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Moderate and Severe Traumatic Brain Injury

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Abstract

Traumatic brain injuries arise from open or closed head injuries. Most traumatic brain injuries result from closed head injuries (an example of an open head injury is an object penetrating the skull). Brain injuries occur as the result of acceleration-deceleration forces (linear or angular), blunt trauma, or both. Traumatic brain injuries occur on a broad continuum of severity, from very mild transient injuries to catastrophic injuries resulting in death or severe disability. The continuum of severity of traumatic brain injury is illustrated in Fig. 21.1.

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References

  • AbdelMalik, P., Husted, J., Chow, E. W., & Bassett, A. S. (2003). Childhood head injury and expression of schizophrenia in multiply affected families. Archives of General Psychiatry, 60(3), 231–236.

    PubMed  Google Scholar 

  • Achte, K., Jarho, L., Kyykka, T., & Vesterinen, E. (1991). Paranoid disorders following war brain damage. Preliminary report. Psychopathology, 24(5), 309–315.

    PubMed  Google Scholar 

  • Adams, H., Mitchell, D. E., Graham, D. I., & Doyle, D. (1977). Diffuse brain damage of immediate impact type. Its relationship to ‘primary brain-stem damage’ in head injury. Brain, 100(3), 489–502.

    PubMed  Google Scholar 

  • Adams, J. H., Graham, D. I., Scott, G., Parker, L. S., & Doyle, D. (1980). Brain damage in fatal non-missile head injury. Journal of Clinical Pathology, 33(12), 1132–1145.

    PubMed  Google Scholar 

  • American Neurological Association Committee on Ethical Affairs. (1993). Persistent vegetative state: Report of the American Neurological Association Committee on Ethical Affairs. ANA Committee on Ethical Affairs. Annals of Neurology, 33(4), 386–390.

    Google Scholar 

  • American Psychiatric Association. (1994). Diagnostic and statistical manual of mental disorders (4th ed.). Washington, DC: American Psychiatric Association.

    Google Scholar 

  • American Psychiatric Association. (2000). Diagnostic and statistical manual of mental disorders (Text Revision 4th ed.). Washington, DC: American Psychiatric Association.

    Google Scholar 

  • Anderson, C. V., & Bigler, E. D. (1995). Ventricular dilation, cortical atrophy, and neuropsychological outcome following traumatic brain injury. The Journal of Neuropsychiatry and Clinical Neurosciences, 7(1), 42–48.

    PubMed  Google Scholar 

  • Annegers, J. F., Grabow, J. D., Kurland, L. T., & Laws, E. R., Jr. (1980). The incidence, causes, and secular trends of head trauma in Olmsted County, Minnesota, 1935–1974. Neurology, 30(9), 912–919.

    PubMed  Google Scholar 

  • Arfanakis, K., Haughton, V. M., Carew, J. D., Rogers, B. P., Dempsey, R. J., & Meyerand, M. E. (2002). Diffusion tensor MR imaging in diffuse axonal injury. American Journal of Neuroradiology, 23(5), 794–802.

    PubMed  Google Scholar 

  • Ashman, T. A., Spielman, L. A., Hibbard, M. R., Silver, J. M., Chandna, T., & Gordon, W. A. (2004). Psychiatric challenges in the first 6 years after traumatic brain injury: Cross-sequential analyses of Axis I disorders. Archives of Physical Medicine and Rehabilitation, 85(4 Suppl 2), S36–S42.

    PubMed  Google Scholar 

  • Asikainen, I., Kaste, M., & Sarna, S. (1996). Patients with traumatic brain injury referred to a rehabilitation and re-employment programme: Social and professional outcome for 508 Finnish patients 5 or more years after injury. Brain Injury, 10(12), 883–899.

    PubMed  Google Scholar 

  • Barkley, J. M., Morales, D., Hayman, L. A., & Diaz-Marchan, P. J. (2007). Static neuroimaging in the evaluation of TBI. In N. D. Zasler, D. I. Katz, & R. D. Zafonte (Eds.), Brain injury medicine: Principles and practice (pp. 129–148). New York: Demos.

    Google Scholar 

  • Bazarian, J. J., McClung, J., Cheng, Y. T., Flesher, W., & Schneider, S. M. (2005). Emergency department management of mild traumatic brain injury in the USA. Emergency Medicine Journal, 22(7), 473–477.

    PubMed  Google Scholar 

  • Berrol, S. (1986). Evolution and the persistent vegetative state. The Journal of Head Trauma Rehabilitation, 1, 7–13.

    Google Scholar 

  • Bigler, E. D. (2005). Structural imaging. London: American Psychiatric Publishing, Inc.

    Google Scholar 

  • Bigler, E. D., Kurth, S. M., Blatter, D., & Abildskov, T. J. (1992). Degenerative changes in traumatic brain injury: Post-injury magnetic resonance identified ventricular expansion compared to pre-injury levels. Brain Research Bulletin, 28(4), 651–653.

    PubMed  Google Scholar 

  • Bijur, P. E., Haslum, M., & Golding, J. (1990). Cognitive and behavioral sequelae of mild head injury in children. Pediatrics, 86(3), 337–344.

    PubMed  Google Scholar 

  • Bleiberg, J., Cernich, A. N., Cameron, K., Sun, W., Peck, K., Ecklund, P. J., et al. (2004). Duration of cognitive impairment after sports concussion. Neurosurgery, 54(5), 1073–1078. discussion 1078–1080.

    PubMed  Google Scholar 

  • Bombardier, C. H., Temkin, N. R., Machamer, J., & Dikmen, S. S. (2003). The natural history of drinking and alcohol-related problems after traumatic brain injury. Archives of Physical Medicine and Rehabilitation, 84(2), 185–191.

