Sex and Gender Differences in the Assessment, Treatment, and Management of Epilepsy

  • Elaine Fletcher-Janzen
Part of the Issues of Diversity in Clinical Neuropsychology book series (ISSUESDIV)


Congenital Adrenal Hyperplasia Seizure Frequency Seizure Control Seizure Threshold Epilepsy Syndrome 


  1. Adab, N. (2006). Therapeutic monitoring of antiepileptic drugs during pregnancy and in the postpartumperiod. CNS Drugs, 20, 791–800.PubMedCrossRefGoogle Scholar
  2. Bauer, J., Isojarvi, J., Herzog, A. G., Reuber, M., Polson, D., Tauboll, E., et al. (2002). Reproductive dysfunction in women with epilepsy: recommendations for evaluation and management. Journal of neurology, neurosurgery, and psychiatry, 73, 121–125.PubMedCrossRefGoogle Scholar
  3. Christensen, J., Kjeldsen, M. J., Andersen, H., Friis, M. L., & Sidenius, P. (2005). Gender differences in epilepsy. Epilepsia, 46, 956–960.PubMedCrossRefGoogle Scholar
  4. Crawford, P. (2005). Best practice guidelines for the management of women with epilepsy. Epilepsia, 46, 117–124.PubMedCrossRefGoogle Scholar
  5. Doggett-Jones. (2007). Contraception for women with epilepsy. Practic Nurse, 33,Google Scholar
  6. (2007). Physcian’s discussion checklist for women with epilepsy. Retrived June 16, 2007 from
  7. Epilepsy Foundation. (2007a). Women’s issues. Retrieved from the World Wide Web on June 18, 2007, from
  8. Epilepsy Foundation. (2007b). Effective communication with women who have epilepsy. Retrieved from the World Wide Web on June 18, 2007, from….
  9. Epilepsy Foundation. (2007c). Epilepsy and the adolescent female. Retrieved from the World Wide Web on June 18, 2007, from
  10. Epilepsy Foundation. (2007d). Hormone-sensitive seizures. Retrieved from the World Wide Web on June 18, 2007, from….
  11. Fletcher-Janzen, E. (2000). Multicultural perspectives on the neuropsychological assessment and treatment of epilepsy. In E. Fletcher-Janzen, T. L. Strickland, & C. R. Reynolds (Eds.), Handbook of cross-cultural neuropsychology (pp. 185–204). New York: Springer.Google Scholar
  12. French, J. A. (2007). Choosing an effective therapy for women and girls. Retrieved from the World Wide Web on June 14, 2007, from….
  13. Galimberti, A., Magri, F., Copello, F., Gavello, L., Casu, M., Patrone, V., & Murialo, G., (2005). Seizure frequency and cortisol and dehydroepiandrosterone sulfate levels in women with epilepsy receiving antiepileptic drug treatment. Epilepsia, 46, 517--523.Google Scholar
  14. Genton, P., Semah, F., & Trinka, E. (2006). Valproic acid in epilepsy: pregnancy-related issues. Drug Safety, 29, 1–21.PubMedCrossRefGoogle Scholar
  15. Gupta, S., Rohatgi, A., Sharma, S. K., & Gurtoo, S. A. (2006). A study of the neurological disorders during pregnancy and puerperium. Annals of the Indian Academy of Neurology, 9, 152–157.CrossRefGoogle Scholar
  16. Harden, C. L. (2005). Polycystic ovaries and polysystic ovary syndrome in epilepsy: evidence for neurogonadal disease. Epilepsy current, 5, 142–146.CrossRefGoogle Scholar
  17. Herzog, A. G. (2000). Hormones and epilepsy. Acta Neurologica Scandinavica, 105, 5.CrossRefGoogle Scholar
  18. Herzog, A. G. (2006). Menstrual disoreders in women with epilepsy. Neurology, 66, S23–S28.PubMedCrossRefGoogle Scholar
  19. Herzog, A. G. (2007). Hormones and menopause. Retrieved from the World Wide Web on June 14, 2007, from….
  20. Herzog, A. G., Coleman, A. E., Jacobs, A. R., Klein, P., Friedman, M. N., Drislane, F. W., et al. (2003). Interictal EEG discharges, reproductive hormones, and menstrual disorders in epilepsy. Annals of Neurology, 54, 625–637.PubMedCrossRefGoogle Scholar
  21. Herzog, A. G., Harden, C. L., Liporace, J., Pennell, P., Schomer, D. L., Sperling, M., et al. (2004). Catamenial epilepsy: the elusive condition. Annals of Neurology, 56, 431–434.PubMedCrossRefGoogle Scholar
  22. Herzog, A. G., Klein, P., & Ransil, B. J. (1997). Three patterns of catamenial epilepsy. Epilepsia, 38, 1082–1088.PubMedCrossRefGoogle Scholar
  23. Jette, N., & Morrell, M. J. (2005). Sex-steroid hormones in women with epilepsy. American Journal of Endochronology, 45, 36–48.Google Scholar
  24. Johnson, J. R., & Leschziner, G. D. (2006). Complications of chronic therapy with antiepileptic drugs. Neurologist, 12, 163–167.CrossRefGoogle Scholar
