Apolipoprotein E Receptor 2 and Very-Low-Density Lipoprotein Receptor: An Overview

  • Hans H. Bock
  • Joachim Herz

It is now well established that members of the low-density lipoprotein (LDL) receptor gene family are crucial regulators of different aspects of neuronal development, synaptic plasticity, maintenance of neuronal homeostasis, and neurodegeneration. This was highlighted in particular by the discovery that the lipoprotein receptors apolipoprotein E receptor-2 (ApoER2) and very-low-density lipoprotein receptor (VLDLR) function as receptors for the neuronal signaling protein Reelin. In this chapter, we will briefly introduce the family of LDL receptor-related proteins and review the functions of its members ApoER2 and VLDLR as Reelin receptors and their role in the developing and adult brain.


Lipoprotein Receptor ApoE Receptor Reelin Signaling Regulate Intramembrane Proteolysis NPXY Motif 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer 2008

Authors and Affiliations

  • Hans H. Bock
    • 1
  • Joachim Herz
    • 1
    • 2
  1. 1.Zentrum für NeurowissenschaftenUniversität FreiburgFreiburgGermany
  2. 2.Department of Molecular GeneticsUniversity of Texas Southwestern Medical CenterDallas

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