    PubMed  Google Scholar 

  • Bombardier, C. H., Fann, J. R., Temkin, N., Esselman, P. C., Pelzer, E., Keough, M., et al. (2006). Posttraumatic stress disorder symptoms during the first six months after traumatic brain injury. The Journal of Neuropsychiatry and Clinical Neurosciences, 18(4), 501–508.

    PubMed  Google Scholar 

  • Brain Association of British Columbia (2002). Retrieved Jan, 2006, from www.lmbia.org/qs/page/1499/0/-1

  • Breslau, N., Lipton, R. B., Stewart, W. F., Schultz, L. R., & Welch, K. M. (2003). Comorbidity of migraine and depression: Investigating potential etiology and prognosis. Neurology, 60(8), 1308–1312.

    PubMed  Google Scholar 

  • British Medical Association Medical Ethics Committee. (1992). Discussion paper of patients in persistent vegetative state. London: BMA.

    Google Scholar 

  • Bushnik, T., Englander, J., & Wright, J. (2008). The experience of fatigue in the first 2 years after moderate-to-severe traumatic brain injury: A preliminary report. The Journal of Head Trauma Rehabilitation, 23(1), 17–24.

    PubMed  Google Scholar 

  • Campbell, M., & Parry, A. (2005). Balance disorder and traumatic brain injury: Preliminary findings of a multi-factorial observational study. Brain Injury, 19(13), 1095–1104.

    PubMed  Google Scholar 

  • Cavallo, M. M., & Kay, T. (2005). The family system. In J. M. Silver, T. W. McAllister, & S. C. Yudofsky (Eds.), Textbook of traumatic brain injury (pp. 533–558). Arlington, VA: American Psychiatric Publishing, Inc.

    Google Scholar 

  • Charness, M. E. (1993). Brain lesions in alcoholics. Alcoholism, Clinical and Experimental Research, 17(1), 2–11.

    PubMed  Google Scholar 

  • Christman, C. W., Grady, M. S., Walker, S. A., Holloway, K. L., & Povlishock, J. T. (1994). Ultrastructural studies of diffuse axonal injury in humans. Journal of Neurotrauma, 11(2), 173–186.

    PubMed  Google Scholar 

  • Corcoran, C., McAllister, T. W., & Malaspina, D. (2005). Psychotic disorders. In J. M. Silver, T. W. McAllister, & S. C. Yudofsky (Eds.), Textbook of traumatic brain injury (pp. 213–229). Arlington, VA: American Psychiatric Publishing, Inc.

    Google Scholar 

  • Corrigan, J. D. (2007). The treatment of substance abuse in persons with TBI. In N. D. Zasler, D. I. Katz, & R. D. Zafonte (Eds.), Brain injury medicine (pp. 1105–1115). New York: Demos Medical Publishing, LLC.

    Google Scholar 

  • Corrigan, J. D., Lamb-Hart, G. L., & Rust, E. (1995). A programme of intervention for substance abuse following traumatic brain injury. Brain Injury, 9(3), 221–236.

    PubMed  Google Scholar 

  • Corrigan, J. D., Smith-Knapp, K., & Granger, C. V. (1998). Outcomes in the first 5 years after traumatic brain injury. Archives of Physical Medicine and Rehabilitation, 79(3), 298–305.

    PubMed  Google Scholar 

  • Corrigan, J. D., Bogner, J. A., Mysiw, W. J., Clinchot, D., & Fugate, L. (2001). Life satisfaction after traumatic brain injury. The Journal of Head Trauma Rehabilitation, 16(6), 543–555.

    PubMed  Google Scholar 

  • Corrigan, J. D., Bogner, J., Lamb-Hart, G., & Sivik-Sears, N. (2003). Technical report on problematic substance use variables. The Center for Outcome Measurement in Brain Injury. Retrieved 18 Mar 2008, from http://www.tbims.org/combi/subst

  • Dawson, D. R., Levine, B., Schwartz, M. L., & Stuss, D. T. (2004). Acute predictors of real-world outcomes following traumatic brain injury: A prospective study. Brain Injury, 18(3), 221–238.

    PubMed  Google Scholar 

  • Dikmen, S., McLean, A., Jr., Temkin, N. R., & Wyler, A. R. (1986). Neuropsychologic outcome at one-month postinjury. Archives of Physical Medicine and Rehabilitation, 67(8), 507–513.

    PubMed  Google Scholar 

  • Dikmen, S., Machamer, J., & Temkin, N. (1993). Psychosocial outcome in patients with moderate to severe head injury: 2-year follow-up. Brain Injury, 7(2), 113–124.

    PubMed  Google Scholar 

  • Dikmen, S., Temkin, N. R., Machamer, J. E., Holubkov, A. L., Fraser, R. T., & Winn, H. R. (1994). Employment following traumatic head injuries. Archives of Neurology, 51(2), 177–186.

    PubMed  Google Scholar 

  • Dikmen, S., Machamer, J. E., Winn, R., & Temkin, N. R. (1995). Neuropsychological outcome 1-year post head injury. Neuropsychology, 9, 80–90.

    Google Scholar 

  • Dikmen, S., Machamer, J., & Temkin, N. (2001). Mild head injury: Facts and artifacts. Journal of Clinical and Experimental Neuropsychology, 23(6), 729–738.

    PubMed  Google Scholar 

  • Dikmen, S., Machamer, J. E., Powell, J. M., & Temkin, N. R. (2003). Outcome 3 to 5 years after moderate to severe traumatic brain injury. Archives of Physical Medicine and Rehabilitation, 84(10), 1449–1457.

    PubMed  Google Scholar 

  • Dikmen, S., Bombardier, C. H., Machamer, J. E., Fann, J. R., & Temkin, N. R. (2004). Natural history of depression in traumatic brain injury. Archives of Physical Medicine and Rehabilitation, 85(9), 1457–1464.

