Reelin, as an extracellular glycoprotein involved in neuronal migration and cerebral cortex layering pattern, has received much attention since the discovery of the gene responsible for the disturbed central nervous system development in the reeler mouse, because of its fundamental functions in cerebral development, its modulatory effects on synaptic plasticity in adult rodents, and its potential involvement in psychiatric disorders (for recent reviews and references see: Jossin, 2004; D’Arcangelo, 2005; Fatemi, 2005; Forster et al., 2006; Herz and Chen, 2006). Our knowledge about effects that reelin may have on peripheral organs, however, remains very scarce. Reelin mRNA and protein have been detected during development and adulthood in several peripheral organs. In the present chapter, we will focus on the presence of reelin in liver and lymphatics and discuss some hypotheses about the functional significance of this presence.
KeywordsStellate Cell Hepatic Stellate Cell Lipoprotein Receptor Peripheral Organ Lymphatic Endothelial Cell
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- Botella-Lopez, A., Burgaya, F., Gavin, R., Garcia-Ayllon, M.S., Gomez-Tortosa, E., Pena-Casanova, J., Urena, J.M., Del Rio, J.A., Blesa, R., Soriano, E., and Saez-Valero, J. (2006). Reelin expression and glycosylation patterns are altered in Alzheimer’s disease. Proc. Natl. Acad. Sci. USA 103: 5573-5578.CrossRefPubMedGoogle Scholar
- Hirotsune, S., Takahara, T., Sasaki, N., Hirose, K., Yoshiki, A., Ohashi, T., Kusakabe, M., Murakami, Y., Muramatsu, M., Watanabe, S., Nakao, K., Katsuki, M., and Hayashizaki, Y. (1995). The reeler gene encodes a protein with an EGF-like motif expressed by pioneer neu-rons. Nature Genet. 10: 77-83.CrossRefPubMedGoogle Scholar
- Kim, D. H., Iijima, H., Goto, K., Ishii, H., Kim, H. J., Suzuki, H., Kondo, H., Saeki, S., and Yamamoto, T. (1996). Human apolipoprotein E receptor 2. A novel lipoprotein receptor of the low density lipoprotein receptor family predominantly expressed in brain. J. Biol. Chem. 271: 8373-8380.CrossRefPubMedGoogle Scholar
- Kobold, D., Grundmann, A., Piscaglia, F., Eisenbach, C., Neubauer, K., Steffgen, J., Ramadori, G., and Knittel, T. (2002). Expression of reelin in hepatic stellate cells and during hepatic tissue repair: a novel marker for the differentiation of HSC from other liver myofibroblasts. J. Hepatol. 36: 607-613.CrossRefPubMedGoogle Scholar
- Samama, B., and Boehm, N. (2005). Reelin immunoreactivity in lymphatics and liver during development and adult life. Anat. Rec. A 285: 595-599.Google Scholar
- Smalheiser, N. R., Costa, E., Guidotti, A., Impagnatiello, F., Auta, J., Lacor, P., Kriho, V., and Pappas, G. D. (2000). Expression of reelin in adult mammalian blood, liver, pituitary pars intermedia, and adrenal chromaffin cells. Proc. Natl. Acad. Sci. USA 97: 1281-1286.CrossRefPubMedGoogle Scholar
- Wilting, J., and Becker, J. (2006). Two endothelial cell lines derived from the somite. Anat. Embryol. (Berl.) 211 (Suppl. 7): 57-63.Google Scholar