T-Cell Signalling, a Complex Process for T-Cell Activation Compromised with Aging: When Membrane Rafts Can Simplify Everything

  • Tamas Fulop
  • Graham Pawelec
  • Carl Fortin
  • Anis Larbi
Part of the Medical Intelligence Unit book series (MIUN)


Aging is associated with altered immune responsiveness, termed “immunosenescence”. It is now well accepted that both arms of the immune system, innate as well as adaptive, undergo immunosenescence. However, the adaptive immune response and especially T-cells are the most affected by aging. Aging is associated with both changes in lymphocytes subpopulations and, importantly, functional changes within these subsets. Indeed, T-cells present functional modifications resulting in a decreased clonal expansion and interleukin-2 production as well as a shift in Th1/Th2 response with aging. Identifying alterations in the activation process involving the TCR, CD28 and IL-2 receptor signalling cascades are crucial to understanding immunoseneescence. The putative reasons for this altered activation of T-cells with aging will be reviewed here, based on our own recent work and international collaborations.


Lipid Raft Clonal Expansion Membrane Raft Immune Synapse Plasma Membrane Microdomains 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Landes Bioscience and Springer Science+Business Media 2007

Authors and Affiliations

  • Tamas Fulop
    • 2
  • Graham Pawelec
    • 2
  • Carl Fortin
    • 2
  • Anis Larbi
    • 1
  1. 1.Tübingen Ageing and Tumour Immunology Group Center for Medical ResearchUniversity of Tübingen Medical SchoolTübingenGermany
  2. 2.Research Center on Aging, Immunology Program, Geriatric Division, Faculty of MedicineUniversity of SherbrookeSherbrookeCanada

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