    PubMed  Google Scholar 

  • Erb, D. E., & Povlishock, J. T. (1991). Neuroplasticity following traumatic brain injury: A study of GABAergic terminal loss and recovery in the cat dorsal lateral vestibular nucleus. Experimental Brain Research, 83(2), 253–267.

    Google Scholar 

  • Fay, G. C., Jaffe, K. M., Polissar, N. L., Liao, S., Martin, K. M., Shurtleff, H. A., et al. (1993). Mild pediatric traumatic brain injury: A cohort study. Archives of Physical Medicine and Rehabilitation, 74(9), 895–901.

    PubMed  Google Scholar 

  • Fellus, J. L., & Elovic, E. P. (2007). Fatigue: Assessment and treatment. In N. D. Zasler, D. I. Katz, & R. D. Zafonte (Eds.), Brain injury medicine (pp. 545–555). New York: Demos Medical Publishing, LLC.

    Google Scholar 

  • Flashman, L. A., & McAllister, T. W. (2002). Lack of awareness and its impact in traumatic brain injury. NeuroRehabilitation, 17(4), 285–296.

    PubMed  Google Scholar 

  • Flashman, L. A., Amador, X., & McAllister, T. W. (2005). Awareness of deficits. In J. M. Silver, T. W. McAllister, & S. C. Yudofsky (Eds.), Textbook of traumatic brain injury (pp. 353–367). Arlington, VA: American Psychiatric Publishing, Inc.

    Google Scholar 

  • Gagnon, I., Forget, R., Sullivan, S. J., & Friedman, D. (1998). Motor performance following a mild traumatic brain injury in children: An exploratory study. Brain Injury, 12(10), 843–853.

    PubMed  Google Scholar 

  • Gean, A. D. (1994). White matter shearing injury and brainstem injury. In A. D. Gean (Ed.), Imaging of head trauma (pp. 207–248). New York: Raven Press.

    Google Scholar 

  • Gennarelli, T. A., & Graham, D. I. (1998). Neuropathology of the head injuries. Seminars in Clinical Neuropsychiatry, 3(3), 160–175.

    PubMed  Google Scholar 

  • Gentilini, M., Nichelli, P., Schoenhuber, R., Bortolotti, P., Tonelli, L., Falasca, A., et al. (1985). Neuropsychological evaluation of mild head injury. Journal of Neurology, Neurosurgery and Psychiatry, 48(2), 137–140.

    Google Scholar 

  • Gentry, L. R., Godersky, J. C., & Thompson, B. (1988a). MR imaging of head trauma: Review of the distribution and radiopathologic features of traumatic lesions. American Journal of Roentgenology, 150(3), 663–672.

    PubMed  Google Scholar 

  • Gentry, L. R., Godersky, J. C., Thompson, B., & Dunn, V. D. (1988b). Prospective comparative study of intermediate-field MR and CT in the evaluation of closed head trauma. American Journal of Roentgenology, 150(3), 673–682.

    PubMed  Google Scholar 

  • Geurts, A. C., Ribbers, G. M., Knoop, J. A., & van Limbeek, J. (1996). Identification of static and dynamic postural instability following traumatic brain injury. Archives of Physical Medicine and Rehabilitation, 77(7), 639–644.

    PubMed  Google Scholar 

  • Gil, S., Caspi, Y., Ben-Ari, I. Z., Koren, D., & Klein, E. (2005). Does memory of a traumatic event increase the risk for posttraumatic stress disorder in patients with traumatic brain injury? A prospective study. The American Journal of Psychiatry, 162(5), 963–969.

    PubMed  Google Scholar 

  • Goldstein, F. C., Levin, H. S., Goldman, W. P., Clark, A. N., & Altonen, T. K. (2001). Cognitive and neurobehavioral functioning after mild versus moderate traumatic brain injury in older adults. Journal of the International Neuropsychological Society, 7(3), 373–383.

    PubMed  Google Scholar 

  • Gorrie, C., Duflou, J., Brown, J., Gibson, T., & Waite, P. M. (2001). Extent and distribution of vascular brain injury in pediatric road fatalities. Journal of Neurotrauma, 18(9), 849–860.

    PubMed  Google Scholar 

  • Grady, M. S., McLaughlin, M. R., Christman, C. W., Valadka, A. B., Fligner, C. L., & Povlishock, J. T. (1993). The use of antibodies targeted against the neurofilament subunits for the detection of diffuse axonal injury in humans. Journal of Neuropathology and Experimental Neurology, 52(2), 143–152.

    PubMed  Google Scholar 

  • Greenspan, A. I., Wrigley, J. M., Kresnow, M., Branche-Dorsey, C. M., & Fine, P. R. (1996). Factors influencing failure to return to work due to traumatic brain injury. Brain Injury, 10(3), 207–218.

    PubMed  Google Scholar 

  • Greenwald, B. D., Cifu, D. X., Marwitz, J. H., Enders, L. J., Brown, A. W., Englander, J. S., et al. (2001). Factors associated with balance deficits on admission to rehabilitation after traumatic brain injury: A multicenter analysis. The Journal of Head Trauma Rehabilitation, 16(3), 238–252.

    PubMed  Google Scholar 

  • Gureje, O., Bamidele, R., & Raji, O. (1994). Early brain trauma and schizophrenia in Nigerian patients. The American Journal of Psychiatry, 151(3), 368–371.

    PubMed  Google Scholar 

  • Harris, J. H., & Harris, W. H. (2000). The radiology of emergency medicine (4th ed.). Philadelphia: Lippincott, Williams & Wilkins.

    Google Scholar 

  • Harvey, A. G., & Bryant, R. A. (2000). Two-year prospective evaluation of the relationship between acute stress disorder and posttraumatic stress disorder following mild traumatic brain injury. The American Journal of Psychiatry, 157(4), 626–628.

