2006). Forensic neuropsychological autopsy of a suicide following occupational ­solvent exposure. Archives of Clinical Neuropsychology, 21, 606.Google Scholar
  59. Singer, R. (2007). Neuropsychological assessment of toxic exposures. In The neuropsychology handbook (3rd ed., Vol. 2). New York: Springer.Google Scholar
  60. Singer, R. (2008). Forensic evaluation of neuropsychological decline following solvent exposure. Archives of Clinical Neuropsychology, 23, 746.Google Scholar
  61. Singer, R. (2010). Forensic neurotoxicology. In A. MacNeill Horton and L. C. Hartlage (Eds.). The Handbook of Forensic Neuropsychology (2nd ed.). (pp. 541–560) New York: Springer.Google Scholar
  62. Singer, R., & Gray, M. (2007). Neuropsychological evaluation of a practicing physician with mold exposure. Archives of Clinical Neuropsychology, 22, 892.Google Scholar
  63. Smith, A. (1982). Symbol Digit Modalities Test (SDMT) manual (revised). Los Angeles: Western Psychological Services.Google Scholar
  64. Stampfer, M. (2009). Welding occupations and mortality from Parkinson’s disease and other neurodegenerative diseases among United States men, 1985-1999. Journal of Occupational and Environmental Hygiene, 6, 267–272.PubMedCrossRefGoogle Scholar
  65. Spreen, O., & Strauss, E. (1998). A Compendium of Neuropsychological Tests (2nd ed.). New York: Oxford University Press.Google Scholar
  66. Suner, S., Partridge, R., Sucov, A., Valente, J., Chee, K., Hughes, A., et al. (2008). Non-invasive pulse CO-oximetry screening in the emergency department identifies occult carbon monoxide toxicity. Journal of Emergency Medicine, 34, 441–450.PubMedCrossRefGoogle Scholar
  67. Thrasher, J. D., & Crawley, S. (2009). The biocontaminants and complexity of damp indoor spaces: more than what meets the eyes. Toxicol Ind Health, 25, 583–615.Google Scholar
  68. Thorne, D. R., Genser, S. G., Sing, H. C., & Hegge, F. W. (1985). The Walter Reed performance assessment battery. Neurobehav Toxicol Teratol, 7(4), 415–8.PubMedGoogle Scholar
  69. Trenerry, M. R., Crosson, B., DeBoe, J., & Leber, W. R. (1990). Visual Search and Attention Test. Lutz, FL: Psychological Assessment Resources.Google Scholar
  70. Valciukas, J., & Singer, R. (1982). The embedded figures test in epidemiological studies of environmental neurotoxic agents. Environmental Research, 28, 183–198.CrossRefGoogle Scholar
  71. Valciukas, J., Lilis, R., Singer, R., Fischbein, A., Anderson, H. A., & Glickman, L. (1980). Lead exposure and behavioral changes: Comparisons of four occupational groups with different levels of lead absorption. American Journal of Industrial Medicine, 1, 421–426.PubMedCrossRefGoogle Scholar
  72. Valciukas, J., Lilis, R., Singer, R., Glickman, L., & Nicholson, W. J. (1985). Neurobehavioral changes among shipyard painters exposed to solvents. Archives of Environmental Health, 40(1), 47–52.PubMedGoogle Scholar
  73. Wanamaker, R. W., & Wiener, S. L. (1997). Tricholthecene mycotoxin. In R. Zajtchuk (Ed.), Textbook of military medicine (Medical aspects of chemical and biological warfare). Washington, DC: Office of the Surgeon General, Borden Institute, Walter Reed Army Medical Center, Office of the Surgeon General United States Army. Chapter 34.Google Scholar
  74. Wechsler, D. (1981). Wechsler Adult Intelligence Scale-Revised. New York: The Psychological Corporation.Google Scholar
  75. Wechsler, D. (1997a). Wechsler Adult Intelligence Scale-3rd ed. (WAIS-III). San Antonio, TX: The Psychological Corporation.Google Scholar
  76. Wechsler, D. (1997b). Wechsler Memory Scale-3rd ed. (WAIS-III). San Antonio, TX: The Psychological Corporation.Google Scholar
  77. Wechsler, D. (2001). Wechsler Abbreviated Scales of Intelligence (WASI). San Antonio, TX: The Psychological Corporation.Google Scholar
  78. Wechsler, D. (2008). Wechsler Adult Intelligence Scale-4th ed. (WAIS-IV). San Antonio, TX: NCS Pearson.Google Scholar
  79. Wechsler, D. (2010). Wechsler Individual Achievement Test-3rd ed. (WIAT-III). San Antonio, TX: NCS Pearson.Google Scholar
  80. Wilkinson, G. S., & Robertson, G. J. (2006). Wide Range Achievement Test-Fourth Edition. Lutz, FL: Psychological Assessment Resources.Google Scholar
  81. Woodcock, R. W., McGrew, K. W., & Mather, N. (2001). Woodcock-Johnson III. Itasca, IL: Riverside Publishing.Google Scholar
  82. World Health Organization (1992). The International Classification of Mental and Behavioral Disorders: Clinical Descriptions and Diagnostic Guidelines (10th ed.). Author: Geneva.Google Scholar

Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.National Academy of Neuropsychology, Association for Psychological Science, American Psychological AssociationSanta FeUSA

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