  25. Kampman, M. T., Johansen, S., Stenvold, H., & Acharya, G. (2005). Management of women with epilepsy: are guidelines being followed? Results from case-not reviews and a patient questionnaire. Epilepsia, 46, 1286–1292.PubMedCrossRefGoogle Scholar
  26. McAuley, J. W., & Anderson, G. D. (2002). Treatment of epilepsy in women of reproductive age: pharmacokinetic considerations. Clinical Pharmacology, 41, 559–579.CrossRefGoogle Scholar
  27. Mead, L. A., & Hampson, E. (1996). Asymmetric effects of ovarian hormones on hemispheric activity: evidence from dichotic and tachistoscopic tests. Neuropsychology, 10, 578–587.CrossRefGoogle Scholar
  28. Meador, K. J., & Zupanc, M. L. (2004). Neurodevelopmental outcomes of children born to mothers with epilepsy. Clevand Clinic Journal of Medicine, 71(Suppl. 2), S38–S41.CrossRefGoogle Scholar
  29. Mikkonen, K., Vainionpaa, L. K., Pakarinen, A. J., Knip, M., Jarvela, I. Y., Tapanainen, J. S., & Isojarvi, J. I. (2004). Long-term reproductive endocrine health in young women with epilepsy during puberty. Neurology, 62, 445–450.PubMedGoogle Scholar
  30. Morey, S. S. (1999). Neurologic group develops recommendations for management of epilepsy. American Family Physician, 59, 2648–2653.PubMedGoogle Scholar
  31. Morrell, M. J. (2007). Seizures and women over the life span. Retrieved from the World Wide Web on June 14, 2007, from….
  32. National Institutes of Health. (2007). Polycystic ovary syndrome (PCOS). Retrieved from the World Wide Web on June 17, 2007, from
  33. National Institute of Neurological Disorders and Stroke. (2007). Seizures and epilepsy: hope through research. Retrieved from the World Wide Web on June 28, 2007, from http://www.ninds.nih.ogv/disorders/epilepsy/detail_epilepsy. htm#92343109.
  34. Penovich, P. E., Eck, K. E., & Economou, V. V. (2004). Recommendations for the care of women with epilepsy. Cleveland Clinic Journal of Medicine, 71(Suppl. 2), S49–S57.PubMedCrossRefGoogle Scholar
  35. Reimers, A., Helde, G., & Brodtkorb, E. (2005). Ethinyl estradiol, not progestogens, reduces lamotrigine serum concentrations. Epilepsia, 46, 1414–1417.PubMedCrossRefGoogle Scholar
  36. Reynolds, E. H. (2001). /LAE/IBE/WHO Global Campaign “Out of the Shadows”: Global and regional developments. Epilepsia, 42, 1094–1100.Google Scholar
  37. Saramma, P. P., Thomas, S. V., & Sarma, P. S. (2006). Child rearing issues for mothers with epilepsy: a case control study. Annals of the Indian Academy of Neurology, 9, 158–162.CrossRefGoogle Scholar
  38. Tan, N. C. K., Mulley, J. C., & Berkovic, S. F. (2004). Genetic associations studies in epilepsy: “The truth is out there”. Epilepsia, 45, 1429–1442.PubMedCrossRefGoogle Scholar
  39. Tettenborn, B. (2006). Management of epilepsy in women of childbearing age: practical recommendations. CNS Drugs, 20, 373–387.PubMedCrossRefGoogle Scholar
  40. Thomas, S. V. (2006). Management of epilepsy and pregnancy. Journal of Postgraduate Medicine, 52, 57–64.PubMedGoogle Scholar
  41. Vajda, F. J. E., Hitchcock, A., Graham, J., Solinas, C., O’Brien, T. J., Lander, C. M., & Eadie, M. J. (2006). Foetal malformations and seizure control: 52 months data of the Australian Pregnancy Registry. European Journal of Neurology, 13, 645–654.PubMedCrossRefGoogle Scholar
  42. Vinayan, K. R., & Nisha, B. (2006). Epilepsy, antiepileptic drugs and bone health. Annuals of the Indian Academy of Neurology, 9, 90–97.CrossRefGoogle Scholar
  43. World Health Organization. (2006). Safety and efficacy issues. WHO Drug Information, 20, 246–247.Google Scholar
  44. Yerby, M. S. (2001). Neurological management of women with epilepsy. Retrieved from the World Wide Web on June 28, 2007, from
  45. Yerby, M. S., Kaplan, P., Tran, T. (2004). Risks and Management of Pregnancy in women with epilepsy. Cleveland Clinic Journal of Medicine, 71, S25–S37.Google Scholar
  46. Yerby, M. S. (2006). Pregnancy and the mother with epilepsy. Retrieved from the World Wide Web on June 28, 2007, from
  47. Yerby, M. S., & Cawthon, M. L. (2007). Infant mortality of infants of mothers with epilepsy. Retrieved from the World Wide Web on June 28, 2007, from

Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Elaine Fletcher-Janzen
    • 1
  1. 1.Private PracticeCleveland

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