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Immune Risk Phenotypes and Associated Parameters in Very Old Humans: A Review of Findings in the Swedish NONA Immune Longitudinal Study

  • Chapter
Immunosenescence

Part of the book series: Medical Intelligence Unit ((MIUN))

Abstract

In the previous OCTO immune longitudinal study of free-living subjects >85 yr. selected for good health, we identified an Immune Risk Phenotype (IRP) associated with increased mortality. The IRP was characterised by high CD8+, low CD4+ T-cell counts and a poor T-cell proliferative response, inversion of the CD4/CD8 ratio and evidence of persistent cytomegalovirus infection. In the NONA immune longitudinal study the aim was to examine whether the same IRP parameters applied to a population-based sample aged 86–94 years who were not selected for very good health. More sophisticated analytical parameters were studied, as well as the role of inflammatory processes in relation to longevity. The immune panel included the analysis of T-cell subsets inflammatory markers, virus serology, cytokines, TCR clonotype mapping and functional and phenotypic analysis of virus-specific CD8+ cells by HLA/peptide multimers, in collaborations between participants of the EU funded T-CIA project.

The present review of findings from a 6 year study of Swedish nonagenarians focuses on the IRP and its associations with persistent virus infection, CD8+ T-cell differentiation, cytokines, cognitive functioning, inflammatory activity, virus-specific CD8+ cells and CD8+ T-cell clonal expansions. It also reports on low grade inflammation processes of importance in predicting longevity in very late life.

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Author information

Authors and Affiliations

  1. Department of Veterinary Science College of Agricultural Sciences, Pennsylvania State University, University Park, Pennsylvania, USA

    Frederick Ferguson

  2. LCG Bioscience, Bourn, Cambridge, UK

    Rosalyn J. Forsey

  3. Research Center on Aging Immunology Graduate Program Geriatric Division, University of Sherbrooke, Sherbrooke, Quebec, Canada

    Tamas Fulop

  4. Tumor Immunology Group Institute of Cancer Biology, Danish Cancer Society, Copenhagen, Denmark

    Sine Reker Hadrup & Per thor Straten

  5. Institute of Gerontology School of Health Sciences, Jönköping University, Jönköping, Sweden

    Boo Johansson

  6. Department of Psychology, Göteborg University, Göteborg, Sweden

    Boo Johansson

  7. Department of Natural Science and Biomedicine, School of Health Sciences, Jönköping University, Box 1026, 551 11, Jönköping, Sweden

    Anders Wikby, Jan Strindhall & Sine Reker Hadrup

Authors
  1. Anders Wikby
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  2. Frederick Ferguson
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  3. Jan Strindhall
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  4. Rosalyn J. Forsey
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  5. Tamas Fulop
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  6. Sine Reker Hadrup
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  7. Per thor Straten
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  8. Graham Pawelec
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  9. Boo Johansson
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© 2007 Landes Bioscience and Springer Science+Business Media

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Wikby, A. et al. (2007). Immune Risk Phenotypes and Associated Parameters in Very Old Humans: A Review of Findings in the Swedish NONA Immune Longitudinal Study. In: Immunosenescence. Medical Intelligence Unit. Springer, New York, NY. https://doi.org/10.1007/978-0-387-76842-7_1

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