Reelin is a large glycoprotein with a repetitive modular structure (D’Arcangelo and Curran, 1999). It consists of a signal sequence, an F-spondin-like region, another region containing at least eight “reelin repeats,” and a C-terminal basic peptide of ∼30 residues (Fig. 5.1A). Each complete reelin repeat contains a central EGF module flanked by two subrepeats of 150–190 amino acids (Fig. 5.1A, inset). The central EGF module is relatively short in length (∼30 residues), but nevertheless has consensus signatures, including the spacings between cysteines (Campbell and Bork, 1993). Although the homology between subrepeat A and subrepeat B was first noted during the cloning of the reelin gene (D’Arcangelo et al., 1995), these repeats have failed to show any sequence homology to known protein domains.
KeywordsRoot Mean Square Concave Side Clostridium Thermocellum Reelin Gene Reelin Protein
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