    PubMed  Google Scholar 

  • Hawley, C. A., Ward, A. B., Magnay, A. R., & Mychalkiw, W. (2004). Return to school after brain injury. Archives of Disease in Childhood, 89(2), 136–142.

    PubMed  Google Scholar 

  • Hibbard, M. R., Uysal, S., Kepler, K., Bogdany, J., & Silver, J. (1998). Axis I psychopathology in individuals with traumatic brain injury. The Journal of Head Trauma Rehabilitation, 13(4), 24–39.

    PubMed  Google Scholar 

  • Hibbard, M. R., Ashman, T. A., Spielman, L. A., Chun, D., Charatz, H. J., & Melvin, S. (2004). Relationship between depression and psychosocial functioning after traumatic brain injury. Archives of Physical Medicine and Rehabilitation, 85(4 Suppl 2), S43–S53.

    PubMed  Google Scholar 

  • Hickling, E. J., Gillen, R., Blanchard, E. B., Buckley, T., & Taylor, A. (1998). Traumatic brain injury and posttraumatic stress disorder: a preliminary investigation of neuropsychological test results in PTSD secondary to motor vehicle accidents. Brain Injury, 12(4), 265–274.

    PubMed  Google Scholar 

  • Higashi, K., Sakata, Y., Hatano, M., Abiko, S., Ihara, K., Katayama, S., et al. (1977). Epidemiological studies on patients with a persistent vegetative state. Journal of Neurology, Neurosurgery and Psychiatry, 40(9), 876–885.

    Google Scholar 

  • Hillbom, E. (1960). After-effects of brain-injuries. Research on the symptoms causing invalidism of persons in Finland having sustained brain-injuries during the wars of 1939–1940 and 1941–1944. Acta Psychiatrica Scandinavica. Supplementum, 35(142), 1–195.

    PubMed  Google Scholar 

  • Hillier, S. L., Sharpe, M. H., & Metzer, J. (1997). Outcomes 5 years post-traumatic brain injury (with further reference to neurophysical impairment and disability). Brain Injury, 11(9), 661–675.

    PubMed  Google Scholar 

  • Horner, M. D., Ferguson, P. L., Selassie, A. W., Labbate, L. A., Kniele, K., & Corrigan, J. D. (2005). Patterns of alcohol use 1 year after traumatic brain injury: A population-based, epidemiological study. Journal of the International Neuropsychological Society, 11(3), 322–330.

    PubMed  Google Scholar 

  • Hughes, D. G., Jackson, A., Mason, D. L., Berry, E., Hollis, S., & Yates, D. W. (2004). Abnormalities on magnetic resonance imaging seen acutely following mild traumatic brain injury: Correlation with neuropsychological tests and delayed recovery. Neuroradiology, 46(7), 550–558.

    PubMed  Google Scholar 

  • Huisman, T. A., Schwamm, L. H., Schaefer, P. W., Koroshetz, W. J., Shetty-Alva, N., Ozsunar, Y., et al. (2004). Diffusion tensor imaging as potential biomarker of white matter injury in diffuse axonal injury. American Journal of Neuroradiology, 25(3), 370–376.

    PubMed  Google Scholar 

  • Inglese, M., Bomsztyk, E., Gonen, O., Mannon, L. J., Grossman, R. I., & Rusinek, H. (2005a). Dilated perivascular spaces: Hallmarks of mild traumatic brain injury. American Journal of Neuroradiology, 26(4), 719–724.

    PubMed  Google Scholar 

  • Inglese, M., Makani, S., Johnson, G., Cohen, B. A., Silver, J. A., Gonen, O., et al. (2005b). Diffuse axonal injury in mild traumatic brain injury: A diffusion tensor imaging study. Journal of Neurosurgery, 103(2), 298–303.

    PubMed  Google Scholar 

  • Iverson, G. L. (2005). Outcome from mild traumatic brain injury. Current Opinion in Psychiatry, 18, 301–317.

    PubMed  Google Scholar 

  • Jagger, J., Levine, J. I., Jane, J. A., & Rimel, R. W. (1984). Epidemiologic features of head injury in a predominantly rural population. The Journal of Trauma, 24(1), 40–44.

    PubMed  Google Scholar 

  • Jennett, B. (1996). Clinical and pathological features of vegetative survival. In H. S. Levin, A. L. Benton, J. P. Muizelaar, & H. M. Eisenberg (Eds.), Catastrophic brain injury. New York: Oxford University Press.

    Google Scholar 

  • Jennett, B., & Bond, M. (1975). Assessment of outcome after severe brain damage. Lancet, 1(7905), 480–484.

    PubMed  Google Scholar 

  • Jones, G. A. (1989). Alcohol abuse and traumatic brain injury. Alcohol Health and Research World, 13(2), 104–109.

    Google Scholar 

  • Jorge, R. E., Robinson, R. G., Starkstein, S. E., & Arndt, S. V. (1993). Depression and anxiety following traumatic brain injury. The Journal of Neuropsychiatry and Clinical Neurosciences, 5(4), 369–374.

    PubMed  Google Scholar 

  • Jorge, R. E., Robinson, R. G., Moser, D., Tateno, A., Crespo-Facorro, B., & Arndt, S. (2004). Major depression following traumatic brain injury. Archives of General Psychiatry, 61(1), 42–50.

    PubMed  Google Scholar 

  • Kapoor, N., & Ciuffreda, K. J. (2005). Vision problems. In J. M. Silver, T. W. McAllister, & S. C. Yudofsky (Eds.), Textbook of traumatic brain injury (pp. 405–415). Arlington, VA: American Psychiatric Publishing.

    Google Scholar 

  • Kaufman, K. R., Brey, R. H., Chou, L. S., Rabatin, A., Brown, A. W., & Basford, J. R. (2006). Comparison of subjective and objective measurements of balance disorders following traumatic brain injury. Medical Engineering & Physics, 28(3), 234–239.

