Reelin/Dab1 Signaling in the Developing Cerebral Cortex

  • Eric C. Olson
  • Christopher A. Walsh


Mice lacking the cytoplasmic adapter protein Dab1 (Disabled homolog-1) display histological defects in the central nervous system (CNS) that are essentially indistinguishable from those observed in the reeler mouse. Dab1 is expressed in virtually all Reelin-responsive cells and is rapidly phosphorylated in response to Reelin application. The finding of a near identity in phenotype, coupled with a direct biochemical response to Reelin, has raised great interest in understanding Dab1 function, both as an exemplar of an adapter protein with a profound phenotypic contribution, and as a means of decoding mechanisms of Reelin signaling. What has emerged from these studies is a surprisingly complex picture of Dab1 at the genomic, mRNA, protein, and functional levels. This chapter will summarize some of the key features of Dab1, and its role as a transducer of the Reelin signal in the developing cerebral cortex.


Marginal Zone Reeler Mouse Reelin Signaling Neuronal Position Dab1 Expression 
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Copyright information

© Springer 2008

Authors and Affiliations

  • Eric C. Olson
    • 1
  • Christopher A. Walsh
    • 2
  1. 1.Department of Neuroscience and PhysiologySUNY Upstate Medical UniversitySyracuse
  2. 2.Howard Hughes Medical Institute, BIDMC, Division of Genetics, Boston Children’s HospitalHarvard Medical SchoolBoston

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