Immune Risk Phenotypes and Associated Parameters in Very Old Humans: A Review of Findings in the Swedish NONA Immune Longitudinal Study

  • Anders Wikby
  • Frederick Ferguson
  • Jan Strindhall
  • Rosalyn J. Forsey
  • Tamas Fulop
  • Sine Reker Hadrup
  • Per thor Straten
  • Graham Pawelec
  • Boo Johansson
Part of the Medical Intelligence Unit book series (MIUN)


In the previous OCTO immune longitudinal study of free-living subjects >85 yr. selected for good health, we identified an Immune Risk Phenotype (IRP) associated with increased mortality. The IRP was characterised by high CD8+, low CD4+ T-cell counts and a poor T-cell proliferative response, inversion of the CD4/CD8 ratio and evidence of persistent cytomegalovirus infection. In the NONA immune longitudinal study the aim was to examine whether the same IRP parameters applied to a population-based sample aged 86–94 years who were not selected for very good health. More sophisticated analytical parameters were studied, as well as the role of inflammatory processes in relation to longevity. The immune panel included the analysis of T-cell subsets inflammatory markers, virus serology, cytokines, TCR clonotype mapping and functional and phenotypic analysis of virus-specific CD8+ cells by HLA/peptide multimers, in collaborations between participants of the EU funded T-CIA project.

The present review of findings from a 6 year study of Swedish nonagenarians focuses on the IRP and its associations with persistent virus infection, CD8+ T-cell differentiation, cytokines, cognitive functioning, inflammatory activity, virus-specific CD8+ cells and CD8+ T-cell clonal expansions. It also reports on low grade inflammation processes of importance in predicting longevity in very late life.


Clonal Expansion Late Life Allostatic Load Persistent Virus Infection Immune Risk Profile 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Landes Bioscience and Springer Science+Business Media 2007

Authors and Affiliations

  • Anders Wikby
    • 7
  • Frederick Ferguson
    • 1
  • Jan Strindhall
    • 7
  • Rosalyn J. Forsey
    • 2
  • Tamas Fulop
    • 3
  • Sine Reker Hadrup
    • 7
    • 4
  • Per thor Straten
    • 4
  • Graham Pawelec
  • Boo Johansson
    • 5
    • 6
  1. 1.Department of Veterinary Science College of Agricultural SciencesPennsylvania State UniversityUniversity ParkUSA
  2. 2.LCG BioscienceCambridgeUK
  3. 3.Research Center on Aging Immunology Graduate Program Geriatric DivisionUniversity of SherbrookeSherbrookeCanada
  4. 4.Tumor Immunology Group Institute of Cancer BiologyDanish Cancer SocietyCopenhagenDenmark
  5. 5.Institute of Gerontology School of Health SciencesJönköping UniversityJönköpingSweden
  6. 6.Department of PsychologyGöteborg UniversityGöteborgSweden
  7. 7.Department of Natural Science and Biomedicine, School of Health SciencesJönköping UniversityJönköpingSweden

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