A Matter of Life and Death of T-Lymphocytes in Immunosenescence

  • Sudhir Gupta
Part of the Medical Intelligence Unit book series (MIUN)


Aging is associated with progressive decline in T-cell functions. A number of mechanisms have been proposed to explain immunosenescence. In this chapter I will discuss a role of apoptosis of T-lymphocytes in immunosenescence. Molecular signaling of different pathways of apoptosis and their alterations in human aging will be reviewed.


Death Receptor Aged Human Intermembrane Space Central Memory Receptor Interactive Protein 


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Copyright information

© Landes Bioscience and Springer Science+Business Media 2007

Authors and Affiliations

  • Sudhir Gupta
    • 1
  1. 1.Medical Sciences I, C-240University of CaliforniaIrvineUSA

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