Multiple Sclerosis and Other Demyelinating Disorders

  • Julie A. Bobholz
  • Shelley Gremley


Demyelinating disorders are characterized by the destruction of the myelin sheaths of the nerves following normal myelin development. Types of demyelinating conditions can be generally characterized as immune-mediated diseases, infection-mediated diseases, inherited disorders, and toxic disorders (see (Table 20.1
Table 20.1

Types of demyelinating conditions that resemble MS

Immune-mediated diseases

•Acute disseminated encephalomyelitis

•Systemic inflammatory or autoimmune diseases

Infection-mediated diseases

•Progressive multifocal leukoencephalitis

•Human T-cell Lymphotropic Virus Type 1

Inherited disorders

•Dysmyelinating disorders (leukodystrophies)

Toxic disorders

•Toxic optic neuropathy, subacute myelo-optic neuropathy

; and Joy and Johnston, 2001, for detailed review). This chapter will begin with a brief description of demyelinating conditions representing these categories. Multiple Sclerosis (MS) is the most common demyelinating condition and will be the primary topic of this chapter.


Multiple Sclerosis Multiple Sclerosis Patient Cognitive Dysfunction Optic Neuritis Secondary Progressive Multiple Sclerosis 
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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Department of NeurologyMedical College of WisconsinMilwaukeeUSA
  2. 2.Alexian Neurosciences InstituteElk Grove VillageUSA

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