    Google Scholar 

  • Klauber, M. R., Barrett-Connor, E., Marshall, L. F., & Bowers, S. A. (1981). The epidemiology of head injury: A prospective study of an entire community-San Diego County, California, 1978. American Journal of Epidemiology, 113(5), 500–509.

    PubMed  Google Scholar 

  • Kneipp, S., & Rubin, A. (2007). Community re-entry issues and long-term care. In N. D. Zasler, D. I. Katz, & R. D. Zafonte (Eds.), Brain injury medicine (pp. 1085–1104). New York: Demos Medical Publishing, LLC.

    Google Scholar 

  • Kochanek, P. M., Clark, R. S. B., & Jenkins, L. W. (2007). TBI: Pathobiology. In N. D. Zasler, D. I. Katz, & R. D. Zafonte (Eds.), Brain injury medicine: Principles and practice (pp. 81–96). New York: Demos.

    Google Scholar 

  • Koponen, S., Taiminen, T., Portin, R., Himanen, L., Isoniemi, H., Heinonen, H., et al. (2002). Axis I and II psychiatric disorders after traumatic brain injury: A 30-year follow-up study. The American Journal of Psychiatry, 159(8), 1315–1321.

    PubMed  Google Scholar 

  • Kraus, J. F., & Chu, L. D. (2005). Epidemiology. In J. M. Silver, T. W. McAllister, & S. C. Yudofsky (Eds.), Textbook of traumatic brain injury (pp. 3–26). Arlington, VA: American Psychiatric Publishing, Inc.

    Google Scholar 

  • Kraus, J. F., Fife, D., Ramstein, K., Conroy, C., & Cox, P. (1986). The relationship of family income to the incidence, external causes, and outcomes of serious brain injury, San Diego County, California. American Journal of Public Health, 76(11), 1345–1347.

    PubMed  Google Scholar 

  • Kraus, J., Schaffer, K., Ayers, K., Stenehjem, J., Shen, H., & Afifi, A. A. (2005). Physical complaints, medical service use, and social and employment changes following mild traumatic brain injury: A 6-month longitudinal study. The Journal of Head Trauma Rehabilitation, 20(3), 239–256.

    PubMed  Google Scholar 

  • Krauss, J., & Jankovic, J. (2007). Movement disorders after TBI. In N. D. Zasler, D. I. Katz, & R. D. Zafonte (Eds.), Brain injury medicine (pp. 469–489). New York, NY: Demos Medical Publishing, LLC.

    Google Scholar 

  • Kreutzer, J. S., Witol, A. D., & Marwitz, J. H. (1996). Alcohol and drug use among young persons with traumatic brain injury. Journal of Learning Disabilities, 29(6), 643–651.

    PubMed  Google Scholar 

  • Lahmeyer, H. W., & Bellur, S. N. (1987). Cardiac regulation and depression. Journal of Psychiatry Research, 21(1), 1–6.

    Google Scholar 

  • Langlois, J. A., Rutland-Brown, W., & Thomas, K. E. (2004). Traumatic brain injury in the United States: Emergency department visits, hospitalizaitons, and deaths. Atlanta, GA: Centers for Disease Control and Prevention, National Center for Injury Prevention and Control.

    Google Scholar 

  • Le, T. H., Mukherjee, P., Henry, R. G., Berman, J. I., Ware, M., & Manley, G. T. (2005). Diffusion tensor imaging with three-dimensional fiber tractography of traumatic axonal shearing injury: An imaging correlate for the posterior callosal “disconnection” syndrome: Case report. Neurosurgery, 56(1), 189.

    PubMed  Google Scholar 

  • Levin, H. S. (2003). Neuroplasticity following non-penetrating traumatic brain injury. Brain Injury, 17(8), 665–674.

    PubMed  Google Scholar 

  • Levin, H. S., Williams, D. H., Valastro, M., Eisenberg, H. M., Crofford, M. J., & Handel, S. F. (1990). Corpus callosal atrophy following closed head injury: Detection with magnetic resonance imaging. Journal of Neurosurgery, 73(1), 77–81.

    PubMed  Google Scholar 

  • Levin, H. S., Brown, S. A., Song, J. X., McCauley, S. R., Boake, C., Contant, C. F., et al. (2001). Depression and posttraumatic stress disorder at 3 months after mild to moderate traumatic brain injury. Journal of Clinical and Experimental Neuropsychology, 23(6), 754–769.

    PubMed  Google Scholar 

  • Lezak, M. D., Howieson, D. B., & Loring, D. W. (2004). Neuropsychological assessment (4th ed.). New York: Oxford University Press.

    Google Scholar 

  • Lovell, M. R., Collins, M. W., Iverson, G. L., Johnston, K. M., & Bradley, J. P. (2004). Grade 1 or “ding” concussions in high school athletes. The American Journal of Sports Medicine, 32(1), 47–54.

    PubMed  Google Scholar 

  • Lucas, J. A. (1998). Traumatic brain injury and post concussive syndrome. In P. J. Snyder & P. D. Nussbaum (Eds.), Clinical neuropsychology (pp. 243–265). Washington, DC: American Psychological Association.

    Google Scholar 

  • Macciocchi, S. N., Barth, J. T., Alves, W., Rimel, R. W., & Jane, J. A. (1996). Neuropsychological functioning and recovery after mild head injury in collegiate athletes. Neurosurgery, 39(3), 510–514.

    PubMed  Google Scholar 

  • MacKenzie, E. J., Edelstein, S. L., & Flynn, J. P. (1989). Hospitalized head-injured patients in Maryland: Incidence and severity of injuries. Maryland Medical Journal, 38(9), 725–732.

