A Matter of Life and Death of T-Lymphocytes in Immunosenescence

  • Sudhir Gupta
Part of the Medical Intelligence Unit book series (MIUN)


Aging is associated with progressive decline in T-cell functions. A number of mechanisms have been proposed to explain immunosenescence. In this chapter I will discuss a role of apoptosis of T-lymphocytes in immunosenescence. Molecular signaling of different pathways of apoptosis and their alterations in human aging will be reviewed.


Death Receptor Aged Human Intermembrane Space Central Memory Receptor Interactive Protein 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Landes Bioscience and Springer Science+Business Media 2007

Authors and Affiliations

  • Sudhir Gupta
    • 1
  1. 1.Medical Sciences I, C-240University of CaliforniaIrvineUSA

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