    PubMed  Google Scholar 

  • MacKenzie, J. D., Siddiqi, F., Babb, J. S., Bagley, L. J., Mannon, L. J., Sinson, G. P., et al. (2002). Brain atrophy in mild or moderate traumatic brain injury: A longitudinal quantitative analysis. American Journal of Neuroradiology, 23(9), 1509–1515.

    PubMed  Google Scholar 

  • Malaspina, D., Goetz, R. R., Friedman, J. H., Kaufmann, C. A., Faraone, S. V., Tsuang, M., et al. (2001). Traumatic brain injury and schizophrenia in members of schizophrenia and bipolar disorder pedigrees. The American Journal of Psychiatry, 158(3), 440–446.

    PubMed  Google Scholar 

  • Mather, F. J., Tate, R. L., & Hannan, T. J. (2003). Post-traumatic stress disorder in children following road traffic accidents: A comparison of those with and without mild traumatic brain injury. Brain Injury, 17(12), 1077–1087.

    PubMed  Google Scholar 

  • Mayou, R. A., Black, J., & Bryant, B. (2000). Unconsciousness, amnesia and psychiatric symptoms following road traffic accident injury. The British Journal of Psychiatry, 177, 540–545.

    PubMed  Google Scholar 

  • Mazaux, J. M., Masson, F., Levin, H. S., Alaoui, P., Maurette, P., & Barat, M. (1997). Long-term neuropsychological outcome and loss of social autonomy after traumatic brain injury. Archives of Physical Medicine and Rehabilitation, 78(12), 1316–1320.

    PubMed  Google Scholar 

  • McAllister, T. W., Sparling, M. B., Flashman, L. A., & Saykin, A. J. (2001). Neuroimaging findings in mild traumatic brain injury. Journal of Clinical and Experimental Neuropsychology, 23(6), 775–791.

    PubMed  Google Scholar 

  • McCrea, M., Kelly, J. P., Randolph, C., Cisler, R., & Berger, L. (2002). Immediate neurocognitive effects of concussion. Neurosurgery, 50(5), 1032–1040.

    PubMed  Google Scholar 

  • McCrea, M., Guskiewicz, K. M., Marshall, S. W., Barr, W., Randolph, C., Cantu, R. C., et al. (2003). Acute effects and recovery time following concussion in collegiate football players: The NCAA Concussion Study. Journal of the American Medical Association, 290(19), 2556–2563.

    PubMed  Google Scholar 

  • Mearns, J., & Lees-Haley, P. R. (1993). Discriminating neuropsychological sequelae of head injury from alcohol-abuse-induced deficits: A review and analysis. Journal of Clinical Psychology, 49(5), 714–720.

    PubMed  Google Scholar 

  • Miles, L., Grossman, R. I., Johnson, G., Babb, J. S., Diller, L., & Inglese, M. (2008). Short-term DTI predictors of cognitive dysfunction in mild traumatic brain injury. Brain Injury, 22(2), 115–122.

    PubMed  Google Scholar 

  • Miller, N. S. (1991). The pharmacology of alcohol and drugs of abuse and addiction. New York: Springer-Verlag.

    Google Scholar 

  • Mitsikostas, D. D., & Thomas, A. M. (1999). Comorbidity of headache and depressive disorders. Cephalalgia, 19(4), 211–217.

    PubMed  Google Scholar 

  • Morales, D., Diaz-Daza, O., Hlatky, R., & Hayman, L. A. (2007). Brain, Contusion. Retrieved April 22, 2009, from http://emedicine.medscape.com/article/337782-overview

  • Nakayama, N., Okumura, A., Shinoda, J., Yasokawa, Y. T., Miwa, K., Yoshimura, S. I., et al. (2006). Evidence for white matter disruption in traumatic brain injury without macroscopic lesions. Journal of Neurology, Neurosurgery and Psychiatry, 77(7), 850–855.

    Google Scholar 

  • Nevin, N. C. (1967). Neuropathological changes in the white matter following head injury. Journal of Neuropathology and Experimental Neurology, 26(1), 77–84.

    PubMed  Google Scholar 

  • O’Shanick, G. J., & O’Shanick, A. M. (2005). Personality disorders. In J. M. Silver, T. W. McAllister, & S. C. Yudofsky (Eds.), Textbook of traumatic brain injury (pp. 245–258). Arlington, VA: American Psychiatric Publishing, Inc.

    Google Scholar 

  • Olver, J. H., Ponsford, J. L., & Curran, C. A. (1996). Outcome following traumatic brain injury: A comparison between 2 and 5 years after injury. Brain Injury, 10(11), 841–848.

    PubMed  Google Scholar 

  • Oppenheimer, D. R. (1968). Microscopic lesions in the brain following head injury. Journal of Neurology, Neurosurgery and Psychiatry, 31(4), 299–306.

    Google Scholar 

  • Orrison, W. W., Gentry, L. R., Stimac, G. K., Tarrel, R. M., Espinosa, M. C., & Cobb, L. C. (1994). Blinded comparison of cranial CT and MR in closed head injury evaluation. American Journal of Neuroradiology, 15(2), 351–356.

    PubMed  Google Scholar 

  • Padula, W., Wu, L., Vicci, V., Thomas, J., Nelson, C., Gottlieb, D., et al. (2007). Evaluating and treating visual dysfunction. In N. D. Zasler, D. I. Katz, & R. D. Zafonte (Eds.), Brain injury medicine (pp. 511–528). New York: Demos Medical Publishing, LLC.

    Google Scholar 

  • Peerless, S. J., & Rewcastle, N. B. (1967). Shear injuries of the brain. Canadian Medical Association Journal, 96(10), 577–582.

    PubMed  Google Scholar 

  • Pettus, E. H., Christman, C. W., Giebel, M. L., & Povlishock, J. T. (1994). Traumatically induced altered membrane permeability: Its relationship to traumatically induced reactive axonal change. Journal of Neurotrauma, 11(5), 507–522.

    PubMed  Google Scholar 

  • Pine, D. S., Cohen, P., & Brook, J. (1996). The association between major depression and headache: Results of a longitudinal epidemiologic study in youth. Journal of Child and Adolescent Psychopharmacology, 6(3), 153–164.

    PubMed  Google Scholar 

  • Ponsford, J. L., Olver, J. H., Curran, C., & Ng, K. (1995). Prediction of employment status 2 years after traumatic brain injury. Brain Injury, 9(1), 11–20.

    PubMed  Google Scholar 

  • Ponsford, J., Willmott, C., Rothwell, A., Cameron, P., Kelly, A. M., Nelms, R., et al. (2000). Factors influencing outcome following mild traumatic brain injury in adults. Journal of the International Neuropsychological Society, 6(5), 568–579.

    PubMed  Google Scholar 

  • Povlishock, J. T. (1993). Pathobiology of traumatically induced axonal injury in animals and man. Annals of Emergency Medicine, 22(6), 980–986.

    PubMed  Google Scholar 

  • Povlishock, J. T., & Becker, D. P. (1985). Fate of reactive axonal swellings induced by head injury. Laboratory Investigation, 52(5), 540–552.

    PubMed  Google Scholar 

  • Povlishock, J. T., Becker, D. P., Cheng, C. L., & Vaughan, G. W. (1983). Axonal change in minor head injury. Journal of Neuropathology and Experimental Neurology, 42(3), 225–242.

    PubMed  Google Scholar 

  • Rao, V., Rollings, P., & Spiro, J. (2005). Fatigue and sleep problems. In J. M. Silver, T. W. McAllister, & S. C. Yudofsky (Eds.), Textbook of traumatic brain injury (pp. 369–384). Arlington, VA: American Pychiatric Publishing, Inc.

    Google Scholar 

  • Rinne, M. B., Pasanen, M. E., Vartiainen, M. V., Lehto, T. M., Sarajuuri, J. M., & Alaranta, H. T. (2006). Motor performance in physically well-recovered men with traumatic brain injury. Journal of Rehabilitation Medicine, 38(4), 224–229.

    PubMed  Google Scholar 

  • Robinson, R. G., & Jorge, R. E. (2005). Mood disorders. In J. M. Silver, T. W. McAllister, & S. C. Yudofsky (Eds.), Textbook of traumatic brain injury (pp. 201–212). Arlington, VA: American Psychiatric Publishing.

    Google Scholar 

  • Ruff, R. M., Marshall, L. F., Crouch, J., Klauber, M. R., Levin, H. S., Barth, J., et al. (1993). Predictors of outcome following severe head trauma: Follow-up data from the Traumatic Coma Data Bank. Brain Injury, 7(2), 101–111.

    PubMed  Google Scholar 

  • Ruffolo, C. F., Friedland, J. F., Dawson, D. R., Colantonio, A., & Lindsay, P. H. (1999). Mild traumatic brain injury from motor vehicle accidents: Factors associated with return to work. Archives of Physical Medicine and Rehabilitation, 80(4), 392–398.

    PubMed  Google Scholar 

  • Salmond, C. H., Menon, D. K., Chatfield, D. A., Williams, G. B., Pena, A., Sahakian, B. J., et al. (2006). Diffusion tensor imaging in chronic head injury survivors: Correlations with learning and memory indices. Neuroimage, 29(1), 117–124.

    PubMed  Google Scholar 

  • Sandel, M. E., Delmonico, R., & Kotch, M. J. (2007). Sexuality, reproduction, and neuroendocrine disorders following TBI. In N. D. Zasler, D. I. Katz, & R. D. Zafonte (Eds.), Brain injury medicine (pp. 673–695). New York: Demos Medical Publishing, LLC.

    Google Scholar 

  • Sbordone, R. J., & Liter, J. C. (1995). Mild traumatic brain injury does not produce post-traumatic stress disorder. Brain Injury, 9, 405–412.

    PubMed  Google Scholar 

  • Schretlen, D. J., & Shapiro, A. M. (2003). A quantitative review of the effects of traumatic brain injury on cognitive functioning. International Review of Psychiatry, 15(4), 341–349.

    PubMed  Google Scholar 

  • Schwartz, J. H. (1991). Synthesis and trafficking of neural proteins. In E. R. Kandel, J. H. Schwartz, & T. M. Jessell (Eds.), Principles of neural science (3rd ed., pp. 49–65). New York: Elsevier.

    Google Scholar 

  • Silver, J. M., Kramer, R., Greenwald, S., & Weissman, M. (2001). The association between head injuries and psychiatric disorders: Findings from the New Haven NIMH epidemiologic catchment area study. Brain Injury, 15(11), 935–945.

    PubMed  Google Scholar 

  • Slemmer, J. E., Matser, E. J., De Zeeuw, C. I., & Weber, J. T. (2002). Repeated mild injury causes cumulative damage to hippocampal cells. Brain, 125(Pt 12), 2699–2709.

    PubMed  Google Scholar 

  • Smith, D. H., Wolf, J. A., Lusardi, T. A., Lee, V. M., & Meaney, D. F. (1999). High tolerance and delayed elastic response of cultured axons to dynamic stretch injury. The Journal of Neuroscience, 19(11), 4263–4269.

    PubMed  Google Scholar 

  • Sosin, D. M., Sniezek, J. E., & Thurman, D. J. (1996). Incidence of mild and moderate brain injury in the United States, 1991. Brain Injury, 10(1), 47–54.

    PubMed  Google Scholar 

  • Spikman, J. M., Timmerman, M. E., van Zomeren, A. H., & Deelman, B. G. (1999). Recovery versus retest effects in attention after closed head injury. Journal of Clinical and Experimental Neuropsychology, 21(5), 585–605.

    PubMed  Google Scholar 

  • Stambrook, M., Moore, A. D., Peters, L. C., Deviaene, C., & Hawryluk, G. A. (1990). Effects of mild, moderate and severe closed head injury on long-term vocational status. Brain Injury, 4(2), 183–190.

    PubMed  Google Scholar 

  • Strich, S. J. (1961). Shearing of nerve fibers as a cause of brain damage due to head injury. Lancet, 2, 443–438.

    Google Scholar 

  • Sundgren, P. C., Dong, Q., Gomez-Hassan, D., Mukherji, S. K., Maly, P., & Welsh, R. (2004). Diffusion tensor imaging of the brain: Review of clinical applications. Neuroradiology, 46(5), 339–350.

    PubMed  Google Scholar 

  • Thaxton, L. L., & Patel, A. R. (2007). Sleep disturbance: Epidemiology, assessment, and treatment. In N. D. Zasler, D. I. Katz, & R. D. Zafonte (Eds.), Brain injury medicine (pp. 557–575). New York: Demos Medical Publishing, LLC.

    Google Scholar 

  • Thomsen, I. V. (1984). Late outcome of very severe blunt head trauma: A 10–15 year second follow-up. Journal of Neurology, Neurosurgery and Psychiatry, 47(3), 260–268.

    Google Scholar 

  • Thurman, D., & Guerrero, J. (1999). Trends in hospitalization associated with traumatic brain injury. Journal of the American Medical Association, 282(10), 954–957.

    PubMed  Google Scholar 

  • Thurman, D. J., Coronado, V., & Selassie, A. (2007). The epidemiology of TBI: Implications for public health. In N. D. Zasler, D. I. Katz, & R. D. Zafonte (Eds.), Brain injury medicine (pp. 45–55). New York: Demos Medical Publishing, LLC.

    Google Scholar 

  • Uzzell, B. P., Langfitt, T. W., & Dolinskas, C. A. (1987). Influence of injury severity on quality of survival after head injury. Surgical Neurology, 27(5), 419–429.

    PubMed  Google Scholar 

  • Varney, N., Martzke, J., & Roberts, R. (1987). Major depression in patients with closed head injury. Neuropsychology, 1, 7–8.

    Google Scholar 

  • Warden, D. L., & Labbate, L. A. (2005). Posttraumatic stress disorder and other anxiety disorders. In J. M. Silver, T. W. McAllister, & S. C. Yudofsky (Eds.), Textbook of traumatic brain injury (pp. 231–243). Arlington, VA: American Psychiatric Publishing.

    Google Scholar 

  • West, M., Targett, P., Yasuda, S., & Wehman, P. (2007). Return to work following TBI. In N. D. Zasler, D. I. Katz, & R. D. Zafonte (Eds.), Brain injury medicine (pp. 1131–1147). New York: Demos Medical Publishing, LLC.

    Google Scholar 

  • Whitman, S., Coonley-Hoganson, R., & Desai, B. T. (1984). Comparative head trauma experiences in two socioeconomically different Chicago-area communities: A population study. American Journal of Epidemiology, 119(4), 570–580.

    PubMed  Google Scholar 

  • Whyte, J., Schuster, K., Polansky, M., Adams, J., & Coslett, H. B. (2000). Frequency and duration of inattentive behavior after traumatic brain injury: Effects of distraction, task, and practice. Journal of the International Neuropsychological Society, 6(1), 1–11.

    PubMed  Google Scholar 

  • Wilde, E. A., Chu, Z., Bigler, E. D., Hunter, J. V., Fearing, M. A., Hanten, G., et al. (2006). Diffusion tensor imaging in the corpus callosum in children after moderate to severe traumatic brain injury. Journal of Neurotrauma, 23(10), 1412–1426.

    PubMed  Google Scholar 

  • Wrightson, P., & Gronwall, D. (1981). Time off work and symptoms after minor head injury. Injury, 12(6), 445–454.

    PubMed  Google Scholar 

  • Yaghmai, A., & Povlishock, J. (1992). Traumatically induced reactive change as visualized through the use of monoclonal antibodies targeted to neurofilament subunits. Journal of Neuropathology and Experimental Neurology, 51(2), 158–176.

    PubMed  Google Scholar 

  • Zasler, N. D., Horn, L. J., Martelli, M. F., & Nicolson, K. (2007). Post-traumatic pain disorders: Medical assessment and management. In N. D. Zasler, D. I. Katz, & R. D. Zafonte (Eds.), Brain injury medicine (pp. 697–721). New York: Demos Medical Publishing, LLC.

    Google Scholar 

  • Zwart, J. A., Dyb, G., Hagen, K., Odegard, K. J., Dahl, A. A., Bovim, G., et al. (2003). Depression and anxiety disorders associated with headache frequency. The Nord-Trondelag Health Study. European Journal of Neurology, 10(2), 147–152.

    PubMed  Google Scholar 

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Acknowledgments

The authors thank Ms. Elena Dupont for providing Figs. 21.2, 21.3, 21.5, and 21.6.

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  1. University of British Columbia, Vancouver, BC, Canada

    Grant L. Iverson

  2. British Columbia Mental Health and Addiction Services, Coquitlam, BC, Canada

    Grant L. Iverson

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  1. School of Medicine, Dept. Neurology, University of South Florida, Euclid Avenue 11100, Tampa, 44106, Florida, USA

    Mike R. Schoenberg

  2. Dept. Psychiatry & Behavioral Health, Health Sciences Center, University of Oklahoma, Oklahoma, Oklahoma, USA

    James G. Scott

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Iverson, G.L., Lange, R.T. (2011). Moderate and Severe Traumatic Brain Injury. In: Schoenberg, M., Scott, J. (eds) The Little Black Book of Neuropsychology. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-76978-3_21

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